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Remote ischaemic pre-conditioning, kidney injury, and outcomes after coronary angiography and intervention: a randomized trial 冠状动脉造影和介入治疗后的远程缺血预处理、肾损伤和预后：随机试验
IF 39.3 1区 医学
European Heart Journal Pub Date : 2025-03-11 DOI: 10.1093/eurheartj/ehaf135
Ping Jia, Gang Zhao, Yuli Huang, Zhouping Zou, Qi Zeng, Weize Chen, Ting Ren, Yang Li, Xiaoyan Wang, Tingting Kang, Zhihe Liu, Mengqing Ma, Jiwei Yu, Qiong Wu, Bing Deng, Xiaoxiang Yan, Xin Wan, Xin Chen, Changchun Cao, Junbo Ge, Xiaoqiang Ding
{"title":"Remote ischaemic pre-conditioning, kidney injury, and outcomes after coronary angiography and intervention: a randomized trial","authors":"Ping Jia, Gang Zhao, Yuli Huang, Zhouping Zou, Qi Zeng, Weize Chen, Ting Ren, Yang Li, Xiaoyan Wang, Tingting Kang, Zhihe Liu, Mengqing Ma, Jiwei Yu, Qiong Wu, Bing Deng, Xiaoxiang Yan, Xin Wan, Xin Chen, Changchun Cao, Junbo Ge, Xiaoqiang Ding","doi":"10.1093/eurheartj/ehaf135","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf135","url":null,"abstract":"Background and Aims Remote ischaemic pre-conditioning (RIPC) delivered shortly prior to an angiographic procedure may reduce contrast-associated acute kidney injury (CA-AKI). Whether a longer interval between RIPC and contrast administration also reduces CA-AKI and post-procedural complications after coronary angiography (CAG) or percutaneous coronary intervention (PCI) is unknown. Methods This was a multicentre, randomized trial of patients at risk of CA-AKI undergoing elective CAG or PCI comparing delayed RIPC (four cycles of 5 min inflations on one upper arm 24 h before the procedure) with sham RIPC. The primary endpoint was the incidence of AKI, defined according to the Kidney Disease Improving Global Outcomes criteria. Secondary endpoints included renal replacement therapy during hospitalization, changes in urinary biomarkers of kidney injury, and occurrence of non-fatal myocardial infarction, stroke, re-hospitalization, and all-cause mortality by day 90. Results Altogether, 501 patients (age, 74 [66, 78] years) were randomly assigned to delayed (n = 250) or sham (n = 251) RIPC, of which 467 (93.2%) completed outcome assessments at day 90. The incidence of CA-AKI was 7.6% with sham and 3.2% with delayed RIPC (odds ratio 0.4, 95% confidence interval 0.17–0.94; P = .03). The trial was not adequately powered to show effects on secondary outcomes. Conclusions Among at-risk patients undergoing CAG or PCI, the incidence of CA-AKI was lower in patients receiving delayed compared with sham RIPC. These results should be confirmed in larger trials to investigate whether reductions in CA-AKI with delayed RIPC lead to important clinical benefits.","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"54 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143599828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epicardial adipose tissue and malignant ventricular arrhythmias in phospholamban p.(Arg14del) variant carriers.
IF 37.6 1区 医学
European Heart Journal Pub Date : 2025-03-11 DOI: 10.1093/eurheartj/ehaf118
Belend Mahmoud, Moniek G P J Cox, Remco de Brouwer, Myrthe Y C van der Heide, Thomas M Gorter, Laura M G Meems, Arthur A M Wilde, Dirk J van Veldhuisen, Rudolf A de Boer, B Daan Westenbrink
{"title":"Epicardial adipose tissue and malignant ventricular arrhythmias in phospholamban p.(Arg14del) variant carriers.","authors":"Belend Mahmoud, Moniek G P J Cox, Remco de Brouwer, Myrthe Y C van der Heide, Thomas M Gorter, Laura M G Meems, Arthur A M Wilde, Dirk J van Veldhuisen, Rudolf A de Boer, B Daan Westenbrink","doi":"10.1093/eurheartj/ehaf118","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf118","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":""},"PeriodicalIF":37.6,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143603815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cardiovascular safety of assisted reproductive technologies: what have we learned and what remains unknown?
IF 37.6 1区 医学
European Heart Journal Pub Date : 2025-03-11 DOI: 10.1093/eurheartj/ehaf108
Zhenjiao Liang, Dongna Wang, Xiaoping Wang
{"title":"Cardiovascular safety of assisted reproductive technologies: what have we learned and what remains unknown?","authors":"Zhenjiao Liang, Dongna Wang, Xiaoping Wang","doi":"10.1093/eurheartj/ehaf108","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf108","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":""},"PeriodicalIF":37.6,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143603470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cardiovascular safety of assisted reproductive technologies: what is next?
IF 37.6 1区 医学
European Heart Journal Pub Date : 2025-03-11 DOI: 10.1093/eurheartj/ehaf088
Carlo Andrea Pivato, Giulio Stefanini
{"title":"Cardiovascular safety of assisted reproductive technologies: what is next?","authors":"Carlo Andrea Pivato, Giulio Stefanini","doi":"10.1093/eurheartj/ehaf088","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf088","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":""},"PeriodicalIF":37.6,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143603558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Oral health benefits and safety of xylitol and potential cardiovascular risk: questioning the validity of the model of Witkowski et al.
IF 37.6 1区 医学
European Heart Journal Pub Date : 2025-03-11 DOI: 10.1093/eurheartj/ehaf058
Gregory C Valentine, Eva Söderling, Peter Milgrom
{"title":"Oral health benefits and safety of xylitol and potential cardiovascular risk: questioning the validity of the model of Witkowski et al.","authors":"Gregory C Valentine, Eva Söderling, Peter Milgrom","doi":"10.1093/eurheartj/ehaf058","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf058","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":""},"PeriodicalIF":37.6,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143603822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Xylitol and cardiovascular risks.
IF 37.6 1区 医学
European Heart Journal Pub Date : 2025-03-11 DOI: 10.1093/eurheartj/ehaf059
Marco Witkowski, Stanley L Hazen
{"title":"Xylitol and cardiovascular risks.","authors":"Marco Witkowski, Stanley L Hazen","doi":"10.1093/eurheartj/ehaf059","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf059","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":""},"PeriodicalIF":37.6,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143603751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cardiology in Armenia: reflecting on progress and challenges.
IF 37.6 1区 医学
European Heart Journal Pub Date : 2025-03-10 DOI: 10.1093/eurheartj/ehaf065
Hamlet G Hayrapetyan, Parounak H Zelveian, Aram Chilingaryan
{"title":"Cardiology in Armenia: reflecting on progress and challenges.","authors":"Hamlet G Hayrapetyan, Parounak H Zelveian, Aram Chilingaryan","doi":"10.1093/eurheartj/ehaf065","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf065","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":""},"PeriodicalIF":37.6,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Systematic review and meta-analysis of cardiovascular outcome trials: importance of post hoc studies.
IF 37.6 1区 医学
European Heart Journal Pub Date : 2025-03-10 DOI: 10.1093/eurheartj/ehaf089
Alireza Oraii, Jeff S Healey, William F McIntyre
{"title":"Systematic review and meta-analysis of cardiovascular outcome trials: importance of post hoc studies.","authors":"Alireza Oraii, Jeff S Healey, William F McIntyre","doi":"10.1093/eurheartj/ehaf089","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf089","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":""},"PeriodicalIF":37.6,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Double counting in meta-analyses: a statistical complication in cardiovascular medicine trials.
IF 37.6 1区 医学
European Heart Journal Pub Date : 2025-03-10 DOI: 10.1093/eurheartj/ehaf086
Shivani Mehta, Ernesto Calderon Martinez
{"title":"Double counting in meta-analyses: a statistical complication in cardiovascular medicine trials.","authors":"Shivani Mehta, Ernesto Calderon Martinez","doi":"10.1093/eurheartj/ehaf086","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf086","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":""},"PeriodicalIF":37.6,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Great debate: default duration of dual antiplatelet treatment after percutaneous coronary intervention in acute coronary syndrome should be 12 months.
IF 37.6 1区 医学
European Heart Journal Pub Date : 2025-03-08 DOI: 10.1093/eurheartj/ehaf070
Robert A Byrne, Marco Valgimigli, Deepak L Bhatt, J J Coughlan, C Michael Gibson, Xavier Rossello, Diana A Gorog, Borja Ibanez, Stefan James, Antonio Landi, P Gabriel Steg, Gregg W Stone, Felicita Andreotti
{"title":"Great debate: default duration of dual antiplatelet treatment after percutaneous coronary intervention in acute coronary syndrome should be 12 months.","authors":"Robert A Byrne, Marco Valgimigli, Deepak L Bhatt, J J Coughlan, C Michael Gibson, Xavier Rossello, Diana A Gorog, Borja Ibanez, Stefan James, Antonio Landi, P Gabriel Steg, Gregg W Stone, Felicita Andreotti","doi":"10.1093/eurheartj/ehaf070","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf070","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":""},"PeriodicalIF":37.6,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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