European Heart Journal最新文献

{"title":"Correction to: Optimal medical care and coronary flow capacity-guided myocardial revascularization vs usual care for chronic coronary artery disease: the CENTURY trial.","authors":"","doi":"10.1093/eurheartj/ehaf446","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf446","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":""},"PeriodicalIF":37.6,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144527000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of multiple embryonal rhabdomyosarcoma in left atrium.","authors":"Jinping Li, Hongyu Huang, Fengxu Yu","doi":"10.1093/eurheartj/ehaf147","DOIUrl":"10.1093/eurheartj/ehaf147","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":"2354"},"PeriodicalIF":37.6,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Timing of coffee consumption and mortality: a critical perspective.","authors":"Fan Zhang, Chang Liu, Min Cao","doi":"10.1093/eurheartj/ehaf154","DOIUrl":"10.1093/eurheartj/ehaf154","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":"2351"},"PeriodicalIF":37.6,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"European Research Council-funded grant: maintenance of platelet homeostasis.","authors":"Dulce Papy-Garcia, Omer Dushek, Yotis A Senis","doi":"10.1093/eurheartj/ehae881","DOIUrl":"10.1093/eurheartj/ehae881","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":"2258-2260"},"PeriodicalIF":37.6,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early and multicomponent intervention after adverse pregnancy outcomes: an opportunity to win hearts and minds.","authors":"Abbi D Lane","doi":"10.1093/eurheartj/ehaf381","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf381","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"27 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early and multicomponent intervention after adverse pregnancy outcomes: an opportunity to win hearts and minds.","authors":"Abbi D Lane","doi":"10.1093/eurheartj/ehaf381","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf381","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":""},"PeriodicalIF":37.6,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144505239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immune checkpoint inhibitor-associated myocarditis: a novel risk score.","authors":"John R Power, Charles Dolladille, Benay Ozbay, Adrien Procureur, Stephane Ederhy, Nicolas L Palaskas, Lorenz H Lehmann, Jennifer Cautela, Pierre-Yves Courand, Salim S Hayek, Han Zhu, Vlad G Zaha, Richard K Cheng, Joachim Alexandre, François Roubille, Lauren A Baldassarre, Yen-Chou Chen, Alan H Baik, Michal Laufer-Perl, Yuichi Tamura, Aarti Asnani, Sanjeev Francis, Elizabeth M Gaughan, Peter P Rainer, Guillaume Bailly, Danette Flint, Dimitri Arangalage, Eve Cariou, Roberta Florido, Anna Narezkina, Yan Liu, Shahneen Sandhu, Darryl Leong, Nahema Issa, Nicolas Piriou, Lucie Heinzerling, Giovanni Peretto, Shanthini M Crusz, Nausheen Akhter, Joshua E Levenson, Isik Turker, Assié Eslami, Charlotte Fenioux, Pedro Moliner, Michel Obeid, Wei Ting Chan, Stephen M Ewer, Seyed Ebrahim Kassaian, Douglas B Johnson, Anju Nohria, Osnat Itzhaki Ben Zadok, Javid J Moslehi, Joe-Elie Salem","doi":"10.1093/eurheartj/ehaf315","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf315","url":null,"abstract":"<p><strong>Background and aims: </strong>Immune checkpoint inhibitors (ICI) are associated with life-threatening myocarditis but milder presentations are increasingly recognized. The same autoimmune process that causes ICI myocarditis can manifest concurrent generalized myositis, myasthenia-like syndrome, and respiratory muscle failure. Prognostic factors for this 'cardiomyotoxicity' are lacking. The main aim of this study was to determine predictors and construct a risk score associated with negative outcomes in patients admitted for ICI myocarditis.</p><p><strong>Methods: </strong>A multicentre registry collected data retrospectively from 17 countries between 2014 and 2023. A multivariable Cox regression model was used to determine risk factors for the primary composite outcome: time to severe arrhythmia, heart failure, respiratory muscle failure, and/or cardiomyotoxicity-related death. Covariates included demographics, comorbidities, cardiomuscular symptoms, diagnostics, and treatments. Time-dependent covariates were used, and missing data were imputed. A point-based prognostic risk score was derived and externally validated.</p><p><strong>Results: </strong>In 748 patients (67% male, age 23-94 years), 30-day incidence of the primary composite outcome, cardiomyotoxic death, and overall death were 33%, 13%, and 17%, respectively. By multivariable analysis, the primary composite outcome was associated with active thymoma (hazard ratio [HR] 3.6, 95% confidence interval [CI] 1.7-7.7), presence of cardiomuscular symptoms (HR 2.6 [1.5-4.2]), low QRS voltage on presenting electrocardiogram (HR for ≤0.5 mV vs >1 mV 1.9 [1.1-3.1]), left ventricular ejection fraction (LVEF) < 50% (HR 1.7 [1.1-2.6]), and incremental troponin elevation (HR 1.8 [1.4-2.4], 2.9 [1.8-4.7], and 4.6 [2.3-9.3], for 20, 200, and 2000-fold above upper reference limit, respectively). A prognostic risk score developed using these parameters showed good performance; 30-day primary outcome incidence increased gradually from 4% (risk score = 0) to 81% (risk score ≥ 4). This risk score was externally validated in two independent French and US cohorts. This risk score was used prospectively in the external French cohort to identify low-risk patients who were managed with no immunosuppression resulting in no cardiomyotoxic events.</p><p><strong>Conclusions: </strong>ICI-associated myocarditis can manifest with high morbidity and mortality. Myocarditis severity is associated with magnitude of troponin, thymoma, low QRS voltage, depressed LVEF, and cardiomuscular symptoms. A risk score incorporating these features performed well.</p><p><strong>Clinical trial registration: </strong>NCT04294771 and NCT05454527.</p>","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":""},"PeriodicalIF":37.6,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144505240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plaque erosion: unmasking the complexity of atherosclerotic disease.","authors":"Gerard Pasterkamp, Hester M den Ruijter, Michal Mokry","doi":"10.1093/eurheartj/ehaf197","DOIUrl":"10.1093/eurheartj/ehaf197","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":"2220-2222"},"PeriodicalIF":37.6,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obesity accelerates cardiovascular ageing.","authors":"Celia Ruperez, Frank Madeo, Rafael de Cabo, Guido Kroemer, Mahmoud Abdellatif","doi":"10.1093/eurheartj/ehaf216","DOIUrl":"10.1093/eurheartj/ehaf216","url":null,"abstract":"<p><p>A global obesity pandemic, coupled with an increasingly ageing population, is exacerbating the burden of cardiovascular disease. Indeed, clinical and experimental evidence underscores a potential connection between obesity and ageing in the pathogenesis of various cardiovascular disorders. This is further supported by the notion that weight reduction not only effectively reduces major cardiovascular events in elderly individuals but is also considered the gold standard for lifespan extension, in obese and non-obese model organisms. This review evaluates the intricate interplay between obesity and ageing from molecular mechanisms to whole organ function within the cardiovascular system. By comparatively analysing their characteristic features, shared molecular and cell biological signatures between obesity and ageing are unveiled, with the intent to shed light on how obesity accelerates cardiovascular ageing. This review also elaborates on how emerging metabolic interventions targeting obesity might protect from cardiovascular diseases largely through antagonizing key molecular mechanisms of the ageing process itself. In sum, this review aims to provide valuable insight into how understanding these interconnected processes could guide the development of novel and effective cardiovascular therapeutics for a growing aged population with a concerning obesity problem.</p>","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":"2161-2185"},"PeriodicalIF":37.6,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12167665/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SiglecF+ neutrophils link periodontitis to impaired post-myocardial infarction repair.","authors":"Hatim Boughanem, Andrea Herrero-Cervera, Oliver Soehnlein","doi":"10.1093/eurheartj/ehaf165","DOIUrl":"10.1093/eurheartj/ehaf165","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":"2239-2241"},"PeriodicalIF":37.6,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}