European Heart Journal最新文献

{"title":"The year in cardiovascular medicine 2024: the top 10 papers in heart failure.","authors":"Johann Bauersachs, Shelley Zieroth, Rudolf A de Boer","doi":"10.1093/eurheartj/ehaf017","DOIUrl":"10.1093/eurheartj/ehaf017","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":"1014-1016"},"PeriodicalIF":37.6,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143022762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How can we counsel patients desiring subsequent pregnancy after peripartum cardiomyopathy?","authors":"Olayinka Agboola, Garima Sharma","doi":"10.1093/eurheartj/ehae888","DOIUrl":"10.1093/eurheartj/ehae888","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":"1041-1043"},"PeriodicalIF":37.6,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Transthyretin amyloid cardiomyopathy: a paradigm for advancing precision medicine.","authors":"","doi":"10.1093/eurheartj/ehaf144","DOIUrl":"10.1093/eurheartj/ehaf144","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":"1027"},"PeriodicalIF":37.6,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11905743/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic utility of respiratory chain enzyme analysis in isolated mitochondrial cardiomyopathy mimicking hypertrophic cardiomyopathy.","authors":"Ryo Abe, Mitsunobu Kitamura, Morimasa Takayama","doi":"10.1093/eurheartj/ehae920","DOIUrl":"10.1093/eurheartj/ehae920","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":"1079"},"PeriodicalIF":37.6,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142946777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Focus on amyloidosis, peripartum cardiomyopathy, and heart failure prediction by artificial intelligence applied to ECG.","authors":"Filippo Crea","doi":"10.1093/eurheartj/ehaf084","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf084","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"46 11","pages":"987-990"},"PeriodicalIF":37.6,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Takotsubo syndrome during percutaneous coronary intervention: the role of myocardial ischaemia and microvascular dysfunction in pathophysiology.","authors":"Taiji Okada, Osamu Kurihara, Masamichi Takano","doi":"10.1093/eurheartj/ehae902","DOIUrl":"10.1093/eurheartj/ehae902","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":"1078"},"PeriodicalIF":37.6,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142881634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pregnancies in women after peri-partum cardiomyopathy: the global European Society of Cardiology EuroObservational Research Programme Peri-Partum Cardiomyopathy Registry.","authors":"Karen Sliwa, Alice Jackson, Charle Viljoen, Albertino Damasceno, Irina Mbanze, Hassan Al Farhan, Israa Fadhil Yaseen, Amam Mbakwem, Triwedya Indra Dewi, Zofia Dzielinska, Timur Abdullaev, Sorel Goland, Denise Hilfiker-Kleiner, Julia Hahnle, Carmen Basic, Alexandra Frogoudaki, Petar Seferovic, Peter van der Meer, Mark C Petrie, Johann Bauersachs","doi":"10.1093/eurheartj/ehaf006","DOIUrl":"10.1093/eurheartj/ehaf006","url":null,"abstract":"<p><strong>Background and aims: </strong>The risk of heart failure progression or mortality in patients with peri-partum cardiomyopathy (PPCM) during subsequent pregnancies (SSPs) is a significant concern for patients, their families, and healthcare providers. However, there is limited contemporary, prospective data on SSP outcomes in PPCM patients from diverse ethnic and sociodemographic groups. This study aimed to assess maternal and neonatal outcomes in PPCM patients undergoing SSPs.</p><p><strong>Methods: </strong>This is a sub-study on PPCM and SSPs of the global European Society of Cardiology PPCM Registry that recruited patients from 2012 to 2023. Maternal and neonatal outcomes were reported.</p><p><strong>Results: </strong>From 332 patients with PPCM, there were 98 SSPs among 73 women. Of these, 25 (26%) SSPs ended prematurely due to therapeutic termination (20/25), miscarriage (4/25), and stillbirth (1/25). The median follow-up from the end of the SSP was 198 days (inter-quartile range 160-240). Left ventricular ejection fraction (LVEF) was persistently reduced to <50% prior to the SSP in 26% of patients, with only 6% having an LVEF <40%. Patient characteristics were similar, irrespective of SSP baseline LVEF. Clinical worsening [composite of all-cause death, cardiovascular rehospitalization, or decline in LVEF ≥10% (percentage points) and to <50%] occurred in 20% SSPs, with 2% all-cause maternal mortality. Signs/symptoms of heart failure and worsening of New York Heart Association class occurred in 26% and 22% of SSPs, respectively. At follow-up, the mean LVEF was 50% (±12%), and in 69% of SSPs, the LVEF was ≥50%. African women had similar outcome as the other ethnic groups. Pre-term delivery occurred in 24% of SSPs, 20% of babies were of low birth weight, and there was 3% all-cause neonatal mortality. Compared with women with SSP baseline LVEF <50%, fewer women with LVEF ≥50% were on heart failure pharmacotherapies prior to the SSP, and in this group of women, there was a significant decline in LVEF.</p><p><strong>Conclusions: </strong>Maternal morbidity and mortality rates were lower than anticipated. Baseline LVEF <50% was not associated with an increased frequency of adverse maternal outcomes, and no further decline in LVEF was observed in this group. In contrast, women with SSPs and a baseline LVEF ≥50% experienced a decline in LVEF, potentially attributable to reduced use of heart failure pharmacotherapy during pregnancy and the post-partum period. Therapeutic termination was performed in approximately a fifth of cases. The findings suggest that reclassification of a SSP with persisting mild left ventricular impairment from modified World Health Organization (mWHO) Class IV (contraindicated) to mWHO III may be considered, while remaining under the care of an experienced medical team and with appropriate pharmacological management.</p>","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":"1031-1040"},"PeriodicalIF":37.6,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143398708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Weekly Journal Scan: HELIOS-B sheds light on new therapeutic options for transthyretin amyloidosis with cardiomyopathy.","authors":"Daniela Pedicino, Massimo Volpe","doi":"10.1093/eurheartj/ehae838","DOIUrl":"10.1093/eurheartj/ehae838","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":"1080-1081"},"PeriodicalIF":37.6,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wild-type transthyretin cardiac amyloidosis: the need for a comprehensive geriatric assessment beyond age.","authors":"Marianna Fontana, Carlo Fumagalli, Francesco Cappelli","doi":"10.1093/eurheartj/ehae491","DOIUrl":"10.1093/eurheartj/ehae491","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":"1071-1073"},"PeriodicalIF":37.6,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bromocriptine treatment and outcomes in peripartum cardiomyopathy: the EORP PPCM registry.","authors":"Peter van der Meer, Bart Johan van Essen, Charle Viljoen, Michael Böhm, Alice Jackson, Denise Hilfiker-Kleiner, Julian Hoevelmann, Alexandre Mebazaa, Hasan Ali Farhan, Sorel Goland, Wouter Ouwerkerk, Mark C Petrie, Petar M Seferović, Jasper Tromp, Karen Sliwa, Johann Bauersachs","doi":"10.1093/eurheartj/ehae559","DOIUrl":"10.1093/eurheartj/ehae559","url":null,"abstract":"<p><strong>Background and aims: </strong>Peripartum cardiomyopathy (PPCM) remains a serious threat to maternal health around the world. While bromocriptine, in addition to standard treatment for heart failure, presents a promising pathophysiology-based disease-specific treatment option in PPCM, the evidence regarding its efficacy remains limited. This study aimed to determine whether bromocriptine treatment is associated with improved maternal outcomes in PPCM.</p><p><strong>Methods: </strong>Peripartum cardiomyopathy patients from the EORP PPCM registry with available follow-up were included. The main exposure of this exploratory non-randomized analysis was bromocriptine treatment, and the main outcome was a composite endpoint of maternal outcome [death or hospital readmission within the first 6 months after diagnosis, or persistent severe left ventricular dysfunction (left ventricular ejection fraction < 35%) at 6-month follow-up]. Inverse probability weighting was used to minimize the effects of confounding by indication. Multiple imputation was used to account for the missing data.</p><p><strong>Results: </strong>Among the 552 patients with PPCM, 85 were treated with bromocriptine (15%). The primary endpoint was available in 491 patients (89%) and occurred in 18 out of 82 patients treated with bromocriptine in addition to standard of care (22%) and in 136 out of 409 patients treated with standard of care (33%) (P = .044). In complete case analysis, bromocriptine treatment was associated with reduced adverse maternal outcome [odds ratio (OR) 0.29, 95% confidence interval (CI) 0.10-0.83, P = .021]. This association remained after applying multiple imputation and methods to correct for confounding by indication (inverse probability weighted model on imputed data: OR 0.47, 95% CI 0.31-0.70, P < 0.001). Thromboembolic events were observed in 6.0% of the patients in the bromocriptine group vs. 5.6% in the standard of care group (P = .900).</p><p><strong>Conclusions: </strong>Among women with PPCM, bromocriptine treatment in addition to standard of care was associated with better maternal outcomes after 6 months.</p>","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":"1017-1027"},"PeriodicalIF":37.6,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11905762/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142105666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}