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Sugar, stress, and the arterial wall: a metabolic link in aortic aneurysms. 糖、压力和动脉壁：主动脉瘤的代谢联系。
IF 39.3 1区 医学
European Heart Journal Pub Date : 2025-09-05 DOI: 10.1093/eurheartj/ehaf586
Felix Kirchhoff,Lars Maegdefessel
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引用次数: 0
Apolipoprotein B at the core: another step forward. 载脂蛋白B的核心：又向前迈进了一步。
IF 39.3 1区 医学
European Heart Journal Pub Date : 2025-09-05 DOI: 10.1093/eurheartj/ehaf572
Angela Pirillo,Alberico L Catapano
{"title":"Apolipoprotein B at the core: another step forward.","authors":"Angela Pirillo,Alberico L Catapano","doi":"10.1093/eurheartj/ehaf572","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf572","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"64 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144995927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Weekly Journal Scan: semaglutide in patients with peripheral artery disease and diabetes-a real STRIDE in their management? 周刊扫描：外周动脉疾病和糖尿病患者使用西马鲁肽——在治疗上的真正突破？
IF 39.3 1区 医学
European Heart Journal Pub Date : 2025-09-05 DOI: 10.1093/eurheartj/ehaf535
Rocco Vergallo,Giovanna Liuzzo
{"title":"Weekly Journal Scan: semaglutide in patients with peripheral artery disease and diabetes-a real STRIDE in their management?","authors":"Rocco Vergallo,Giovanna Liuzzo","doi":"10.1093/eurheartj/ehaf535","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf535","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"24 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144995960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Strengthening the case for earlier LDL cholesterol lowering. 加强早期降低低密度脂蛋白胆固醇的理由。
IF 39.3 1区 医学
European Heart Journal Pub Date : 2025-09-05 DOI: 10.1093/eurheartj/ehaf589
Wendy S Post,Ron Blankstein
{"title":"Strengthening the case for earlier LDL cholesterol lowering.","authors":"Wendy S Post,Ron Blankstein","doi":"10.1093/eurheartj/ehaf589","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf589","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"23 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144995662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Titin and the mystery of cardiomyopathy incidence. Titin与心肌病发病的奥秘。
IF 39.3 1区 医学
European Heart Journal Pub Date : 2025-09-05 DOI: 10.1093/eurheartj/ehaf470
Sean J Jurgens,Roddy Walsh
{"title":"Titin and the mystery of cardiomyopathy incidence.","authors":"Sean J Jurgens,Roddy Walsh","doi":"10.1093/eurheartj/ehaf470","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf470","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"13 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144995889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The electrocardiogram reimagined: AI-ECG as a prognostic beacon for valvular heart disease. 心电图重新构想：AI-ECG作为瓣膜性心脏病的预后信标。
IF 39.3 1区 医学
European Heart Journal Pub Date : 2025-09-05 DOI: 10.1093/eurheartj/ehaf584
Antonis A Armoundas
{"title":"The electrocardiogram reimagined: AI-ECG as a prognostic beacon for valvular heart disease.","authors":"Antonis A Armoundas","doi":"10.1093/eurheartj/ehaf584","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf584","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"33 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144995922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anticoagulation for cancer-associated venous thromboembolism: navigating between risks of recurrence and bleeding. 抗凝治疗癌症相关静脉血栓栓塞：在复发和出血风险之间导航。
IF 39.3 1区 医学
European Heart Journal Pub Date : 2025-09-05 DOI: 10.1093/eurheartj/ehaf585
Sabine Eichinger,Paul A Kyrle
{"title":"Anticoagulation for cancer-associated venous thromboembolism: navigating between risks of recurrence and bleeding.","authors":"Sabine Eichinger,Paul A Kyrle","doi":"10.1093/eurheartj/ehaf585","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf585","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"33 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144995929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Arachidonic acid fuels inflammation by unlocking macrophage protein phosphatase 5 after myocardial infarction. 花生四烯酸在心肌梗死后通过解锁巨噬细胞蛋白磷酸酶5来刺激炎症。
IF 39.3 1区 医学
European Heart Journal Pub Date : 2025-09-04 DOI: 10.1093/eurheartj/ehaf493
Zhipeng Chen,Jiawei Song,Suli Feng,Mingming Liu,Yan Zhang,Xilin Shen,Ting Zhou,Zhong Xian,Hongfeng Jiang,Chen Chen,Daowen Wang,Wenbin Cai,Mulin Jun Li,Hongxi Yang,Lei Shi,Haoyu Weng,Fangfang Fan,Jianping Li,Qiang Liu,Ding Ai
{"title":"Arachidonic acid fuels inflammation by unlocking macrophage protein phosphatase 5 after myocardial infarction.","authors":"Zhipeng Chen,Jiawei Song,Suli Feng,Mingming Liu,Yan Zhang,Xilin Shen,Ting Zhou,Zhong Xian,Hongfeng Jiang,Chen Chen,Daowen Wang,Wenbin Cai,Mulin Jun Li,Hongxi Yang,Lei Shi,Haoyu Weng,Fangfang Fan,Jianping Li,Qiang Liu,Ding Ai","doi":"10.1093/eurheartj/ehaf493","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf493","url":null,"abstract":"BACKGROUND AND AIMSAn overactive inflammatory response and immune cell infiltration following myocardial infarction (MI) impair cardiac tissue repair. This study investigates the mechanistic role of the arachidonic acid (AA) metabolic cascade in mediating post-MI inflammation.METHODSSingle-cell RNA-sequencing analysis was performed to characterize cardiac macrophage heterogeneity in post-MI mice. Metabolomic analyses were conducted to profile polyunsaturated fatty acid metabolites in both plasma from MI patients and cardiac tissue from infarcted mice to identify key factors influencing MI progression.RESULTSLeukotriene B4 (LTB4), an AA metabolite, was consistently elevated in MI patients and mouse models, demonstrating significantly higher plasma concentrations in recurrent MI cases. Mechanistically, AA promotes nuclear translocation of protein phosphatase 5 (PP5), which subsequently dephosphorylates 5-lipoxygenase at Thr218, driving sustained LTB4 production. This process enhances CXCL13-mediated B-cell recruitment and amplifies inflammation through macrophage-B-cell crosstalk. Disruption of PP5 in mouse macrophages prevents these adverse changes.CONCLUSIONSThe findings elucidate the conserved role of 5-lipoxygenase phosphorylation regulated LTB4 levels in MI and identify PP5 as a potential therapeutic target for the treatment of MI.","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"20 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144962705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cardiovascular prevention 2024, lipid disorders: insights from the National Societies of Cardiology Journals of the European Society of Cardiology. 心血管预防2024，脂质紊乱：来自欧洲心脏病学会国家心脏病学会期刊的见解。
IF 39.3 1区 医学
European Heart Journal Pub Date : 2025-09-04 DOI: 10.1093/eurheartj/ehaf463
Jean-Jacques Monsuez,Plamen Gatzov,Fernando Alfonso,
{"title":"Cardiovascular prevention 2024, lipid disorders: insights from the National Societies of Cardiology Journals of the European Society of Cardiology.","authors":"Jean-Jacques Monsuez,Plamen Gatzov,Fernando Alfonso, ","doi":"10.1093/eurheartj/ehaf463","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf463","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"2 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144962668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In memoriam: Alan Howard, former Chief Executive Officer of the European Society of Cardiology. 纪念：Alan Howard，欧洲心脏病学会前首席执行官。
IF 39.3 1区 医学
European Heart Journal Pub Date : 2025-09-04 DOI: 10.1093/eurheartj/ehaf415
Thomas F Lüscher
{"title":"In memoriam: Alan Howard, former Chief Executive Officer of the European Society of Cardiology.","authors":"Thomas F Lüscher","doi":"10.1093/eurheartj/ehaf415","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf415","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"28 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144962673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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