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Single-nucleus RNA sequencing identifies cell-type-specific effects of sodium-glucose co-transporter 2 inhibitors in human myocardial slices. 单核 RNA 测序确定钠-葡萄糖共转运体 2 抑制剂对人体心肌切片细胞类型的特异性影响。
IF 37.6 1区 医学
European Heart Journal Pub Date : 2024-09-14 DOI: 10.1093/eurheartj/ehae472
Kevin Schmidt, Maximilian Fuchs, Natalie Weber, Christopher Werlein, Jan D Schmitto, Fabio Ius, Arjang Ruhparwar, Christian Bär, Jan Fiedler, Thomas Thum
{"title":"Single-nucleus RNA sequencing identifies cell-type-specific effects of sodium-glucose co-transporter 2 inhibitors in human myocardial slices.","authors":"Kevin Schmidt, Maximilian Fuchs, Natalie Weber, Christopher Werlein, Jan D Schmitto, Fabio Ius, Arjang Ruhparwar, Christian Bär, Jan Fiedler, Thomas Thum","doi":"10.1093/eurheartj/ehae472","DOIUrl":"10.1093/eurheartj/ehae472","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":null,"pages":null},"PeriodicalIF":37.6,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11400937/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141855179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Artificial intelligence-enhanced patient evaluation: bridging art and science. 人工智能增强型患者评估：艺术与科学的桥梁。
IF 37.6 1区 医学
European Heart Journal Pub Date : 2024-09-14 DOI: 10.1093/eurheartj/ehae415
Evangelos K Oikonomou, Rohan Khera
{"title":"Artificial intelligence-enhanced patient evaluation: bridging art and science.","authors":"Evangelos K Oikonomou, Rohan Khera","doi":"10.1093/eurheartj/ehae415","DOIUrl":"10.1093/eurheartj/ehae415","url":null,"abstract":"<p><p>The advent of digital health and artificial intelligence (AI) has promised to revolutionize clinical care, but real-world patient evaluation has yet to witness transformative changes. As history taking and physical examination continue to rely on long-established practices, a growing pipeline of AI-enhanced digital tools may soon augment the traditional clinical encounter into a data-driven process. This article presents an evidence-backed vision of how promising AI applications may enhance traditional practices, streamlining tedious tasks while elevating diverse data sources, including AI-enabled stethoscopes, cameras, and wearable sensors, to platforms for personalized medicine and efficient care delivery. Through the lens of traditional patient evaluation, we illustrate how digital technologies may soon be interwoven into routine clinical workflows, introducing a novel paradigm of longitudinal monitoring. Finally, we provide a skeptic's view on the practical, ethical, and regulatory challenges that limit the uptake of such technologies.</p>","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":null,"pages":null},"PeriodicalIF":37.6,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11400875/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141558374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to: Atherosclerosis in ancient mummified humans: the global HORUS study. 更正：古代木乃伊化人类的动脉粥样硬化：全球 HORUS 研究。
IF 37.6 1区 医学
European Heart Journal Pub Date : 2024-09-14 DOI: 10.1093/eurheartj/ehae536
{"title":"Correction to: Atherosclerosis in ancient mummified humans: the global HORUS study.","authors":"","doi":"10.1093/eurheartj/ehae536","DOIUrl":"10.1093/eurheartj/ehae536","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":null,"pages":null},"PeriodicalIF":37.6,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141970910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical trials in-a-dish for cardiovascular medicine 心血管内科的 "菜中菜 "式临床试验
IF 39.3 1区 医学
European Heart Journal Pub Date : 2024-09-14 DOI: 10.1093/eurheartj/ehae519
Xuekun Wu, Kyle Swanson, Zehra Yildirim, Wenqiang Liu, Ronglih Liao, Joseph C Wu
{"title":"Clinical trials in-a-dish for cardiovascular medicine","authors":"Xuekun Wu, Kyle Swanson, Zehra Yildirim, Wenqiang Liu, Ronglih Liao, Joseph C Wu","doi":"10.1093/eurheartj/ehae519","DOIUrl":"https://doi.org/10.1093/eurheartj/ehae519","url":null,"abstract":"Cardiovascular diseases persist as a global health challenge that requires methodological innovation for effective drug development. Conventional pipelines relying on animal models suffer from high failure rates due to significant interspecies variation between humans and animal models. In response, the recently enacted Food and Drug Administration Modernization Act 2.0 encourages alternative approaches including induced pluripotent stem cells (iPSCs). Human iPSCs provide a patient-specific, precise, and screenable platform for drug testing, paving the way for cardiovascular precision medicine. This review discusses milestones in iPSC differentiation and their applications from disease modelling to drug discovery in cardiovascular medicine. It then explores challenges and emerging opportunities for the implementation of ‘clinical trials in-a-dish’. Concluding, this review proposes a framework for future clinical trial design with strategic incorporations of iPSC technology, microphysiological systems, clinical pan-omics, and artificial intelligence to improve success rates and advance cardiovascular healthcare.","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":null,"pages":null},"PeriodicalIF":39.3,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142233491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clearing up misunderstandings: addressing issues in recent cardiovascular risk review. 消除误解：解决近期心血管风险审查中的问题。
IF 39.3 1区 医学
European Heart Journal Pub Date : 2024-09-13 DOI: 10.1093/eurheartj/ehae530
Mina Bakhit,Paul Glasziou,Magnolia Cardona
{"title":"Clearing up misunderstandings: addressing issues in recent cardiovascular risk review.","authors":"Mina Bakhit,Paul Glasziou,Magnolia Cardona","doi":"10.1093/eurheartj/ehae530","DOIUrl":"https://doi.org/10.1093/eurheartj/ehae530","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":null,"pages":null},"PeriodicalIF":39.3,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142233494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Difficulties in running clinical trials on physical activity. 开展体育活动临床试验的困难。
IF 39.3 1区 医学
European Heart Journal Pub Date : 2024-09-13 DOI: 10.1093/eurheartj/ehae582
Emmanuel A Zavalis,Pontus Andell
{"title":"Difficulties in running clinical trials on physical activity.","authors":"Emmanuel A Zavalis,Pontus Andell","doi":"10.1093/eurheartj/ehae582","DOIUrl":"https://doi.org/10.1093/eurheartj/ehae582","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":null,"pages":null},"PeriodicalIF":39.3,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142233495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cardiovascular disease risk communication alone is not enough: why a recent review may be misleading. 仅进行心血管疾病风险交流是不够的：为什么最近的一篇评论可能会产生误导？
IF 39.3 1区 医学
European Heart Journal Pub Date : 2024-09-13 DOI: 10.1093/eurheartj/ehae529
Sophie Griffiths,Brian McMillan,Y Kiera Bartlett,David French
{"title":"Cardiovascular disease risk communication alone is not enough: why a recent review may be misleading.","authors":"Sophie Griffiths,Brian McMillan,Y Kiera Bartlett,David French","doi":"10.1093/eurheartj/ehae529","DOIUrl":"https://doi.org/10.1093/eurheartj/ehae529","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":null,"pages":null},"PeriodicalIF":39.3,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142233496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Asymptomatic female heterozygous Fabry disease diagnosed through medical check-up. 通过体检确诊为无症状女性杂合子法布里病。
IF 39.3 1区 医学
European Heart Journal Pub Date : 2024-09-13 DOI: 10.1093/eurheartj/ehae608
Hiroto Kawamura,Kazuto Nakamura,Akira Sato
{"title":"Asymptomatic female heterozygous Fabry disease diagnosed through medical check-up.","authors":"Hiroto Kawamura,Kazuto Nakamura,Akira Sato","doi":"10.1093/eurheartj/ehae608","DOIUrl":"https://doi.org/10.1093/eurheartj/ehae608","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":null,"pages":null},"PeriodicalIF":39.3,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142233493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Re-evaluating concurrent training strategies for cardiovascular risk reduction in overweight or obese adults. 重新评估降低超重或肥胖成年人心血管风险的同步训练策略。
IF 39.3 1区 医学
European Heart Journal Pub Date : 2024-09-13 DOI: 10.1093/eurheartj/ehae583
Jiawei Du,Jinghua Hou
{"title":"Re-evaluating concurrent training strategies for cardiovascular risk reduction in overweight or obese adults.","authors":"Jiawei Du,Jinghua Hou","doi":"10.1093/eurheartj/ehae583","DOIUrl":"https://doi.org/10.1093/eurheartj/ehae583","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":null,"pages":null},"PeriodicalIF":39.3,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142233500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Red blood cells: a new target to prevent cardiovascular disease? 红细胞：预防心血管疾病的新目标？
IF 39.3 1区 医学
European Heart Journal Pub Date : 2024-09-11 DOI: 10.1093/eurheartj/ehae454
John Pernow,Jiangning Yang
{"title":"Red blood cells: a new target to prevent cardiovascular disease?","authors":"John Pernow,Jiangning Yang","doi":"10.1093/eurheartj/ehae454","DOIUrl":"https://doi.org/10.1093/eurheartj/ehae454","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":null,"pages":null},"PeriodicalIF":39.3,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142170769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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