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Correction to: Myocardial infarction with non-obstructive coronary arteries as compared with myocardial infarction and obstructive coronary disease: outcomes in a Medicare population. 修正：非阻塞性冠状动脉心肌梗死与心肌梗死和阻塞性冠状动脉疾病的比较：医疗保险人群的结果。
IF 35.6 1区 医学
European Heart Journal Pub Date : 2025-09-08 DOI: 10.1093/eurheartj/ehaf708
{"title":"Correction to: Myocardial infarction with non-obstructive coronary arteries as compared with myocardial infarction and obstructive coronary disease: outcomes in a Medicare population.","authors":"","doi":"10.1093/eurheartj/ehaf708","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf708","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":""},"PeriodicalIF":35.6,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145014171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sepsis-induced cardiomyopathy. Sepsis-induced心肌病。
IF 35.6 1区 医学
European Heart Journal Pub Date : 2025-09-08 DOI: 10.1093/eurheartj/ehaf340
Nadia Aissaoui, Florence Boissier, Michelle Chew, Mervyn Singer, Philippe Vignon
{"title":"Sepsis-induced cardiomyopathy.","authors":"Nadia Aissaoui, Florence Boissier, Michelle Chew, Mervyn Singer, Philippe Vignon","doi":"10.1093/eurheartj/ehaf340","DOIUrl":"10.1093/eurheartj/ehaf340","url":null,"abstract":"<p><p>Sepsis remains the most common cause of death in critically ill patients worldwide and the most frequent non-cardiac disease diagnosed in the Coronary Care Unit. Myocardial dysfunction caused by sepsis, usually termed 'sepsis-induced cardiomyopathy' (SICM), is common and has long been a subject of interest for intensivists and cardiologists. Despite the lack of a consensus definition, SICM is widely recognized as a reversible condition characterized by acute single or bi-ventricular systolic and/or diastolic dysfunction unrelated to coronary artery disease. While indications for monitoring and treating septic cardiomyopathy are directed towards restoring tissue perfusion, a better understanding of the course and implications of septic cardiomyopathy may help to optimize interventions and improve clinical outcomes. The present review aims to summarize current knowledge on the epidemiology, pathophysiology and clinical presentation of SICM, and to provide insights to aid clinicians in managing affected patients.</p>","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":"3339-3353"},"PeriodicalIF":35.6,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144173403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to: Stroke and bleeding risk in atrial fibrillation with CHA2DS2-VASC risk score of one: the Norwegian AFNOR study. 修正：CHA2DS2-VASC风险评分为1分的房颤卒中和出血风险：挪威AFNOR研究。
IF 35.6 1区 医学
European Heart Journal Pub Date : 2025-09-08 DOI: 10.1093/eurheartj/ehaf434
{"title":"Correction to: Stroke and bleeding risk in atrial fibrillation with CHA2DS2-VASC risk score of one: the Norwegian AFNOR study.","authors":"","doi":"10.1093/eurheartj/ehaf434","DOIUrl":"10.1093/eurheartj/ehaf434","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":"3381"},"PeriodicalIF":35.6,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144559567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Myocarditis after COVID-19, sepsis-induced cardiomyopathy, and haemodynamic assessment of heart failure: focus on the myocardium. COVID-19后心肌炎、败血症性心肌病和心力衰竭的血流动力学评估：重点关注心肌。
IF 39.3 1区 医学
European Heart Journal Pub Date : 2025-09-08 DOI: 10.1093/eurheartj/ehaf593
Filippo Crea
{"title":"Myocarditis after COVID-19, sepsis-induced cardiomyopathy, and haemodynamic assessment of heart failure: focus on the myocardium.","authors":"Filippo Crea","doi":"10.1093/eurheartj/ehaf593","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf593","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"26 1","pages":"3315-3318"},"PeriodicalIF":39.3,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145008702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The 'visitor' in the heart and inferior vena cava: benign metastasizing leiomyoma. 心脏和下腔静脉的“来访者”：良性转移性平滑肌瘤。
IF 35.6 1区 医学
European Heart Journal Pub Date : 2025-09-08 DOI: 10.1093/eurheartj/ehaf400
Yiyang Liu, Hongliang Li, Qingyu Ji
{"title":"The 'visitor' in the heart and inferior vena cava: benign metastasizing leiomyoma.","authors":"Yiyang Liu, Hongliang Li, Qingyu Ji","doi":"10.1093/eurheartj/ehaf400","DOIUrl":"10.1093/eurheartj/ehaf400","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":"3390"},"PeriodicalIF":35.6,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lipoprotein(a) and forms of dementia: an area of complexity. 脂蛋白(a)和痴呆的形式：一个复杂的领域。
IF 39.3 1区 医学
European Heart Journal Pub Date : 2025-09-05 DOI: 10.1093/eurheartj/ehaf526
Florian Kronenberg
{"title":"Lipoprotein(a) and forms of dementia: an area of complexity.","authors":"Florian Kronenberg","doi":"10.1093/eurheartj/ehaf526","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf526","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"22 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144995930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The evolving landscape of targets for lipid lowering: from molecular mechanisms to translational implications. 降脂靶点的演变景观：从分子机制到翻译意义。
IF 39.3 1区 医学
European Heart Journal Pub Date : 2025-09-05 DOI: 10.1093/eurheartj/ehaf606
Christie M Ballantyne,Giuseppe D Norata
{"title":"The evolving landscape of targets for lipid lowering: from molecular mechanisms to translational implications.","authors":"Christie M Ballantyne,Giuseppe D Norata","doi":"10.1093/eurheartj/ehaf606","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf606","url":null,"abstract":"Cardiovascular disease remains a major global health challenge, with dyslipidaemia being a key modifiable risk factor. While low density lipoprotein cholesterol (LDL-C) is the primary target for lipid-lowering therapies, recent evidence highlights the importance of triglycerides, apolipoprotein B (apoB), and lipoprotein(a) [Lp(a)] for residual cardiovascular risk. Current lipid-lowering therapies target key enzymes and proteins involved in cholesterol and lipid metabolism. Statins inhibit HMG-CoA reductase, reducing cholesterol biosynthesis and increasing LDL receptor (LDLR) expression in the liver. Bempedoic acid inhibits ATP citrate lyase, the enzyme upstream of HMG-CoA reductase in the mevalonate pathway, offering an alternative to statins by selectively acting in the liver, minimizing muscle-related side effects. Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors [evolocumab, alirocumab, inclisiran, lerodalcibep, and enlicitide decanoate (MK0616)] prevent LDLR degradation, while ezetimibe limits intestinal cholesterol absorption. Emerging lipid-lowering targets include angiopoietin-like 3 protein (ANGPTL3) and apolipoprotein C-III (apoC-III). Inhibiting ANGPTL3 reduces both triglycerides and LDL-C independently of LDL receptor. Inhibition of apoC-III unleashes lipoprotein lipase (LPL) activity, promoting triglyceride-rich particle catabolism, even in complete LPL deficiency. Cholesteryl ester transfer protein (CETP) inhibition also increases the catabolism of apoB-containing lipoproteins. Ongoing research into strategies to reduce Lp(a), primarily but not exclusively through antisense therapies, aims to demonstrate the cardiovascular benefits of targeting this lipoprotein. In summary, the field of targets for lipid and lipoprotein lowering is constantly evolving and offers new strategies for patients resistant to current therapies or with specific lipid profile abnormalities.","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"49 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144995921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Eclampsia and short-term cardiovascular risk: important but neglected. 子痫与短期心血管风险：重要但被忽视。
IF 39.3 1区 医学
European Heart Journal Pub Date : 2025-09-05 DOI: 10.1093/eurheartj/ehaf522
Rosa Maria Bruno,Jacques Blacher
{"title":"Eclampsia and short-term cardiovascular risk: important but neglected.","authors":"Rosa Maria Bruno,Jacques Blacher","doi":"10.1093/eurheartj/ehaf522","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf522","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"30 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144995925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epicardial and pericardial adipose tissue: a plea for standardized definitions and assessment. 心外膜和心包脂肪组织：标准化定义和评估的请求。
IF 39.3 1区 医学
European Heart Journal Pub Date : 2025-09-05 DOI: 10.1093/eurheartj/ehaf583
Michelle Lobeek,Jeroen L A van Vugt,Thomas M Gorter
{"title":"Epicardial and pericardial adipose tissue: a plea for standardized definitions and assessment.","authors":"Michelle Lobeek,Jeroen L A van Vugt,Thomas M Gorter","doi":"10.1093/eurheartj/ehaf583","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf583","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"11 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144995928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Aortic stenosis: need for treatment of co-existent cardiac amyloidosis? 主动脉瓣狭窄：是否需要治疗并存的心脏淀粉样变性？
IF 39.3 1区 医学
European Heart Journal Pub Date : 2025-09-05 DOI: 10.1093/eurheartj/ehaf558
Sarah A M Cuddy
{"title":"Aortic stenosis: need for treatment of co-existent cardiac amyloidosis?","authors":"Sarah A M Cuddy","doi":"10.1093/eurheartj/ehaf558","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf558","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"23 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144995926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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