European Heart Journal最新文献

{"title":"CCN5 suppresses injury-induced vascular restenosis by inhibiting smooth muscle cell proliferation and facilitating endothelial repair via thymosin β4 and Cd9 pathway.","authors":"Qi Zhang, Hongda Li, Tao Zhuang, Lehua Xu, Wenrun Wu, Jingjiang Pi, Pengxiong Zhu, Liang Geng, Yunhao Duan, Jianfei Xu, Jinnan Yue, Xiuxiang Liu, Chenlong He, Xiaoli Chen, Chengchao Ruan, Shougang Zhuang, Zhongmin Liu, Yilong Wang, Lin Zhang, Jie Liu, Yuzhen Zhang","doi":"10.1093/eurheartj/ehae911","DOIUrl":"10.1093/eurheartj/ehae911","url":null,"abstract":"<p><strong>Background and aims: </strong>Members of the CCN matricellular protein family are crucial in various biological processes. This study aimed to characterize vascular cell-specific effects of CCN5 on neointimal formation and its role in preventing in-stent restenosis (ISR) after percutaneous coronary intervention (PCI).</p><p><strong>Methods: </strong>Stent-implanted porcine coronary artery RNA-seq and mouse injury-induced femoral artery neointima single-cell RNA sequencing were performed. Plasma CCN5 levels were measured by enzyme-linked immunosorbent assay. Endothelial cell (EC)- and vascular smooth muscle cell (VSMC)-specific CCN5 loss-of-function and gain-of-function mice were generated. Mass spectrometry and co-immunoprecipitation were conducted to identify CCN5 interacting proteins. Additionally, CCN5 recombinant protein (CCN5rp)-coated stents were deployed to evaluate its anti-ISR effects in a porcine model.</p><p><strong>Results: </strong>Plasma CCN5 levels were significantly reduced and correlated closely with the degree of restenosis in ISR patients. CCN5 expression was significantly decreased in VSMCs of stent-implanted porcine coronary segments and injured mouse femoral arteries, especially in synthetic VSMCs. In contrast, elevated CCN5 expression was observed in regenerating ECs of injured vessels. Endothelial cell- and VSMC-specific CCN5 deletion mice exhibited exacerbation of injury-induced neointimal hyperplasia, while CCN5 gain-of-function alleviated neointimal formation. Mechanistic studies identified thymosin β4 (Tβ4) as a CCN5 interacting protein in ECs and EC-CCN5 promoted injury repair through Tβ4 cleavage product Ac-SDKP. Also, CCN5rp promoted EC repair to suppress neointimal hyperplasia via interaction with Cd9 extracellular domain. Moreover, implantation with CCN5rp-coated stent significantly increased stent strut coverage with ECs, which suppressed neointimal formation and ultimately alleviated ISR.</p><p><strong>Conclusions: </strong>CCN5 exerts a dual protective effect on ISR by inhibiting VSMC proliferation and facilitating EC repair. CCN5rp-coated stent might be promising in the prevention of ISR after PCI.</p>","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":"1645-1658"},"PeriodicalIF":37.6,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143051977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unilateral pulmonary oedema.","authors":"William Griffin, Charles McCreery, Alessandro N Franciosi","doi":"10.1093/eurheartj/ehaf095","DOIUrl":"10.1093/eurheartj/ehaf095","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":"1686"},"PeriodicalIF":37.6,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Loss of the Y chromosome in coronary artery disease.","authors":"Soichi Sano, Kenneth Walsh","doi":"10.1093/eurheartj/ehaf072","DOIUrl":"10.1093/eurheartj/ehaf072","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":"1617-1619"},"PeriodicalIF":37.6,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Weekly Journal Scan: is a SMART-CHOICE of clopidogrel monotherapy after coronary stenting supported by adequate evidence?","authors":"Mattia Galli,Carlo Patrono","doi":"10.1093/eurheartj/ehaf290","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf290","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"7 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143903042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Colchicine for secondary prevention of vascular events: a meta-analysis of trials","authors":"Marc-André d’Entremont, Michiel H F Poorthuis, Aernoud T L Fiolet, Pierre Amarenco, Kevin Emery Boczar, Ian Buysschaert, Noel C Chan, Jan H Cornel, Jalina Jannink, Shirley Jansen, Sasko Kedev, Anthony C Keech, Jamie Layland, Nathan Mewton, Gilles Montalescot, Domingo A Pascual-Figal, Alfredo E Rodriguez, Binita Shah, Martin Teraa, Aimee van Zelm, Yongjun Wang, Arend Mosterd, Peter Kelly, John Eikelboom, Sanjit S Jolly","doi":"10.1093/eurheartj/ehaf210","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf210","url":null,"abstract":"Background and Aims Randomized trials of colchicine in secondary prevention of atherosclerotic cardiovascular disease have shown mixed results. Methods A systematic review and study-level meta-analysis of randomized controlled trials was performed comparing colchicine vs no colchicine in a secondary-prevention atherosclerotic cardiovascular disease population. A fixed-effect inverse variance model was applied using the intention-to-treat population from the included trials. The primary outcome was the composite of cardiovascular death, myocardial infarction, or stroke. Results Nine trials, including 30 659 patients (colchicine 15 255, no colchicine 15 404) with known coronary artery disease or stroke, were included. Compared with no colchicine, patients randomized to colchicine had a relative risk (RR) of 0.88 [95% confidence interval (CI) 0.81–0.95, P = .002] for the primary composite outcome, including a RR of 0.94 for cardiovascular death (95% CI 0.78–1.13, P = .5), a RR of 0.84 for myocardial infarction (95% CI 0.73–0.97, P = .016), and a RR of 0.90 for stroke (95% CI 0.80–1.02, P = .09). Colchicine was associated with a RR of 1.35 for hospitalization for gastrointestinal events (95% CI 1.10–1.66, P = .004) with no increase in hospitalization for pneumonia, newly diagnosed cancers, or non-cardiovascular death. Conclusions In patients with prior coronary disease or stroke, colchicine reduced the composite of cardiovascular death, myocardial infarction, or stroke by 12%.","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"16 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143901784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extracellular vesicles to mediate RNA therapies.","authors":"Jes-Niels Boeckel, Junjie Xiao","doi":"10.1093/eurheartj/ehaf046","DOIUrl":"10.1093/eurheartj/ehaf046","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":"1677-1679"},"PeriodicalIF":37.6,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk prediction for cardiovascular diseases in Asia-Pacific: to separate subtypes or not, that is a new question.","authors":"Songchun Yang, Jun Lv","doi":"10.1093/eurheartj/ehae854","DOIUrl":"10.1093/eurheartj/ehae854","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":"1680-1681"},"PeriodicalIF":37.6,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new European Society of Cardiology Mentoring Programme for young cardiovascular professionals.","authors":"Martin Manninger,Maria Rubini,C Fielder Camm","doi":"10.1093/eurheartj/ehaf178","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf178","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"52 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143893208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Highlights of the 7th annual conference of the ESC Council on Stroke.","authors":"Panteleimon E Papakonstantinou,Jacopo Francesco Imberti,Dimitrios N Nikas,","doi":"10.1093/eurheartj/ehaf184","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf184","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"20 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143893209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EuroHeart and the National Outcomes Evaluation Programme in Italy: relevance and perspectives.","authors":"Sergio Leonardi,Giovanni Baglio,Aldo Pietro Maggioni","doi":"10.1093/eurheartj/ehaf262","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf262","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"30 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143893206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}