European Heart Journal最新文献

{"title":"Cardiovascular magnetic resonance in the assessment of the risk of fatal or life-threatening ventricular arrhythmias in suspected vs diagnosed cardiac sarcoidosis.","authors":"Pauli Pöyhönen,Riina Kandolin,Markku Kupari","doi":"10.1093/eurheartj/ehaf758","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf758","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"13 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145134044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The great mimicker: aortic extramural haematoma secondary to multi-branch systemic arterial rupture.","authors":"Min Liu,Wei Yu,Ziyang Zhu","doi":"10.1093/eurheartj/ehaf752","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf752","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"15 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145134046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ascending aortic pseudoaneurysm with sternal erosion and protrusion towards the body surface in a multiply reoperated Marfan patient: multimodal imaging.","authors":"Tingting Li,Xinran Xu,Wei Yu","doi":"10.1093/eurheartj/ehaf755","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf755","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"81 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145134067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drug-coated vs non-drug-coated devices for femoropopliteal artery interventions: long-term outcomes of the SAFE-PAD study.","authors":"Joseph M Kim,Robert W Yeh,Yang Song,Eric A Secemsky","doi":"10.1093/eurheartj/ehaf721","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf721","url":null,"abstract":"BACKGROUND AND AIMSFemoropopliteal artery disease is associated with high rates of post-revascularization restenosis. Drug-coated devices (DCD), including drug-coated balloons (DCBs) and drug-eluting stents (DES), have demonstrated efficacy in reducing restenosis rates compared to non-drug-coated devices (NDCDs). However, concerns about potential long-term mortality risks have led to regulatory scrutiny. This study represents the final report from the Safety Assessment of Femoropopliteal Endovascular Treatment with Paclitaxel-Coated Devices (SAFE-PAD) study, a pre-specified analysis designed with the US Food and Drug Administration to evaluate the long-term mortality associated with femoropopliteal DCD use.METHODSSAFE-PAD was a retrospective cohort study of 168 553 Medicare fee-for-service beneficiaries (≥66 years) who underwent femoropopliteal artery revascularization between 2015 and 2018. Device exposure (DCDs vs. NDCDs) was identified using Medicare claims data. The primary outcome was all-cause mortality, assessed between treatment groups using inverse probability treatment weighting. Secondary outcomes included all-cause hospitalizations, repeat revascularization, major amputation, and cardiovascular medication use. Sensitivity analyses included instrumental variable methods, falsification endpoints, and simulation of hypothetical unmeasured confounders. Subgroup analyses examined outcomes in inpatient vs outpatient settings, in younger/low-risk populations, and in high-risk chronic limb-threatening ischaemia patients.RESULTSAt a median follow-up of 4.3 years (maximum: 9.0 years), DCD use was not associated with increased mortality (adjusted hazard ratio: 0.98; 95% confidence interval: 0.97, 0.99), meeting the pre-specified 5% non-inferiority relative margin. Sensitivity analyses supported the validity of the primary result. Secondary outcomes showed similar hospitalization and amputation rates between groups but an increase in repeat revascularization with DCDs. Subgroup analyses confirmed safety findings across high/low-risk subgroups and across clinical settings.CONCLUSIONSIn this final report from the SAFE-PAD study, there was no evidence of long-term mortality risk associated with DCDs used for femoropopliteal revascularization. The SAFE-PAD study helped inform the reversal of regulatory warnings against routine DCD use.","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"2 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145134070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex differences in atrial fibrillation-related atrial remodelling assessed by electroanatomic mapping and biopsy.","authors":"Kana Nakashima,Takanori Yamaguchi,Yuya Takahashi,Toyokazu Otsubo,Shigeki Shichida,Ryosuke Osako,Kodai Shinzato,Kotaro Tsuruta,Yuki Nishimura,Makoto Edayoshi,Yuki Kawano,Yukako Shintani-Domoto,Kai Miyazaki,Akira Fukui,Atsushi Kawaguchi,Shigehisa Aoki,Seitaro Nomura,Naohiko Takahashi,Kyoko Soejima,Kaoru Ito,Koichi Node","doi":"10.1093/eurheartj/ehaf768","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf768","url":null,"abstract":"BACKGROUND AND AIMSHistopathological sex differences in atrial structural remodelling in patients with non-valvular atrial fibrillation (AF) require further investigation.METHODSRight atrial biopsy was performed on 282 patients undergoing AF ablation and high-density voltage mapping (66 ± 12 years; 81 women). Of the 58 patients without AF undergoing supraventricular tachycardia ablation included, 26 underwent atrial biopsy and 41 underwent voltage mapping. The voltage at the biopsy site (Vbiopsy), global left atrial voltage (VGLA), and histopathological parameters (fibrosis, intercellular space, myofibrillar loss, myocardial nuclear density, and cardiomyocyte diameter) were evaluated.RESULTSVbiopsy (7.4 ± 2.6 vs 9.3 ± 3.2 mV, P < .001) and VGLA (4.9 ± 1.8 vs 6.7 ± 2.2 mV, P < .001) were significantly lower in women with AF. A similar relationship was observed in patients without AF: Vbiopsy (7.8 ± 2.7 vs 10.9 ± 2.6 mV, P < .001) and VGLA (7.3 ± 1.7 vs 9.4 ± 1.4 mV, P < .001) were lower in women. Vbiopsy and VGLA positively correlated in both groups (r = 0.70 and 0.60, P < .001), supporting an integrated interpretation of the voltage and histopathological data. No significant sex differences were observed among the histopathological parameters. In 34 patients with minimal histological change, small cardiomyocytes (<10 μm) were more frequent in women (37% ± 23% vs 20% ± 19%, P = .029).CONCLUSIONSDespite consistently lower voltage in women, no significant histopathological sex differences were identified in non-valvular cases, likely due to their inherently smaller atrial mass.","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"93 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145140252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Importance of basic science and research training for the future generation of cardiologists.","authors":"Gemma Chiva-Blanch,Elisa Liehn,Ioanna Andreadou,Julien Barc,Bianca J J M Brundel,Sean M Davidson,Perry Elliott,Paul C Evans,Zoltan Giricz,Monika Gladka,Can Gollmann-Tepeköylü,Petra Kleinbongard,Thomas Krieg,Cecilia Linde,Thomas F Lüscher,Tomasz Guzik,Ange Maguy,Theresa McDonagh,Melanie Paillard,Radoslaw Parma,Maurizio Pesce,Giulio Pompilio,Maria Rubini,Katrin Streckfuss-Bömeke,Matthias Thielmann,Carlo G Tocchetti,Sophie Van Linthout,Panagiotis Vardas,Pascal Vranckx,Johann Wojta,Cinzia Perrino","doi":"10.1093/eurheartj/ehaf738","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf738","url":null,"abstract":"Advances in the battle against cardiovascular diseases depend upon continuously translating emerging scientific knowledge from preclinical studies and clinical trials into innovative and effective therapeutic strategies. Over the past three decades, molecular and cellular biology have undergone a profound transformation, and large-scale, single-cell, and multi-omics studies have enabled investigations on cardiac disease mechanisms with unprecedented precision. However, these rapid advancements have also contributed to a divergence between the needs and aspirations of basic researchers and those of clinical scientists and practicians, to the detriment of discovery science, precision medicine, and cardiovascular healthcare. The present document highlights the importance of education and training in overcoming the gap between discovery and clinical science, by promoting a common language aimed at designing more translationally relevant and impactful discovery science. To achieve this aim, multidisciplinary efforts will be required to better define learning objectives within training programmes, including education in discovery and clinical sciences, promotion of specific mentorship paths, collaborative research efforts, promotion of equality, diversity, and inclusion, and protection of research time and activity within academic, clinical, and research careers.","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"41 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145134066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular magnetic resonance phenotyping: the new standard for primary prevention implantable cardioverter-defibrillator decision-making in cardiac sarcoidosis.","authors":"Harold Mathijssen,Parag H Bawaskar,Chetan Shenoy","doi":"10.1093/eurheartj/ehaf759","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf759","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"37 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145140320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interleukin-17 receptor-A signalling: atheroprotective role in JAK2 clonal haematopoiesis.","authors":"Kun Zhao,Cheng-Chieh Hsu,Yash Pershad,Caitlyn Vlasschaert,Robert W Corty,Nan Wang,Jonathan Brett Heimlich,Alan R Tall,Alexander G Bick","doi":"10.1093/eurheartj/ehaf737","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf737","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"9 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145127176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Remote ischaemic conditioning in stroke: turning a corner?","authors":"Hans Erik Bøtker","doi":"10.1093/eurheartj/ehaf610","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf610","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"1 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145117132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shear stress-induced endothelial HEG1 signalling regulates vascular tone and blood pressure.","authors":"Wenrun Wu,Jun Liu,Xiaoli Chen,Pengxiong Zhu,Jianfei Xu,Jinnan Yue,Xiuxiang Liu,Ji Fang,Xiaohui Chen,Jingjiang Pi,Liang Zheng,Qi Zhang,Lin Zhang,Carolin Victoria Schneider,Kai Markus Schneider,Christian Trautwein,Pingjin Gao,Muredach P Reilly,Yuzhen Zhang,Xiangjian Zheng,Jie Liu","doi":"10.1093/eurheartj/ehaf742","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf742","url":null,"abstract":"BACKGROUND AND AIMSEndothelial cells (ECs) sense flow shear stress for vasodilation, a crucial mechanism for maintaining systemic blood pressure (BP). Impaired shear stress signalling contributes to endothelial dysfunction and hypertension. Heart development protein with EGF-like domain 1 (HEG1), a flow-sensitive, endothelial-derived protein, is inversely associated with cardiovascular risks. This study aimed to elucidate the role of endothelial HEG1 in BP regulation and the underlying mechanisms.METHODSPhenome-wide association study, computational fluid dynamics analysis, single-cell RNA sequencing, artery and plasma samples from independent cohorts, and in vitro shear stress analysis were used to assess the association between hypertension, shear stress, and HEG1 levels. Endothelial-specific Heg1 deletion mice, BP monitoring, and vascular function analysis were employed to characterize the roles of EC-HEG1 in endothelial function and hypertension. Proteomics, transcriptomics, and ubiquitination assays were used to identify the regulatory pathways involved.RESULTSPlasma HEG1 levels were down-regulated in hypertensive subjects due to reduced wall shear stress on the endothelium, which diminished HEG1 expression and its release into circulation. Endothelial-specific Heg1 deletion in mice resulted in elevated BP, impaired endothelium-dependent vasodilation, and hypertensive levels especially in an ApoeKO dyslipidaemia background. Mechanistically, HEG1 facilitated CUL3-mediated degradation of PHACTR1. HEG1 deletion led to increased PHACTR1 levels, nuclear translocation, and suppression of SP1-mediated eNOS transcription and NO production. Inhibition of PHACTR1 nuclear localization by CCG-1423 prevented impaired vasodilation and hypertension.CONCLUSIONSOur study identifies a novel shear-sensitive endothelial HEG1 signalling pathway in BP regulation, providing potential therapeutic targets for hypertension.","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"80 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145127175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}