{"title":"European Society of Cardiology Clinical Practice Guidelines: fostering implementation in low-resource settings.","authors":"Eva Prescott","doi":"10.1093/eurheartj/ehaf075","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf075","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":""},"PeriodicalIF":37.6,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143729500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Abdominal Aortic Aneurysm screening is working but could be targeted to a more specific high-risk population.","authors":"Matti T Laine, Kevin Mani, Anders Wanhainen","doi":"10.1093/eurheartj/ehaf151","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf151","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":""},"PeriodicalIF":37.6,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Emphasizing life-course prevention for atherosclerosis with focus on blood pressure.","authors":"Arno Schmidt-Trucksäss","doi":"10.1093/eurheartj/ehaf159","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf159","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":""},"PeriodicalIF":37.6,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143709161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Rate acceleration in heart failure with preserved ejection fraction: towards different strokes for different folks.","authors":"Tim van Loon, Kevin Vernooy, Joost Lumens","doi":"10.1093/eurheartj/ehaf110","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf110","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":""},"PeriodicalIF":37.6,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Weekly Journal Scan: Is there adequate evidence for targeting only one pathway of platelet activation shortly after an acute coronary syndrome?","authors":"Giovanna Liuzzo, Carlo Patrono","doi":"10.1093/eurheartj/ehaf146","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf146","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":""},"PeriodicalIF":37.6,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Routine left atrial appendage surgical closure for all patients undergoing cardiac surgery?","authors":"Andrea Colli, Laura Besola, Raffaele De Caterina","doi":"10.1093/eurheartj/ehaf122","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf122","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":""},"PeriodicalIF":37.6,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Claudia Montanaro, Alexandra Arvanitaki, William Kerrigan, Zehra Kadani, Rosaria Barracano, Giancarlo Scognamiglio, Aleksander Kempny, Wei Li, Margarita Brida, Ella McDonnell, Hajar Habibi, Konstantinos Dimopoulos, Isma Rafiq, Heng Ee Ling, Harith Alam, Berardo Sarubbi, Gerhard-Paul Diller, Michael A Gatzoulis
{"title":"The Fontan Adult Brompton clinical score and mortality risk.","authors":"Claudia Montanaro, Alexandra Arvanitaki, William Kerrigan, Zehra Kadani, Rosaria Barracano, Giancarlo Scognamiglio, Aleksander Kempny, Wei Li, Margarita Brida, Ella McDonnell, Hajar Habibi, Konstantinos Dimopoulos, Isma Rafiq, Heng Ee Ling, Harith Alam, Berardo Sarubbi, Gerhard-Paul Diller, Michael A Gatzoulis","doi":"10.1093/eurheartj/ehaf137","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf137","url":null,"abstract":"<p><strong>Background and aims: </strong>Adults with congenital heart disease who underwent a Fontan palliation are at increased risk of premature death. This study aimed to identify a risk score based on widely available clinical variables at the first adult visit and facilitate personalized care.</p><p><strong>Methods: </strong>A single tertiary centre retrospective study included adults with a Fontan circulation during their first adults with congenital heart disease outpatient visit. Anatomic and periprocedural data, clinical, laboratory, and echocardiographic parameters at the first visit, and mortality or heart transplantation data were examined. A stepwise backward conditional approach was used to build a multivariate prognostic model, validated in an external retrospective cohort.</p><p><strong>Results: </strong>Overall, 230 patients (49.6% female), the median age of 21.7 [interquartile range (IQR) 18.7-28.0] years, were included. Within 10.2 years of follow-up, 44 patients died and two received heart transplantation. A score including age at the first visit, history of atrial tachyarrhythmia, heart failure, New York Heart Association class, systolic blood pressure, and resting arterial oxygen saturation was derived, discriminating patients into low, intermediate, and high risk of death or transplantation [C-index: 0.71, 95% confidence interval (CI) 0.62-0.80]; discriminative ability was excellent (C-index 0.92, 95% CI 0.90-0.95) when externally validated in a cohort of 80 patients [41.2% female, median age 18.4 (IQR 17.3-24.8) years] with similar freedom from transplantation survival with the derivation cohort (log-rank P = .77).</p><p><strong>Conclusions: </strong>This novel, readily available, externally validated, clinical score identifies adult patients with a Fontan palliation at risk of mortality or transplantation and can be applied towards personalized care in this growing population with complex congenital heart disease.</p>","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":""},"PeriodicalIF":37.6,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yaxing Meng, Juhani S Koskinen, Russell Thomson, Markus Juonala, Katja Pahkala, Juha Mykkänen, Suvi P Rovio, Mika Kähönen, Terho Lehtimäki, Jorma S A Viikari, Olli T Raitakari, Costan G Magnussen
{"title":"Blood pressure in childhood, young- and mid-adulthood: association with carotid plaque severity.","authors":"Yaxing Meng, Juhani S Koskinen, Russell Thomson, Markus Juonala, Katja Pahkala, Juha Mykkänen, Suvi P Rovio, Mika Kähönen, Terho Lehtimäki, Jorma S A Viikari, Olli T Raitakari, Costan G Magnussen","doi":"10.1093/eurheartj/ehaf139","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf139","url":null,"abstract":"<p><strong>Background and aims: </strong>Blood pressure (BP) is a key modifiable risk factor for atherosclerosis. How BP across different life stages associates with carotid plaque in mid-adulthood remains unclear, which is the aim of this study.</p><p><strong>Methods: </strong>The sample included 1889 participants from the Cardiovascular Risk in Young Finns Study who had their BP measured in childhood (6-18 years), young adulthood (21-39 years), and mid-adulthood (40-56 years). Outcomes were the carotid plaque presence and area in mid-adulthood. A Bayesian relevant life-course exposure model was used to estimate the life-course association of BP with carotid plaque and determine the relative contributions attributed to each life stage.</p><p><strong>Results: </strong>After a 38-year follow-up, 745 participants (39.4%) developed carotid plaques. Cumulative systolic BP (SBP) from childhood, young-, and mid-adulthood was associated with carotid plaque presence in mid-adulthood [for each 1-SD increase (∼12 mm Hg), relative risk (95% credible intervals (CrIs)): 1.22 (1.10-1.36)], with SBP at each life stage contributing approximately equally (relative weights: childhood, 39.4%; young adulthood, 37.9%; mid-adulthood, 22.7%). Cumulative SBP was associated with carotid plaque areas [β (95% CrIs), 0.16 (0.08-0.23)] square millimetre, with mid-adulthood SBP showing a higher contribution (relative weights: childhood, 12.5%; young adulthood, 25.0%; mid-adulthood, 62.5%). Similar patterns were observed for diastolic BP, pulse pressure, and mean arterial pressure.</p><p><strong>Conclusions: </strong>Blood pressure at each life stage contributes equally to carotid plaque presence, with mid-adulthood BP associated with a greater contribution to plaque area. These findings underscore the importance of maintaining normal BP throughout life to reduce atherosclerosis risk and suggest that intensive BP management in mid-adulthood may help slow plaque progression.</p>","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":""},"PeriodicalIF":37.6,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143709132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}