European Heart Journal最新文献

{"title":"Biomarkers predict cardiovascular outcomes in European cohort.","authors":"Hao Xing,Yazhen Su","doi":"10.1093/eurheartj/ehaf486","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf486","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"105 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144693232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Giant unruptured non-coronary sinus of Valsalva aneurysm protruding into the right atrium.","authors":"Chunyan Jiang,Xiangfeng Gong,Zhenghua Xiao","doi":"10.1093/eurheartj/ehaf483","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf483","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"33 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144693237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decision-making for older adults with advanced heart disease: a framework for balancing benefit versus futility.","authors":"Marc Arcens,James N Kirkpatrick,Jonathan Afilalo","doi":"10.1093/eurheartj/ehaf351","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf351","url":null,"abstract":"Medical futility in the cardiovascular care of older adults presents unique challenges that necessitate a nuanced understanding of both clinical and ethical dimensions. This state-of-the-art review explores the evolving concept of futility in the context of an ageing patient population and expanding armamentarium purported to treat even the most dire of cardiovascular diseases. The first objective is to delineate a framework for clinicians to elicit the different dimensions of futility, their relative importance to the patient, and their potential for improvement with the intervention being considered. Definitions are elaborated for quantitative futility-interventions with statistically negligible benefits-and qualitative futility-interventions misaligned with patient-specific goals and values. The second objective is to highlight the determinants of prohibitive risk, from the cardiovascular disease and procedural morbidity, to competing non-cardiovascular risks and frailty. A distinction is made between frailty and futility, and manifestations of severe frailty are reviewed based on the A-B-C-D-E mnemonic. The third and final objective is to discuss strategies and actionable approaches to care for patients once futility has been invoked. In addition to ongoing compassionate dialogue with the patient and family members, early initiation and aggressive pursuit of palliative care measures is beneficial for symptom control and quality of life. Ultimately, informed shared decision-making with a patient-centered philosophy is essential to uphold dignity and enhance the quality of life for older adults facing complex cardiovascular conditions.","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"15 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144693231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitochondrial cardiomyopathies: pathogenesis, diagnosis, and treatment.","authors":"Christoph Maack,Jan Dudek,Edoardo Bertero,Emmanouil Tampakakis,Hilary J Vernon","doi":"10.1093/eurheartj/ehaf491","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf491","url":null,"abstract":"Mitochondrial cardiomyopathies are a heterogeneous group of disorders caused by dysfunction of mitochondrial energy production due to genetic mutations affecting mitochondrial or nuclear DNA. Mitochondrial cardiomyopathies can include a wide range of cardiac manifestations and are frequently associated with other multisystemic symptoms, including skeletal myopathy, neurological deficits, and metabolic disturbances. Advances in genetic testing have improved diagnostic accuracy, but early identification remains challenging due to the variable clinical presentation and clinical overlap with other cardiomyopathies. Therapeutic strategies are still evolving, with current management focusing on symptom control and mitigation of mitochondrial dysfunction. This review aims to provide a comprehensive overview of the pathophysiology, clinical features, diagnostic approaches, and treatment options for mitochondrial cardiomyopathies, highlighting the ongoing need for research into effective therapies and improved patient outcomes.","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"699 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144693235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cryoballoon vs radiofrequency ablation in persistent atrial fibrillation: the CRRF-PeAF trial.","authors":"Koji Miyamoto,Koshiro Kanaoka,Kenji Yodogawa,Yuhi Fujimoto,Hiroshi Fukunaga,So Asano,Takahiko Nagase,Muryo Terasawa,Takahiro Kusume,Yasuyuki Takada,Ken Takarada,Yuichiro Sagawa,Takatoshi Shigeta,Junichi Ooka,Masahiro Ishikura,Masue Yoh,Hiroki Takahashi,Yuko Inoue,Satoshi Nagase,Takeshi Aiba,Naoya Kataoka,Masahiko Takagi,Shintaro Yamagami,Suguru Nishiuchi,Yasuhiro Sasaki,Atsushi Kobori,Yasuteru Yamauchi,Yoshinao Yazaki,Kazuhiro Satomi,Junichi Nitta,Shingo Mizuno,Masato Murakami,Keiichi Ashikaga,Jun Kishihara,Hidehira Fukaya,Yu-Ki Iwasaki,Wataru Shimizu,Kengo Kusano","doi":"10.1093/eurheartj/ehaf451","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf451","url":null,"abstract":"BACKGROUND AND AIMSThere are limited prospective data on the efficacy, safety, and impact on reverse remodelling of cryoballoon ablation as compared to radiofrequency ablation for persistent atrial fibrillation.METHODSA prospective, multicentre, randomized, non-inferiority clinical trial was conducted to compare the efficacy and safety of cryoballoon vs radiofrequency ablation for persistent atrial fibrillation. A total of 500 patients with persistent atrial fibrillation were randomized across 12 centres. The primary endpoint was the occurrence of atrial tachyarrhythmias at 1 year with a 90-day blanking period after ablation.RESULTSThe final analysis included 499 patients, with a median age of 69 years (interquartile range, 61-74); 249 patients were allocated to the cryoballoon group, and 250 to the radiofrequency group. In the intention-to-treat analysis, the primary endpoint was observed in 56 patients (22.5%) in the cryoballoon group and 58 (23.2%) in the radiofrequency group, and the cryoballoon group demonstrated non-inferiority compared to the radiofrequency group for the primary endpoint (hazard ratio .99; 95% confidence interval, .69-1.43; P = .96). The radiofrequency group showed a greater reduction in left atrial size (left atrial volume index) at 1 year than the cryoballoon group [-11 mL/m2 (interquartile range, -19 to -4) vs -4 mL/m2 (interquartile range, -13 to 3), P < .001].CONCLUSIONSIn this randomized trial, cryoballoon ablation was non-inferior to radiofrequency ablation for the occurrence of atrial tachyarrhythmias at 1 year in patients with persistent atrial fibrillation.","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"115 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144693233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Near-universal prevalence of central adiposity in heart failure with preserved ejection fraction: the PARAGON-HF trial.","authors":"","doi":"10.1093/eurheartj/ehaf512","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf512","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"55 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144701127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A stitch in time: easily measured biomarkers to enhance cardiovascular risk prediction in primary prevention.","authors":"Jordan M Kraaijenhof,Nick S Nurmohamed,Paul M Ridker","doi":"10.1093/eurheartj/ehaf488","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf488","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"23 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144693236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seek and you shall find: red flags in hypertrophic phenotypes.","authors":"Ahmad Masri","doi":"10.1093/eurheartj/ehaf242","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf242","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"25 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144684356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Immune checkpoint inhibitor-associated myocarditis: a novel risk score.","authors":"","doi":"10.1093/eurheartj/ehaf529","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf529","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"18 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144684109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Co-creation of a national action plan to increase heart health in The Netherlands: the Dutch cardiovascular agenda.","authors":"Rebecca Y Abma-Schouten,Joanne J A van Bavel,Arthur A M Wilde","doi":"10.1093/eurheartj/ehaf376","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf376","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"14 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144678017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}