European Heart Journal最新文献

{"title":"European Research Council-funded grant: long non-coding RNA in adipocytes.","authors":"Alastair G Kerr","doi":"10.1093/eurheartj/ehaf129","DOIUrl":"10.1093/eurheartj/ehaf129","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":"1881-1882"},"PeriodicalIF":37.6,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Empagliflozin enhances metabolic efficiency and improves left ventricular hypertrophy in a hypertrophic cardiomyopathy mouse model.","authors":"Tomas Baka,Jarrod Moore,Fuzhong Qin,Salva R Yurista,Aifeng Zhang,Huamei He,Jordan M Chambers,Dominique Croteau,Raghuveera K Goel,Hunter Smith,Miranda C Wang,Christopher S Chen,Ion A Hobai,Martina Rombaldova,Ondrej Kuda,Jil C Tardiff,James A Balschi,David R Pimentel,Christine E Seidman,Jonathan G Seidman,Andrew Emili,Wilson S Colucci,Ivan Luptak","doi":"10.1093/eurheartj/ehaf324","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf324","url":null,"abstract":"BACKGROUND AND AIMSHypertrophic cardiomyopathy (HCM) is a genetic cardiac disorder characterized by left ventricular hypertrophy (LVH), diastolic dysfunction, and impaired metabolic efficiency. This study investigates the therapeutic potential of the sodium-glucose cotransporter 2 inhibitor (SGLT2i) empagliflozin (EMPA) in ameliorating these pathological features in a mouse model carrying the myosin R403Q mutation.METHODSMale mice harbouring the R403Q mutation were treated with EMPA for 16 weeks. Multi-nuclear magnetic resonance spectroscopy (31P, 13C, and 23Na MRS), echocardiography, transcriptomic, proteomic, and phosphoproteomic profiling were utilized to assess metabolic, structural, and functional changes.RESULTSEmpagliflozin facilitated the coupling of glycolysis with glucose oxidation and normalized elevated intracellular sodium levels. Treatment resulted in a significant reduction in LVH and myocardial fibrosis as evidenced by echocardiography and histopathology. These structural improvements correlated with enhancements in mitochondrial adenosine triphosphate (ATP) synthesis, fatty acid oxidation, and branched-chain amino acid catabolism. Furthermore, EMPA improved left ventricular diastolic function and contractile reserve, underscored by improved ATP production and reduced energy cost of contraction. Notably, these benefits were linked to down-regulation of the mammalian target of rapamycin signalling pathway and normalization of myocardial substrate metabolic fluxes.CONCLUSIONSEmpagliflozin significantly mitigates structural and metabolic dysfunctions in a mouse model of HCM, underscoring its potential as a therapeutic agent for managing this condition. These findings suggest broader applicability of SGLT2i in cardiovascular diseases, including those due to myocardial-specific mutations, warranting further clinical investigation.","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"33 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144103731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Common and divergent cellular aetiologies underlying hypoplastic left heart syndrome and hypoplastic right heart syndrome.","authors":"Yang Yu, Cankun Wang, Shiqiao Ye, Hannah Qin, Matthew Alonzo, Angela Onorato, Aaron Argall, Karen Texter, Qin Ma, Vidu Garg, Ming-Tao Zhao","doi":"10.1093/eurheartj/ehaf121","DOIUrl":"10.1093/eurheartj/ehaf121","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":"1946-1949"},"PeriodicalIF":37.6,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12093140/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143572634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2024 Revision of the level of evidence grading system for ESC clinical practice guideline recommendations I: therapy and prevention.","authors":"Peter Jüni, Sotiris Antoniou, Elena Arbelo, Sergio Buccheri, Maja Cikes, Bruno R da Costa, Laurent Fauchier, Chris P Gale, Sigrun Halvorsen, Stefan James, Konstantinos C Koskinas, Dipak Kotecha, Ulf Landmesser, Basil S Lewis, Maja-Lisa Løchen, Jens Cosedis Nielsen, Xavier Rosselló, Ilonca Vaartjes, Eva B Prescott, Colin Baigent","doi":"10.1093/eurheartj/ehaf009","DOIUrl":"10.1093/eurheartj/ehaf009","url":null,"abstract":"<p><p>The level of evidence (LOE) grading system for ESC Clinical Practice Guidelines classifies the quality of the evidence supporting a recommendation. However, the current taxonomy does not fully consider the optimal study design necessary to establish evidence for such recommendations. Therefore, two separate taskforces of clinical and methodological experts were appointed by the Clinical Practice Guidelines Committee, with the first tasked with updating the LOE grading system for therapy and prevention, and the second responsible for developing a LOE grading system for diagnosis and prediction. The updated system for therapy and prevention presented here maintains the three-level grading structure but uses revised definitions. Level of evidence A represents conclusive evidence usually from ≥2 adequately powered randomized controlled trials (RCTs) free from major bias, with substantial evidence against the play of chance when combined in a meta-analysis (e.g. P < .005 for superiority). Additional criteria are specified to define substantial evidence against the play of chance in case of non-inferiority, equivalence, and harm. Level of evidence B is now subdivided into B1 and B2. Level of evidence B1 represents suggestive evidence usually from ≥1 adequately powered RCT free from major bias, or a meta-analysis of such RCTs, with some evidence against the play of chance (e.g. P < .05 for superiority). Level of evidence B2 represents limited evidence from ≥2 adequately powered non-randomized studies with careful control of major sources of bias or from a meta-analysis of small, underpowered RCTs. Level of evidence C represents preliminary evidence from either non-randomized studies without careful control of major sources of bias, a single small, underpowered RCT, or expert consensus.</p>","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":"1885-1894"},"PeriodicalIF":37.6,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute myocardial infarction diagnosis: impact of artificial intelligence-powered ECG interpretation.","authors":"I Min Chiu, David Ouyang","doi":"10.1093/eurheartj/ehaf142","DOIUrl":"10.1093/eurheartj/ehaf142","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":"1930-1932"},"PeriodicalIF":37.6,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143709131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exercise electrocardiography stress testing in suspected angina and non-obstructive coronary arteries.","authors":"Robert Sykes,Andrew J Morrow,Bethany Stanley,Daniel Ang,Giles Roditi,David Stobo,David Corcoran,Ninian N Lang,Ahmed Mahrous,Robin Young,David Carrick,Ross McGeoch,Margaret B McEntegart,Alex McConnachie,Novalia P Sidik,Colin Berry","doi":"10.1093/eurheartj/ehaf208","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf208","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"131 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144103736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Weekly Journal Scan: The five-year follow-up of FAME 3 keeps open the never-ending debate about coronary artery bypass grafting vs percutaneous coronary intervention in patients with three-vessel disease.","authors":"Antonio Maria Leone,Rocco Vergallo","doi":"10.1093/eurheartj/ehaf345","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf345","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"9 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144103728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antithrombotic treatment following revascularization for chronic limb-threatening ischaemia: a scientific statement of the European Society of Cardiology Working Group on Aorta and Peripheral Vascular Diseases and the European Society of Cardiology Working Group on Cardiovascular Pharmacotherapy.","authors":"Oliver Schlager,Marco De Carlo,Lucia Mazzolai,Alessandra Bura-Riviere,Christian Heiss,Jose Rodriguez Palomares,Joao C A Morais,Sabine Steiner,Marianne Brodmann,Victor Aboyans,Raffaele De Caterina","doi":"10.1093/eurheartj/ehaf317","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf317","url":null,"abstract":"Chronic limb-threatening ischaemia (CLTI) is defined as ischaemic rest pain, or non-healing ulceration, requiring endovascular or surgical lower limb revascularization (LLR). Lower limb revascularization in CLTI entails a high risk of major adverse limb events (MALE) and major adverse cardiovascular events (MACE). This scientific statement addresses this risk based on a systematic review. A structured literature search was performed, and articles were independently evaluated by two investigators. In total, 1678 articles were identified, of which 34 were included in the final analysis. Only three randomized controlled trials (RCTs) addressed antithrombotic therapy in CLTI following LLR. None of these demonstrated superiority of any antithrombotic regimen over the other. Eight RCTs investigated antithrombotic therapy following LLR in populations with peripheral arterial disease including CLTI subgroups and suggest a benefit of dual antiplatelet therapy on limb events. One large RCT demonstrated that dual pathway inhibition with aspirin and vascular-dose rivaroxaban reduced the risk of MALE, MACE, and unplanned target limb revascularization. Data from 22 observational studies suggest a benefit of dual antiplatelet therapy on overall survival and amputation-free survival after LLR as compared with single antiplatelet therapy. Intensified antithrombotic treatment should be proposed in patients with CLTI following LLR to reduce the risk of MALE and MACE. Randomized controlled trials on antithrombotic therapy in patients with CLTI following LLR are scarce. Dual pathway inhibition is the only regimen for which an RCT demonstrated a reduction of MALE and MACE following LLR. Dual antiplatelet therapy appears to be associated with a reduced risk of MALE in CLTI following LLR.","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"166 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144103772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myopericardial complications following COVID-19 disease and vaccination: a clinical consensus statement of the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases.","authors":"Massimo Imazio,Cristina Basso,Antonio Brucato,Karin Klingel,Petr Kuchynka,George Lazaros,Marco Merlo,Gianfranco Sinagra,Yehuda Adler,Chiara Bucciarelli Ducci,Matteo Cameli,Silvia Castelletti,Alida Linda Caforio,Lia Crotti,Lorenzo Dagna,Andrea Frustaci,Allan Klein,Johanna Kuusisto,Angela Lopez Sainz,Renzo Marcolongo,Antonis Pantazis,Angelos G Rigopoulos,Arsen Ristic,Petar Seferovic,Mary Sheppard,Carsten Tschöpe,Thomas Lüscher","doi":"10.1093/eurheartj/ehaf222","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf222","url":null,"abstract":"The aim of the present clinical consensus statement of the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases is to review the current knowledge on the epidemiology, pathogenesis, diagnosis, therapy, and outcomes of myocardial and pericardial complications of coronavirus disease 2019 (COVID-19) and vaccination in order to improve the awareness and clinical confidence on the management of patients with these complications. The risk of myopericardial complications is especially higher within 1 month of COVID-19 disease and vaccination. Forms related to the disease are generally more common and severe than those related to vaccination. Even if vaccination against COVID-19 increases myocarditis risk, this risk is lower in vaccinated than non-vaccinated COVID-19 individuals, supporting the vaccine use. Overall, COVID-19 related complications, especially myocarditis, are relatively rare.","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"18 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144097722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atrial amyloidosis identified by biopsy in atrial fibrillation: prevalence and clinical presentation.","authors":"Kodai Shinzato,Yuya Takahashi,Takanori Yamaguchi,Toyokazu Otsubo,Kana Nakashima,Goro Yoshioka,Kensuke Yokoi,Kotaro Tsuruta,Ryosuke Osako,Shigeki Shichida,Yuki Nishimura,Makoto Edayoshi,Yuki Kawano,Yukako Shintani-Domoto,Kai Miyazaki,Akira Fukui,Atsushi Kawaguchi,Shigehisa Aoki,Seitaro Nomura,Naohiko Takahashi,Kaoru Ito,Koichi Node","doi":"10.1093/eurheartj/ehaf332","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf332","url":null,"abstract":"BACKGROUND AND AIMSThis study aimed to assess the prevalence of cardiac amyloidosis (CA) in patients with non-valvular atrial fibrillation (AF) and to test the hypothesis that early-stage CA can be identified through atrial biopsy.METHODSAtrial biopsy was performed on 578 patients during AF ablation, with right ventricular (RV) biopsy conducted in 385 patients. The amyloid type was assessed using immunohistochemistry. Patients were classified into groups of atrial biopsy-detected CA (abio-CA) and non-CA, with an additional 58 patients clinically diagnosed with CA comprising the clinical CA group.RESULTSAmyloid deposits were identified in atrial samples from 40 patients (7%), including 25 amyloid transthyretin (ATTR) types. Prevalence increased to 20%-40% with advancing age, left ventricular (LV) hypertrophy, and the presence of low-voltage areas in the left atrium. The abio-CA group exhibited a thinner LV posterior wall (11.3 ± 2.2 vs 15.3 ± 4.6 mm, P < .001) compared with the clinical CA group. The abio-CA group displayed a thicker LV posterior wall (11.3 ± 2.2 vs 9.6 ± 1.4 mm, P < .001) and a higher frequency of low-voltage areas defined as <0.5 mV (45% vs 13%, P < .001) compared with the non-CA group. Right ventricular biopsy identified amyloid deposits in 13 patients (3%), comprising 11 ATTR and 2 light-chain types. Among the 26 patients in the abio-CA group who underwent RV biopsy, 13 had no amyloid deposits in RV samples, indicating confined atrial amyloidosis.CONCLUSIONSAtrial biopsy revealed amyloid deposits in 7% of patients undergoing AF ablation, identifying early-stage CA.","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"1 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144103771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}