European Heart Journal最新文献

{"title":"Clonal haematopoiesis and cardiovascular diseases: challenges and opportunities.","authors":"Cesar De Jeronimo Diaz,Trevor P Fidler,Dina Levy-Lambert","doi":"10.1093/eurheartj/ehaf812","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf812","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"12 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145305576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacoepidemiology as the delicate science of constructing robust plausibility where there is no certainty: the case for hypertension in young adults.","authors":"Antoine Pariente","doi":"10.1093/eurheartj/ehaf712","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf712","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"1 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145305621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond the scar: risk prediction in non-dilated left ventricular cardiomyopathy.","authors":"Elena Arbelo","doi":"10.1093/eurheartj/ehaf566","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf566","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"9 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145305638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Killing three birds with one stone: transcatheter salvage of aorto-atrial fistula and paravalvular leaks following transcatheter tricuspid valve replacement.","authors":"Yuliang Long,Daxin Zhou,Wenzhi Pan","doi":"10.1093/eurheartj/ehaf796","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf796","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"46 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145305639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urinary tract infection and continuation of sodium-glucose cotransporter-2 inhibitors in diabetic patients.","authors":"Mei-Zhen Wu,Ran Guo,Chanchal Chandramouli,Lin Liu,Anthony Ma-On Tung,Christopher Tze-Wei Tsang,Yi-Kei Tse,Yap-Hang Chan,Chi-Ho Lee,Jia-Yi Huang,Jing-Nan Zhang,Wen-Li Gu,Qing-Wen Ren,Ching-Yan Zhu,Yik-Ming Hung,Carolyn S P Lam,Kai-Hang Yiu","doi":"10.1093/eurheartj/ehaf788","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf788","url":null,"abstract":"BACKGROUND AND AIMSTo investigate the impact of incident urinary tract infection (UTI) and subsequent sodium-glucose cotransporter-2 (SGLT2) inhibitors discontinuation on clinical outcomes among patients with type 2 diabetes mellitus (T2DM) prescribed SGLT2 inhibitors.METHODSThis territory-wide cohort study analysed patients with T2DM prescribed SGLT2 inhibitors from January 2015 to June 2022. Primary outcomes included primary cardiovascular composite outcomes (heart failure hospitalization, stroke, myocardial infarction, or all-cause mortality) and primary renal composite outcomes (50% decline in estimated glomerular filtration rate [eGFR], end-stage renal failure, or all-cause mortality). The secondary outcome was recurrent UTI. A target trial emulation was applied to estimate the impact of discontinuing SGLT2 inhibitors.RESULTSAmong 61 606 eligible patients, 3921 (6.36%) had at least one UTI incidence during follow-up. Patients with incident UTI exhibited a higher risk of primary cardiovascular composite outcomes [hazards ratio (HR): 3.18, 95% confidence interval (CI): 2.88-3.51] and primary renal composite outcomes (HR: 2.51, 95% CI: 2.32-2.72) compared to those without UTI. Following a UTI, 32.31% of patients discontinued SGLT2 inhibitors. Discontinuation was associated with a higher cardiovascular (HR: 1.35, 95% CI: 1.20-1.53) and renal (HR: 1.35, 95% CI: 1.21-1.51) risks compared to continued use, while the risk of recurrent UTI was similar (HR: 0.96, 95% CI: 0.22-4.29).CONCLUSIONSNew-onset UTI was associated with an increased risk of cardiovascular and renal events in patients with T2DM prescribed SGLT2 inhibitors. Discontinuing SGLT2 inhibitors after a UTI was linked to a higher risk of cardiovascular and renal outcomes but was not associated with fewer recurrent UTI.","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"1 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145305578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing the conversation of data sharing in cardiovascular clinical research.","authors":"Ankeet S Bhatt,Scott D Solomon","doi":"10.1093/eurheartj/ehaf730","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf730","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"66 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145311182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcatheter edge-to-edge repair for atrial functional mitral regurgitation: the final frontier.","authors":"Benedict McDonaugh,Simon Redwood,Tiffany Patterson","doi":"10.1093/eurheartj/ehaf792","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf792","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"62 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145305759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of moderate mixed aortic valve stenosis and regurgitation.","authors":"Pilar Lopez Santi,Jérémy Bernard,Aileen Chua,Dorien Laenens,Andréanne Powers,Kathia Abdoun,Bart J J Velders,Camille Sarrazyn,Paolo Springhetti,Jingnan Zhang,Mohammed R Amanullah,See Hooi Ewe,Kai-Hang Yiu,Meindert Palmen,Jesper Hjortnaes,Philippe Pibarot,Marie-Annick Clavel,Jeroen J Bax,Nina Ajmone Marsan","doi":"10.1093/eurheartj/ehaf791","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf791","url":null,"abstract":"BACKGROUND AND AIMSThere are limited data on mortality in patients with moderate mixed aortic valve disease (MAVD), defined as the combination of moderate aortic stenosis (AS) and moderate aortic regurgitation (AR). Consequently, current guidelines lack specific recommendations for aortic valve replacement (AVR) in this population. This study aims to compare survival between moderate MAVD and isolated severe AS or severe AR, and to evaluate the impact of symptoms or left ventricular ejection fraction (LVEF) < 50%, as current criteria for AVR in severe AS or AR.METHODSOverall, 1926 patients were included from four centers: 527 with moderate MAVD, 413 with severe AR, and 986 with severe AS. The primary endpoint was all-cause mortality.RESULTSOver a median follow-up of 7.2 (interquartile range 3.4-11.3) years, 748 patients died. After adjusting for clinical and echocardiographic variables (including New York Heart Association [NYHA] class, LVEF < 50%, and AVR as time-dependent covariate), moderate MAVD patients showed 10-year survival similar to severe AS but worse than severe AR (62%, 55%, and 79%, respectively; P < .001). Symptomatic moderate MAVD patients showed adjusted mortality comparable to symptomatic severe AS, while asymptomatic moderate MAVD patients had adjusted mortality similar to severe AR (symptomatic and asymptomatic). Moderate MAVD patients with LVEF < 50% had adjusted mortality comparable to severe AS with LVEF < 50%, while those with LVEF ≥ 50% showed mortality similar to severe AR (regardless of left ventricular dysfunction).CONCLUSIONSIn moderate MAVD, the presence of symptoms or LVEF < 50% is associated with increased mortality, comparable to isolated severe AS under similar conditions. Therefore, patients with moderate MAVD should benefit from AVR in the presence of symptoms or left ventricular dysfunction.","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"58 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145305640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Angina after percutaneous coronary interventions.","authors":"Marco Lombardi, Laurie-Anne Boivin-Proulx, Adrian Jerónimo, Hernán Mejía-Rentería, Nieves Gonzalo, Tommaso Gori, Roxana Mehran, Javier Escaned","doi":"10.1093/eurheartj/ehaf771","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf771","url":null,"abstract":"<p><p>Persistence or recurrence of angina after percutaneous coronary intervention (PCI) has gained recognition as an unfortunately common condition, which defeats the most frequent purpose of performing PCI in patients with stable coronary artery disease, the relief or reduction of anginal symptoms. Many aspects of this problem remain unknown and underexplored, with clinical practice guidelines providing limited information on guidance for its causative diagnosis, prevention and management. This review article aims to provide a contemporary perspective on the problem of post-PCI angina, leveraging recent advancements on the pathophysiological mechanisms that frequently underlie this condition, including sub-optimal functional results of PCI and non-obstructive causes of myocardial ischaemia. The opportunities provided by new functional coronary angiography tools are explored. A practical structured approach to the aetiological diagnosis and treatment of these patients is proposed.</p>","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":""},"PeriodicalIF":35.6,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145307333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-linear Mendelian randomization analyses on 25-hydroxyvitamin D and the risk of cardiovascular outcomes.","authors":"Elina Hyppönen,Ang Zhou","doi":"10.1093/eurheartj/ehaf785","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf785","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"104 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145305575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}