European Heart Journal最新文献

{"title":"ACNAP 2025: advancing nursing and allied professions leadership.","authors":"Leonie Klompstra,Julie Sanders,Eleni Kletsiou","doi":"10.1093/eurheartj/ehaf613","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf613","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"76 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145153366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ESC consensus statement on stroke risk management in carotid atherosclerotic disease: 10 key points.","authors":"Piotr Musialek,Iris Q Grunwald,Adnan H Siddiqui","doi":"10.1093/eurheartj/ehaf614","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf614","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"95 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145140274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Persistent left common cardinal vein: an incidental discovery during patent foramen ovale closure.","authors":"Junzhou Pu,Yizhen Yang,Wenhui Wu","doi":"10.1093/eurheartj/ehaf751","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf751","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"41 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145140406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EuroHeart: improving cardiovascular care through data collection and international collaboration.","authors":"Lars Wallentin,Eva Prescott,Stefan James","doi":"10.1093/eurheartj/ehaf587","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf587","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"15 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145140158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Taiwan Society of Cardiology: past, present, and future.","authors":"Yi-Heng Li,Hung-I Yeh,I-Chang Hsieh","doi":"10.1093/eurheartj/ehaf574","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf574","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"3 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145153363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anticholinergic medications and out-of-hospital sudden cardiac arrest: a new piece to the puzzle?","authors":"Larisa G Tereshchenko","doi":"10.1093/eurheartj/ehaf727","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf727","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"25 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145140276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heart Failure 2025 Congress: a recent remarkable success in heart failure.","authors":"Petar M Seferović,Marco Metra,Wilfried Mullens","doi":"10.1093/eurheartj/ehaf619","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf619","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"41 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145140278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transient anticholinergic burden and out-of-hospital cardiac arrest: a case-crossover study.","authors":"Ming-Jen Tsai,Chris Tzu-Ting Su,Sheng-Feng Sung,Hsin-Yi Yang,Michael Chun-Yuan Cheng,Albert Tzu-Ming Chuang,Shih-Chieh Shao,Edward Chia-Cheng Lai","doi":"10.1093/eurheartj/ehaf723","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf723","url":null,"abstract":"BACKGROUND AND AIMSAnticholinergic burden has been linked to cardiovascular events and mortality, but its association with out-of-hospital cardiac arrest (OHCA) remains unclear. This study investigated whether transient increases in anticholinergic burden elevate OHCA risk in middle-aged and older populations.METHODSA nationwide case-crossover, case-time-control, and case-case-time-control study using Taiwan's National Health Insurance Research Database involved 173 974 adults aged ≥40 years who experienced OHCA between 2011 and 2021. The participants were middle-aged (40-64 years) or older (≥65 years). Anticholinergic burden was assessed using established scales and categorized as 0, 1-2, and 3 or more points. Each participant's burden during the hazard period (days -30 to -1 before OHCA) was compared to a randomly selected 30-day reference period (from days -180 to -61). Conditional logistic regression was used to estimate odds ratios (ORs) with 95% confidence intervals (CIs).RESULTSCase-crossover analysis showed more patients having higher anticholinergic burden during the hazard period than during the reference period in both age groups. The ORs for OHCA were 1.48 (95% CI: 1.42-1.55) and 1.56 (95% CI: 1.52-1.61) for scores of 1-2, compared with 0, and 2.03 (95% CI: 1.95-2.11) and 2.21 (95% CI: 2.15-2.27) for scores of 3 or more, compared to 0, in the middle-aged and older groups, respectively. Case-time-control and case-case-time-control analyses consistently showed a dose-response relationship, with results confirmed by sensitivity analyses.CONCLUSIONSTransient increases in anticholinergic burden significantly raise OHCA risk, particularly among individuals with higher burden levels.","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"94 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145134069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antihypertensive treatment in young adults and cardiovascular risk: a population-based cohort study.","authors":"Federico Rea,Gabriella Morabito,Giovanni Corrao,Giuseppe Mancia","doi":"10.1093/eurheartj/ehaf744","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf744","url":null,"abstract":"BACKGROUND AND AIMSThe efficacy of antihypertensive drug treatment in reducing hypertension-related outcomes has been documented in old and middle age but never in younger individuals. The aim of this study was to assess the protective effect of antihypertensive drugs in young adults (18-39 years) by comparing the risk of nonfatal and fatal outcomes in patients with different adherence to antihypertensive drugs. Analysis was extended to middle-aged patients (40-55 years) for comparison.METHODSUsing the healthcare utilization database of the Lombardy region (Italy), 286 751 residents, aged 18-55 years, who were newly prescribed antihypertensive drugs between 2009 and 2017 were identified. Adherence to drug therapy was measured by the proportion of the follow-up covered by antihypertensive drug prescription, and data were compared for adherent vs non-adherent patients, i.e. drug coverage ≥ 80% vs <80% of the follow-up duration. The primary outcome was hospital admissions for cardiovascular (CV) events. Secondary outcomes were CV and all-cause death. Cox and the cause-specific hazard regression models were used to estimate hazard ratio (HR) and 95% confidence interval (CI).RESULTSOver a follow-up of about 6 years, the HR of hospitalization for a CV outcome associated with adherence to antihypertensive drugs was 0.78 (95% CI 0.65-0.94) and 0.80 (95% CI 0.76-0.84) among patients aged 18-39 and 40-55 years, respectively. Adherence to antihypertensive drugs was negatively associated with CV and all-cause mortality in the older group (-18%, 6-28%; -30%, 27-33%), while showing no significant effects on these outcomes in the younger one.CONCLUSIONSIn a real-life setting, adherence to antihypertensive drug treatment reduced CV risk in young adults as much as in middle-aged patients.","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"17 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145134137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EP4/ANXA2 axis in pulmonary arterial hypertension: therapeutic implications.","authors":"Hu Xu,Lan Ye,Chunxiu Du,Hui Tang,Qi Zheng,Chunhua Zhu,Bo Liang,Yali Wang,Xiuhui Mao,Qing Liang,Jiayao Zhang,Huishu Shao,Xiaowan Sun,Ruqiang Yuan,Weijing Yun,Changbiao Luo,Jiaming Xiu,Wen Su,Fenling Fan,Zhiyu Dai,Lihong Chen,Youfei Guan,Xiaoyan Zhang","doi":"10.1093/eurheartj/ehaf763","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf763","url":null,"abstract":"BACKGROUND AND AIMSPulmonary arterial hypertension (PAH) is a progressive condition marked by the abnormal proliferation of pulmonary artery smooth muscle cells (PASMCs), leading to significant remodelling of the pulmonary arteries (PAs). The cyclooxygenase metabolite of arachidonic acid prostaglandin E2 and its receptor EP4 are crucial for maintaining vascular homeostasis. This study aimed to determine the role of EP4 in the pathogenesis of PAH and evaluate the potential of EP4 as a therapeutic target for PAH.METHODSTwo well-established PAH models, the monocrotaline-induced rat model and hypoxia/Su5416-induced mouse model, were used in this study. Both pharmacological interventions (including the EP4 antagonist grapiprant and MF498 and the agonist Cay10598) and genetic strategies (including vascular smooth muscle cell [VSMC]-specific EP4 knockout mice and VSMC-specific human EP4 transgenic mice) were used to comprehensively investigate the role of EP4 in the pathogenesis of PAH. Multiple cellular and molecular biology approaches were employed to investigate the underlying mechanisms.RESULTSThe results showed that the pharmacological blockade of the EP4 receptor and genetic deletion of the EP4 gene in VSMCs led to a significant improvement in PAH and PA remodelling. Conversely, pharmacological activation and VSMC-specific overexpression of EP4 exacerbate PAH progression. Further analysis identified annexin A2 (ANXA2) as a critical downstream mediator in EP4-induced PAH progression. Mechanistically, EP4 activation was found to enhance the translation of ANXA2 and phosphorylation of ANXA2 at Thr208 via the cAMP/PKA pathway, promoting PASMC proliferation and migration through increased nuclear translocation of β-catenin, a key signalling molecule in the canonical Wnt pathway. Importantly, pharmacological inhibition or genetic deletion of ANXA2 effectively protected PAH in rodents, suggesting its pathogenic role in PAH development.CONCLUSIONSThis study reveals a crucial pathway involving EP4 and ANXA2 in PAH development and progression. Targeting EP4 and its downstream effector ANXA2 represents promising therapeutic strategies for PAH management.","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"93 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145140401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}