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Transcatheter reclosure for residual shunting with incomplete degradation of a biodegradable patent foramen ovale occluder. 生物可降解卵圆孔未闭闭塞器不完全降解的残留分流的经导管再闭合。
IF 45.3 1区 医学
European Heart Journal Pub Date : 2026-10-13 DOI: 10.1093/eurheartj/ehag821
Ang Liu, Yifei Lv, Chaowu Yan
{"title":"Transcatheter reclosure for residual shunting with incomplete degradation of a biodegradable patent foramen ovale occluder.","authors":"Ang Liu, Yifei Lv, Chaowu Yan","doi":"10.1093/eurheartj/ehag821","DOIUrl":"https://doi.org/10.1093/eurheartj/ehag821","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":""},"PeriodicalIF":45.3,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149180139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Direct oral anticoagulants vs dual antiplatelet therapy after left atrial appendage occlusion: a meta-analysis of trials. 左心耳闭塞后直接口服抗凝剂vs双重抗血小板治疗：试验荟萃分析
IF 45.3 1区 医学
European Heart Journal Pub Date : 2026-10-13 DOI: 10.1093/eurheartj/ehag817
Ahmed Samy Badran, Gregg W Stone
{"title":"Direct oral anticoagulants vs dual antiplatelet therapy after left atrial appendage occlusion: a meta-analysis of trials.","authors":"Ahmed Samy Badran, Gregg W Stone","doi":"10.1093/eurheartj/ehag817","DOIUrl":"https://doi.org/10.1093/eurheartj/ehag817","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":""},"PeriodicalIF":45.3,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149180215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Serbia's national initiative on asymptomatic valvular disease. 塞尔维亚关于无症状瓣膜病的国家倡议。
IF 45.3 1区 医学
European Heart Journal Pub Date : 2026-10-13 DOI: 10.1093/eurheartj/ehag767
Marko Banovic, Danijela Trifunovic-Zamaklar, Svetozar Putnik
{"title":"Serbia's national initiative on asymptomatic valvular disease.","authors":"Marko Banovic, Danijela Trifunovic-Zamaklar, Svetozar Putnik","doi":"10.1093/eurheartj/ehag767","DOIUrl":"https://doi.org/10.1093/eurheartj/ehag767","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":""},"PeriodicalIF":45.3,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149180203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Building Zanzibar's first cardiac catheterization lab: closing the chain of survival. 建立桑给巴尔第一个心导管实验室：关闭生存之链。
IF 45.3 1区 医学
European Heart Journal Pub Date : 2026-10-13 DOI: 10.1093/eurheartj/ehag776
Khuzeima Khanbhai, Mohamed Janabi, Sahrai Saeed
{"title":"Building Zanzibar's first cardiac catheterization lab: closing the chain of survival.","authors":"Khuzeima Khanbhai, Mohamed Janabi, Sahrai Saeed","doi":"10.1093/eurheartj/ehag776","DOIUrl":"https://doi.org/10.1093/eurheartj/ehag776","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":""},"PeriodicalIF":45.3,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149164097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CardioPharmaGENET: a new European network for pharmacogenomics-driven cardiovascular care. CardioPharmaGENET：一个新的欧洲药物基因组学驱动的心血管护理网络。
IF 45.3 1区 医学
European Heart Journal Pub Date : 2026-10-13 DOI: 10.1093/eurheartj/ehag772
Adna Asic, Svetlana Frolova, Yvan Devaux
{"title":"CardioPharmaGENET: a new European network for pharmacogenomics-driven cardiovascular care.","authors":"Adna Asic, Svetlana Frolova, Yvan Devaux","doi":"10.1093/eurheartj/ehag772","DOIUrl":"https://doi.org/10.1093/eurheartj/ehag772","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":""},"PeriodicalIF":45.3,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Connecting the dots in cardiovascular medicine: endometriosis, chronic inflammation, and venous thromboembolism. 连接心血管医学中的点：子宫内膜异位症，慢性炎症和静脉血栓栓塞。
IF 45.3 1区 医学
European Heart Journal Pub Date : 2026-10-12 DOI: 10.1093/eurheartj/ehag722
Elvira Grandone
{"title":"Connecting the dots in cardiovascular medicine: endometriosis, chronic inflammation, and venous thromboembolism.","authors":"Elvira Grandone","doi":"10.1093/eurheartj/ehag722","DOIUrl":"https://doi.org/10.1093/eurheartj/ehag722","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":""},"PeriodicalIF":45.3,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149166352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Meta-analyses limitations and the compelling case for a contemporary, pragmatic trial of clopidogrel vs aspirin for secondary prevention of coronary heart disease: clopidogrel is not superior to aspirin in non-East Asian patients. 荟萃分析的局限性和clopidogrel vs阿司匹林用于冠心病二级预防的当代实用试验的令人信服的案例：在非东亚患者中，clopidogrel并不优于阿司匹林。
IF 45.3 1区 医学
European Heart Journal Pub Date : 2026-10-10 DOI: 10.1093/eurheartj/ehag805
Mattia Galli, Jurrien Ten Berg, Colin Berry
{"title":"Meta-analyses limitations and the compelling case for a contemporary, pragmatic trial of clopidogrel vs aspirin for secondary prevention of coronary heart disease: clopidogrel is not superior to aspirin in non-East Asian patients.","authors":"Mattia Galli, Jurrien Ten Berg, Colin Berry","doi":"10.1093/eurheartj/ehag805","DOIUrl":"https://doi.org/10.1093/eurheartj/ehag805","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":""},"PeriodicalIF":45.3,"publicationDate":"2026-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149147602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Arrhythmia and dementia: time to think beyond atrial fibrillation. 心律失常和痴呆：是时候考虑房颤之外的问题了。
IF 45.3 1区 医学
European Heart Journal Pub Date : 2026-10-10 DOI: 10.1093/eurheartj/ehag391
Avia Abramovitz Fouks, Emily Ramage, Vincent N Thijs
{"title":"Arrhythmia and dementia: time to think beyond atrial fibrillation.","authors":"Avia Abramovitz Fouks, Emily Ramage, Vincent N Thijs","doi":"10.1093/eurheartj/ehag391","DOIUrl":"https://doi.org/10.1093/eurheartj/ehag391","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":""},"PeriodicalIF":45.3,"publicationDate":"2026-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149147438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Monopolar biphasic pulsed field ablation and coronary endothelial function: the Vasc-PFA study. 单极双相脉冲场消融与冠状动脉内皮功能：Vasc-PFA研究。
IF 45.3 1区 医学
European Heart Journal Pub Date : 2026-10-10 DOI: 10.1093/eurheartj/ehag781
Tasnim Mohaissen, Andreina Josefina Gil-Ramirez, Julie Norup Hertel, Charles Ye, Sevasti-Maria Chaldoupi, Benedikt Linz, Jim Hansen, Samuel N Baldwin, Jessica L Meades, Arnela Saljic, Sarah Dalgas Nissen, Thomas Jespersen, Thomas A Jepps, Dominik Linz
{"title":"Monopolar biphasic pulsed field ablation and coronary endothelial function: the Vasc-PFA study.","authors":"Tasnim Mohaissen, Andreina Josefina Gil-Ramirez, Julie Norup Hertel, Charles Ye, Sevasti-Maria Chaldoupi, Benedikt Linz, Jim Hansen, Samuel N Baldwin, Jessica L Meades, Arnela Saljic, Sarah Dalgas Nissen, Thomas Jespersen, Thomas A Jepps, Dominik Linz","doi":"10.1093/eurheartj/ehag781","DOIUrl":"https://doi.org/10.1093/eurheartj/ehag781","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":""},"PeriodicalIF":45.3,"publicationDate":"2026-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149147883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Palmitic acid promotes hypertrophic memory in cardiomyocytes via KDM5A/H3K4me3. 棕榈酸通过KDM5A/H3K4me3促进心肌细胞肥厚记忆。
IF 45.3 1区 医学
European Heart Journal Pub Date : 2026-10-10 DOI: 10.1093/eurheartj/ehag761
Kun Yang, Rifeng Gao, Jiaran Shi, Xiang Wei, Xujia Lu, Hanchuan Chen, Wei Wei, Jingjing Hu, Juntao Chen, Yang Lyu, Pingjin Gao, Chaofu Ke, Aijun Sun
{"title":"Palmitic acid promotes hypertrophic memory in cardiomyocytes via KDM5A/H3K4me3.","authors":"Kun Yang, Rifeng Gao, Jiaran Shi, Xiang Wei, Xujia Lu, Hanchuan Chen, Wei Wei, Jingjing Hu, Juntao Chen, Yang Lyu, Pingjin Gao, Chaofu Ke, Aijun Sun","doi":"10.1093/eurheartj/ehag761","DOIUrl":"https://doi.org/10.1093/eurheartj/ehag761","url":null,"abstract":"<p><strong>Background and aims: </strong>Palmitic acid (PA), the most abundant saturated fatty acid (SFA), is positively associated with heart failure (HF) risk. However, its role and mechanism underlying HF remain unclear. This study aimed to investigate the effects of a PA-enriched diet and potential therapeutic targets in HF.</p><p><strong>Methods: </strong>The association between plasma SFAs and HF was investigated in a cohort of 232 592 UK Biobank participants. Mice were randomly categorized into three groups, where they were fed a PA-enriched, olive oil-enriched, or control diet for 4 weeks, followed by a 4-week dietary adaptation period on the control diet. A pressure overload model was established by transverse aortic constriction in these mice and cardiac-specific lysine demethylase 5A (Kdm5A)-knockout mice.</p><p><strong>Results: </strong>The UK Biobank database revealed an association between high plasma SFA levels and increased HF risk. Our in vitro and in vivo results demonstrated that short-term PA treatment promoted cardiac hypertrophy and HF without further exposure to high levels of PA, indicating a pro-hypertrophic memory in cardiomyocytes. Mechanistically, PA promoted palmitoylation-driven KDM5A degradation via the ubiquitination pathway, thereby up-regulating histone 3 lysine 4 tri-methylation (H3K4me3). KDM5A/H3K4me3 promoted a pro-hypertrophic memory in cardiomyocytes, thus causing cardiac hypertrophy via a monocarboxylate transporter 4 (MCT4)-induced metabolic imbalance. Furthermore, KDM5A agonist D18 ameliorated this PA-mediated cardiac hypertrophy and HF.</p><p><strong>Conclusions: </strong>A PA-enriched diet promotes pro-hypertrophic memory in cardiomyocytes, cardiac hypertrophy, and HF via KDM5A/H3K4me3/MCT4. The application of D18 may represent a promising therapeutic approach for PA-mediated cardiac hypertrophy and HF.</p>","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":""},"PeriodicalIF":45.3,"publicationDate":"2026-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149147048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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