European Heart Journal最新文献

{"title":"Improving understanding and management of acute heart failure, myocarditis, pericarditis, amyloidosis, mitochondrial cardiomyopathies, hypertrophic cardiomyopathy, and takotsubo syndrome.","authors":"Filippo Crea","doi":"10.1093/eurheartj/ehaf782","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf782","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"1 1","pages":"3939-3943"},"PeriodicalIF":39.3,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145338673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac myosin inhibitors in hypertrophic cardiomyopathy: the need for precision medicine.","authors":"Ali Yilmaz","doi":"10.1093/eurheartj/ehaf507","DOIUrl":"10.1093/eurheartj/ehaf507","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":"4087-4089"},"PeriodicalIF":35.6,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144872093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of aficamten in patients with obstructive hypertrophic cardiomyopathy and mild symptoms: results from the SEQUOIA-HCM trial.","authors":"Martin S Maron,Juan Ramon Gimeno,Josef Veselka,Roberto Barriales-Villa,Brian L Claggett,Caroline J Coats,Sheila M Hegde,James L Januzzi,Ian J Kulac,Ahmad Masri,Michael E Nassif,John A Spertus,Daniel L Jacoby,Stephen B Heitner,Stuart Kupfer,Fady I Malik,Amy Wohltman,Iacopo Olivotto","doi":"10.1093/eurheartj/ehaf364","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf364","url":null,"abstract":"BACKGROUND AND AIMSPatients with obstructive hypertrophic cardiomyopathy (oHCM) treated with aficamten in SEQUOIA-HCM (NCT05186818) demonstrated marked improvement in symptoms and functional capacity. This analysis explores whether oHCM and mild symptoms patients experience similar clinical benefits with aficamten as patients with more advanced limitations.METHODSPatients in SEQUOIA-HCM (N = 282) were grouped at baseline according to symptom severity. Mild symptoms (n = 118) were defined as New York Heart Association (NYHA) class II and Kansas City Cardiomyopathy Questionnaire Clinical Summary Score (KCCQ-CSS) ≥ 80, and moderate to severe symptoms (n = 150) as NYHA class II/III/IV and KCCQ-CSS <80. Primary endpoint was change in peak oxygen uptake (pVO2) from baseline to Week 24; secondary endpoints included change in NYHA class, KCCQ-CSS, outflow tract gradients, and N-terminal pro-B-type natriuretic peptide (NT-proBNP).RESULTSIn aficamten-treated patients, change at Week 24 was not different between moderate to severe (1.8 mL/kg/min; n = 71) and mild (1.6 mL/kg/min; n = 62) symptom groups (P = .8). Likewise, the change in secondary endpoints (NYHA class, resting or Valsalva gradients, and NT-proBNP) did not differ significantly between the two symptom groups. Both groups experienced statistically significant improvements in KCCQ-CSS, but the extent of improvement was greater in the advanced symptom group (P = .02 for interaction). Treatment-emergent serious adverse events were infrequent in both groups.CONCLUSIONSPatients with oHCM and mild symptoms treated with aficamten achieved significant improvement across a range of clinically relevant outcomes and generally similar to patients with more advanced symptoms. Less severely symptomatic patients could be considered for aficamten treatment.","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"39 1","pages":"4076-4086"},"PeriodicalIF":39.3,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145338672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new journal for the cardiovascular community.","authors":"Thomas F Lüscher, Filippo Crea","doi":"10.1093/eurheartj/ehaf544","DOIUrl":"10.1093/eurheartj/ehaf544","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":"3944-3946"},"PeriodicalIF":35.6,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144947618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulmonary arterial wedge pressure exceeding left atrial pressure: clinical implications.","authors":"Atsushi Tada, Kazunori Omote, Ahmed U Fayyaz, Trevor J Simard, William R Miranda, Jwan A Naser, Yogesh N V Reddy, Margaret M Redfield, Barry A Borlaug","doi":"10.1093/eurheartj/ehaf392","DOIUrl":"10.1093/eurheartj/ehaf392","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":"4123-4126"},"PeriodicalIF":35.6,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12539908/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144527002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2025 ESC Guidelines for the management of myocarditis and pericarditis.","authors":"Jeanette Schulz-Menger, Valentino Collini, Jan Gröschel, Yehuda Adler, Antonio Brucato, Vanessa Christian, Vanessa M Ferreira, Estelle Gandjbakhch, Bettina Heidecker, Mathieu Kerneis, Allan L Klein, Karin Klingel, George Lazaros, Roberto Lorusso, Elena G Nesukay, Kazem Rahimi, Arsen D Ristić, Marcin Rucinski, Leyla Elif Sade, Hannah Schaubroeck, Anne Grete Semb, Gianfranco Sinagra, Jens Jakob Thune, Massimo Imazio","doi":"10.1093/eurheartj/ehaf192","DOIUrl":"10.1093/eurheartj/ehaf192","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":"3952-4041"},"PeriodicalIF":35.6,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144947579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perioperative discontinuation of renin-angiotensin system inhibitors in non-cardiac surgery: is it time to change what we tell our patients?","authors":"Maura Marcucci,Matthieu Legrand,P J Devereaux","doi":"10.1093/eurheartj/ehaf691","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf691","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"53 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145331693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mortality in female bodybuilding athletes.","authors":"Marco Vecchiato, Andrea Ermolao, Lara Zane, Silvia Giagio, Andrea Aghi, Stefano Palermi, Nicola Borasio, Alessandro Zorzi, Daniel Neunhaeuserer","doi":"10.1093/eurheartj/ehaf789","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf789","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":""},"PeriodicalIF":35.6,"publicationDate":"2025-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145336813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Controlling thrombosis without bleeding: a challenging concept that gathers pace.","authors":"Meinrad Paul Gawaz,Manuel Sigle","doi":"10.1093/eurheartj/ehaf612","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf612","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"28 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145305634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early management of mild ischaemic stroke: role of dual antiplatelet treatment.","authors":"Jan F Scheitz,Matthias Endres","doi":"10.1093/eurheartj/ehaf734","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf734","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"54 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145311180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}