European Heart Journal最新文献

{"title":"Mediterranean diet, neutrophil count, and atherosclerosis.","authors":"Christian Saleh, Knarik Hovhannisyan, Hrvoje Budincevic","doi":"10.1093/eurheartj/ehaf169","DOIUrl":"10.1093/eurheartj/ehaf169","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":"2709"},"PeriodicalIF":37.6,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The double-edged sword of heart rate lowering in cardiovascular disease.","authors":"Franz H Messerli, Louis Hofstetter, Sripal Bangalore","doi":"10.1093/eurheartj/ehaf310","DOIUrl":"10.1093/eurheartj/ehaf310","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":"2670-2672"},"PeriodicalIF":37.6,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Xylitol and cardiovascular risks.","authors":"Marco Witkowski, Stanley L Hazen","doi":"10.1093/eurheartj/ehaf059","DOIUrl":"10.1093/eurheartj/ehaf059","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":"2707-2708"},"PeriodicalIF":37.6,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143603751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discussion on Mediterranean diet, neutrophil count, and atherosclerosis.","authors":"Jose Lopez-Miranda","doi":"10.1093/eurheartj/ehaf171","DOIUrl":"10.1093/eurheartj/ehaf171","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":"2710-2711"},"PeriodicalIF":37.6,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Hospitalization for cardiovascular disease in the year after delivery of twin pregnancies.","authors":"","doi":"10.1093/eurheartj/ehaf263","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf263","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"11 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144603894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Infected native aortic aneurysms: epidemiology, management, and outcomes based on a nationwide population-based study","authors":"Chih-Chun Lee, Feng-Cheng Chang, Ming-Jer Hsieh, Chun-Yu Chen, Jih-Kai Yeh, Victor Chien-Chia Wu, Yi-Hsin Chan, Yu-Ting Cheng, Pao-Hsien Chu, Shao-Wei Chen","doi":"10.1093/eurheartj/ehaf449","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf449","url":null,"abstract":"Background and Aims Large-scale investigations with longitudinal data on infected native aortic aneurysms (INAAs), a rare but life-threatening emergency, are lacking. The epidemiology, treatment trends, and outcomes of INAAs were investigated in a nationwide population-based cohort. Methods A total of 2387 hospitalisations for INAAs were identified between 2001 and 2021 in the Taiwanese National Health Insurance Research Database. A retrospective cohort was analysed using data spanning a 21-year study period. In-hospital and post-discharge adverse events, including 1-, 3-, 5- and 10-year mortality, were assessed. Results The cohort had a mean age of 73.8 ± 11.8 years, with 77.6% being men. There was an increasing trend in INAAs over time, with a high prevalence of comorbid renal insufficiency (53%). Most patients were treated with third-generation cephalosporins and anti-methicillin-resistant Staphylococcus aureus agents. Conservative treatment was associated with the highest mortality rates, including in-hospital death and post-discharge death. The risk of in-hospital mortality was significantly lower in the endovascular aortic repair (EVAR) group compared with the open repair group [odds ratio 0.76, 95% confidence interval (CI): 0.63–0.91]. At the end of follow-up, patients who underwent EVAR demonstrated high mortality risks (hazard ratio 1.13, 95% CI: 1.04–1.23 at the end of follow-up) than open repair. Conclusions Surgical repair is associated with significantly more favourable post-discharge survival compared with EVAR, underscoring the importance of open repair for optimal management of INAAs. In selected high-risk patients, EVAR may serve as a temporising or palliative option, particularly when definitive open repair is not immediately feasible.","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"4 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144602883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitral valve replacement or repair and long-term risk of infective endocarditis: a Danish nationwide study.","authors":"Amna Alhakak,Jawad Haider Butt,Eva Havers-Borgersen,Lauge Østergaard,Peter Laursen Graversen,Jarl Emanuel Strange,Katia Al-Chaer,Morten Holdgaard Smerup,Henning Bundgaard,Lars Køber,Emil Loldrup Fosbøl","doi":"10.1093/eurheartj/ehaf342","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf342","url":null,"abstract":"BACKGROUND AND AIMSInfective endocarditis (IE) after mitral valve (MV) interventions is a serious complication. However, information on the long-term risk of first-time IE after MV replacement or repair is lacking. The 10-year incidence of first-time IE was examined in patients undergoing MV replacement or repair, compared with those at moderate risk of IE.METHODSUsing Danish nationwide registries (2000-2020), the study population included patients undergoing isolated MV replacement or repair and patients at moderate risk of IE. The moderate-risk group included cardiac implantable electronic devices, congenital heart valve anomalies, hypertrophic cardiomyopathy, rheumatic heart diseases, and non-rheumatic degenerative valve diseases. The Aalen-Johansen estimator and cause-specific Cox regression models were used to determine the 10-year comparative incidences of IE.RESULTSThe study population included 1220 patients undergoing MV replacement, 3239 undergoing MV repair, and 209 517 at moderate risk of IE. The 10-year cumulative incidences of IE were 6.1% [95% confidence interval (CI) 4.8%-7.7%] for MV replacement, 1.6% (95% CI 1.1%-2.1%) for MV repair, and 1.7% (95% CI 1.6%-1.7%) for the moderate-risk group. Compared with the moderate-risk group, after multivariable adjustment, MV replacement was associated with a higher 10-year IE rate (hazard ratio 3.52, 95% CI 2.73-4.52), whereas MV repair was not associated with IE (hazard ratio 0.76, 95% CI 0.56-1.04).CONCLUSIONSIn this nationwide study, MV replacement was associated with a 3.5-fold increased 10-year IE rate, whereas MV repair was not significantly associated with IE, compared with patients at moderate risk of IE. These findings highlight the need for further investigation into preventive measures, including targeted antibiotic prophylaxis.","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"4 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144603968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Profound iodine enhancement of the myocardium on a native CT scan one hour after invasive coronary angiography and revascularization.","authors":"Stefan Gherca,Jasper Boeddinghaus,Philip Haaf","doi":"10.1093/eurheartj/ehaf490","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf490","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"114 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144603966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the risk of infective endocarditis after mitral valve replacement and mitral valve repair.","authors":"Daniele Giacoppo","doi":"10.1093/eurheartj/ehaf099","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf099","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"107 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144603969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex differences in dual antiplatelet therapy de-escalation strategies after percutaneous coronary intervention: a network meta-analysis","authors":"Giovanni Occhipinti, Claudio Laudani, Mattia Galli, Luis Ortega-Paz, Vijay Kunadian, Guiomar Mendieta, Riccardo Rinaldi, Felicita Andreotti, Roxana Mehran, Teresa López-Sobrino, Davide Capodanno, Dominick J Angiolillo, Manel Sabaté Tenas, Salvatore Brugaletta","doi":"10.1093/eurheartj/ehaf473","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf473","url":null,"abstract":"Background and Aims Dual antiplatelet therapy (DAPT) de-escalation strategies improve outcomes after percutaneous coronary intervention (PCI) compared to standard DAPT. However, the potential impact of sex on the safety and efficacy of these strategies is yet to be fully investigated. Methods Randomized controlled trials comparing de-escalated vs standard DAPT regimens in patients without baseline indication for oral anticoagulation reporting outcomes stratified by sex were included. The co-primary endpoints were trial-defined major adverse cardiovascular events (MACE) and major bleeding. Hazard ratios (HR) with 95% confidence intervals (CI) were computed to account for different follow-up durations. A network meta-analysis including ranking of treatments was performed to explore the comparative effects of different DAPT de-escalation strategies among females and males. Results Overall, 71 272 patients from 20 trials were included, and 23.3% were female. De-escalation strategies were grouped into (1) DAPT discontinuation, by aspirin or the P2Y12 inhibitor; or (2) P2Y12 inhibitor switch or dose reduction. With DAPT discontinuation vs standard DAPT, a significant interaction between treatment effect and sex was found for both MACE (Pint = .028) and major bleeding (Pint = .015). Indeed, DAPT discontinuation reduced MACE in females (HR, 0.86; 95% CI, 0.75–0.98) but not in males (HR, 1.04; 95% CI 0.93–1.16), while reducing major bleeding in males (HR, 0.60; 95% CI, 0.44–0.82) but not in females (HR, 1.04; 95% CI, 0.76–1.43), compared to standard DAPT. Conversely, no interactions by sex were found with P2Y12 inhibitor switch or dose reduction vs standard DAPT for both MACE (Pint = .668) and major bleeding (Pint = .858). At treatment ranking, aspirin discontinuation ranked best for most outcomes in females, while P2Y12 inhibitor switch to clopidogrel showed the best outcomes in males. Conclusions Sex may influence the safety and efficacy of antiplatelet de-escalation strategies after PCI, particularly those involving the shortening of DAPT. Aspirin discontinuation may represent the optimal strategy for females, while P2Y12 inhibitor switch to clopidogrel may be most effective for males.","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"9 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144603765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}