European Journal of Dermatology最新文献_第7页

Diagnostic and therapeutic impact of miR-142, miR-146a, and miR-155 on cutaneous T-cell lymphoma. miR-142、miR-146a和miR-155对皮肤t细胞淋巴瘤的诊断和治疗作用。

IF 1.5 4区医学

European Journal of Dermatology Pub Date : 2025-06-01 DOI: 10.1684/ejd.2025.4887

Marianna Papadaki, Marilena M Bourdakou, Christina Piperi, Evangelos Karatzas, Georgia Damoraki, George M Spyrou, Evangelia Papadavid

{"title":"Diagnostic and therapeutic impact of miR-142, miR-146a, and miR-155 on cutaneous T-cell lymphoma.","authors":"Marianna Papadaki, Marilena M Bourdakou, Christina Piperi, Evangelos Karatzas, Georgia Damoraki, George M Spyrou, Evangelia Papadavid","doi":"10.1684/ejd.2025.4887","DOIUrl":"https://doi.org/10.1684/ejd.2025.4887","url":null,"abstract":"Mycosis fungoides (MF) is the most common form of cutaneous T-cell lymphoma (CTCL). The diagnosis of early-stage MF can be very challenging due to shared clinical and histopathological features with benign inflammatory dermatoses. Moreover, a lack of understanding of the aetiopathology is having a negative impact on efficient diagnosis and therapy. State-of-the-art bioinformatics tools were used to identify differentially expressed miRNAs that are potentially involved in the molecular pathogenesis of MF, with further investigation of their potential role as diagnostic biomarkers or therapeutic targets. The expression of miRNAs (miR-26a, miR-92a, miR-106b, miR-142, miR-146a, miR-155, miR-181a, miR-222, and miR-494) was evaluated in the serum of early-stage MF patients using RT-PCR as well as skin biopsies and CTCL cell lines (MyLa and SeAx). Our data showed that these miRNAs were significantly upregulated in plasma and biopsies of early-stage MF patients and CTCL cell lines compared to controls (p<0.05). Downregulation of miR-142, miR-146a, and miR-155 in CTCL cell lines using specific antagomirs significantly decreased cell proliferation and increased apoptosis of malignant cells. Overall, detailed bioinformatics analysis, followed by experimental validation in CTCL plasma, tissues, and cell lines, indicated that detection of miR-142, miR-146a, and miR-155 upregulation by liquid biopsy may represent a potential non-invasive diagnostic technique as well as a new therapeutic targeting approach for early-stage MF.","PeriodicalId":11968,"journal":{"name":"European Journal of Dermatology","volume":"35 3","pages":"174-191"},"PeriodicalIF":1.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144752741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prolonged Harlequin phenomenon observed at 31 months of age. 在31月龄时观察到延长的丑角现象。

IF 1.5 4区医学

European Journal of Dermatology Pub Date : 2025-06-01 DOI: 10.1684/ejd.2025.4885

Chika Fujie, Sayuri Sato, Aika Shionoya, Toshiya Handa, Lisa Igarashi, Takuro Sakai, Hisashi Uhara

引用次数: 0

Primary cutaneous carcinosarcoma: an unusual tumour. 原发性皮肤癌肉瘤：一种不寻常的肿瘤。

IF 1.5 4区医学

European Journal of Dermatology Pub Date : 2025-06-01 DOI: 10.1684/ejd.2025.4907

Luis Jiménez Briones, Lucía Barchino Ortiz

引用次数: 0

A case of breast cancer mimicking basal cell carcinoma in a male patient. 男性患者的类似基底细胞癌的乳腺癌病例。

IF 1.5 4区医学

European Journal of Dermatology Pub Date : 2025-06-01 DOI: 10.1684/ejd.2025.4876

Rie Teranishi, Hiroyuki Goto, Aiko Kobayashi, Chika Hirata, Yongsu Choi, Hiroto Kuwabiraki, Sho Hiroyasu, Daisuke Tsuruta

引用次数: 0

Causal relationship between immunocytes and circulating cytokines in post-herpetic neuralgia: a Mendelian randomization study. 免疫细胞和循环细胞因子在疱疹后神经痛中的因果关系：一项孟德尔随机研究。

IF 1.5 4区医学

European Journal of Dermatology Pub Date : 2025-06-01 DOI: 10.1684/ejd.2025.4927

Yiheng Liu, Mingsheng Huang, Weiran Dai

{"title":"Causal relationship between immunocytes and circulating cytokines in post-herpetic neuralgia: a Mendelian randomization study.","authors":"Yiheng Liu, Mingsheng Huang, Weiran Dai","doi":"10.1684/ejd.2025.4927","DOIUrl":"https://doi.org/10.1684/ejd.2025.4927","url":null,"abstract":"Post-herpetic neuralgia (PHN) poses a significant challenge in pain management following herpes zoster infection, involving both the central and peripheral immune system. Inflammatory cells and mediators induce local inflammation, enhance neuronal excitability, and alter pain transmission pathways. Different immune cells contribute variably to PHN, with some immune cells exhibiting dual roles. An understanding of the roles of different immune cells and inflammatory factors in PHN is therefore important and may aid in identifying new immunotherapeutic approaches. To investigate the effects of diverse cytokines and immune cell phenotypes on PHN. Materials & Methods: We conducted Mendelian randomization (MR) analysis utilizing publicly available genome-wide association study data. Instrumental variable selection adhered to stringent criteria to ensure robustness. We employed various analytical methods, including the Inverse Variance Weighted method, sensitivity analyses, and reverse MR, to assess causal relationships. Our study identified causal relationships between PHN and various cytokines and immune phenotypes using two-sample MR analysis. One cytokine and five immune phenotypes were shown to reduce the risk of PHN, notably CD8dim T cell absolute count (OR: 0.483, 95% CI: 0.239-0.976, p=0.043). Conversely, one cytokine and one immune phenotype were shown to increase the risk of PHN. SNP selection indicated robust instrumental variables, and sensitivity analyses confirmed no significant heterogeneity or horizontal pleiotropy. Reverse MR revealed no causal effect of PHN on these factors, suggesting a unidirectional relationship. Our study provides insights into the role of immune factors in PHN, revealing potential targets for therapeutic interventions. Further research is warranted to validate these findings and explore personalized treatment strategies for PHN management.","PeriodicalId":11968,"journal":{"name":"European Journal of Dermatology","volume":"35 3","pages":"192-202"},"PeriodicalIF":1.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144752737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Concurrence of cutaneous arteritis and giant cell arteritis successfully treated by tocilizumab. 托珠单抗成功治疗皮肤动脉炎和巨细胞动脉炎并发。

IF 1.5 4区医学

European Journal of Dermatology Pub Date : 2025-06-01 DOI: 10.1684/ejd.2025.4901

Akiko Hasegawa, Kazuki M Matsuda, Hirohito Kotani, Asako Yoshizaki-Ogawa, Ayumi Yoshizaki, Shinichi Sato

引用次数: 0

Effective dupilumab treatment for lichen amyloidosis with GATA3+ cell infiltration. dupilumab治疗地衣淀粉样变性伴GATA3+细胞浸润的有效方法。

IF 2 4区医学

European Journal of Dermatology Pub Date : 2025-04-01 DOI: 10.1684/ejd.2025.4872

Ryosuke Matsumura, Takahiro Suzuki, Shiori Meguro, Tetsuya Honda

引用次数: 0

A paediatric case of severe atopic dermatitis with prurigo nodularis successfully treated with nemolizumab as second-line therapy. 1例小儿重症特应性皮炎伴结节性痒疹成功用奈莫单抗作为二线治疗。

IF 2 4区医学

European Journal of Dermatology Pub Date : 2025-04-01 DOI: 10.1684/ejd.2025.4844

Masaya Kato, Ken Igawa, Yusuke Ando, Manabu Miyamoto, Yuji Fujita, Hideaki Shiraishi, Shigemi Yoshihara

引用次数: 0

Successful treatment of severe acrodermatitis continua of Hallopeau (ACH) coexisting with plaque psoriasis and non-pustular palmoplantar psoriasis in an elderly patient with bimekizumab. 比美珠单抗成功治疗1例老年患者伴斑块性银屑病和非脓疱性掌足底银屑病的严重持续性埃洛珀（ACH）

IF 2 4区医学

European Journal of Dermatology Pub Date : 2025-04-01 DOI: 10.1684/ejd.2025.4868

Chiara Assorgi, Maria Concetta Fargnoli, Norma Cameli, Annunziata Dattola, Diego Orsini

引用次数: 0

Paget-Schroetter syndrome caused by a heavy backpack. 由沉重的背包引起的佩吉-施罗德综合症。

IF 2 4区医学

European Journal of Dermatology Pub Date : 2025-04-01 DOI: 10.1684/ejd.2025.4861

Azusa Kobayashi, Naohiko Aozasa, Yosuke Sasaki, Koichiro Nakamura, Yuichiro Tsunemi

引用次数: 0