{"title":"Improvement of interstitial lung disease during brodalumab treatment in a patient with psoriasis and systemic immune-mediated inflammation.","authors":"Jun Yamamoto, Teie Egawa, Yoshihide Asano","doi":"10.1684/ejd.2026.5126","DOIUrl":"https://doi.org/10.1684/ejd.2026.5126","url":null,"abstract":"","PeriodicalId":11968,"journal":{"name":"European Journal of Dermatology","volume":"36 4","pages":"380-382"},"PeriodicalIF":1.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148900160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Rapidly progressive alopecia areata with early recovery following discontinuation of secukinumab treatment for psoriasis.","authors":"Yusuke Saida, Yasuaki Ogura, Katsuji Yamanaka, Tetsuya Honda","doi":"10.1684/ejd.2026.5114","DOIUrl":"https://doi.org/10.1684/ejd.2026.5114","url":null,"abstract":"","PeriodicalId":11968,"journal":{"name":"European Journal of Dermatology","volume":"36 4","pages":"376-378"},"PeriodicalIF":1.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148900179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"sQUIZ your knowledge! A dirty-appearing plaque on the neck of a toddler.","authors":"Shirui Chen, Yanyan Feng","doi":"10.1684/ejd.2026.5123","DOIUrl":"https://doi.org/10.1684/ejd.2026.5123","url":null,"abstract":"","PeriodicalId":11968,"journal":{"name":"European Journal of Dermatology","volume":"36 4","pages":"392-393"},"PeriodicalIF":1.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148900204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"sQUIZ your knowledge! An indolent subungual mass on the toe.","authors":"José Miguel Alvarenga, André Coelho, Inês Lobo","doi":"10.1684/ejd.2026.5119","DOIUrl":"https://doi.org/10.1684/ejd.2026.5119","url":null,"abstract":"","PeriodicalId":11968,"journal":{"name":"European Journal of Dermatology","volume":"36 4","pages":"388-389"},"PeriodicalIF":1.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148900209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Raffaele Aguglia, Tobias Niederegger, Murtaja Satea, Leonard Knoedler, Moshé Assouline, Curtis L Cetrulo, Michael Atlan, Alexandre G Lellouch
{"title":"High-frequency high-intensity focused ultrasound (HF-HIFU) for ablation of benign, premalignant, and malignant cutaneous lesions: a systematic review.","authors":"Raffaele Aguglia, Tobias Niederegger, Murtaja Satea, Leonard Knoedler, Moshé Assouline, Curtis L Cetrulo, Michael Atlan, Alexandre G Lellouch","doi":"10.1684/ejd.2026.5115","DOIUrl":"https://doi.org/10.1684/ejd.2026.5115","url":null,"abstract":"<p><p>High-frequency high-intensity focused ultrasound (HF-HIFU) is a non-invasive ablative technology that enables precise, depth-controlled thermal destruction of superficial cutaneous lesions. Its potential dermatological applications include benign, premalignant, and selected malignant tumours; however, current evidence is fragmented across indications and study designs. This systematic review evaluated the clinical role of HF-HIFU for cutaneous lesion ablation. The review followed PRISMA 2020 guidelines and was prospectively registered in PROSPERO (CRD420261326294). Eligible studies investigated HF-HIFU for benign, premalignant, or malignant skin lesions. Methodological quality was assessed using the Newcastle-Ottawa Scale and the Oxford Centre for Evidence-Based Medicine Levels of Evidence. Given substantial heterogeneity in lesion types, treatment parameters, and outcome reporting, results were synthesized narratively with pooled descriptive outcomes. Fifteen studies including 92 patients treated with a 20-MHz dermatological HF-HIFU system were analysed. For malignant lesions, lesion-level analysis suggested high initial clearance rates (96%, n=28), although evidence was limited and largely noncomparative. Actinic keratosis demonstrated complete clearance rates exceeding 70%, with additional partial responses in most remaining lesions. Outcomes for benign lesions varied by depth and histology, with best results in superficial epithelial tumours and lower efficacy for deeper dermal lesions. Procedural pain depended on anatomical location and treatment extent, being higher in head-and-neck and acral lesions. Adverse events were predictable, and transient. Follow-up was generally short, and histological confirmation was infrequent. HF-HIFU appears to be a promising minimally invasive option for selected cutaneous lesions, but larger prospective studies with long-term follow-up and routine histological verification are needed to define its clinical role.</p>","PeriodicalId":11968,"journal":{"name":"European Journal of Dermatology","volume":"36 4","pages":"312-323"},"PeriodicalIF":1.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148900193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A case of refractory eczema with severe nutritional deficiency and depletion of epidermal Langerhans cells in a young woman.","authors":"Yuna Yamada, Soichiro Watanabe, Hirotaka Akita, Kazumitsu Sugiura","doi":"10.1684/ejd.2026.5109","DOIUrl":"https://doi.org/10.1684/ejd.2026.5109","url":null,"abstract":"","PeriodicalId":11968,"journal":{"name":"European Journal of Dermatology","volume":"36 4","pages":"371-372"},"PeriodicalIF":1.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148900322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Can Baykal, Funda Akturk Gozel, Yildiz Yesim Aydogan, Tugba Atci
{"title":"A comparison of clinical characteristics of keratoacanthomas in Muir-Torre syndrome and xeroderma pigmentosum.","authors":"Can Baykal, Funda Akturk Gozel, Yildiz Yesim Aydogan, Tugba Atci","doi":"10.1684/ejd.2026.5113","DOIUrl":"https://doi.org/10.1684/ejd.2026.5113","url":null,"abstract":"<p><p>Data on the clinical characteristics of keratoacanthomas (KAs) associated with Muir-Torre syndrome (MTS) and xeroderma pigmentosum (XP) are limited. To compare the clinical features of KAs in patients with MTS and XP. Consecutive patients diagnosed with MTS or XP were evaluated for the occurrence of KA in a single dermatology centre. Age at onset, number, size, localization, association with cutaneous horn, and regression patterns of KAs were compared in both groups and with sporadic KAs. A total of 26 KAs were observed in 7 of 38 patients with XP and 11 lesions in 4 of 8 patients with MTS with a mean age at onset of 11.4±6.5 and 50.5±8.5 years, respectively. Most individuals with both syndromes presented with multiple KAs. In MTS patients, lesions involved both facial and truncal sites and were frequently >1 cm in diameter, and spontaneous regression commonly resulted in depressed or hypopigmented, atrophic scars surrounded by a thin rim, and mutilation was observed in one case. In contrast, KAs in XP patients were predominantly localized to the head and neck, with occasional mucosal involvement, and were sometimes associated with cutaneous horn and typically healed with minimal or no scarring. Sporadic KAs manifested mostly as solitary lesions, predominantly on the face, in 14 patients with a mean age of 60.2±14.2 years. KAs in XP and MTS patients differ with regards to age at onset, distribution, associated features, and regression patterns. Truncal involvement, larger size and prominent scarring favour MTS, whereas early onset, mucosal involvement, and association with cutaneous horn are more characteristic of XP.</p>","PeriodicalId":11968,"journal":{"name":"European Journal of Dermatology","volume":"36 4","pages":"332-338"},"PeriodicalIF":1.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148900331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}