European Journal of Dermatology最新文献

Journal Club: Histiocytoses. 期刊俱乐部：组织细胞。

IF 2 4区医学

European Journal of Dermatology Pub Date : 2024-08-01 DOI: 10.1684/ejd.2024.4745

Jorge Martin-Nieto Gonzalez, Angel Manuel Rosell-Diaz, Ines Chircop, Ana Maria Le, Tassilo Dege, Niamh Byrne, Victoire Reynaud, Paloma Garcia-Piqueras

引用次数: 0

A case of dermatomyositis with positivity to both anti-MDA5 and anti-ARS antibodies. 一例皮肌炎患者的抗 MDA5 和抗ARS 抗体均呈阳性。

IF 2 4区医学

European Journal of Dermatology Pub Date : 2024-08-01 DOI: 10.1684/ejd.2024.4742

Sara Matsumoto, Yasuhito Hamaguchi, Tasuku Kitano, Kouhei Takehara, Kyouke Oishi, Shintaro Maeda, Takashi Matsushita

引用次数: 0

Beyond the genome: protecting the proteome may be the key to preventing skin aging. 超越基因组：保护蛋白质组可能是防止皮肤老化的关键。

IF 2 4区医学

European Journal of Dermatology Pub Date : 2024-08-01 DOI: 10.1684/ejd.2024.4739

Brigitte Dréno, Isabelle Benoit, Eric Perrier, Miroslav Radman

{"title":"Beyond the genome: protecting the proteome may be the key to preventing skin aging.","authors":"Brigitte Dréno, Isabelle Benoit, Eric Perrier, Miroslav Radman","doi":"10.1684/ejd.2024.4739","DOIUrl":"https://doi.org/10.1684/ejd.2024.4739","url":null,"abstract":"Skin aging is associated with a progressive decline in physiological functions, skin cancers and, ultimately, death. It may be categorized as intrinsic or extrinsic, whereby intrinsic aging is attributed to chronological and genetic factors. At the molecular level, skin aging involves changes in protein conformation and function. The skin proteome changes constantly, mainly through carbonylation; an irreversible phenomenon leading to protein accumulation as toxic aggregates that impair cellular physiology and accelerate skin aging. This review details the central role of proteostasis during skin aging and why proteome protection may be a promising approach in mitigating skin aging. A comprehensive literature review of 87 articles focusing on the proteome, proteostasis, proteotoxicity, protein carbonylation, and the impact of the damaged proteome on aging, and in particular skin aging, was conducted. Skin aging is associated with deficiencies in the repair mechanisms of DNA, transcriptional control, mitochondrial function, cell cycle control, apoptosis, cellular metabolism, changes in hormonal levels secondary to toxicity of damaged proteins, and cell-to-cell communication for tissue homeostasis, which are largely controlled by proteins. In this context, a damaged proteome that leads to the loss of proteostasis may be considered as the first step in tissue aging. There is growing evidence that a healthy proteome plays a central role in skin and in maintaining healthy tissues, thus slowing down the process of skin aging. Hence, protecting the proteome against oxidative or other damage may be an appropriate strategy to prevent and delay skin aging.","PeriodicalId":11968,"journal":{"name":"European Journal of Dermatology","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142079784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Keloids and COVID-19: no causal association based on a bidirectional Mendelian randomization study. 瘢痕疙瘩与 COVID-19：基于双向孟德尔随机研究的无因果关系。

IF 2 4区医学

European Journal of Dermatology Pub Date : 2024-08-01 DOI: 10.1684/ejd.2024.4689

Rui Wang, Yi Liang, Jun-Zhang Chen, Liang Liu, Bo Liang

引用次数: 0

Epidemiological and clinical characteristics of adult patients with chronic spontaneous urticaria in Latvia: insights from a two-centre study. 拉脱维亚慢性自发性荨麻疹成年患者的流行病学和临床特征：一项双中心研究的启示。

IF 2 4区医学

European Journal of Dermatology Pub Date : 2024-08-01 DOI: 10.1684/ejd.2024.4741

Artūrs Sokolovskis, Lāsma Lapiņa, Anna Lauva, Sindija Papirte, Maksims Zolovs, Līga Ciekure, Egīls Mauliņš, Līga Lielmane, Petra Kriķe, Marija Selicka, Signe Puriņa, Nataļja Kurjāne

{"title":"Epidemiological and clinical characteristics of adult patients with chronic spontaneous urticaria in Latvia: insights from a two-centre study.","authors":"Artūrs Sokolovskis, Lāsma Lapiņa, Anna Lauva, Sindija Papirte, Maksims Zolovs, Līga Ciekure, Egīls Mauliņš, Līga Lielmane, Petra Kriķe, Marija Selicka, Signe Puriņa, Nataļja Kurjāne","doi":"10.1684/ejd.2024.4741","DOIUrl":"10.1684/ejd.2024.4741","url":null,"abstract":"Chronic spontaneous urticaria (CSU) significantly impacts the quality of life of affected individuals. This study aimed to elucidate the epidemiological and clinical profiles of adult CSU patients in Latvia. Patient interviews and electronic medical records from two study centres in Riga, Latvia, were reviewed. PROMs, including UCT, UAS7, USS, and CU-Q2oL, were used to assess disease control, activity, severity, and quality of life. Statistical analysis was performed using Jamovi v. 2.3.28 and IBM SPSS v. 29.0.0.0. The cohort included 140 CSU patients (76.4% female; mean age 41.3 ± 14.9 years), mostly urban residents (87.1%) and non-smokers (53.6%). Urticaria with angioedema occurred in 52.1% and isolated urticaria in 47.9%, with 40% experiencing CSU for 1-5 years. Accompanying symptoms were reported by 63% and triggers by 72.9%. Allergy history and autoimmune disease diagnosis were noted in 49.3% and 29.3%. Treatment mainly involved second-generation antihistamines (85.7%) and omalizumab (17.9%). Mean scores for USS, UCT, and UAS7 were 28.8 (SD: 17.8), 8.2 (SD: 3.7), and 17.2 (SD: 14.1). UAS7 indicated severe CSU in 28.6%, and UCT suggested poorly controlled disease in 77.9%. CU-Q2oL total scores revealed mental status as the most affected domain (mean score: 51.7, SD: 28.7), with a significant association between accompanying symptoms and questionnaire scores. This study provides insights into the demographic and clinical aspects of CSU patients in Latvia, highlighting areas for potential improvement in patient care and emphasizing the need for further investigation into treatment outcomes and patient quality of life.","PeriodicalId":11968,"journal":{"name":"European Journal of Dermatology","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142079789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nasal natural killer/T-cell lymphoma presenting with extensive cutaneous disease. 鼻腔自然杀伤/T细胞淋巴瘤伴有大面积皮肤病。

IF 2 4区医学

European Journal of Dermatology Pub Date : 2024-08-01 DOI: 10.1684/ejd.2024.4746

Niamh Byrne, Neda Alband, Sarah Mcdonald, Shiu Chan, Andrew Carmichael, Dima El-Sharkawi

引用次数: 0

Response to biological drugs and JAK inhibitors following cyclosporine in patients with atopic dermatitis. 特应性皮炎患者使用环孢素后对生物药物和 JAK 抑制剂的反应。

IF 2 4区医学

European Journal of Dermatology Pub Date : 2024-08-01 DOI: 10.1684/ejd.2024.4727

Clara Ureña-Paniego, Raquel Sanabria-De-La-Torre, Arena Ramírez-Muñoz, Alberto Soto-Moreno, Salvador Arias-Santiago, Trinidad Montero-Vílchez

{"title":"Response to biological drugs and JAK inhibitors following cyclosporine in patients with atopic dermatitis.","authors":"Clara Ureña-Paniego, Raquel Sanabria-De-La-Torre, Arena Ramírez-Muñoz, Alberto Soto-Moreno, Salvador Arias-Santiago, Trinidad Montero-Vílchez","doi":"10.1684/ejd.2024.4727","DOIUrl":"10.1684/ejd.2024.4727","url":null,"abstract":"The therapeutic arsenal for atopic dermatitis (AD) has increased in recent years. The use of biologics or Janus kinase inhibitors (JAKi) is advocated following failure or contraindication to cyclosporine (CSA), however, it is not known whether treatment with CSA can impact the response to biologics or JAKi. The aim of this study was to evaluate the effect of previous treatment with CSA on response to biologics or JAKi in patients with AD. This was a retrospective observational study including patients with AD treated for 16 weeks with a biologic or JAKi, who had previously received cyclosporine for at least four weeks. Thirty patients with AD, with a mean age of 25.07±9.91 years, of whom 18 (60%) were women, were included. The mean duration of CSA treatment was 43.39±31.32 weeks. After 16 weeks of biologic or JAKi treatment, 17 (56.7%) patients achieved EASI75. These patients had a higher cumulative dose of CSA (3,6815 vs.76,993.33 mg; p=0.022) and a longer treatment duration (24.5 vs.57.4 weeks; p=0.003). Additionally, a negative correlation was observed between cumulative dose of CSA and EASI or SCORAD at 16 weeks. Previous cumulative dose and longer duration of CSA treatment does not appear to have a negative impact on response to biologics and JAKi in patients with AD.","PeriodicalId":11968,"journal":{"name":"European Journal of Dermatology","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142079800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sunlight-triggered facial oedema. 阳光引发的面部水肿。

IF 2 4区医学

European Journal of Dermatology Pub Date : 2024-08-01 DOI: 10.1684/ejd.2024.4724

Yanjun Chu, Jiong Zhou

引用次数: 0

Decreased expression of galectin-3 in the epidermis of psoriasis patients. 银屑病患者表皮中 galectin-3 的表达减少。

IF 2 4区医学

European Journal of Dermatology Pub Date : 2024-08-01 DOI: 10.1684/ejd.2024.4733

Xin Zhou, Jing Su, Chun-Lei Zhang, Hui Dai, Wen-Hui Wang

{"title":"Decreased expression of galectin-3 in the epidermis of psoriasis patients.","authors":"Xin Zhou, Jing Su, Chun-Lei Zhang, Hui Dai, Wen-Hui Wang","doi":"10.1684/ejd.2024.4733","DOIUrl":"10.1684/ejd.2024.4733","url":null,"abstract":"Conventional histopathological features of psoriasis and atopic dermatitis often overlap. We aimed to investigate Galectin-3 (Gal-3) expression in psoriatic skin lesions and its potential as an immunohistochemical marker for distinguishing between psoriasis and atopic dermatitis on a pathological basis. Based on immunohistochemical analysis, we assessed Gal-3 expression in formalin-fixed, paraffin-embedded tissue sections from 21 patients with psoriasis and 15 patients with atopic dermatitis. Quantitative analysis of expression intensity was performed using the average density (average optical density) method. We analysed the relationship between Gal-3 expression and clinical characteristics, as well as conventional histopathological features. Patients with psoriasis exhibited significantly decreased Gal-3 expression in the epidermis (0.11±0.05) compared to the atopic dermatitis group (0.36±0.15) and healthy controls (0.49±0.13) (p<0.0001). Reduction in Gal-3 expression in the psoriatic epidermis around areas of neutrophil aggregation was more pronounced than around areas of non-neutrophil aggregation (0.07±0.02 vs 0.16±0.05, p<0.01). In both psoriasis (r=-0.48, p<0.05) and atopic dermatitis groups (r=-0.70, p<0.01), Gal-3 expression negatively correlated with epidermal thickness. When epidermal thickness was matched between the two groups, the decrease in epidermal Gal-3 expression remained significant in the psoriasis group compared to the atopic dermatitis group (0.14±0.05 Vs 0.30±0.07, p<0.01). Patients with psoriasis show specific downregulation of epidermal Gal-3, correlating with epidermal thickness and neutrophil-related factors. Gal-3 may serve as an auxiliary discriminative marker between psoriasis and atopic dermatitis, potentially associated with keratinocyte proliferation and neutrophil function.","PeriodicalId":11968,"journal":{"name":"European Journal of Dermatology","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142079787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictors of disease severity, length of hospitalization, and recurrence in inpatients with single-organ cutaneous small vessel vasculitis. 单器官皮肤小血管炎住院患者疾病严重程度、住院时间和复发的预测因素。

IF 2 4区医学

European Journal of Dermatology Pub Date : 2024-08-01 DOI: 10.1684/ejd.2024.4723

Thilo Gambichler, Larisa Ardabili, Belanna Domin, Laura Susok, Nessr Abu Rached

{"title":"Predictors of disease severity, length of hospitalization, and recurrence in inpatients with single-organ cutaneous small vessel vasculitis.","authors":"Thilo Gambichler, Larisa Ardabili, Belanna Domin, Laura Susok, Nessr Abu Rached","doi":"10.1684/ejd.2024.4723","DOIUrl":"https://doi.org/10.1684/ejd.2024.4723","url":null,"abstract":"There is a lack of systematic studies on single-organ cutaneous small vessel vasculitis (SOCV). To evaluate prognostic clinical and laboratory parameters, including systemic immune-inflammation biomarkers (SIIB) in SOCV inpatients. This study investigated the clinical and laboratory data of 178 inpatients. Blood tests were performed at baseline. SIIB were assessed based on neutrophil-to-lymphocyte ratio (NLR) and pan-immune-inflammation value (PIV). Univariable and multivariable statistics were performed. Both NLR and PIV were significantly higher in SOCV patients than in healthy controls. However, the SIIB values observed in SOCV patients were as high as those in psoriasis patients. On logistic regression analysis, disease manifestation on the upper extremities strongly predicted the absence of severe disease (OR: 0.31, 95% CI: 0.13 to 0.73; p = 0.0071). Moreover, older age (OR: 2.3, 95% CI: 1.11 to 4.77; p = 0.025) and severe disease (OR: 2.4, 95% CI: 1.16 to 4.94, p = 0.018) were significant independent predictors of longer hospital stay, whereas female sex was an independent protective factor for longer hospitalization (OR: 0.52, 95% CI: 0.28 to 0.96, p = 0.038). Lower serum C3 was a strong independent predictor of disease recurrence (OR: 13.9, 95% CI 3 to 63.4; p = 0.0007). The increase in SIIB observed in patients with SOCV reflects that systemic inflammatory alterations also play a role in SOCV patients. We identified several clinical and laboratory-based independent predictors of SOCV severity, length of hospitalization, and disease recurrence that may aid prognostication of SOCV patients.","PeriodicalId":11968,"journal":{"name":"European Journal of Dermatology","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142079799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0