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European Journal of Dermatology最新文献

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Testing the safety of nature-based microbial exposure in atopic dermatitis patients: a randomized, placebo-controlled, double-blinded pilot trial. 在特应性皮炎患者中检测天然微生物暴露的安全性：一项随机、安慰剂对照、双盲先导试验
IF 1.9 4区 医学
European Journal of Dermatology Pub Date : 2026-10-17 DOI: 10.1684/ejd.2026.5168
Johanna E Kalmari, Iida Rantalainen, Laura Kummola, Marja Roslund, Heini Huhtala, Riikka Puhakka, Pekka Autio, Heikki Hyöty, Vesa P Hytönen, Aki Sinkkonen, Olli H Laitinen
{"title":"Testing the safety of nature-based microbial exposure in atopic dermatitis patients: a randomized, placebo-controlled, double-blinded pilot trial.","authors":"Johanna E Kalmari, Iida Rantalainen, Laura Kummola, Marja Roslund, Heini Huhtala, Riikka Puhakka, Pekka Autio, Heikki Hyöty, Vesa P Hytönen, Aki Sinkkonen, Olli H Laitinen","doi":"10.1684/ejd.2026.5168","DOIUrl":"https://doi.org/10.1684/ejd.2026.5168","url":null,"abstract":"<p><p>The biodiversity hypothesis posits that contact with microbial biodiversity is beneficial for human health, and that the loss of such contact may contribute to immune-mediated diseases such as atopy. Based on this hypothesis, we aimed to investigate whether a lotion containing a highly diverse mixture of inactivated natural microbes is a safe and feasible method to administer nature-based microbial exposure to humans, and to assess its effects on healthy and atopic skin. Participants with atopic dermatitis applied a lotion containing 1% of inactivated microbial extract to one side of their body and a placebo lotion to the other side for 28 days. No other creams were used simultaneously on the areas examined. The followed parameters were transepidermal water loss and erythema measurements, SCORAD index (scoring of AD), adverse effects, cytokines from skin tape strip samples and the skin microbiome. Microbial extract in lotion was well tolerated. It did not significantly affect atopic eczema severity, transepidermal water loss, erythema, total bacterial community composition or pro-inflammatory cytokines of atopic skin compared to placebo. Levels of the cytokines IL-1β, IL-22, IL-33, and the antimicrobial peptide hBD-2 decreased on atopic lesions, but this effect could not be separated from placebo. Daily use of diverse, inactivated microbial extract in lotion was well tolerated by participants with atopic dermatitis in a 28-day trial under supervision of a dermatologist. This method offers a novel and safe approach to introducing nature-based microbial exposure for healthy individuals and those with atopic dermatitis.</p>","PeriodicalId":11968,"journal":{"name":"European Journal of Dermatology","volume":"36 5","pages":"0"},"PeriodicalIF":1.9,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149215443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ink matters: the ink test improves diagnostic confidence for seborrhoeic keratosis. 墨水很重要：墨水测试提高了脂溢性角化病的诊断信心。
IF 1.9 4区 医学
European Journal of Dermatology Pub Date : 2026-10-01 DOI: 10.1684/ejd.2026.5132
Husnaa Fathima Ali Azamathullah Khan, Tugba Aydin, Iona Watts, Ryan Syed, Amy Prideaux, Kalina Bridgewater, Kyriaki Stefania Mitsaki, Daniel Keith
{"title":"Ink matters: the ink test improves diagnostic confidence for seborrhoeic keratosis.","authors":"Husnaa Fathima Ali Azamathullah Khan, Tugba Aydin, Iona Watts, Ryan Syed, Amy Prideaux, Kalina Bridgewater, Kyriaki Stefania Mitsaki, Daniel Keith","doi":"10.1684/ejd.2026.5132","DOIUrl":"https://doi.org/10.1684/ejd.2026.5132","url":null,"abstract":"","PeriodicalId":11968,"journal":{"name":"European Journal of Dermatology","volume":"36 5","pages":"464-465"},"PeriodicalIF":1.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149164117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A novel frameshift mutation in the GNAS gene causes plate-like osteoma cutis. 一种新的移码突变在GNAS基因引起板样骨瘤皮肤。
IF 1.9 4区 医学
European Journal of Dermatology Pub Date : 2026-10-01 DOI: 10.1684/ejd.2026.5150
Bei Qin, Lixin Chen, Ying Wang, ChengKai Li, Qinfeng Li, Zekun Gong
{"title":"A novel frameshift mutation in the GNAS gene causes plate-like osteoma cutis.","authors":"Bei Qin, Lixin Chen, Ying Wang, ChengKai Li, Qinfeng Li, Zekun Gong","doi":"10.1684/ejd.2026.5150","DOIUrl":"https://doi.org/10.1684/ejd.2026.5150","url":null,"abstract":"","PeriodicalId":11968,"journal":{"name":"European Journal of Dermatology","volume":"36 5","pages":"475-476"},"PeriodicalIF":1.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149165397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long-term apremilast treatment in a patient with HIV infection, previous HBV/HCV infection, and subsequent diffuse large B-cell lymphoma. 长期阿普米司特治疗HIV感染，既往HBV/HCV感染，随后弥漫性大b细胞淋巴瘤患者。
IF 1.9 4区 医学
European Journal of Dermatology Pub Date : 2026-10-01 DOI: 10.1684/ejd.2026.5135
Tomoyuki Hioki, Yoko Mizutani, En Shu, Hiroaki Iwata
{"title":"Long-term apremilast treatment in a patient with HIV infection, previous HBV/HCV infection, and subsequent diffuse large B-cell lymphoma.","authors":"Tomoyuki Hioki, Yoko Mizutani, En Shu, Hiroaki Iwata","doi":"10.1684/ejd.2026.5135","DOIUrl":"https://doi.org/10.1684/ejd.2026.5135","url":null,"abstract":"","PeriodicalId":11968,"journal":{"name":"European Journal of Dermatology","volume":"36 5","pages":"459-461"},"PeriodicalIF":1.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149165640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lichen planus pemphigoides induced by pembrolizumab: a case report. 派姆单抗诱导的类天疱疮扁平苔藓1例。
IF 1.9 4区 医学
European Journal of Dermatology Pub Date : 2026-10-01 DOI: 10.1684/ejd.2026.5163
Diana Bernardo, Marco Sousa, João Domingues, Ana Maria Lé, André Coelho, Glória Cunha Velho
{"title":"Lichen planus pemphigoides induced by pembrolizumab: a case report.","authors":"Diana Bernardo, Marco Sousa, João Domingues, Ana Maria Lé, André Coelho, Glória Cunha Velho","doi":"10.1684/ejd.2026.5163","DOIUrl":"https://doi.org/10.1684/ejd.2026.5163","url":null,"abstract":"","PeriodicalId":11968,"journal":{"name":"European Journal of Dermatology","volume":"36 5","pages":"486-487"},"PeriodicalIF":1.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149164464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Successful cemiplimab treatment of functionally inoperable conjunctival squamous cell carcinoma avoiding the need for orbital exenteration. 成功的西米单抗治疗功能不能手术的结膜鳞状细胞癌，避免了眼眶剜除的需要。
IF 1.9 4区 医学
European Journal of Dermatology Pub Date : 2026-10-01 DOI: 10.1684/ejd.2026.5162
Simon Goller, Franziska Seifert, Natalie Brückl, Matthias Goebeler, Valerie Glutsch, Anja Gesierich
{"title":"Successful cemiplimab treatment of functionally inoperable conjunctival squamous cell carcinoma avoiding the need for orbital exenteration.","authors":"Simon Goller, Franziska Seifert, Natalie Brückl, Matthias Goebeler, Valerie Glutsch, Anja Gesierich","doi":"10.1684/ejd.2026.5162","DOIUrl":"https://doi.org/10.1684/ejd.2026.5162","url":null,"abstract":"","PeriodicalId":11968,"journal":{"name":"European Journal of Dermatology","volume":"36 5","pages":"484-485"},"PeriodicalIF":1.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149166325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative drug survival of biologic classes in psoriasis: a Japanese single-centre cohort study. 银屑病生物类的比较药物生存期：日本单中心队列研究。
IF 1.9 4区 医学
European Journal of Dermatology Pub Date : 2026-10-01 DOI: 10.1684/ejd.2026.5140
Daisuke Watabe, Kanako Tsunoda, Akemi Hamabata, Maki Goto, Wakako Yoshioka, Hiroo Amano
{"title":"Comparative drug survival of biologic classes in psoriasis: a Japanese single-centre cohort study.","authors":"Daisuke Watabe, Kanako Tsunoda, Akemi Hamabata, Maki Goto, Wakako Yoshioka, Hiroo Amano","doi":"10.1684/ejd.2026.5140","DOIUrl":"10.1684/ejd.2026.5140","url":null,"abstract":"<p><p>Drug survival reflects the long-term effectiveness, safety, and tolerability of biologic therapies in routine clinical practice. To compare drug survival among currently available biologic classes in Japanese patients with psoriasis and to evaluate reason-specific discontinuation. We conducted a retrospective cohort study including 538 biologic treatment episodes from 311 patients treated at a tertiary dermatology centre in Japan. Tumour necrosis factor, interleukin-17, interleukin-23, and interleukin-12/23 inhibitors were compared. Overall drug discontinuation was assessed using multivariable Cox proportional hazards models with cluster-robust standard errors. Discontinuation due to ineffectiveness and adverse events was evaluated using Fine-Gray competing risk models. Compared with tumour necrosis factor inhibitors, interleukin-23 inhibitors were associated with more favourable overall drug survival (adjusted hazard ratio: 0.43, 95% confidence interval: 0.25-0.74; p=0.002), which remained significant in the 104-week analysis (hazard ratio: 0.50, 95% confidence interval: 0.28-0.91; p=0.023). Interleukin-17 inhibitors and ustekinumab did not differ significantly from tumour necrosis factor inhibitors in the primary analysis. In competing risk analyses, interleukin-23 inhibitors showed a lower risk of adverse event-related discontinuation than tumour necrosis factor inhibitors (subdistribution hazard ratio: 0.10, 95% confidence interval: 0.02-0.59; p=0.010), whereas no significant class differences were observed for ineffectiveness-related discontinuation. Interleukin-23 inhibitors showed the most favourable drug survival profile, primarily driven by reduced adverse event-related discontinuation.</p>","PeriodicalId":11968,"journal":{"name":"European Journal of Dermatology","volume":"36 5","pages":"432-438"},"PeriodicalIF":1.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149164833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Alterations of circulating free fatty acids in patients with non-segmental vitiligo. 非节段性白癜风患者循环游离脂肪酸的改变。
IF 1.9 4区 医学
European Journal of Dermatology Pub Date : 2026-10-01 DOI: 10.1684/ejd.2026.5134
Maria Efenesia Baffa, Roberto Maglie, Simone Baldi, Valentina Capacci, Stefano Colabrese, Carlo Pipitò, Vincenzina Rubino, Francesco Vannucci, Sasha Visinoni, Gianluca Bartolucci, Amedeo Amedei, Emiliano Antiga
{"title":"Alterations of circulating free fatty acids in patients with non-segmental vitiligo.","authors":"Maria Efenesia Baffa, Roberto Maglie, Simone Baldi, Valentina Capacci, Stefano Colabrese, Carlo Pipitò, Vincenzina Rubino, Francesco Vannucci, Sasha Visinoni, Gianluca Bartolucci, Amedeo Amedei, Emiliano Antiga","doi":"10.1684/ejd.2026.5134","DOIUrl":"https://doi.org/10.1684/ejd.2026.5134","url":null,"abstract":"","PeriodicalId":11968,"journal":{"name":"European Journal of Dermatology","volume":"36 5","pages":"461-462"},"PeriodicalIF":1.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149164989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mixed abscesses due to Klebsiella pneumoniae-Candida albicans of the lower legs complicated by septic pulmonary embolism: a case report and comprehensive review. 肺炎克雷伯菌-白色念珠菌所致下肢混合性脓肿合并脓毒性肺栓塞1例报告及综合复习。
IF 1.9 4区 医学
European Journal of Dermatology Pub Date : 2026-10-01 DOI: 10.1684/ejd.2026.5154
Junko Kunioka, Yuko Ehara, Shotaro Ishihara, Tsuyoshi Kitaura, Yuichi Yoshida
{"title":"Mixed abscesses due to Klebsiella pneumoniae-Candida albicans of the lower legs complicated by septic pulmonary embolism: a case report and comprehensive review.","authors":"Junko Kunioka, Yuko Ehara, Shotaro Ishihara, Tsuyoshi Kitaura, Yuichi Yoshida","doi":"10.1684/ejd.2026.5154","DOIUrl":"https://doi.org/10.1684/ejd.2026.5154","url":null,"abstract":"","PeriodicalId":11968,"journal":{"name":"European Journal of Dermatology","volume":"36 5","pages":"476-478"},"PeriodicalIF":1.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149170843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
sQUIZ your knowledge! Papular eruption on the upper abdomen of a young woman. 测试你的知识！年轻女子上腹部的丘疹。
IF 1.9 4区 医学
European Journal of Dermatology Pub Date : 2026-10-01 DOI: 10.1684/ejd.2026.5164
Inês Pereira Amaral, Ivânia Soares, Joana Antunes
{"title":"sQUIZ your knowledge! Papular eruption on the upper abdomen of a young woman.","authors":"Inês Pereira Amaral, Ivânia Soares, Joana Antunes","doi":"10.1684/ejd.2026.5164","DOIUrl":"https://doi.org/10.1684/ejd.2026.5164","url":null,"abstract":"","PeriodicalId":11968,"journal":{"name":"European Journal of Dermatology","volume":"36 5","pages":"489-490"},"PeriodicalIF":1.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149164654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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