改善患者护理途径和多学科管理是化脓性汗腺炎治疗的主要挑战。

IF 2 4区 医学 Q3 DERMATOLOGY
Ziad Reguiaï
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引用次数: 0

摘要

化脓性汗腺炎(HS)是一种慢性炎症性疾病,是遗传易感性、自身炎症途径机制失调、对细菌生物膜变化的功能失调反应以及可能加剧疾病的环境因素密切相互作用的结果。其皮肤表现可能只是冰山一角,因为许多合并症可能与该疾病有关。发生炎症性肠病的风险是一般人群的三倍。至少5%的患者同时患有脊柱炎,心血管事件和心肌梗死死亡的风险显著增加。精神合并症,从严重焦虑到抑郁和自杀风险,也极大地增加了疾病负担。耀斑的疼痛和慢性性质以及HS病变的高度明显外观,无论是炎症性的还是永久性的疤痕,都可能导致社会孤立和成瘾,特别是对止痛药。尽管其频率高,易于诊断,严重影响患者的日常生活,并且发现了新的治疗方法,但许多患者仍然经历了长时间的诊断延迟,治疗惰性和混乱,不适当的管理。对于HS和相关主要并发症的预防,确定其管理中的破裂点,改进护理途径和多学科治疗方法是一个社会关注的问题,也是一个重大的公共卫生挑战。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Improving the patient care pathway and multidisciplinary management are major challenges in Hidradenitis suppurativa treatment.

Hidradenitis suppurativa (HS) is a chronic inflammatory disease resulting from the close interplay between genetic predisposition, dysregulation of the mechanisms involved in autoinflammatory pathways, dysfunctional response to bacterial biofilm changes, and environmental factors that potentially exacerbate the disease. Its cutaneous manifestations may represent just the tip of the iceberg, as numerous comorbidities may be associated with the disease. The risk of occurrence of inflammatory bowel disease is three times higher than that in the general population. At least 5% of patients also have spondylarthritis, and the risk of cardiovascular events and death from myocardial infarction is significantly increased. Psychiatric co-morbidities, ranging from severe anxiety to depression and suicidal risk, also contribute greatly to the disease burden. The painful and chronic nature of the flares and the highly conspicuous appearance of HS lesions, whether inflammatory or permanent scarring, can lead to social isolation and addiction, particularly to analgesics. Despite its high frequency, easy diagnosis, severe impact on patients' daily lives, and the discovery of new treatments, many patients still experience prolonged diagnostic delays, therapeutic inertia, and chaotic, inappropriate management. For HS and the prevention of associated major complications, the identification of the points of rupture in its management, an improved care pathway and a multidisciplinary therapeutic approach are a societal concern and a major public health challenge.

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来源期刊
European Journal of Dermatology
European Journal of Dermatology 医学-皮肤病学
CiteScore
2.00
自引率
4.00%
发文量
129
审稿时长
6-12 weeks
期刊介绍: The European Journal of Dermatology is an internationally renowned journal for dermatologists and scientists involved in clinical dermatology and skin biology. Original articles on clinical dermatology, skin biology, immunology and cell biology are published, along with review articles, which offer readers a broader view of the available literature. Each issue also has an important correspondence section, which contains brief clinical and investigative reports and letters concerning articles previously published in the EJD. The policy of the EJD is to bring together a large network of specialists from all over the world through a series of editorial offices in France, Germany, Italy, Spain and the USA.
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