European Journal of Dermatology最新文献_第10页

The use of oral colchicine as a therapeutic and prophylactic approach in a case of PFAPA syndrome with recurrent genital ulcers: an under-recognized manifestation? 在一例伴有复发性生殖器溃疡的 PFAPA 综合征病例中使用口服秋水仙碱作为治疗和预防方法：一种未得到充分认识的表现？

IF 2 4区医学

European Journal of Dermatology Pub Date : 2024-04-01 DOI: 10.1684/ejd.2024.4653

Shiori Sekine, Noritaka Oyama, Koichi Io, Tetsuya Fuseda, Minoru Hasegawa

引用次数: 0

Topical rapamycin (sirolimus) for the treatment of facial discoid dermatosis. 外用雷帕霉素（西罗莫司）治疗面部盘状皮肤病。

IF 2 4区医学

European Journal of Dermatology Pub Date : 2024-04-01 DOI: 10.1684/ejd.2024.4651

Yi-Wei Huang, Tsen-Fang Tsai

引用次数: 0

Sexual dimorphism of the increment rate of age-specific incidence of actinic keratoses: an observational, single-centre study. 光化性角化病特定年龄发病率递增率的性别二态性：一项观察性单中心研究。

IF 2 4区医学

European Journal of Dermatology Pub Date : 2024-04-01 DOI: 10.1684/ejd.2024.4649

Despoina Exadaktylou, Anastasia Ioannidou, Panagiota Spyridonos, Effrosyni Tsele, Ioannis Bassukas

引用次数: 0

A case of pigmented Bartholin cyst mimicking mucosal melanoma. 一例模仿粘膜黑色素瘤的色素性巴氏腺囊肿。

IF 2 4区医学

European Journal of Dermatology Pub Date : 2024-04-01 DOI: 10.1684/ejd.2024.4640

Young Joon Park, Du Jin Baek, Dong Chan Kim, You Chan Kim

引用次数: 0

sQuiz your knowledge! A pale and indurated nodule on the ala of the nose. 测试您的知识！鼻翼上有一个苍白、化脓的结节。

IF 2 4区医学

European Journal of Dermatology Pub Date : 2024-04-01 DOI: 10.1684/ejd.2024.4672

María Zulaika-Lloret, José María Llamas-Molina, Ricardo Ruiz-Villaverde

引用次数: 0

Reflectance confocal microscopy for the early diagnosis of herpes zoster. 反射共聚焦显微镜用于带状疱疹的早期诊断。

IF 2 4区医学

European Journal of Dermatology Pub Date : 2024-04-01 DOI: 10.1684/ejd.2024.4639

Chuhan Fu, Zhen Tang, Ling Jiang, Jing Chen, Xiaoliang Tong, Li Lei

{"title":"Reflectance confocal microscopy for the early diagnosis of herpes zoster.","authors":"Chuhan Fu, Zhen Tang, Ling Jiang, Jing Chen, Xiaoliang Tong, Li Lei","doi":"10.1684/ejd.2024.4639","DOIUrl":"https://doi.org/10.1684/ejd.2024.4639","url":null,"abstract":"For herpes zoster (HZ) infection, early diagnosis and treatment are important in order to shorten the course of the disease and reduce sequelae, however, there is a lack of non-invasive diagnostic methods. Reflectance confocal microscopy (RCM) is a non-invasive technique often used to diagnose dyspigmented dermatosis, skin tumours, human papillomavirus infectious dermatosis, etc. To evaluate the clinical value of RCM for the early diagnosis of HZ. We collected RCM images from 30 HZ patients with typical vesicles in order to analyse their features. We then utilized RCM to analyse early lesions of another 12 HZ patients, who presented with localized erythema or papules, but not typical vesicles. In addition, we recruited one patient with HZ and observed the lesions over 14 days also using RCM. RCM images showed that the typical lesions of HZ mainly involved oedema of the spinous layer, intraepidermal blister formation, ballooning multinucleated giant (BMG) cells, and dermal papillary oedema. Among them, BMG cells were of specific diagnostic value. Early lesions of HZ patients without typical vesicles showed BMG cells under RCM. A few BMG cells were observed during the early stage of HZ. However, the number of BMG cells increased significantly as typical clustered blisters gradually appeared in the lesions. With the regression of the lesions, the number of BMG cells decreased gradually. RCM, with the advantages of being non-invasive, rapid, and convenient, has an important role in monitoring the evolution of HZ.","PeriodicalId":11968,"journal":{"name":"European Journal of Dermatology","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141440355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IL-17A and TNF-α-induced Dectin-1 expression may promote keratinocyte proliferation in psoriatic lesions. IL-17A 和 TNF-α 诱导的 Dectin-1 表达可促进银屑病皮损中角质细胞的增殖。

IF 2 4区医学

European Journal of Dermatology Pub Date : 2024-04-01 DOI: 10.1684/ejd.2024.4662

Wenya Cui, Jiaying Liu, Shumin Kong, Huayu Huang, Lian Liu, Yuchun Cao, Zhichao Gu

{"title":"IL-17A and TNF-α-induced Dectin-1 expression may promote keratinocyte proliferation in psoriatic lesions.","authors":"Wenya Cui, Jiaying Liu, Shumin Kong, Huayu Huang, Lian Liu, Yuchun Cao, Zhichao Gu","doi":"10.1684/ejd.2024.4662","DOIUrl":"10.1684/ejd.2024.4662","url":null,"abstract":"Psoriasis is a common skin disease with a high recurrence rate. Aberrant keratinocyte proliferation is a significant pathogenic characteristic of psoriatic lesions, and studies have revealed that the development of psoriasis is significantly influenced by pro-inflammatory cytokines, such as IL-17A and TNF-α. Biologics targeting these cytokines have been widely used in psoriasis treatment and achieve remarkable effects, however, the underlying mechanism of how IL-17A and TNF-α specifically regulate keratinocyte proliferation has not been fully elucidated. Dectin-1 is an essential membrane protein that is directly related to the immune microenvironment and the proliferation of multiple cell types. To elucidate how IL-17A and TNF-α may promote keratinocyte proliferation in psoriatic lesions and whether Dectin-1 is involved. The expression of Dectin-1 in keratinocytes from psoriatic lesions was detected by real-time PCR, western blot and immunofluorescence. Correlation analysis and cytological experiments were then performed to determine the relationship between Dectin-1 and IL-17A/TNF-α in psoriatic lesions. Finally, we investigated the signalling pathway through which Dectin-1 may promote keratinocyte proliferation. Dectin-1 was significantly increased in keratinocytes from psoriatic lesions. Moreover, IL-17A and TNF-α effectively induced the expression of Dectin-1 in HaCaT cells, which was shown to activate the Syk/NF-κB signalling pathway and promote the proliferation of keratinocytes. IL-17A and TNF-α may promote the proliferation of keratinocytes in psoriatic lesions through induction of Dectin-1, indicating that Dectin-1 could be a potential therapeutic target for the treatment of psoriasis.","PeriodicalId":11968,"journal":{"name":"European Journal of Dermatology","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141440347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A prediction model for reactivation of Langerhans cell histiocytosis based on machine-learning algorithms. 基于机器学习算法的朗格汉斯细胞组织细胞增生症再激活预测模型。

IF 2 4区医学

European Journal of Dermatology Pub Date : 2024-04-01 DOI: 10.1684/ejd.2024.4645

Siqi Tan, Ziyan Chen, Xuefei Hua, Suhan Zhang, Yanshan Zhu, Ruifang Wu, Yuwen Su, Peng Zhang, Yu Liu

{"title":"A prediction model for reactivation of Langerhans cell histiocytosis based on machine-learning algorithms.","authors":"Siqi Tan, Ziyan Chen, Xuefei Hua, Suhan Zhang, Yanshan Zhu, Ruifang Wu, Yuwen Su, Peng Zhang, Yu Liu","doi":"10.1684/ejd.2024.4645","DOIUrl":"https://doi.org/10.1684/ejd.2024.4645","url":null,"abstract":"Langerhans cell histiocytosis (LCH) is a rare inflammatory myeloid neoplasm characterized by the clonal proliferation of myeloid progenitor cells. The reactivation rate of LCH exceeds 30%. However, an effective prediction model to predict reactivation is lacking. To select potential prognostic factors of LCH and construct an easy-to-use predictive model based on machine-learning algorithms. Clinical records of LCH inpatients in the Second Xiangya Hospital of Central South University, from 2008 to 2022, were retrospectively studied. Seventy-six patients were classified into a reactivated/progressive group or a stable group. Clinical features and laboratory outcomes were compared, and machine-learning algorithms were used for building prognostic prediction models. Clinical classification (single-system LCH, multiple-system LCH, and central nervous system/lung LCH), level of anemia, bone involvement, skin involvement, and elevated monocyte count were the best performing factors and were finally chosen for the construction of the prediction models. Our results show that the above-mentioned five factors can be used together in a prediction model for the prognosis of LCH patients. The major limitations of this study include its retrospective nature and the relatively small sample size.","PeriodicalId":11968,"journal":{"name":"European Journal of Dermatology","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141440332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hydroa vacciniforme lymphoproliferative disorder: a retrospective study of 42 paediatric cases. Hydroa vacciniforme 淋巴增生性疾病：42 例儿科病例的回顾性研究。

IF 2 4区医学

European Journal of Dermatology Pub Date : 2024-04-01 DOI: 10.1684/ejd.2024.4648

Yimeng Zhang, Yuanxiang Liu, Jiaosheng Xu, Yuan Liang, Zigang Xu

{"title":"Hydroa vacciniforme lymphoproliferative disorder: a retrospective study of 42 paediatric cases.","authors":"Yimeng Zhang, Yuanxiang Liu, Jiaosheng Xu, Yuan Liang, Zigang Xu","doi":"10.1684/ejd.2024.4648","DOIUrl":"https://doi.org/10.1684/ejd.2024.4648","url":null,"abstract":"Hydroa vacciniforme lymphoproliferative disorder (HVLPD) is a rare disease related to Epstein-Barr virus (EBV), mainly in children, and is an EBV-associated cutaneous T and natural killer (NK) cell lymphoproliferative disorder. The disorder in some patients may progress to EBV-associated systemic T or NK-cell lymphoma. To summarize the characteristics of HVLPD in Chinese paediatric patients and to examine the risk factors indicating poor prognosis. We performed a retrospective analysis of patients with HVLPD from the Department of Dermatology, Beijing Children's Hospital. Based on diagnosis, medical history, examination results, and immunophenotype, we analysed HVLPD in 42 paediatric cases in order to examine the clinical features, prognoses, and risk factors. Forty-two paediatric patients were enrolled, with a median onset age of five years. All patients presented with papulovesicular lesions, and 32 systemic HVLPD (sHVLPD) patients had systemic symptoms, including fever, lymphadenopathy, hepatomegaly, splenomegaly, and liver dysfunction. Of the sHVLPD cases, 13 also had severe mosquito bite allergy (SMBA). Twenty-five cases were T-type, and nine were CD56+-dominant type. Follow-up data showed that 12 patients had complete remission, and three patients died. SMBA is a risk factor for disease progression in patients with HVLPD, and the pathological CD56+-dominant phenotype is associated with poor prognosis.","PeriodicalId":11968,"journal":{"name":"European Journal of Dermatology","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141440345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of xeroderma pigmentosum group C with rare compound heterozygous mutations. 一例伴有罕见复合杂合突变的 C 组色素性角化病。

IF 2 4区医学

European Journal of Dermatology Pub Date : 2024-04-01 DOI: 10.1684/ejd.2024.4660

Kozo Kawaguchi, Makiko Kido-Nakahara, Yoko Kuba-Fuyuno, Gaku Tsuji, Ryusuke Ono, Chikako Nishigori, Takeshi Nakahara

引用次数: 0