Diana Bernardo, José Miguel Alvarenga, Tiago Torres
{"title":"Effectiveness and safety of dupilumab in adults with moderate-to-severe atopic dermatitis previously treated with JAK inhibitors.","authors":"Diana Bernardo, José Miguel Alvarenga, Tiago Torres","doi":"10.1684/ejd.2025.4834","DOIUrl":"https://doi.org/10.1684/ejd.2025.4834","url":null,"abstract":"","PeriodicalId":11968,"journal":{"name":"European Journal of Dermatology","volume":"35 1","pages":"64-65"},"PeriodicalIF":2.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Platelet-related parameters as systemic markers of erythrodermic psoriasis.","authors":"Lan Guo, Biao Song, Chao Wu, Hong-Zhong Jin","doi":"10.1684/ejd.2025.4811","DOIUrl":"https://doi.org/10.1684/ejd.2025.4811","url":null,"abstract":"<p><p>Erythrodermic psoriasis (EP) is a severe disease with systemic inflammation and complications. The pathogenesis remains largely unknown. Recent studies have shown that platelets play important roles in psoriasis, but the association between platelets and EP is unclear. This study aimed to analyse, for the first time, the clinical significance of platelet-related parameters in EP patients. We retrospectively investigated the clinical and laboratory data of 92 EP patients, 93 sex/age-matched psoriasis vulgaris (PsV) patients, and 93 matched healthy controls (HC). The platelet-related parameters, including platelet count, plateletcrit (PCT), mean platelet volume (MPV), platelet distribution width (PDW), platelet large cell ratio (P-LCR) and platelet/lymphocyte ratio (PLR), were compared between the three groups. Associations between these parameters and disease severity, and between platelet count and complications of EP were analysed, and compared before and after treatment. Platelet count, PCT, and PLR were significantly elevated in EP compared with PsV and HC (p < 0.001). MPV was higher in EP patients compared with HC (p < 0.001). Based on ROC analyses, moderate-to-severe and mild EP could be clearly distinguished based on platelet count and PCT. In terms of complications, a platelet count level ≥ 270 × 109/L was associated with a significantly higher rate of hypoalbuminemia and abnormal liver function. After treatment, platelet count, PCT, and PLR were significantly reduced. Our data show, for the first time, a significant alteration of platelet-related parameters in EP patients, indicating a strong association between platelets and EP. Platelet count and PCT may be used as cost-effective and simple tools to serve as systemic markers for EP.</p>","PeriodicalId":11968,"journal":{"name":"European Journal of Dermatology","volume":"35 1","pages":"9-15"},"PeriodicalIF":2.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Elisa Molinelli, Edoardo De Simoni, Daisy Gambini, Andrea Maurizi, Maria Luisa Dragonetti, Sara Belleggia, Giulio Rizzetto, Annamaria Offidani, Oriana Simonetti
{"title":"Viral infection as a trigger of hidradenitis suppurativa disease activity: the role of SARS-CoV-2 infection in acute flares.","authors":"Elisa Molinelli, Edoardo De Simoni, Daisy Gambini, Andrea Maurizi, Maria Luisa Dragonetti, Sara Belleggia, Giulio Rizzetto, Annamaria Offidani, Oriana Simonetti","doi":"10.1684/ejd.2025.4835","DOIUrl":"https://doi.org/10.1684/ejd.2025.4835","url":null,"abstract":"<p><p>Hidradenitis suppurativa (HS) is a severe chronic relapsing inflammatory disorder of the hair follicle unit that affects intertriginous areas. Several studies have reported the occurrence of HS exacerbation following SARS-Cov2 vaccination. However, few data exist on the role of bacterial and viral infections in HS acute flares. The aim of the study was to investigate the occurrence of HS flares following SARS-Cov2 infection. We conducted a retrospective, single-centre, observational study at the Dermatology Clinic of Azienda Ospedaliero-Universitaria delle Marche between April 2020 and December 2022. Patients aged 18 years or older with a diagnosis of HS were included and completed a questionnaire in order to investigate the incidence and characteristics of HS manifestations after SARS-Cov2 infection. In total, 228 patients were enrolled; 143 (62.7%) reported at least one episode of SARS-CoV-2 infection, and 27.3% of patients with SARS-Cov2 infection experienced disease flares. Relapses were more frequently observed in patients with concomitant HS-related disease (flares vs no flares: 67% vs 43%; p=0.016), and the occurrence of flares negatively correlated with antibiotic treatment for HS during SARS-CoV-2 infection (flares vs no flares: 39% vs 20%; p=0.025). Although our data suggest that SARS-CoV-2 infection may act as a disease trigger in patients with HS, further studies are needed.</p>","PeriodicalId":11968,"journal":{"name":"European Journal of Dermatology","volume":"35 1","pages":"38-42"},"PeriodicalIF":2.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Carlos Llamas-Segura, Marta Cebolla-Verdugo, Israel Pérez-López
{"title":"sQuiz your knowledge! Erythematous-violaceous tumour in the right preauricular region.","authors":"Carlos Llamas-Segura, Marta Cebolla-Verdugo, Israel Pérez-López","doi":"10.1684/ejd.2025.4840","DOIUrl":"https://doi.org/10.1684/ejd.2025.4840","url":null,"abstract":"","PeriodicalId":11968,"journal":{"name":"European Journal of Dermatology","volume":"35 1","pages":"83-85"},"PeriodicalIF":2.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ana Maria Lé, Rita Carrilho Pichel, Miguel Horta, Alexandra Araújo
{"title":"Cemiplimab for recurrent locally advanced cutaneous squamous cell carcinoma.","authors":"Ana Maria Lé, Rita Carrilho Pichel, Miguel Horta, Alexandra Araújo","doi":"10.1684/ejd.2025.4852","DOIUrl":"https://doi.org/10.1684/ejd.2025.4852","url":null,"abstract":"","PeriodicalId":11968,"journal":{"name":"European Journal of Dermatology","volume":"35 1","pages":"78-80"},"PeriodicalIF":2.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}