European Journal of Dermatology最新文献_第3页

A novel biomarker of type VII collagen degradation increases in patients with atopic dermatitis and decreases upon treatment with immunosuppressants. 在特应性皮炎患者中，一种新型的VII型胶原降解生物标志物增加，并在免疫抑制剂治疗后减少。

IF 2 4区医学

European Journal of Dermatology Pub Date : 2025-04-01 DOI: 10.1684/ejd.2025.4854

Matej Andelic, Solveig Skovlund Groen, Jesper Grønlund Holm, Alexander Egeberg, Jacob P Thyssen, Valdemar W Nielsen, Morten Karsdal, Anne-Christine Bay-Jensen, Signe Holm Nielsen, Simon Francis Thomsen

{"title":"A novel biomarker of type VII collagen degradation increases in patients with atopic dermatitis and decreases upon treatment with immunosuppressants.","authors":"Matej Andelic, Solveig Skovlund Groen, Jesper Grønlund Holm, Alexander Egeberg, Jacob P Thyssen, Valdemar W Nielsen, Morten Karsdal, Anne-Christine Bay-Jensen, Signe Holm Nielsen, Simon Francis Thomsen","doi":"10.1684/ejd.2025.4854","DOIUrl":"https://doi.org/10.1684/ejd.2025.4854","url":null,"abstract":"Remodelling of the extracellular matrix (ECM) is a continuous process necessary for maintaining skin tissue architecture and function. Disruption of type VII and XVII collagen turnover within the ECM is a contributing factor in the pathogenesis of skin conditions such as atopic dermatitis (AD). To investigate the turnover of type VII and XVII collagens in AD using novel biomarkers of ECM turnover. Type VII (C7M) and XVII (PRO-C17) collagen turnover were measured using ELISAs. The cohort comprised 158 AD patients and 20 matched healthy donors (HD), with 53 of the AD patients treated with topical calcineurin inhibitors. Disease severity was assessed using the SCORAD index, categorizing patients into mild (SCORAD < 25), moderate (SCORAD: 25-50), and severe (SCORAD > 50) groups. AD patients across all severity groups had higher C7M levels (all: p < 0.0001), while the levels of PRO-C17 were higher in mild AD patients versus HD (p = 0.0399). The C7M marker demonstrated an AUC of 0.96, and its levels were decreased in AD patients undergoing topical calcineurin inhibitor treatment (p=0.0073). The turnover of type VII and XVII collagens, measured by the biomarkers C7M and PRO-C17, is elevated in patients with AD. The biomarker C7M may have the potential to serve as a diagnostic and treatment response biomarker in AD.","PeriodicalId":11968,"journal":{"name":"European Journal of Dermatology","volume":"35 2","pages":"91-97"},"PeriodicalIF":2.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

C/EBPα mediates UVA-induced MMP1 overexpression in a histone H3 acetylation-dependent manner during skin photoaging. C/EBPα以组蛋白H3乙酰化依赖的方式介导uva诱导的皮肤光老化过程中MMP1的过表达。

IF 2 4区医学

European Journal of Dermatology Pub Date : 2025-04-01 DOI: 10.1684/ejd.2025.4867

Lingxue Hu, Ruijian Ren, Yu Rao, Xiaoliang Tong, Aiyuan Guo, Shu Ding

{"title":"C/EBPα mediates UVA-induced MMP1 overexpression in a histone H3 acetylation-dependent manner during skin photoaging.","authors":"Lingxue Hu, Ruijian Ren, Yu Rao, Xiaoliang Tong, Aiyuan Guo, Shu Ding","doi":"10.1684/ejd.2025.4867","DOIUrl":"https://doi.org/10.1684/ejd.2025.4867","url":null,"abstract":"UVA-induced skin photoaging mechanisms involve inflammation and dysregulation of matrix metalloproteinase (MMP) expression. In UVA-induced photoaging, MMP1 expression is increased in dermal fibroblasts, thereby facilitating skin damage and degradation of extracellular matrix (ECM) components, such as type I collagen. To investigate whether UVA influences the level of histone H3 acetylation of the MMP1 promoter via C/EBPα/P300. In this study, skin samples (from both exposed and unexposed areas) were collected from 10 subjects, and a fibroblast photoaging model was concurrently established. RT-qPCR, western blotting, and ChIP-qPCR were employed to assess C/EBPα, P300, MMP1, and COL1A1 expression levels in the dermis and primary fibroblasts. Additionally, ChIP-qPCR was utilized to validate the binding of C/EBPα to the MMP1 promoter region, while co-immunoprecipitation was performed to confirm interaction between C/EBPα and P300. ChIP-qPCR was employed to examine the level of binding of relevant genes to the MMP1 promoter after exposure to light. Transfection with overexpression plasmids and siRNA targeting C/EBPα and P300 was performed, followed by RT-qPCR, western blotting, and ChIP-qPCR, to ascertain whether the regulation of MMP1 by C/EBPα is dependent on P300. We observed increased MMP1 mRNA and protein levels in UVA-exposed samples, which significantly positively correlated with histone H3 acetylation of the MMP1 promoter. This phenomenon may be related to UVA-induced C/EBPα-P300 complex formation, mediated by histone acetylation of the MMP1 promoter. Our findings reveal that UVA-induced upregulation of MMP1 expression, mediated by C/EBPα, is partially dependent on acetylation, and that this mechanism might be a potential therapeutic target for photoaging.","PeriodicalId":11968,"journal":{"name":"European Journal of Dermatology","volume":"35 2","pages":"98-107"},"PeriodicalIF":2.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Treatment of mesotherapy-induced skin fibro-proliferation with baricitinib. 巴西替尼治疗中西医结合诱导的皮肤纤维增生。

IF 2 4区医学

European Journal of Dermatology Pub Date : 2025-04-01 DOI: 10.1684/ejd.2025.4865

Xuechen Ai, Leying Liu, Pengfei Song, Jing Wang, Zhenying Zhang

引用次数: 0

Morphological features and prognostic significance of lesions located on the hands and feet in a large series of patients with mycosis fungoides. 大量蕈样真菌病患者手足部位病变的形态学特征及预后意义。

IF 2 4区医学

European Journal of Dermatology Pub Date : 2025-04-01 DOI: 10.1684/ejd.2025.4866

Tugba Atci, Sule Ozturk Sari, Fatma K Gul Ciftci, Nesimi Buyukbabani, Can Baykal

{"title":"Morphological features and prognostic significance of lesions located on the hands and feet in a large series of patients with mycosis fungoides.","authors":"Tugba Atci, Sule Ozturk Sari, Fatma K Gul Ciftci, Nesimi Buyukbabani, Can Baykal","doi":"10.1684/ejd.2025.4866","DOIUrl":"https://doi.org/10.1684/ejd.2025.4866","url":null,"abstract":"Hand and foot (acral) involvement is uncommon in mycosis fungoides (MF). To determine the frequency, clinical features and prognostic significance of acral involvement in the course of MF. MF subtypes, clinical features of acral lesions, and disease stage were documented retrospectively to assess possible associations. We evaluated 28 consecutive patients with acral involvement in a cohort of 773 MF patients (3.6%) over 24 years. The median age of acral involvement was 55 years. None of the patients exhibited isolated acral involvement. In 53.6% of patients, acral lesions were present at the time of MF diagnosis. Classic MF (71.4%) was the most common subtype, followed by folliculotropic (32.2%). The plantar region was the most common localization of acral involvement (53.6%), presenting typically with erythematous squamous/hyperkeratotic papules or plaques, tumours, and diffuse micropapular lesions with erosions. The dorsum of the hand and foot, and palms were mostly involved with tumoral lesions and/or erythematous squamous plaques. Although 64.3% of patients were diagnosed with early-stage MF, most of them (75%) exhibited advanced-stage disease during the course. All lesions in the acral location were associated with the involvement of other body parts in our cases. They occurred with a relatively higher ratio in folliculotropic MF. Acral lesions display a diverse clinical spectrum, including grouped micropapular lesions with erosions in the plantar region. Considering the high rate of advanced-stage cases, acral involvement seems to be an independent risk factor for disease progression in MF.","PeriodicalId":11968,"journal":{"name":"European Journal of Dermatology","volume":"35 2","pages":"108-117"},"PeriodicalIF":2.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Paradoxical development of prurigo nodularis during ixekizumab therapy in a patient with generalized pustular psoriasis and psoriatic arthritis. 一名广泛性脓疱性银屑病和银屑病关节炎患者在ixekizumab治疗期间出现结节性痒疹的矛盾发展。

IF 2 4区医学

European Journal of Dermatology Pub Date : 2025-04-01 DOI: 10.1684/ejd.2025.4843

Joohyung Youh, Takuya Mizukami, Yuri Nagata, Kei Ito, Keiko Tokuchi, Yusuke Morita

引用次数: 0

A case of desmoplastic squamous cell carcinoma in a patient treated with a Janus kinase inhibitor. 用Janus激酶抑制剂治疗的患者的结缔组织增生鳞状细胞癌一例。

IF 2 4区医学

European Journal of Dermatology Pub Date : 2025-04-01 DOI: 10.1684/ejd.2025.4845

Sadanori Furudate, Haruka Nakagawa, Keiki Inoue, Yoshihide Asano

引用次数: 0

A severe soft tissue infection affecting the upper eyelid caused by group A Streptococcus. 由A群链球菌引起的严重的上眼睑软组织感染。

IF 2 4区医学

European Journal of Dermatology Pub Date : 2025-04-01 DOI: 10.1684/ejd.2025.4871

Anna Takeuchi, Ryunosuke Umeda, Yoshiko Suyama, Naomi Tani, Yuichi Yoshida

引用次数: 0

Efficacy and tolerance of a prebiotic, panthenol-containing repair balm in patients diagnosed with skin lesions requiring regenerative care. 一种益生元、含泛醇修复软膏在诊断为需要再生护理的皮肤病变患者中的疗效和耐受性。

IF 2 4区医学

European Journal of Dermatology Pub Date : 2025-04-01 DOI: 10.1684/ejd.2025.4855

Stamatios Gregoriou, Efstratios Vakirlis, Efterpi Zafiriou

{"title":"Efficacy and tolerance of a prebiotic, panthenol-containing repair balm in patients diagnosed with skin lesions requiring regenerative care.","authors":"Stamatios Gregoriou, Efstratios Vakirlis, Efterpi Zafiriou","doi":"10.1684/ejd.2025.4855","DOIUrl":"https://doi.org/10.1684/ejd.2025.4855","url":null,"abstract":"Skin lesions requiring regenerative care often present significant challenges for patient treatment and management. To assess the efficacy and tolerance of a soothing and repairing balm product (Cicaplast Baume B5+, La Roche-Posay, France) when used for the treatment of skin lesions requiring regenerative care, as well as its impact on quality of life (QoL) and patient satisfaction. Patients requiring regenerative care for superficial wounds or irritative dermatitis, or requiring sedative skin care after irritating treatments, such as for actinic keratosis (AK), or skin care following a dermatological procedure were included in the study. Initially, patients' QoL and clinical characteristics were assessed, and the product was then administered appropriately. During a second visit, all clinical and QoL parameters were re-evaluated, and product tolerance rate and satisfaction were assessed. In total, 2,337 subjects participated in the study. After the recommended period of use, a significant improvement in all clinical parameters examined was observed, with ≥64.9% of patients demonstrating an improvement of at least one grade for all assessed clinical symptoms, compared to the initial visit. A significant improvement in all skin discomfort parameters examined was also observed, with ≥81.2% of patients showing an improvement of at least one grade, along with a significant reduction in DLQI and CDLQI mean scores, by 67.7% and 69.8%, respectively (p<0.001), with a high tolerance rate and overall product satisfaction. This product showed significant improvement for all evaluated clinical parameters and patient QoL, with high tolerance and satisfaction rates.","PeriodicalId":11968,"journal":{"name":"European Journal of Dermatology","volume":"35 2","pages":"118-126"},"PeriodicalIF":2.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erythema multiforme-like eruption with severe epidermal necrosis after administration of enfortumab vedotin. 服用维多汀后出现多形红斑样疹伴严重表皮坏死。

IF 2 4区医学

European Journal of Dermatology Pub Date : 2025-04-01 DOI: 10.1684/ejd.2025.4864

Yu Imura, Satoshi Yoshida, Kazuki Yatsuzuka, Naoya Sugihara, Nobushige Kohri, Katsuhiko Nishihara, Noriyoshi Miura, Jun Muto, Ken Shiraishi, Yasuhiro Fujisawa

引用次数: 0

Complete therapeutic response to upadacitinib as a continued treatment for alopecia areata universalis. upadacitinib作为普遍斑秃持续治疗的完全治疗反应。

IF 2 4区医学

European Journal of Dermatology Pub Date : 2025-04-01 DOI: 10.1684/ejd.2025.4862

Gustavo U Machado, Marina S Silverio, Gleison V Duarte, Paulo Rl Machado, Audrey Nosbaum

引用次数: 0