European Journal of Dermatology最新文献

{"title":"Improvement of disseminated superficial porokeratosis during tildrakizumab treatment for psoriasis vulgaris.","authors":"Jianling Zhang, Yoshio Kawakami, Satoru Sugihara, Tomoko Miyake, Yoshinori Shirafuji, Shin Morizane","doi":"10.1684/ejd.2026.5124","DOIUrl":"https://doi.org/10.1684/ejd.2026.5124","url":null,"abstract":"","PeriodicalId":11968,"journal":{"name":"European Journal of Dermatology","volume":"36 5","pages":"446-448"},"PeriodicalIF":1.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149165620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Journal Club: Brepocitinib in dermatology - from mechanistic rationale to emerging clinical evidence in dermatomyositis and other skin and hair diseases.","authors":"César Ferreira, Belén Rodríguez Sánchez, Jorge Martín-Nieto González, Luis Jiménez-Briones, Simon Goller, Paloma Garcia Piqueras","doi":"10.1684/ejd.2026.5161","DOIUrl":"https://doi.org/10.1684/ejd.2026.5161","url":null,"abstract":"","PeriodicalId":11968,"journal":{"name":"European Journal of Dermatology","volume":"36 5","pages":"481-484"},"PeriodicalIF":1.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149166156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Piebaldism with café-au-lait macules in a fair-skinned infant: a diagnostic pitfall in the differential diagnosis of NF1 and Legius syndrome.","authors":"Minami Takahashi, Tokimasa Hida, Masae Okura, Aki Ishikawa, Masaki Kobayashi, Hisashi Uhara","doi":"10.1684/ejd.2026.5137","DOIUrl":"https://doi.org/10.1684/ejd.2026.5137","url":null,"abstract":"","PeriodicalId":11968,"journal":{"name":"European Journal of Dermatology","volume":"36 5","pages":"456-457"},"PeriodicalIF":1.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149165364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cutaneous tertiary lymphoid structures in an evolving unilateral heliotrope rash of anti-MDA5 dermatomyositis.","authors":"Tomoyuki Hioki, Ryota Asahina, Kayoko Tanaka, En Shu, Riho Yamaguchi, Hirofumi Oshima, Shodai Tateyama, Ichiro Mori, Hiroaki Iwata","doi":"10.1684/ejd.2026.5153","DOIUrl":"https://doi.org/10.1684/ejd.2026.5153","url":null,"abstract":"","PeriodicalId":11968,"journal":{"name":"European Journal of Dermatology","volume":"36 5","pages":"478-480"},"PeriodicalIF":1.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149165438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prominent intralesional vascularity on Doppler ultrasound in a Wnt/β-catenin-activated nonpilomatrical carcinoma of the skin.","authors":"Masashi Iwata, Kazuyasu Fujii, Megumi Aoki, Keisuke Goto, Shigeto Matsushita","doi":"10.1684/ejd.2026.5160","DOIUrl":"https://doi.org/10.1684/ejd.2026.5160","url":null,"abstract":"","PeriodicalId":11968,"journal":{"name":"European Journal of Dermatology","volume":"36 5","pages":"0"},"PeriodicalIF":1.9,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149011978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HPV-16-positive squamous cell carcinoma in situ of the upper lip.","authors":"Yuri Soma, Shinpei Miura, Kazushi Anzawa, Akira Shimizu, Hiroo Amano","doi":"10.1684/ejd.2026.5149","DOIUrl":"https://doi.org/10.1684/ejd.2026.5149","url":null,"abstract":"","PeriodicalId":11968,"journal":{"name":"European Journal of Dermatology","volume":"36 5","pages":"0"},"PeriodicalIF":1.9,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149012032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Binary dermoscopic classification inadequately stratifies urgent and convenience excision decisions in community dermatology practice.","authors":"Calogero Pagliarello, Davide Geat, Carlo Renè Girardelli","doi":"10.1684/ejd.2026.5167","DOIUrl":"https://doi.org/10.1684/ejd.2026.5167","url":null,"abstract":"<p><p>Dermoscopy is traditionally framed as a binary benign-malignant tool. Yet real-world practice uses multi-level triage: dermatologists allocate lesions to urgent excision, non-urgent excision, or surveillance based on dermoscopic atypia, contextual factors, and surveillance feasibility. Convenience excisions -low-suspicion lesions removed when monitoring is impractical - are a common, unacknowledged pattern. Dermoscopic literature reports only binary outcomes, ignoring this process. To evaluate whether clinical urgency classification captures melanoma risk beyond isolated dermoscopic assessment in community practice with limited surveillance capacity. We retrospectively analysed 371 consecutively excised melanocytic lesions. Two blinded dermatologists independently assigned four-level gestalt atypia scores. Referring dermatologists prospectively classified excisions as urgent or non-urgent, integrating morphological concern with surveillance constraints. Histopathology identified melanoma prevalence and number needed to excise (NNE). Multivariable regression evaluated predictors of melanoma. Melanoma prevalence was 23.2% (86 melanomas: 41 in situ, 45 invasive; NNE=4.3). Inter-rater agreement for morphology-only assessment was poor (κ=0.16), with weak histopathological correlation (ρ=0.23-0.29). Most excisions (75%) were non-urgent, predominantly convenience excisions, yet captured 44 of 86 melanomas (51%). For invasive melanoma alone, NNE rose to 8.2, still favourable versus the 1:10 benchmark. Age predicted melanoma-in situ diagnoses, but age-stratified analysis showed no disproportionate overdiagnosis. Clinical urgency -which integrates morphological concern with contextual factors and shares information with dermoscopic assessment- predicted melanoma (OR=3.05, p=0.002) beyond gestalt scores, age, and phenotypic complexity. Binary dermoscopic frameworks inadequately reflect real-world multi-factorial triage. Effective melanoma detection depends on integrating morphology with patient-specific risk and system-level factors beyond dermoscopy alone.</p>","PeriodicalId":11968,"journal":{"name":"European Journal of Dermatology","volume":"36 5","pages":"0"},"PeriodicalIF":1.9,"publicationDate":"2026-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149012004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"En coup de sabre morphea with prominent nasal ala atrophy: a paediatric case report.","authors":"Hongwei Fang, Lixin Chen, Ying Wang, Qinfeng Li","doi":"10.1684/ejd.2026.5158","DOIUrl":"https://doi.org/10.1684/ejd.2026.5158","url":null,"abstract":"","PeriodicalId":11968,"journal":{"name":"European Journal of Dermatology","volume":"36 5","pages":"0"},"PeriodicalIF":1.9,"publicationDate":"2026-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149012014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bimekizumab-associated eyelid dermatitis in psoriasis: a real-world clinical case series.","authors":"Carlos Llamas-Segura, Francisco José Navarro-Triviño, Marta Cebolla-Verdugo, Ricardo Ruiz-Villaverde","doi":"10.1684/ejd.2026.5156","DOIUrl":"https://doi.org/10.1684/ejd.2026.5156","url":null,"abstract":"","PeriodicalId":11968,"journal":{"name":"European Journal of Dermatology","volume":"36 5","pages":"0"},"PeriodicalIF":1.9,"publicationDate":"2026-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149012023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Routine blood biomarkers associated with clinical response to tralokinumab in patients with atopic dermatitis: a 48-week real-world study in Japan.","authors":"Mizuki Shiba, Teppei Hagino, Akihiko Uchiyama, Hidehisa Saeki, Eita Fujimoto, Sei-Ichiro Motegi, Naoko Kanda","doi":"10.1684/ejd.2026.5144","DOIUrl":"https://doi.org/10.1684/ejd.2026.5144","url":null,"abstract":"<p><p>Tralokinumab is effective for atopic dermatitis (AD), however, biomarkers reflecting its therapeutic effects have not been fully established. To evaluate whether blood biomarkers are associated with clinical response to tralokinumab during 48 weeks of treatment for AD. We conducted a prospective two-centre observational study of 203 patients with moderate-to-severe AD treated with tralokinumab between October 2023 and October 2025. Eczema Area and Severity Index (EASI) and Peak Pruritus-Numerical Rating Scale (PP-NRS) were evaluated at weeks 0, 4, 12, 16, 24, 36, and 48. Serum immunoglobulin E (IgE), thymus and activation-regulated chemokine (TARC), lactate dehydrogenase (LDH), and total eosinophil count were evaluated simultaneously. Percent reduction of TARC correlated with decreased EASI and PP-NRS at weeks 4 and 12. Percent reduction of IgE correlated with decreased EASI at weeks 4 and 12 and decreased PP-NRS at week 4. Percent reduction of LDH correlated with decreased EASI at weeks 4, 12, and 24, whereas a correlation with PP-NRS was significant only at week 4. The level of TARC may reflect the early therapeutic effects of tralokinumab on both clinical signs and pruritus in patients with AD. IgE may also reflect early treatment response, particularly for clinical signs, whereas LDH may reflect early and mid-term improvement of clinical signs.</p>","PeriodicalId":11968,"journal":{"name":"European Journal of Dermatology","volume":"36 5","pages":"0"},"PeriodicalIF":1.9,"publicationDate":"2026-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148896893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}