European Journal of Dermatology最新文献

{"title":"Binary dermoscopic classification inadequately stratifies urgent and convenience excision decisions in community dermatology practice.","authors":"Calogero Pagliarello, Davide Geat, Carlo Renè Girardelli","doi":"10.1684/ejd.2026.5167","DOIUrl":"https://doi.org/10.1684/ejd.2026.5167","url":null,"abstract":"<p><p>Dermoscopy is traditionally framed as a binary benign-malignant tool. Yet real-world practice uses multi-level triage: dermatologists allocate lesions to urgent excision, non-urgent excision, or surveillance based on dermoscopic atypia, contextual factors, and surveillance feasibility. Convenience excisions -low-suspicion lesions removed when monitoring is impractical - are a common, unacknowledged pattern. Dermoscopic literature reports only binary outcomes, ignoring this process. To evaluate whether clinical urgency classification captures melanoma risk beyond isolated dermoscopic assessment in community practice with limited surveillance capacity. We retrospectively analysed 371 consecutively excised melanocytic lesions. Two blinded dermatologists independently assigned four-level gestalt atypia scores. Referring dermatologists prospectively classified excisions as urgent or non-urgent, integrating morphological concern with surveillance constraints. Histopathology identified melanoma prevalence and number needed to excise (NNE). Multivariable regression evaluated predictors of melanoma. Melanoma prevalence was 23.2% (86 melanomas: 41 in situ, 45 invasive; NNE=4.3). Inter-rater agreement for morphology-only assessment was poor (κ=0.16), with weak histopathological correlation (ρ=0.23-0.29). Most excisions (75%) were non-urgent, predominantly convenience excisions, yet captured 44 of 86 melanomas (51%). For invasive melanoma alone, NNE rose to 8.2, still favourable versus the 1:10 benchmark. Age predicted melanoma-in situ diagnoses, but age-stratified analysis showed no disproportionate overdiagnosis. Clinical urgency -which integrates morphological concern with contextual factors and shares information with dermoscopic assessment- predicted melanoma (OR=3.05, p=0.002) beyond gestalt scores, age, and phenotypic complexity. Binary dermoscopic frameworks inadequately reflect real-world multi-factorial triage. Effective melanoma detection depends on integrating morphology with patient-specific risk and system-level factors beyond dermoscopy alone.</p>","PeriodicalId":11968,"journal":{"name":"European Journal of Dermatology","volume":"36 5","pages":"0"},"PeriodicalIF":1.9,"publicationDate":"2026-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149012004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"En coup de sabre morphea with prominent nasal ala atrophy: a paediatric case report.","authors":"Hongwei Fang, Lixin Chen, Ying Wang, Qinfeng Li","doi":"10.1684/ejd.2026.5158","DOIUrl":"https://doi.org/10.1684/ejd.2026.5158","url":null,"abstract":"","PeriodicalId":11968,"journal":{"name":"European Journal of Dermatology","volume":"36 5","pages":"0"},"PeriodicalIF":1.9,"publicationDate":"2026-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149012014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bimekizumab-associated eyelid dermatitis in psoriasis: a real-world clinical case series.","authors":"Carlos Llamas-Segura, Francisco José Navarro-Triviño, Marta Cebolla-Verdugo, Ricardo Ruiz-Villaverde","doi":"10.1684/ejd.2026.5156","DOIUrl":"https://doi.org/10.1684/ejd.2026.5156","url":null,"abstract":"","PeriodicalId":11968,"journal":{"name":"European Journal of Dermatology","volume":"36 5","pages":"0"},"PeriodicalIF":1.9,"publicationDate":"2026-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149012023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Routine blood biomarkers associated with clinical response to tralokinumab in patients with atopic dermatitis: a 48-week real-world study in Japan.","authors":"Mizuki Shiba, Teppei Hagino, Akihiko Uchiyama, Hidehisa Saeki, Eita Fujimoto, Sei-Ichiro Motegi, Naoko Kanda","doi":"10.1684/ejd.2026.5144","DOIUrl":"https://doi.org/10.1684/ejd.2026.5144","url":null,"abstract":"<p><p>Tralokinumab is effective for atopic dermatitis (AD), however, biomarkers reflecting its therapeutic effects have not been fully established. To evaluate whether blood biomarkers are associated with clinical response to tralokinumab during 48 weeks of treatment for AD. We conducted a prospective two-centre observational study of 203 patients with moderate-to-severe AD treated with tralokinumab between October 2023 and October 2025. Eczema Area and Severity Index (EASI) and Peak Pruritus-Numerical Rating Scale (PP-NRS) were evaluated at weeks 0, 4, 12, 16, 24, 36, and 48. Serum immunoglobulin E (IgE), thymus and activation-regulated chemokine (TARC), lactate dehydrogenase (LDH), and total eosinophil count were evaluated simultaneously. Percent reduction of TARC correlated with decreased EASI and PP-NRS at weeks 4 and 12. Percent reduction of IgE correlated with decreased EASI at weeks 4 and 12 and decreased PP-NRS at week 4. Percent reduction of LDH correlated with decreased EASI at weeks 4, 12, and 24, whereas a correlation with PP-NRS was significant only at week 4. The level of TARC may reflect the early therapeutic effects of tralokinumab on both clinical signs and pruritus in patients with AD. IgE may also reflect early treatment response, particularly for clinical signs, whereas LDH may reflect early and mid-term improvement of clinical signs.</p>","PeriodicalId":11968,"journal":{"name":"European Journal of Dermatology","volume":"36 5","pages":"0"},"PeriodicalIF":1.9,"publicationDate":"2026-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148896893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ambient temperature and palmoplantar pustulosis exacerbation-related healthcare visits: a 20-year observational cohort.","authors":"Sijie Ma, Jiaqi Wang, Zhongrui Xu, Jingyu Du, Wenyao Chen, Biqing Tian, Xiaohua Wang, Bin Yang, Gang Wang, Shuai Shao","doi":"10.1684/ejd.2026.5142","DOIUrl":"https://doi.org/10.1684/ejd.2026.5142","url":null,"abstract":"<p><p>Palmoplantar pustulosis (PPP) is a chronic inflammatory skin disease marked by recurrent pustules and erythema on the palms and soles. Whether ambient temperature is associated with PPP activity remains insufficiently defined. To evaluate the association between ambient temperature and PPP exacerbation-related healthcare visits. We conducted a 20-year retrospective observational study including 3,834 patients with dermatologist-diagnosed PPP treated between January 2004 and December 2024. Clinical visit data were linked to historical meteorological records according to patients' residential region and visit month. The primary outcome was defined as PPP exacerbation-related healthcare visits, an operational visit-based proxy for clinically active or suspected active PPP. Skin biopsy was performed in 47.4% (n=1,818) of patients. PPP outpatient visits and the proportion of PPP cases among all psoriasis patients peaked during summer. Compared with a simulated random distribution stratified by year and geographic region, the month of PPP exacerbation-related healthcare visits showed a shift toward higher ambient temperatures. In rank-based analyses, 47.9% (n=1,768) of visits occurred in the hottest month relative to the preceding three months. In addition, 58.6% of patients experienced an increase in ambient temperature before the PPP-related visit. Sensitivity analyses restricted to records suggestive of recurrence, progression, or treatment failure showed generally consistent temperature-related patterns. Elevated ambient temperature was associated with PPP exacerbation-related healthcare visits. These findings should be interpreted as associations rather than evidence of causality and require confirmation in prospectively defined PPP cohorts.</p>","PeriodicalId":11968,"journal":{"name":"European Journal of Dermatology","volume":"36 5","pages":"0"},"PeriodicalIF":1.9,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148886729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PTPN11 variants in four Chinese patients: a case series and genotype-phenotype analysis.","authors":"Piaoping Zhao, Qin Zeng, Qiaoyu Cao, Rui Lei, Haisheng Huang, Qin Yan, Feng Tian, Ming Li","doi":"10.1684/ejd.2026.5151","DOIUrl":"https://doi.org/10.1684/ejd.2026.5151","url":null,"abstract":"<p><p>Noonan syndrome (NS) and LEOPARD syndrome (LS) are well-characterized RAS/MAPK pathway-related disorders with strong genotype-phenotype correlations. Most cases of both syndromes are caused by variants in the PTPN11 gene, with specific sites predisposing to either NS or LS. The association between PTPN11 and granular cell tumours (GCTs) remains largely unexplored. To further investigate the phenotypic spectrum of patients with PTPN11 variants. We performed whole-exome sequencing on four Chinese children who presented with café-au-lait macules as the initial cutaneous manifestation. To confirm the mutation, Sanger sequencing was performed on DNA samples obtained from the patient and both parents. Histopathological examination and immunohistochemical staining were performed on a subcutaneous nodule from patient 1 to characterize the lesion. Three PTPN11 variants were identified: c.1391G>C (p. Gly464Ala), c.1403C>T (p. Thr468Met), and c.1493G>T (p. Arg498Leu). Notably, patient 1, who carried the PTPN11 c.1391G>C variant, presented with coexisting granular cell tumours -an association that has not previously been reported for this specific variant. The association with granular cell tumours highlights the clinical importance of long-term surveillance of neural crest-derived neoplasms in PTPN11 variant carriers and broadens our understanding of the diverse phenotypic outcomes associated with PTPN11 variants.</p>","PeriodicalId":11968,"journal":{"name":"European Journal of Dermatology","volume":"36 5","pages":"0"},"PeriodicalIF":1.9,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148864061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Everything is awesome- using Lego to build positive experiences in laser dermatology: a prospective service evaluation of play-based distraction during laser procedures.","authors":"Kyriaki Stefania Mitsaki, Polly Stevenson, Samadi Annakkarage, Frances Johnson-Wynne, Louise Nevitte, Alexandra Phillips, Harshita Ryali, Iona Watts, Charankumal Singh Thandi, Christopher Wearn, Kay Thomas, Daniel James Keith","doi":"10.1684/ejd.2026.5145","DOIUrl":"https://doi.org/10.1684/ejd.2026.5145","url":null,"abstract":"","PeriodicalId":11968,"journal":{"name":"European Journal of Dermatology","volume":"36 5","pages":"0"},"PeriodicalIF":1.9,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148864056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improvement of pruritus with baricitinib in a patient with prurigo nodularis refractory to multiple biologic therapies.","authors":"Yoshihito Mima, Masako Yamamoto, Ken Iozumi","doi":"10.1684/ejd.2026.5131","DOIUrl":"https://doi.org/10.1684/ejd.2026.5131","url":null,"abstract":"","PeriodicalId":11968,"journal":{"name":"European Journal of Dermatology","volume":"36 5","pages":"0"},"PeriodicalIF":1.9,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148864023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eczematous eruption during bimekizumab treatment for plaque psoriasis: a biopsy-confirmed case with elevated serum TARC and peripheral eosinophilia.","authors":"Kazuma Kaneda, Shinichi Moriwaki, Atsushi Fukunaga","doi":"10.1684/ejd.2026.5152","DOIUrl":"https://doi.org/10.1684/ejd.2026.5152","url":null,"abstract":"","PeriodicalId":11968,"journal":{"name":"European Journal of Dermatology","volume":"36 5","pages":"0"},"PeriodicalIF":1.9,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148863959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term apremilast treatment in a patient with HIV infection, previous HBV/HCV infection, and subsequent diffuse large B-cell lymphoma.","authors":"Tomoyuki Hioki, Yoko Mizutani, En Shu, Hiroaki Iwata","doi":"10.1684/ejd.2026.5135","DOIUrl":"https://doi.org/10.1684/ejd.2026.5135","url":null,"abstract":"","PeriodicalId":11968,"journal":{"name":"European Journal of Dermatology","volume":"36 5","pages":"0"},"PeriodicalIF":1.9,"publicationDate":"2026-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148850143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}