European Journal of Dermatology最新文献_第8页

Clues on dermoscopy: Arborizing and dotted vessels: an atypical vascular pattern associated with atrophic dermatofibroma. 皮肤镜的线索：树枝状和点状血管：与萎缩性皮纤维瘤相关的非典型血管形态。

IF 2 4区医学

European Journal of Dermatology Pub Date : 2024-10-01 DOI: 10.1684/ejd.2024.4775

María Córdoba García-Rayo, Elisa Hernández De La Torre Ruiz, Paloma García Piqueras

引用次数: 0

sQuiz your knowledge! An erythematous nodule on the leg: the importance of dermoscopy for diagnosis. 知识问答腿部红斑结节：皮肤镜检查对诊断的重要性。

IF 2 4区医学

European Journal of Dermatology Pub Date : 2024-10-01 DOI: 10.1684/ejd.2024.4777

Turki Kmar, Fatma Hammami, Hamida Turki

引用次数: 0

Parallel pigmented network in lentigo maligna: a case series and correlation with in vivo reflectance confocal microscopy. 恶性白斑中的平行色素网：病例系列及与活体反射共聚焦显微镜的相关性。

IF 2 4区医学

European Journal of Dermatology Pub Date : 2024-10-01 DOI: 10.1684/ejd.2024.4747

Giulia Greta Dradi, Reyes Gamo Villegas, María Uxmal Floristán Murzubal, Fernando Pinedo Moraleda, Claudia Sarró Fuente, José Luis López Estebaranz

{"title":"Parallel pigmented network in lentigo maligna: a case series and correlation with in vivo reflectance confocal microscopy.","authors":"Giulia Greta Dradi, Reyes Gamo Villegas, María Uxmal Floristán Murzubal, Fernando Pinedo Moraleda, Claudia Sarró Fuente, José Luis López Estebaranz","doi":"10.1684/ejd.2024.4747","DOIUrl":"https://doi.org/10.1684/ejd.2024.4747","url":null,"abstract":"Lentigo maligna (LM) often poses a diagnostic challenge due to its clinical and dermoscopic mimicry of benign lesions, leading to delayed diagnosis. Focal areas of reticular disruption have been described as one of the earliest dermoscopic signs observed. To describe a novel dermoscopic sign in LM, namely the presence of a parallel pigmented network. Case series of 22 histopathologically-proven LM and lentigo maligna melanoma (LMM), diagnosed between 2018 and 2023, at a tertiary centre. All lesions showed a parallel network upon dermoscopy, in the form of parallel reticular lines, light or dark brown in colour, not emanating from the follicle, with an asymmetrical distribution. Reflectance confocal microscopy (RCM) images were reviewed to correlate these areas. The median age of patients was 73 years old. The majority of lesions were in situ (91%) and extrafacial (82%). Lesions showed minimal signs of atypia other than a parallel network and mostly focal erased areas (100%), followed by perifollicular linear projections (18%) and asymmetrical follicular pigmentation (18%). On RCM, focally areas correlated with atypical junctional thickenings distributed in a parallel fashion (100%) and mitochondria-like structures (23%). Most cases (88%) showed atypical cells in the epidermis, mostly in the form of isolated dendritic cells (41%). Parallel network emerges as a potential dermoscopic sign associated with LM. We hypothesize that in early stages of LM transformation, disruption of the reticular network manifests as parallel lines and/or radial perifollicular lines. Validation with larger studies is warranted.","PeriodicalId":11968,"journal":{"name":"European Journal of Dermatology","volume":"34 5","pages":"490-496"},"PeriodicalIF":2.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142716021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Psoriasis induced at the injection sites of interferon beta in a patient with multiple sclerosis. 一名多发性硬化症患者注射干扰素 beta 的部位诱发牛皮癣。

IF 2 4区医学

European Journal of Dermatology Pub Date : 2024-10-01 DOI: 10.1684/ejd.2024.4772

Chang-Yu Hsieh, Tsen-Fang Tsai

引用次数: 0

sQUIZ your knowledge! An ulcerated and friable plaque on the leg of a middle-aged woman. 测验您的知识！一位中年妇女腿上的溃疡和易碎斑块。

IF 2 4区医学

European Journal of Dermatology Pub Date : 2024-10-01 DOI: 10.1684/ejd.2024.4779

Ana Serrano Ordóñez, Alejandro Arroyo Córdoba, Alexandra Perea Polak

引用次数: 0

A case of anaphylaxis to kumquat (Citrus japonica). 一例金橘过敏性休克病例。

IF 2 4区医学

European Journal of Dermatology Pub Date : 2024-10-01 DOI: 10.1684/ejd.2024.4759

Shogo Ikezawa, Emi Yokoyama, Hitoshi Urakami, Mikiko Takigawa, Tomoko Miyake, Yoji Hirai, Yoshio Kawakami, Shin Morizane

引用次数: 0

Recurrence of penile tuberculid after primary surgical resection. 原发性手术切除后阴茎结核复发。

IF 2 4区医学

European Journal of Dermatology Pub Date : 2024-10-01 DOI: 10.1684/ejd.2024.4757

Takanao Matsumoto, Satoshi Nakamura, Atsushi Yamada, Naoka Umemoto, Toshio Demitsu

引用次数: 0

Effectiveness and tolerance of tralokinumab after failure with dupilumab and baricitinib in a patient with atopic dermatitis. 一名特应性皮炎患者在使用杜匹鲁单抗和巴利昔尼失败后，对曲妥珠单抗的疗效和耐受性产生了怀疑。

IF 2 4区医学

European Journal of Dermatology Pub Date : 2024-10-01 DOI: 10.1684/ejd.2024.4773

Egídio Freitas, Orhan Yilmaz, Tiago Torres

引用次数: 0

Prognostic clinical characteristics and systemic immune inflammatory biomarkers in 520 inpatients with herpes zoster: a retrospective analysis based on tertiary care hospitals. 520 名带状疱疹住院患者的预后临床特征和全身免疫炎症生物标志物：基于三级医院的回顾性分析。

IF 2 4区医学

European Journal of Dermatology Pub Date : 2024-10-01 DOI: 10.1684/ejd.2024.4749

Thilo Gambichler, Meike Beilenhoff, Nessr Abu Rached, Laura Susok

{"title":"Prognostic clinical characteristics and systemic immune inflammatory biomarkers in 520 inpatients with herpes zoster: a retrospective analysis based on tertiary care hospitals.","authors":"Thilo Gambichler, Meike Beilenhoff, Nessr Abu Rached, Laura Susok","doi":"10.1684/ejd.2024.4749","DOIUrl":"10.1684/ejd.2024.4749","url":null,"abstract":"Herpes zoster (HZ) is a very common disease associated with a considerable individual and public health burden. To evaluate prognostic clinical and laboratory parameters, including systemic immune inflammatory biomarkers (SIIB) in inpatients with HZ. We investigated clinical and laboratory data of 520 inpatients with HZ. Complete blood count was determined at baseline. SIIB was assessed based on neutrophil-to-lymphocyte ratio (NLR), pan-immune-inflammation value (PIV), and absolute eosinopenia (AEP). Both uni- and multivariable statistics were performed. NRL and PIV were significantly (p < 0.0001) higher in HZ patients vs. healthy controls and. The presence of absolute eosinopenia (OR: 3.9, 95 % CI: 1.9 to 8.3) was a strong predictor of herpes zoster ophthalmicus (HZO). Ramsay-Hunt syndrome (OR: 4.3, 95 % CI: 1.8 to 10.3), bacterial superinfection (OR: 2.3, 95 % CI: 1.3 to 4.1), and age < 65 (OR: 0.51, 95 % CI: 0.33 to 0.78) were associated with length of hospitalisation. The presence of immunosuppression predicted herpes encephalitis (OR: 22.4, 95 % CI: 2.3 to 221) as well as treatment outcome in the intensive care unit (OR: 8.9, 95 % CI: 1.3 to 61.8). Postherpetic neuralgia was associated with absence of intravenous antiviral therapy (OR: 55.2 [16.5 to 184.9]). We identified several clinical and laboratory-based independent predictors that may aid prognostication of HZ patients. The increase in SIIB reflects the possible role of systemic inflammatory alterations in HZ. However, the only effective SIIB studied was AEP which was independently associated with HZO. The use of intravenous antiviral therapy decreases the risk of postherpetic neuralgia.","PeriodicalId":11968,"journal":{"name":"European Journal of Dermatology","volume":"34 5","pages":"502-508"},"PeriodicalIF":2.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142716023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Astragaloside IV alleviates skin fibrosis by modulating fibroblast phenotype in keloids. 黄芪皂苷 IV 通过调节瘢痕疙瘩中成纤维细胞的表型减轻皮肤纤维化。

IF 2 4区医学

European Journal of Dermatology Pub Date : 2024-10-01 DOI: 10.1684/ejd.2024.4754

Hu Gao, Xian Sun, Xiangming Zhang

{"title":"Astragaloside IV alleviates skin fibrosis by modulating fibroblast phenotype in keloids.","authors":"Hu Gao, Xian Sun, Xiangming Zhang","doi":"10.1684/ejd.2024.4754","DOIUrl":"https://doi.org/10.1684/ejd.2024.4754","url":null,"abstract":"Keloids are fibroproliferative diseases featuring abnormal fibroblast proliferation and extracellular matrix (ECM) deposition. Current therapeutic methods for keloids are unsatisfactory, and the recurrence rates of keloids are high. Astragaloside IV (AS-IV) is a key active component of Astragalus membranaceus Bunge, and has been reported to exert potent anti-fibrotic effects. Accordingly, our research aimed to explore whether AS-IV suppresses fibroblast dysfunction and skin fibrosis during the development of keloids. Human keloid-derived fibroblasts (KFs) were stimulated by TGF-β1 to evaluate the influence of AS-IV on abnormal proliferation, migration, and accumulation of ECM in vitro. A bleomycin (BLM)-induced skin fibrosis model was established to assess the influence of AS-IV on ECM deposition and skin fibrosis in vivo. TGF-β1 stimulation enhanced the proliferation, migration, and accumulation of ECM in KFs, which were abolished by AS-IV treatment. The in vivo assay revealed that AS-IV administration restrained ECM accumulation and skin fibrosis in mouse models. AS-IV plays an anti-fibrotic role in keloids by suppressing fibroblast dysfunction and reducing ECM deposition.","PeriodicalId":11968,"journal":{"name":"European Journal of Dermatology","volume":"34 5","pages":"472-479"},"PeriodicalIF":2.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142715779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0