{"title":"Polymorphisms in lncRNA HOTAIR and Susceptibility to Acute Myeloid Leukemia in Iranian Patients","authors":"A. Sayad, A. Hajifathali, M. Taheri","doi":"10.15412/J.JBTW.01060203","DOIUrl":"https://doi.org/10.15412/J.JBTW.01060203","url":null,"abstract":"One of the recent aspects in the cancer research is about the investigation of the etiological role of long noncoding RNAs as a new regulator for the expression of proto-oncogenes or tumor suppressor genes in cancer. Among them HOX transcript antisense RNA (HOTAIR) is increasingly indicated to be deregulated in different cancers such as AML. According to the important regulatory role the gene in the developing and prognosis of the hematological malignancies we investigate whether there is an association between rs12826786, rs1899663, and rs4759314 common polymorphisms of the gene with AML patients. The results have shown no relation between any of the analyzed Single Nucleotide Polymorphisms and AML either in genotypic frequencies or in haplotype analysis. The data derived from the present study suggested that pathogenic role of the HOTAIR to increase the susceptibility of AML should be considered from other aspects and further analysis are needed to explore the exact mechanism underlying the pathogenesis.","PeriodicalId":119340,"journal":{"name":"Journal of Biology and Today`s World","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127609556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Nanotechnological Approaches for Enhancing the Oral Bioavailability of Curcumin","authors":"R. Nazari-Vanani, N. Sattarahmady, H. Heli","doi":"10.15412/J.JBTW.01060702","DOIUrl":"https://doi.org/10.15412/J.JBTW.01060702","url":null,"abstract":"Turmeric is a member of the ginger family (Zingiberaceae). It contains i) curcumin, ii) demethoxycurcumin, and iii) bisdemethoxycurcumin. Curcumin is the active component in the turmeric and has promising pharmacological properties. Despite promising clinical potentials, it has limited clinical use due to poor bioavailability. Thus, improving the water-solubility and bioavailability of curcumin are very interested. One of the approaches to overcome low bioavailability of curcumin is the formulation of curcumin into nanoscale drug delivery systems working as nanocarriers. They are emerging strategies for therapeutic agents that cannot be used effectively as conventional drug formulations. In addition, they have many advantages such as improving the stability, ease of preparation, reducing the dose, reduction of side effects, and solubility enhancement. For this purposes, the aspects and role of nanoscale drug delivery systems in the solubility enhancement of curcumin was presented and discussed in this review.","PeriodicalId":119340,"journal":{"name":"Journal of Biology and Today`s World","volume":"195 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114591234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Leila Kholusi, K. Aghakhani, M. Ameri, Naimeh Farhidnia, M. Abolghasemi
{"title":"Evaluating the Mortality-Related Risk Factors in Patients with Burn Injuries Hospitalized in Shahid Motahari Burn Hospital of Tehran","authors":"Leila Kholusi, K. Aghakhani, M. Ameri, Naimeh Farhidnia, M. Abolghasemi","doi":"10.15412/J.JBTW.01060703","DOIUrl":"https://doi.org/10.15412/J.JBTW.01060703","url":null,"abstract":"In addition to the considerable developments in medical and surgery techniques, patients with burn injuries are at risk of many complications such as mortality. The current cross-sectional study evaluated the effect of different variables, such as age, gender, pregnancy, underlying diseases, total body surface area (TBSA), burning degree, the burned member, motivation, addiction, inhalation injury, admission to the intensive care unit, intubation, initial fluid therapy, simultaneous trauma, the time elapsed from the burning to admission, and the name of referring center (if the patient was referred) on the treatment response. The current prospective study evaluated all patients hospitalized in Shahid Motahari Burn Hospital of Tehran, Iran, from Sep. 2014 for four months, due to severe burning. Hence, a checklist was completed for each patient. To evaluate the effect of the mentioned variables the univariate logistic regression was employed for statistical analysis. Four hundred-fifty-two patients were admitted to the hospital for burning within the four months period of the study. In the current study, the rate of mortality was 14.18%. Mortality was independently related to the inhalation injury (aOR: 11.6, P < 0.001), burning degree (aOR: 1.7, P = 0.006), TBSA (aOR: 1.1, P < 0.001) and age (aOR: 1.1, P < 0.001). Values are significant at P < 0.05. It is important to consider inhalation injury, burning degree, TBSA, and age of the patient in rapid evaluations. To reduce burning events, it is necessary to teach educational and preventing programs for the general public. It is also recommended to design and implement retraining programs regarding handling the patients with burning injuries for the medical staff.","PeriodicalId":119340,"journal":{"name":"Journal of Biology and Today`s World","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129073566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Long Non-coding RNAs Expression in Renal Cell Carcinoma","authors":"M. Taheri, M. Omrani, S. Ghafouri-Fard","doi":"10.15412/J.JBTW.01061201","DOIUrl":"https://doi.org/10.15412/J.JBTW.01061201","url":null,"abstract":"Renal cell carcinoma (RCC) is among common cancers of the urogenital system. Several cancer-related pathways have been shown to be implicated in its pathogenesis. More recently, dysregulation of a group of non-coding RNAs named long non-coding RNAs (lncRNAs) have been demonstrated in many cancer types such as RCC. LncRNAs have been classified to oncogenic and tumor suppressor lncRNAs based on the pattern of expression in RCC samples as well as functional in vitro studies. Expression of several oncogenic lncRNAs such as CCAT2, HOTAIR, UCA1, TUG1 and FTX in RCC samples has been shown to be associated with tumor size and tumor stage. In addition, expression levels of numerous lncRNAs have been demonstrated to be independent prognostic factors in RCC patients. Consequently, lncRNA signature would be applied as diagnostic or prognostic biomarker as well as target for treatment modalities.","PeriodicalId":119340,"journal":{"name":"Journal of Biology and Today`s World","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129211362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Besharat, S. Nabavi, Shiva Geranmayepour, D. Morsali, S. Haghani
{"title":"Mindfulness-based Stress Reduction (MBSR) Program: the Effect of a Novel Psycho-interventional Method on Quality of Life, Mental Health, and Self-efficacy in Female Patients with Multiple Sclerosis: A Randomized Clinical Trial","authors":"M. Besharat, S. Nabavi, Shiva Geranmayepour, D. Morsali, S. Haghani","doi":"10.15412/J.JBTW.01061101","DOIUrl":"https://doi.org/10.15412/J.JBTW.01061101","url":null,"abstract":"Multiple sclerosis (MS) is a disease of central nervous system affecting young population. Burden of the disease, lifelong confrontation with a complex disease with no cure and the need for continuous care lead to chronic stress in patients and their caregivers. Mindfulness stress reduction, as a novel psycho intervention method, might be helpful in MS patients to reduce this chronic stress. A group of female patients diagnosed with definite MS (According to MC Donald criteria 2010 by a neurologist) were randomized to either an immediate MBSR program (n=12) or waitlist (n=12). The intervention consisted of a weekly MBSR group lasting 2.5 hours for 8 weeks plus a 6 hours retreat. Patients completed questionnaires preand postintervention or waitlist period. Preliminary analysis revealed that there was no significant improvement in physical symptoms and mental health (p>0.05). However, a significant improvement was observed in patients' quality of life (p>0.05). These results provide preliminary evidence for the feasibility and efficacy of MBSR intervention as a novel psychotherapeutic method for improving quality of life in patients with MS.","PeriodicalId":119340,"journal":{"name":"Journal of Biology and Today`s World","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128526913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mehrnoosh Shanaki, S. Emamgholipour, M. Naziri, Chiya Amini, Mahnaz Jafarzadeh, Mohammad Zare, M. Negahdary, A. Sayad
{"title":"Best Editorial Members in Journal of Biology and Today's World During 2016-2017","authors":"Mehrnoosh Shanaki, S. Emamgholipour, M. Naziri, Chiya Amini, Mahnaz Jafarzadeh, Mohammad Zare, M. Negahdary, A. Sayad","doi":"10.15412/J.JBTW.01060502","DOIUrl":"https://doi.org/10.15412/J.JBTW.01060502","url":null,"abstract":"We are proud that with the cooperation and efforts of the editorial members of JBTW, this journal was successful be indexed in the Scopus in 2016. This journal is an Iranian Journal that despite no support from the Iranian government could continue its activities firmly and in a high quality way. All researchers in the world are invited to submit their valuable manuscripts in the field of biomedical sciences to this journal. Editorial members of this journal are doing their utmost to have high quality referees and publication. It should be noted, now also this journal in terms of quality in infrastructure software, management and publication design is beyond of all developing countries. This report is provided for the members that have been most cooperative in this biomedical journal.","PeriodicalId":119340,"journal":{"name":"Journal of Biology and Today`s World","volume":"120 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133511901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"An Automatic Leaf Disease Detection System for Legume Species","authors":"Sukhvir Kaur, Shreelekha Pandey, S. Goel","doi":"10.15412/J.JBTW.01060604","DOIUrl":"https://doi.org/10.15412/J.JBTW.01060604","url":null,"abstract":"Legumes are crucial species which are used by the community worldwide. In this manuscript, a two stage approach to identify infected leaf region percentage in legumes (particularly Groundnut and Soybean) is proposed. First stage classifies between a healthy and a diseased leaf sample. Second stage detects the diseased region and identifies the proportion of leaf infected area. The two stage approach provides high accuracy and also, shows that texture features plays an important role for classification of healthy and diseased leaves. The experimental results obtained on a self-collected leaf image dataset show that the proposed approach accurately identifies the diseased region in legumes. The proposed methodology can also be used for the classification of different disease types.","PeriodicalId":119340,"journal":{"name":"Journal of Biology and Today`s World","volume":"65 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122681641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Fast and Efficient Region based Aneurysm Segmentation Model for Medical Image Segmentation","authors":"S. Thirumala, S. R. Chanamallu","doi":"10.15412/J.JBTW.01060903","DOIUrl":"https://doi.org/10.15412/J.JBTW.01060903","url":null,"abstract":"Aneurysm and blood vessel delineation from medical images facilitates efficient diagnosis of the Aneurysm and vessels (Stroke or Hemorrhage and Stenosis or malformations) and registration of patient images obtained at different times. Computer-aided diagnosis and detection of Aneurysms via Segmentation algorithms is a complex and multi-faceted issue in medical image processing, as adjoining vessels are the high-intensity structures whereas aneurysms are of low contrast and intensity. Obviously, segmentation is essential to identify the disease severity by change monitoring and also to know further Haemo-dynamic situation in critical cases. Change detection and further analysis gives the complete picture of the case of interest. For Brain tumor detection and analysis, there are several segmentation algorithms but only few are suitable for aneurysm detection and analysis. There is a necessity to provide an efficient segmentation model for aneurysm analysis, change detection and delineation which overcomes the limitations on speed and accuracy of other models. The objective of this paper is to first, apply local binary fitting (LBF), chan-vese (CV) models to aneurysm analysis. Then perform Region based Aneurysm Segmentation model frame work on data sheets of MR Angiography of brain. It is a perfect level set based Active contour model which converges in short span without requirement of any stability and termination criterions. The key feature of this model is that delineation is independent of choice of mask dimensions. Promising results are obtained with the proposed model","PeriodicalId":119340,"journal":{"name":"Journal of Biology and Today`s World","volume":"152 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123316778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"ClusPhylo: Spark Based Fast and Reliable Approach for Reconstruction of Phylogenetic Network Using Large Databases","authors":"Shamita Malik, S. Khatri, Dolly Sharma","doi":"10.15412/J.JBTW.01060602","DOIUrl":"https://doi.org/10.15412/J.JBTW.01060602","url":null,"abstract":"Phylogenetic examination has turned out to be fundamental part of investigation for evolution of “tree of life”. This investigation is most vital in logical research for development of life; it is a measure of impressions among creatures. It is important during examination that is required in process of arranging scattered information. Due to the expansion of more information in the field of proteomics, the computational biology algorithms should be extremely productive and near to accuracy. The inference of expansive and precise phylogenetic trees has expanded in most recent couple of years. Early methodologies for phylogenetic derivation depended on single processor PCs. Nonetheless, for expansive number of taxa, it is not feasible to utilize single processor. This represents a test for more proficient and adaptable calculations that utilizates parallel and conveyed processing for phylogenetic surmising. In this research paper, a new algorithm ClusPhylo based on clusters is introduced for large datasets. The proposed algorithms upgrades tree development issue by partitioning input arrangement into groups builds beginning sub-trees from arrangements of clusters and consolidations sub-trees into a solitary tree by additive methodology. ClusPhylo is implemented on Apache Spark. The execution of calculation as far as conclusive log probability qualities and execution time is contrasted with understood calculations. The outcome comes about demonstrating that the proposed calculation is computationally effective, delivers better probability values and is versatile on fluctuating number of processors too.","PeriodicalId":119340,"journal":{"name":"Journal of Biology and Today`s World","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127091091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F. Alian, Zahra Asemi-Esfahani, M. Fazilati, S. Habibollahi, A. Palizban
{"title":"Evaluation of Blood Concentrations of Copper and Molybdenum in Type 2 Diabetic Patients","authors":"F. Alian, Zahra Asemi-Esfahani, M. Fazilati, S. Habibollahi, A. Palizban","doi":"10.15412/J.JBTW.01060801","DOIUrl":"https://doi.org/10.15412/J.JBTW.01060801","url":null,"abstract":"Diabetes mellitus is one of the most common metabolic diseases in humans. The blood concentrations of various trace elements, such as copper (Cu) and molybdenum (Mo), are altered in diabetes mellitus, which may have a significant role in the pathogenesis and progress of this disease. This study was aimed to evaluate the levels of copper and molybdenum concentrations in diabetic patients and healthy subjects. A total of 87 patients with type 2 diabetes and 45 participants with normal blood glucose were included in this study. The blood levels of Cu and Mo concentrations were measured by graphite furnace atomic absorption spectroscopy (GF-AAS). Statistical analyses were performed using SPSS 19.0 software. Biochemical factors were compared using student’s t-test, Mann-Whitney test and Pearson correlation coefficient. The results showed a significant increase in mean Cu level in diabetic patients (394.11 ± 10.08) compared to healthy subjects (134.34 ± 3.66), however a significant decrease was found in mean Mo level in diabetic patients (8.41 ± 0.141) compared to healthy subjects (16.45 ± 0.72). Statistical analysis showed a significant positive correlation between the concentrations of each element with diabetes. The study indicates that type 2 diabetes can alter the blood levels of copper and molybdenum. The results of this study confirmed that the level of copper in diabetic patients is higher than healthy subjects, and that the level of molybdenum in diabetic patients is lower than that of healthy subjects. In addition, increasing or decreasing the copper concentration has no significant effect on the concentration of molybdenum in diabetic patients, meaning that there is no significant correlation between the two variables in diabetic patients.","PeriodicalId":119340,"journal":{"name":"Journal of Biology and Today`s World","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129627010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}