Polymorphisms in lncRNA HOTAIR and Susceptibility to Acute Myeloid Leukemia in Iranian Patients

Abstract

One of the recent aspects in the cancer research is about the investigation of the etiological role of long noncoding RNAs as a new regulator for the expression of proto-oncogenes or tumor suppressor genes in cancer. Among them HOX transcript antisense RNA (HOTAIR) is increasingly indicated to be deregulated in different cancers such as AML. According to the important regulatory role the gene in the developing and prognosis of the hematological malignancies we investigate whether there is an association between rs12826786, rs1899663, and rs4759314 common polymorphisms of the gene with AML patients. The results have shown no relation between any of the analyzed Single Nucleotide Polymorphisms and AML either in genotypic frequencies or in haplotype analysis. The data derived from the present study suggested that pathogenic role of the HOTAIR to increase the susceptibility of AML should be considered from other aspects and further analysis are needed to explore the exact mechanism underlying the pathogenesis.