Journal of Biology and Today`s World最新文献_第2页

Redox Imbalance and Reproductive Side Effects of Long and Short Term Nitroglycerin Treatment in Rat Uterus 长期和短期硝酸甘油治疗大鼠子宫氧化还原失衡及生殖副作用

Journal of Biology and Today`s World Pub Date : 2017-08-31 DOI: 10.15412/J.JBTW.01061004

Z. Mostafavi-pour, Sadegh Rajabi, F. Zal, R. Zare, M. Akmali, J. Sharifi‐Rad

{"title":"Redox Imbalance and Reproductive Side Effects of Long and Short Term Nitroglycerin Treatment in Rat Uterus","authors":"Z. Mostafavi-pour, Sadegh Rajabi, F. Zal, R. Zare, M. Akmali, J. Sharifi‐Rad","doi":"10.15412/J.JBTW.01061004","DOIUrl":"https://doi.org/10.15412/J.JBTW.01061004","url":null,"abstract":"Background: Bioactivation of nitroglycerin (NTG) leads to the production of reactive oxygen species and reactive nitrogen species. The aim of this study was to investigate the effects of NTG treatment on the redox homeostasis in rat uterus around the time of implantation and the number of pups. M aterials and Methods: The rats in long-term test groups were treated subcutaneously with NTG (15mg/kg BW) and normal saline (1ml/kg B) in control groups for 4 weeks. Afterwards, they were mated and divided into four groups. Two groups were treated until 5 days after mating. Thereafter, they were sacrificed and the activities of glutathione peroxidase (GPx), catalase (CAT), and glutathione reductase as well as the levels of reduced glutathione (GSH) and malondialdehyde (MDA) in the uterus homogenates were measured. In other two groups, treatments were continued until their pups were counted. In the short-term groups, treatments were started after mating, and all above parameters were measured as similar as long-term groups. R es ults: Long-term NTG treatment significantly increased MDA level and decreased the GPx activity and the pups number compared to the controls (p<0.05), whereas no marked alteration in the activities of GR and CAT and the levels GSH were observed. However, short-term NTG treated groups showed no significant changes in all the parameters mentioned above as compared with the controls. C onclusion: Long-term NTG treatment, unlike short-term treatment, may cause impaired implantation and infertility, but there is also room for further improvement.","PeriodicalId":119340,"journal":{"name":"Journal of Biology and Today`s World","volume":"90 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125145983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

A review on Most Nanoparticles Applied Against Parasitic Infections 纳米颗粒抗寄生虫感染研究进展

Journal of Biology and Today`s World Pub Date : 2017-08-27 DOI: 10.15412/J.JBTW.01061003

R. Norouzi

{"title":"A review on Most Nanoparticles Applied Against Parasitic Infections","authors":"R. Norouzi","doi":"10.15412/J.JBTW.01061003","DOIUrl":"https://doi.org/10.15412/J.JBTW.01061003","url":null,"abstract":"Nanoparticles (NPs) are particles with the size range approximately from 1 to 100 nanometers that are made in different shapes. Nanotechnology is an emerging technology that expected to open some new opportunities in order to destroy and control of microorganisms using of materials and systems at the scale of the atom. Parasitic diseases affect millions of people worldwide, especially in developing countries and are involved with many limitations in treatment methods. Recently, some of parasites demonstrated drug resistance, which increased the need for new effective and safer agents against parasitic infection or improvement of the drugs. There is no vaccine available for the prevention of many parasitic infections, and hence chemotherapy is the current mainstay of control. NPs have received most attention as antiparasitic drugs in few decades since current antiparasitic drugs have some side effects and their efficacy is not fully proved yet. However, little attention has been dealt to the use of nanoparticle derivatives as an antiparasitic drug. In this paper, developments in the use of NPs as anti-parasitic drugs are reviewed. Some researches indicated that gold NPs, oxidized metals, silver, chitosan and etc. have growth inhibitors or cytotoxic effect on diverse parasites, including Giardia, Leishmania, Plasmodium, Toxoplasma and helminthes including, Echinococcus multilocularis, Trichinella spiralis and Fasciola hepatica. NPs can be used separately or in combination with current drugs against parasites. Therefore, NPs are suggested as more effective and less side effects drugs for the prevention and controlling of the parasites.","PeriodicalId":119340,"journal":{"name":"Journal of Biology and Today`s World","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127463392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Assessing the Levels of Preparedness Against Disaster of the Hospitals in North Khorasan; Iran, in 2016 北呼罗珊地区医院备灾水平评估伊朗，2016年

Journal of Biology and Today`s World Pub Date : 2017-08-24 DOI: 10.15412/J.JBTW.01061002

S. Hosseini, Alireza Izadfar, R. Rajabzadeh, Mohammad Sadegh Sadeghi, A. Sadeghi

{"title":"Assessing the Levels of Preparedness Against Disaster of the Hospitals in North Khorasan; Iran, in 2016","authors":"S. Hosseini, Alireza Izadfar, R. Rajabzadeh, Mohammad Sadegh Sadeghi, A. Sadeghi","doi":"10.15412/J.JBTW.01061002","DOIUrl":"https://doi.org/10.15412/J.JBTW.01061002","url":null,"abstract":"Iran is considered as one of the disaster-prone nations. Therefore, its hospitals and healthcare centers should be highly prepared to meet crises and disasters. This study aimed to assess the level of preparedness of the hospitals against disasters. This cross-sectional, descriptive study was conducted in nine hospitals in one of the provinces in the north-east of Iran. Data were collected from the hospitals with a checklist that contained 220 items covering 10 areas. The relative mean of preparedness against disaster in the hospitals included in this study was estimated to be 46/40%, which means that according to the criteria of interest, these hospitals were at the average level of preparedness. The mean scores of the hospitals’ preparedness against disasters for each of the 10 indices assessed were as follow: 50% for emergency, 33.33% for reception, 33.33% for evacuation, 46.66% for traffic, 41.18% for communication, 49.02% for security, 38.9% for education, 44.44% for support, 41.92% for human resources, and 61.90% for command and management. The results showed that there was a significant positive relationship and correlation between the number of ambulances in the hospitals and the level of prepar-edness (P<0.05). The level of preparedness against crises and disasters of the hospitals was at an average level. The lowest preparedness levels of the hospitals studied were related to reception, evacuation, and communication. Each of these areas requires more attention and specific measures in this context.","PeriodicalId":119340,"journal":{"name":"Journal of Biology and Today`s World","volume":"115 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114419916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Polycystic Ovary Syndrome and Sympathoexcitation: Management of Stress and Lifestyle 多囊卵巢综合征和交感神经兴奋:压力和生活方式的管理

Journal of Biology and Today`s World Pub Date : 2017-08-07 DOI: 10.15412/J.JBTW.01060802

F. Zangeneh

{"title":"Polycystic Ovary Syndrome and Sympathoexcitation: Management of Stress and Lifestyle","authors":"F. Zangeneh","doi":"10.15412/J.JBTW.01060802","DOIUrl":"https://doi.org/10.15412/J.JBTW.01060802","url":null,"abstract":"Polycystic ovary syndrome (PCOS) is a heterogeneous disease with unknown etiology, a scientific challenge for researchers and is often a complex condition to manage for clinicians. Life exists by maintaining a complex dynamic equilibrium or homeostasis that is constantly challenged by intrinsic or extrinsic adverse forces, the stressors. Stress reactivity is markedly influenced by both pubertal maturation and the experience in the individual. For example, chronic stress destroys bodies, minds and lives. Chronic stress kills through suicide, violence, heart attack, stroke, and cancer. Much evidence suggests that women with PCO often at risk for secondary complications of this syndrome including reproductive (infertility, hyperandrogenism, hirsutism), metabolic (insulin resistance, impaired glucose tolerance, type 2 diabetes mellitus, adverse cardiovascular risk profiles) and psychological features (increased anxiety, depression and worsened quality of life). The relation-ships between the psychological health aspects and the clinical characteristics of PCOS are not yet clear. In this review, we investigate the key roles of corticotrophin-releasing hormone (CRH) and norepinephrine (NE) in orchestrating the response to stress in women with PCOS.","PeriodicalId":119340,"journal":{"name":"Journal of Biology and Today`s World","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116768902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Histological Alteration in Different Tissues of Indian major carp, Labeo rohita (Hamilton) exposed to Profenofos 50% EC and Carbosulfan 25% EC formulations 印度鲤鱼不同组织的组织学变化，Labeo rohita (Hamilton)暴露于50% EC和25% EC的罗非鱼配方

Journal of Biology and Today`s World Pub Date : 2017-08-03 DOI: 10.15412/J.JBTW.01060301

Nagaraju Bantu, Krishna Chaithanya Karri, Gopalakrishnan Vk, Nirmala Kumari, Rathnamma Vakita

{"title":"Histological Alteration in Different Tissues of Indian major carp, Labeo rohita (Hamilton) exposed to Profenofos 50% EC and Carbosulfan 25% EC formulations","authors":"Nagaraju Bantu, Krishna Chaithanya Karri, Gopalakrishnan Vk, Nirmala Kumari, Rathnamma Vakita","doi":"10.15412/J.JBTW.01060301","DOIUrl":"https://doi.org/10.15412/J.JBTW.01060301","url":null,"abstract":"The objective of the study was to determine the histopathological changes in different tissues of fish, Labeo rohita exposed to two different pesticides. Gill, kidney, liver and Brain of fish were examined after exposure to lethal and sublethal concentrations of organophosphorus pesticide profenofos (96 h LC50 i.e.100 and 10 µg L-1) and carbamates pesticide carbosulfan(1.2 and 0.12 mg L-1) for 24 h and 8 days. Lesions were observed in gill, kidney and liver of L.rohita treated with both pesticide concentrations. Gill filaments of Hyperplasia, fusion due to separation of epithelium. Necrosis, degenerative changes in haemopoietic tissue, swelling of renal tubules, hypertrophy were observed in kidney. Degenerations of cytoplasm in hepatocytes, atrophy, and necrosis, vacuoles formation, rupture of blood vessels, necrosis and disappearance of hepatocyte wall and hepatic cords were observed in liver tissue. Behavioral changes, sensorial system like vision and smell, detection, attack and capture of prey, impair feeding, escape, and reproductive behavior all these functions are connected with various parts of the brain. There is no lesions were seen in control group.","PeriodicalId":119340,"journal":{"name":"Journal of Biology and Today`s World","volume":"540 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127648332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

The Effect of Zinc Sulfate on Duration of Common Cold Symptoms in Children 硫酸锌对儿童普通感冒症状持续时间的影响

Journal of Biology and Today`s World Pub Date : 2017-07-30 DOI: 10.15412/J.JBTW.01061001

P. Yousefichaijan, F. Dorreh, M. Naziri

{"title":"The Effect of Zinc Sulfate on Duration of Common Cold Symptoms in Children","authors":"P. Yousefichaijan, F. Dorreh, M. Naziri","doi":"10.15412/J.JBTW.01061001","DOIUrl":"https://doi.org/10.15412/J.JBTW.01061001","url":null,"abstract":"At the age of 1-7 years, the common cold is prevalence among children. It usually happens 6 to 7 times a year among children. An effective and safe drug is needed to reduce the duration of common colds symptoms in children and reduce subsequent complications. In some studies, zinc sulfate has showed an antiviral effect and immune enhancing activity. Therefore, this study was designed to evaluate the efficacy of zinc sulfate in duration of colds’ symptoms in children. In this study, 112 children with common cold who are between 6-7 years old divided into two groups. Case group received zinc sulfate within 10 days and Control group didn’t receive this drug. The symptoms like rhinorrhea and nasal obstruction, cough, sneezing, fever and duration of illness were checked out in both groups by questionnaire. In children with common cold, a significant decrease was observed in the mean duration of rhinorrhea, cough and nasal obstruction .Compared to the group that didn’t receive zinc sulfate, the zinc group had shorter mean duration of sneezing and fever. The mean duration of illness in patients who had received the zinc sulfate was significantly less than the other group. No side effect was observed in subjects received zinc sulfate. Based on our result, zinc sulfate can be administered with other supportive treatments of common cold, for reduction of symptoms duration and complications in children.","PeriodicalId":119340,"journal":{"name":"Journal of Biology and Today`s World","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121702010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional Properties, Physical Parameters and Sensory Attributes in Extruded Products Based on Cereals, Pulseses and Legumes 谷物、豆类和豆类挤压制品的功能特性、物理参数和感官特性

Journal of Biology and Today`s World Pub Date : 2017-07-28 DOI: 10.15412/J.JBTW.01060902

Mohammad Reza Shadan, F. Khoushabi, J. Sharifi‐Rad

{"title":"Functional Properties, Physical Parameters and Sensory Attributes in Extruded Products Based on Cereals, Pulseses and Legumes","authors":"Mohammad Reza Shadan, F. Khoushabi, J. Sharifi‐Rad","doi":"10.15412/J.JBTW.01060902","DOIUrl":"https://doi.org/10.15412/J.JBTW.01060902","url":null,"abstract":"The typical diet in populations with a high prevalence of malnutrition is consists predominantly of a starch-rich staple, such as a cereal or tuber, limited amounts of fruits, vegetables, legumes, pulses, and little or no animal-source foods. The aim of this study was determine the functional properties and sensory evaluation of extruded products based on cereals, pulses and legumes. Twelve composite flours were prepared using cereals, pulses and legumes; then were formulated and extruded by a twin screw extruder. The extruded samples were analyzed for their densities such as tap, true and bulk densities; also they were analyzed for their extrudate diameter, expansion ratio, expansion area and finally hardness. Samples were evaluated for their water absorption index, water solubility index and water holding capacity. Then the panels of semi-trained judges consisting of 100 members were given the twelve extruded products for assessment their organoleptic characteristics including appearance, color, taste, texture, and overall acceptability based on consumer acceptability studies. Analysis of data indicated that the extruded product of 12 samples had best functional properties compared to others; in addition, found data demonstrated that this combination was significantly better in color, flavor, texture and overall acceptability than others. It is considerable that mixing of cereals, pulses and legumes along with extrusion method will improve the quality of final products.","PeriodicalId":119340,"journal":{"name":"Journal of Biology and Today`s World","volume":"88 1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128189867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fatal Event of the Gallbladder Rupture Following the Blunt Abdominal Trauma: A Case Report 腹部钝性创伤后胆囊破裂致死性事件1例

Journal of Biology and Today`s World Pub Date : 2017-07-19 DOI: 10.15412/J.JBTW.01060803

Roya Kordrostami, M. Ameri, Nahid Dadashzade, T. Ramim

{"title":"Fatal Event of the Gallbladder Rupture Following the Blunt Abdominal Trauma: A Case Report","authors":"Roya Kordrostami, M. Ameri, Nahid Dadashzade, T. Ramim","doi":"10.15412/J.JBTW.01060803","DOIUrl":"https://doi.org/10.15412/J.JBTW.01060803","url":null,"abstract":"The gallbladder traumatic injury rarely happens due to its anatomical location and includes 2%-5% of trauma cases. The diagnoses of isolated gallbladder rupture in the blunt abdominal trauma are usually delayed and mostly revealed during the surgeries. To diagnose gallbladder injuries, the probability of injury in an organ such as gallbladder in the blunt abdominal trauma should be considered and accordingly the detailed diagnostic method should be used. A 85-year-old female was referred to the hospital due to facial and abdominal trauma. There was a mild tenderness in the right upper quadrant (RUQ) area. The hydrops gallbladder was observed in the focused assessment with sonography. The patient was assessed by abdominal ultrasonography after 48 hours and reports liver extensive rupture and sub-capsular hematoma. The patient was assessed by abdominal ultrasonography after 48 hours and reports liver extensive rupture and sub-capsular hematoma. The following day, the patient had severe bradycardia and finally dead due to asystole and cardiac arrest. In autopsy, the gallbladder rupture caused the green purulent bile discharge released over the abdomen. The current paper reports a case on isolated gallbladder injury following the blunt abdominal trauma which was not diagnosed in post-traumatic evaluations and was revealed by autopsy after patient’s death. The best method to diagnose gallbladder injuries is the computed tomography (CT) of the abdomen.","PeriodicalId":119340,"journal":{"name":"Journal of Biology and Today`s World","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116295552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Seasonal Survey in Content of Aflatoxin M1 and Somatic Cell Count in Collected Raw Milk Samples from Qazvin Province, Iran 伊朗加兹温省原料奶中黄曲霉毒素M1含量和体细胞计数的季节调查

Journal of Biology and Today`s World Pub Date : 2017-07-17 DOI: 10.15412/J.JBTW.01060901

Zahra Nemati Niko, M. Alipour

{"title":"Seasonal Survey in Content of Aflatoxin M1 and Somatic Cell Count in Collected Raw Milk Samples from Qazvin Province, Iran","authors":"Zahra Nemati Niko, M. Alipour","doi":"10.15412/J.JBTW.01060901","DOIUrl":"https://doi.org/10.15412/J.JBTW.01060901","url":null,"abstract":"The presence of aflatoxin M1 (AFM1) and somatic cell (Sc) in milk and milk products is a public health concern; also, it is an important index for evaluating the quality and safety of milk. Therefore, monitoring their level in milk has high health importance. The aim of this study was to determine the content AFM1 and somatic cell count )Scc( in raw cow milk samples in Qazvin province during various seasons (warm and cold). In this cross sectional study, 92 raw cow milk samples (produced by six semi industrial farms) was randomly collected from milk collection centers in Qazvin province (Iran) during the warm and the cold seasons in 2016 (23samples for each season). All samples were examined by Enzyme-linked immunosorbent assay (ELISA) and somatic cell counter; the archived data were analyzed using ANOVA and Chi-square test. The results showed that all collected samples were contaminated with AFM1 and AFM1 in raw cow milk samples that were above the maximum residue limits (MRL) (Iran legal limit = 100 ng L-1) in %36.95 samples; in addition, the SCC was above the MRL (Iran legal limit = 500000 cell ml-1) in 45.65 % of milk samples. AFM1 Contamination in warm seasons (%52.17) was significantly higher than in cold seasons (%21.73) (P 0.05). According to the results of this research, comprehensive and careful supervising of the production and supply of milk and evaluation of AFM1 and Scc are necessary.","PeriodicalId":119340,"journal":{"name":"Journal of Biology and Today`s World","volume":"67 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134399318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Discovering the Role of Long non-coding RNAs in Regulation of Steroid Receptors Signaling in Cancer 发现长链非编码rna在肿瘤激素受体信号传导调控中的作用

Journal of Biology and Today`s World Pub Date : 2017-07-11 DOI: 10.15412/J.JBTW.01061202

S. Faramarzi, Ali Dianatpour, S. Ghafouri-Fard

{"title":"Discovering the Role of Long non-coding RNAs in Regulation of Steroid Receptors Signaling in Cancer","authors":"S. Faramarzi, Ali Dianatpour, S. Ghafouri-Fard","doi":"10.15412/J.JBTW.01061202","DOIUrl":"https://doi.org/10.15412/J.JBTW.01061202","url":null,"abstract":"Long non-coding RNAs (lncRNAs) are a major group of transcripts with fundamental roles in almost all physiological aspects of cell. They can regulate expression of genes via different mechanisms. In addition, they have been shown to modulate cancer related signaling pathways. Most of lncRNAs are localized in the nucleus and exert their role through recruitment of chromatin modifiers to DNA. Several lines of evidence suggest their participation in steroid hormone receptor (SHR) signaling. Steroid hormones exert their physiological and pathological functions via modulation of gene expression. Through a computerized search of the MEDLINE/PUBMED, Web of Knowledge, Scopus, ProQuest and Google Scholar databases with key words lncRNA, steroid receptor, estrogen receptor, androgen receptor and glucocorticoid receptor, we found pub-lished studies within the maximal date range until July 2017. Many lncRNAs have been shown to regulate or be regulated by SHRs. Numerous treatment strategies in common cancers such as breast and prostate cancer modulate SHR functions. Accordingly, identification of the regulatory network of SHR would pave the way for designing more effective treatment modalities for cancer especially for endocrine therapy unresponsive cancers. The critical role of lncRNAs in this regulatory network potentiates them as therapeutic targets for such common cancers.","PeriodicalId":119340,"journal":{"name":"Journal of Biology and Today`s World","volume":"76 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124930852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4