European Journal of Integrative Medicine最新文献

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Is traditional Chinese medicine syndrome differentiation important in primary insomnia? An exploratory review with matching recombination indirect comparisons and network meta-analysis 中医辨证对原发性失眠重要吗?采用匹配重组、间接比较和网络元分析的探索性综述
IF 1.9 4区 医学
European Journal of Integrative Medicine Pub Date : 2025-06-17 DOI: 10.1016/j.eujim.2025.102515
Guo-Dong Li , Xin-Yu Hu , Yi Yuan , Xi-Jing Meng , Le-Yan Hu , Yu-Ting Huang , Hui-Juan Cao
{"title":"Is traditional Chinese medicine syndrome differentiation important in primary insomnia? An exploratory review with matching recombination indirect comparisons and network meta-analysis","authors":"Guo-Dong Li ,&nbsp;Xin-Yu Hu ,&nbsp;Yi Yuan ,&nbsp;Xi-Jing Meng ,&nbsp;Le-Yan Hu ,&nbsp;Yu-Ting Huang ,&nbsp;Hui-Juan Cao","doi":"10.1016/j.eujim.2025.102515","DOIUrl":"10.1016/j.eujim.2025.102515","url":null,"abstract":"<div><h3>Introduction</h3><div>Syndrome differentiation is the primary method of Traditional Chinese Medicine (TCM) diagnosis and treatment of diseases and has become the key to the clinical development of acupuncture. However, there is a lack of supporting clinical evidence to determine the impact of syndrome differentiation on the efficacy of acupuncture treatment. Therefore, we aimed to evaluate the importance of point selection based on syndrome differentiation by re-analyzing the trials' results in treating primary insomnia with acupuncture.</div></div><div><h3>Methods</h3><div>We systematically searched 9 databases for eligible trials. Two authors extracted data independently from citations, interventions, and outcomes. Since the \"treatment acupuncture\" and \"control acupuncture\" data compared in this study were from different trials, we matched the data in a 1:1 ratio and minimized heterogeneity between the paired groups. Matching factors included age, sex ratio, and the baseline Pittsburgh Sleep Quality Index (PSQI) score. Meta-analyses were performed using Revman 5.4 software. STATA 15.0 was used for the network meta-analysis. Effect estimation presented continuous data with a standard mean difference (SMD) with a 95 % confidence interval (CI).</div></div><div><h3>Results</h3><div>We included a total of 172 trials. After matching, 19 recombinational pairs of studies were established. Meta-analysis of the 19 pairs showed that PSQI scores in the syndrome differentiation group were lower than the non-syndrome differentiation group (SMD: -0.87, 95 %CI -1.46 to -0.28, <em>P</em> = 0.004). Network meta-analysis of all included trials showed no statistical difference in acupoints selection between syndrome and non-syndrome differentiation (SMD: -0.40, 95 % CI -2.63 to 1.84). However, acupoint selection based on syndrome differentiation (43.9 %) ranks higher than acupoint selection based on non-syndrome differentiation (38.0 %) according to SUCRA curves.</div></div><div><h3>Conclusions</h3><div>Current evidence does not conclusively support the superiority of syndrome differentiation-based acupuncture over non-syndrome differentiation for primary insomnia. While statistically significant large effect size was observed in matched studies, the clinical relevance of this difference remains uncertain due to methodological limitations, heterogeneity, and inconsistent findings across analytical approaches. Future trials with direct comparisons and standardized outcome measures are needed to clarify the clinical utility of syndrome differentiation in acupuncture therapy.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"78 ","pages":"Article 102515"},"PeriodicalIF":1.9,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144572858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Attitudes of parents and primary care practitioners towards natural medicinal products (NMPs) for acute, uncomplicated upper respiratory tract infections and an NMP App: results from an online survey 家长和初级保健从业人员对用于急性、无并发症上呼吸道感染的天然药物(NMP)和NMP应用程序的态度:来自在线调查的结果
IF 1.9 4区 医学
European Journal of Integrative Medicine Pub Date : 2025-06-16 DOI: 10.1016/j.eujim.2025.102514
E. Belt-van Zoen , L. Veldman , N. van Steenbergen , M. Nieuwdorp , E. Baars
{"title":"Attitudes of parents and primary care practitioners towards natural medicinal products (NMPs) for acute, uncomplicated upper respiratory tract infections and an NMP App: results from an online survey","authors":"E. Belt-van Zoen ,&nbsp;L. Veldman ,&nbsp;N. van Steenbergen ,&nbsp;M. Nieuwdorp ,&nbsp;E. Baars","doi":"10.1016/j.eujim.2025.102514","DOIUrl":"10.1016/j.eujim.2025.102514","url":null,"abstract":"<div><h3>Introduction</h3><div>Resistance to antibiotics is an increasing worldwide problem. Hence, identifying and implementing the use of alternatives to antibiotics is crucial. A prototype app providing evidence-based advice on the use of safe and effective natural medicinal products (NMPs) for acute, uncomplicated upper respiratory tract infections (URTIs) is being developed. This study investigates the acceptability of NMPs (for URTIs) and the idea of an NMP app among intended end-users.</div></div><div><h3>Methods</h3><div>An online survey was completed by parents (<em>n</em> = 103), general practitioners (GP; <em>n</em> = 110), nurse practitioners (<em>n</em> = 65), physician assistants (<em>n</em> = 65), and pharmacists (<em>n</em> = 71) working in Dutch primary care.</div></div><div><h3>Results</h3><div>The majority of parents (66–79 %) and professionals (40–98 %) reported past use, current recommendation, or future willingness to use NMPs for URTIs. The majority of respondents (73–82 %) indicated they would use or recommend an NMP app, with main reasons being convenience, practicality, and time-saving. Most important prerequisites for use were safety and effectiveness of the included NMPs. Pharmacists reported they would use an NMP app primarily for professional development and shared decision-making (both 53 %), whereas 72 % of parents and up to 57 % of other professionals would use it mainly to support self-management. Up to 61 % of respondents expected a reduction in antibiotic use, and up to 70 % anticipated fewer primary care visits for URTIs with the introduction of an NMP App.</div></div><div><h3>Conclusions</h3><div>This study indicates broad acceptance of NMPs for URTIs across intended end-user groups. An NMP app seems to be a well-supported tool for reducing antibiotic use and primary care visits for children with URTIs in Dutch primary care. However, a website or web-based tool may be more fitting than a standalone mobile application. Furthermore, to prevent the exacerbation of health inequalities, it is important to also develop tools that are accessible to parents with low (health) literacy and a lower socio-economic position. GP assistants and pharmacy assistants appear key end-users for further research and implementation.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"78 ","pages":"Article 102514"},"PeriodicalIF":1.9,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144580292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The evolution of propolis research: A bibliometric analysis 蜂胶研究的演变:文献计量学分析
IF 1.9 4区 医学
European Journal of Integrative Medicine Pub Date : 2025-06-14 DOI: 10.1016/j.eujim.2025.102518
Tuğba Nigar Bozkuş
{"title":"The evolution of propolis research: A bibliometric analysis","authors":"Tuğba Nigar Bozkuş","doi":"10.1016/j.eujim.2025.102518","DOIUrl":"10.1016/j.eujim.2025.102518","url":null,"abstract":"<div><h3>Introduction</h3><div>Propolis is garnering increasing scientific and commercial interest due to its potential health benefits. Despite a surge in publications, a comprehensive overview of the propolis research landscape using bibliometric methods has been absent. This study aims to fill this gap by providing the first dedicated bibliometric analysis of global propolis research trends over the past two decades.</div></div><div><h3>Methods</h3><div>Data on propolis-related publications from 2004 to 2023 were retrieved from the Web of Science database. The R Bibliometrix package was employed to analyze publication trends, citation patterns, leading authors, institutions, countries, keyword co-occurrence, research themes, and collaboration networks.</div></div><div><h3>Results</h3><div>The analysis confirmed a substantial and consistent growth in propolis research. While publication volume is geographically concentrated (led by Brazil, China, Turkey), citation impact analysis revealed different patterns, with some countries (USA, Japan, Portugal, Bulgaria) demonstrating higher average citations per article, suggesting potential leadership in research quality or visibility. Thematic evolution mapping showed a clear trajectory from foundational studies focused on chemical composition and broad in vitro antioxidant/antimicrobial activity towards more sophisticated investigations into specific mechanisms (apoptosis, oxidative stress pathways), distinct propolis types (Brazilian green, stingless bee), and advanced applications (nanoparticles, nanofibers). Analysis identified central ‘’motor themes’’ (like chemical composition) requiring further development despite high interest, alongside highly developed ‘’niche themes’’ (like oxidative stress). Collaboration networks highlighted strong regional clusters but also opportunities for enhancing global integration, particularly bridging high-volume research hubs with high-impact centers.</div></div><div><h3>Conclusion</h3><div>This bibliometric analysis reveals propolis research as a dynamic, rapidly maturing, and increasingly interdisciplinary field. The divergence between publication quantity and citation impact, the clear evolution of research themes towards mechanistic depth, and the identification of specific developmental needs within the thematic structure offer critical strategic insights. The findings underscore a significant gap between the extensive preclinical investigation of biological activities of propolis and its translation into validated clinical applications. The findings advocate focused efforts on standardization, targeted international collaborations to leverage complementary strengths, and prioritizing clinical trials to substantiate the therapeutic potential suggested by the vast body of existing literature. This analysis provides an evidence-based roadmap to guide future research investments and collaborations effectively.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"78 ","pages":"Article 102518"},"PeriodicalIF":1.9,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144522386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Feasibility and acceptability of a yoga-based mind body intervention for women with a history of hypertensive disorder in pregnancy 以瑜伽为基础的身心干预对妊娠期高血压病史妇女的可行性和可接受性
IF 1.9 4区 医学
European Journal of Integrative Medicine Pub Date : 2025-06-14 DOI: 10.1016/j.eujim.2025.102499
Caroline A Smith , Kylie Barr , Angela Makris , Amanda Henry , Hannah Dahlen , Annemarie Hennessy , Alison Canty , Wendy Pickup
{"title":"Feasibility and acceptability of a yoga-based mind body intervention for women with a history of hypertensive disorder in pregnancy","authors":"Caroline A Smith ,&nbsp;Kylie Barr ,&nbsp;Angela Makris ,&nbsp;Amanda Henry ,&nbsp;Hannah Dahlen ,&nbsp;Annemarie Hennessy ,&nbsp;Alison Canty ,&nbsp;Wendy Pickup","doi":"10.1016/j.eujim.2025.102499","DOIUrl":"10.1016/j.eujim.2025.102499","url":null,"abstract":"<div><h3>Introduction</h3><div>Hypertensive disorders of pregnancy affect 5 to 10% of women and are a significant cause of perinatal morbidity and mortality. This group of women have been shown to have an elevated risk of cardiovascular disease (CVD) and premature mortality. There are currently no interventions specifically targeting this at-risk group of women to reduce relevant risk factors and improve outcomes. In other populations of individuals at high CVD risk, studies suggest yoga may be effective in reducing CVD risk. This study examined the feasibility of yoga in contributing to the management of blood pressure postpartum.</div></div><div><h3>Methods</h3><div>A feasibility study was conducted. The primary objective was to examine recruitment, adherence, satisfaction, and safety of the yoga intervention. Secondary objectives included change in blood pressure, serological measures, quality of life and anxiety. Women were eligible from five to seven months postpartum. An online yoga intervention was delivered over eight weeks.</div></div><div><h3>Results</h3><div>Ten women (16% of those eligible) were recruited. All women completed the intervention. Compliance with the clinical outcome assessments ranged between 70 and 90%. There was high fidelity with intervention engagement. There were no significant changes over time in any clinical outcome, although a trend to overall improved quality of life (p=0.06) was seen. There were no adverse reactions reported.</div></div><div><h3>Conclusion</h3><div>Although uptake was low, women engaged well with postpartum yoga. Further research on yoga is needed to test effectiveness for CVD risk reduction for women with hypertension in the postpartum setting, involving an appropriately powered randomised controlled trial. The study was registered with the Australian and New Zealand Clinical Trial Registry (Registration number ACTRN: 12622000450718).</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"78 ","pages":"Article 102499"},"PeriodicalIF":1.9,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144653321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Training needs for (UK) professional standards authority accredited register and regulated traditional, complementary and integrative medicine professions for supporting patients to make lifestyle and health behaviour changes: A rapid narrative review (联合王国)专业标准管理局认可、注册和管理的传统、补充和综合医学专业人员的培训需求,以支持患者改变生活方式和健康行为:快速叙述审查
IF 1.7 4区 医学
European Journal of Integrative Medicine Pub Date : 2025-06-12 DOI: 10.1016/j.eujim.2025.102517
Jonquil Pinto, Katie Read, Ella Tarabey, Felicity L. Bishop
{"title":"Training needs for (UK) professional standards authority accredited register and regulated traditional, complementary and integrative medicine professions for supporting patients to make lifestyle and health behaviour changes: A rapid narrative review","authors":"Jonquil Pinto,&nbsp;Katie Read,&nbsp;Ella Tarabey,&nbsp;Felicity L. Bishop","doi":"10.1016/j.eujim.2025.102517","DOIUrl":"10.1016/j.eujim.2025.102517","url":null,"abstract":"<div><h3>Introduction</h3><div>Improving healthy lifestyles is a public health priority. Traditional, Complementary and Integrative medicine (TCIM) providers, and certain professions on the UK Professional Standards Authority (PSA) Accredited Registers (AR) may be well-placed to contribute - some TCIM professions already support patients to make behaviour changes. We aimed to map the landscape of training for PSA AR and regulated TCIM practitioners working with individuals to support lifestyle changes, including current provision, gaps and training needs.</div></div><div><h3>Methods</h3><div>We conducted a rapid narrative review of training within PSA AR and regulated TCIM professions. We searched research databases for articles exploring perceptions, experiences and responses to training (for supporting behaviour change) and searched websites of UK professional bodies for educational guidelines for pre-qualification education. We conducted systematic data searching and extraction, quality appraisal and produced a narrative synthesis of research and guidelines which identified patterns across professions.</div></div><div><h3>Results</h3><div>We identified 24 education guidelines (4 were unlocated). A total of 548 research studies were identified from database searches, and we identified 5 further studies. A total of 20 full-text articles were retrieved, 7 were excluded, leaving 13 in the review. While 22 of 24 guidelines mentioned lifestyle or health behaviour, only 4 (chiropractic, nutritional therapy, osteopathy and acupuncture) provided any detailed recommendations about how to support patients to make health behaviour changes (e.g. providing written information or recording/monitoring progress). Eight of the 13 research studies focussed on chiropractic; most studies focussed on physical activity, two on smoking cessation, and several looked at training in broad techniques including motivational interviewing. Practitioners in research studies were generally positive about training in lifestyle and health behaviour change and there was some evidence that such training enhances practitioner self-efficacy or skills.</div></div><div><h3>Conclusions</h3><div>Most evidence of engagement with supporting lifestyle/behaviour change is within four professions: chiropractic, osteopathy, nutritional therapy and acupuncture. To build on existing knowledge and practice, future training for chiropractors, osteopaths, nutritional therapists and acupuncturists could target the capabilities (e.g. knowledge, skills, decision-making), opportunities (e.g. resources) and motivations (e.g. social/professional role) of practitioners. Future research should also evaluate the impact of practitioner training on patients’ lifestyle and health behaviours.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"78 ","pages":"Article 102517"},"PeriodicalIF":1.7,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144772378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diterpenoids from Croton tonkinensis Gagnep as antitumor agents: A systematic review 巴豆中二萜类抗肿瘤物质的系统综述
IF 1.9 4区 医学
European Journal of Integrative Medicine Pub Date : 2025-06-10 DOI: 10.1016/j.eujim.2025.102513
Vo Linh Tu , Tran Thi Thuy Quynh , Nghiem Dinh Van An , Nguyen Le Linh Chi
{"title":"Diterpenoids from Croton tonkinensis Gagnep as antitumor agents: A systematic review","authors":"Vo Linh Tu ,&nbsp;Tran Thi Thuy Quynh ,&nbsp;Nghiem Dinh Van An ,&nbsp;Nguyen Le Linh Chi","doi":"10.1016/j.eujim.2025.102513","DOIUrl":"10.1016/j.eujim.2025.102513","url":null,"abstract":"<div><h3>Introduction</h3><div>Traditional Vietnamese medicine has a long history of using Kho sam (<em>Croton tonkinensis</em> Gagnep) in the treatment of various cancers. Kho sam is an ingredient in numerous remedies for salivary gland cancer, bronchial-lung cancer, colorectal cancer, and liver cancer. This systematic review aims to comprehensively evaluate the existing literature on diterpenoids isolated from <em>C. tonkinensis</em> and their antitumor activities.</div></div><div><h3>Methods</h3><div>The protocol for this systematic review was registered in PROSPERO (CRD42024579468). A search was performed on PubMed, Virtual Health Library (VHL), Global Health Library (GHL), and Google Scholar on September 13, 2024. Two independent members conducted the steps of screening the article, scoring the risk of bias for the article, extracting and writing the results. Due to heterogeneity among the included studies, the results were narrative and no meta-analyses were conducted.</div></div><div><h3>Results</h3><div>From an initial retrieval of 500 articles, 11 met the inclusion criteria. These studies investigated thirty-seven different compounds, among which <em>ent</em>-kaurane diterpenoids with the 16-en-15-one functional group and 8,9-seco-<em>ent</em>-kaurane diterpenoids exhibited particularly cytotoxic effects. These effects were mediated through several molecular pathways, including protein kinase B, hypoxia-inducible factor-dependent transcription, heat shock protein, extracellular signal-regulating kinase 1/2, and AMP-activated protein kinase pathways.</div></div><div><h3>Conclusions</h3><div>Current literature highlights kongensin D, derived from <em>C. tonkinensis</em>, as the most promising candidate, demonstrating high anticancer activity and selectivity, along with <em>in vivo</em> antitumor potential and a favorable safety profile.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"78 ","pages":"Article 102513"},"PeriodicalIF":1.9,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144580177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Japanese traditional medication on males with diarrhea-predominant irritable bowel syndrome and gut microbiome: A single-arm prospective study 日本传统药物对男性腹泻型肠易激综合征和肠道微生物组的影响:一项单臂前瞻性研究
IF 1.9 4区 医学
European Journal of Integrative Medicine Pub Date : 2025-06-07 DOI: 10.1016/j.eujim.2025.102512
Ryutaro Arita , Shin Takayama , Toru Tamahara , Yuichi Aoki , Soichiro Kaneko , Akiko Kikuchi , Junko Kawashima , Yoshiyuki Kasahara , Kota Ishizawa , Ritsuko Shimizu , Tadashi Ishii
{"title":"Effect of Japanese traditional medication on males with diarrhea-predominant irritable bowel syndrome and gut microbiome: A single-arm prospective study","authors":"Ryutaro Arita ,&nbsp;Shin Takayama ,&nbsp;Toru Tamahara ,&nbsp;Yuichi Aoki ,&nbsp;Soichiro Kaneko ,&nbsp;Akiko Kikuchi ,&nbsp;Junko Kawashima ,&nbsp;Yoshiyuki Kasahara ,&nbsp;Kota Ishizawa ,&nbsp;Ritsuko Shimizu ,&nbsp;Tadashi Ishii","doi":"10.1016/j.eujim.2025.102512","DOIUrl":"10.1016/j.eujim.2025.102512","url":null,"abstract":"<div><h3>Introduction</h3><div>Diarrhea-predominant irritable bowel syndrome (IBS-D) is a common disorder of gut-brain interaction. In Japan, IBS-D is treated using Japanese traditional medicine (Kampo medicine); however, its clinical effects and influence on the gut microbiome are unknown. The purpose of this study was 1) to compare the characteristics of IBS-D patients with healthy controls (HCs), and 2) to investigate the effect of Kampo medicine on the symptoms and gut microbiome of patients with IBS-D.</div></div><div><h3>Methods</h3><div>We conducted two studies stepwise. First, we compared the clinical characteristics and gut microbiome of the patients with IBS-D to HCs. Second, we conducted a single-arm prospective clinical study to investigate the effectiveness and safety of Kampo treatment for IBS-D and its effects on gut microbiome alterations in patients with IBS-D. Newly diagnosed male patients with IBS-D received a four-week Kampo treatment (hangeshashinto or rikkunshito). Data on overall clinical improvement, scores on quality of life (QOL), gastrointestinal symptoms, diarrhea, anxiety, and depression were obtained. Fecal microbiomes were analyzed at four time points: (1) before treatment with remission; (2) before treatment with exacerbation; (3) after treatment; and (4) four weeks after treatment.</div></div><div><h3>Results</h3><div>Study 1: No significant difference was observed in the variety of gut microbiome (alpha diversity) between HCs and IBS-D patients. Study 2: After treatment, 81 % of the patients with IBS-D showed clinical improvement. Compared with the baseline, significant improvement was observed in IBS-related QOL, diarrhea, and trait anxiety scores after treatment and after follow-up, with no adverse effects. Microbiome analysis revealed significantly increased alpha diversity, decreased <em>Blautia</em> abundance, and increased <em>Oscillospira</em> abundance after treatment and 4 weeks after treatment compared with those during the exacerbation period before Kampo treatment.</div></div><div><h3>Conclusion</h3><div>Our study shows that no significant difference was observed in gut microbiome diversity between the patients with IBS-D and HCs. After Kampo treatment, abdominal symptoms and anxiety in male IBS-D patients were observed to improve and microbial diversity with specific microbial alterations appeared to be restored. These findings suggest that Kampo medicine could be considered as a potential approach for the symptoms and dysbiosis of IBS-D.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"78 ","pages":"Article 102512"},"PeriodicalIF":1.9,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144580290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Knowledge, attitude, and practice towards traditional Chinese medicine treatment among patients with polycystic ovary syndrome: A cross-sectional study 多囊卵巢综合征患者中医治疗知识、态度与行为的横断面研究
IF 1.9 4区 医学
European Journal of Integrative Medicine Pub Date : 2025-06-06 DOI: 10.1016/j.eujim.2025.102498
Nan Li , Lijun Wang , Hui Zhang , Yudong Zhang , Yuan Pang , Xiaoyue Lang , Yue Yang , Xiaoying Zhao , Xuke Zhang , Wenxi Yin , Yuqi Leng , Jun Bai
{"title":"Knowledge, attitude, and practice towards traditional Chinese medicine treatment among patients with polycystic ovary syndrome: A cross-sectional study","authors":"Nan Li ,&nbsp;Lijun Wang ,&nbsp;Hui Zhang ,&nbsp;Yudong Zhang ,&nbsp;Yuan Pang ,&nbsp;Xiaoyue Lang ,&nbsp;Yue Yang ,&nbsp;Xiaoying Zhao ,&nbsp;Xuke Zhang ,&nbsp;Wenxi Yin ,&nbsp;Yuqi Leng ,&nbsp;Jun Bai","doi":"10.1016/j.eujim.2025.102498","DOIUrl":"10.1016/j.eujim.2025.102498","url":null,"abstract":"<div><h3>Introduction</h3><div>This study aimed to evaluate the knowledge, attitude, and practice of patients with polycystic ovary syndrome (PCOS) regarding Traditional Chinese Medicine (TCM) treatment for PCOS.</div></div><div><h3>Methods</h3><div>This cross-sectional study was conducted among patients with PCOS at the Gynecology Outpatient Department and Reproductive Medicine Center of our hospital between January and May 2024. A self-reported questionnaire was used to assess demographic information, knowledge, attitude, and practice scores toward TCM treatment of PCOS. A threshold of ≥70.0 % of the maximum possible score was set for adequate knowledge, positive attitude, and proactive practice</div></div><div><h3>Results</h3><div>A total of 519 patients completed the questionnaire, 90.4 % aged 18-35. The mean scores for knowledge, attitude, and practice were 7.13 ± 5.41 (range 0-25), 30.74 ± 4.04 (range 8-40), and 16.95 ± 3.63 (range 5-25), respectively. The results of Spearman correlation analysis showed that knowledge score was correlated to the attitude (r = 0.272, P &lt; 0.001) and practice (r = 0.421, P &lt; 0.001) scores. The attitude score was correlated to the practice score (r = 0.410, P &lt; 0.001). The Structural Equation Modeling showed that knowledge directly influenced attitude (β = 0.336, P &lt; 0.001). Attitude directly influenced practice (β = 0.432, P &lt; 0.001).</div></div><div><h3>Conclusions</h3><div>The patients exhibited inadequate knowledge, positive attitude, and proactive practice regarding TCM for PCOS. We recommend improving awareness and acceptance of TCM among patients with PCOS through targeted education, enhanced doctor-patient communication, and promotion of effective treatment models to enhance their quality of life.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"78 ","pages":"Article 102498"},"PeriodicalIF":1.9,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144580291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Meta-analysis and trial sequential analysis of Huaiqihuang granules in treatment of cough variant asthma in pediatrics 怀芪黄颗粒治疗小儿咳嗽变异性哮喘的meta分析和试验序贯分析
IF 1.9 4区 医学
European Journal of Integrative Medicine Pub Date : 2025-06-05 DOI: 10.1016/j.eujim.2025.102511
Qiaoling Li, Jing Peng, Linhui Liu
{"title":"Meta-analysis and trial sequential analysis of Huaiqihuang granules in treatment of cough variant asthma in pediatrics","authors":"Qiaoling Li,&nbsp;Jing Peng,&nbsp;Linhui Liu","doi":"10.1016/j.eujim.2025.102511","DOIUrl":"10.1016/j.eujim.2025.102511","url":null,"abstract":"<div><h3>Introduction</h3><div>Many individuals with cough variant asthma (CVA) utilize Huaiqihuang granules to alleviate symptoms. However, there is a lack of systematic reviews investigating its efficacy and safety for CVA.</div></div><div><h3>Methods</h3><div>A computer-based retrieval of various databases was conducted to search for randomized controlled trials (RCTs) on the treatment of CVA in children using Huaiqihuang granules combined with Western medicine. The search encompassed eight databases, including China National Knowledge Infrastructure (CNKI), Wangfang, VIP (VIP Information Co.Ltd.), PubMed, Web of Science, The Cochrane Library, Embase, and Sinomed database, and covered literature up to April 2025. Articles were screened and selected based on predefined inclusion and exclusion criteria. The quality of the included articles was assessed, followed by a meta-analysis using RevMan5.3. The quality of evidence was graded using the Grade of Recommendations Assessment, Development, and Evaluation (GRADE) system. Additionally, trial sequential analysis (TSA) was performed using TSA 0.9.5.10 beta software.</div></div><div><h3>Results</h3><div>A total of 17 RCTs were included in the analysis, encompassing a total sample size of 1,742 patients. Results showed that the combination of Huaiqihuang granules with conventional Western medicine significantly enhanced clinical efficacy and reduced recurrence rates compared to Western medicine alone. This combination also improved immune parameters, including CD4+/CD8+, and modulated inflammatory markers such as inflammatory factors interleukin-4 (IL-4) and interferon-gamma (IFN-γ), while restoring immunoglobulin levels (IgA, IgE, IgG). Additionally, it improved pulmonary function indices, including FEV1, FEV1/FVC and PEF. No significant differences were observed in the incidence of adverse reactions between the two groups. TSA demonstrated that the total effective rate curve surpassed both the traditional and TSA boundaries, corroborating the clinical efficacy. According to the GRADE assessment, outcomes related to treatment efficacy, recurrence rate, IFN-γ, CD4+, and incidence of adverse reactions were rated as moderate-quality evidence, whereas the remaining outcomes were assessed as low-quality evidence.</div></div><div><h3>Conclusion</h3><div>The integration of Huaiqihuang granules with conventional Western medicine in the management of CVA significantly enhances clinical efficacy, reduces recurrence rates, improves immune parameters, restores pulmonary function, ameliorates inflammatory markers, and normalizes immunoglobulin levels, in comparison to the use of Western medicine alone.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"78 ","pages":"Article 102511"},"PeriodicalIF":1.9,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144523261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Global trends and hotspots in acupuncture for hypertension: a bibliometric study from 1994 to 2024 针灸治疗高血压的全球趋势和热点:1994 - 2024年文献计量学研究
IF 1.9 4区 医学
European Journal of Integrative Medicine Pub Date : 2025-06-04 DOI: 10.1016/j.eujim.2025.102510
Yun-Hua Zheng , Wei Zheng , Jian-Yu Liu
{"title":"Global trends and hotspots in acupuncture for hypertension: a bibliometric study from 1994 to 2024","authors":"Yun-Hua Zheng ,&nbsp;Wei Zheng ,&nbsp;Jian-Yu Liu","doi":"10.1016/j.eujim.2025.102510","DOIUrl":"10.1016/j.eujim.2025.102510","url":null,"abstract":"<div><h3>Introduction</h3><div>Growing interest in non-pharmacological hypertension management has led to increased research in acupuncture as a potential treatment. This bibliometric analysis examines the global research landscape of acupuncture for hypertension using CiteSpace and VOS Viewer software. By analyzing publication trends, key contributors, and collaborative networks, we summarize the current state of research, identify emerging hotspots, and outline future directions in this rapidly evolving field.</div></div><div><h3>Methods</h3><div>We conducted a comprehensive literature search in the Web of Science Core Collection (WOSCC), including the Science Citation Index Expanded (SCI-E) and Emerging Sources Citation Index (ESCI) databases, covering publications from 1994 to 2024. Bibliometric analysis and knowledge mapping were performed using CiteSpace (version 6.2.R4) and VOS Viewer (version 1.6.18) to analyze publication trends, research collaborations, and thematic evolution.</div></div><div><h3>Results</h3><div>The analysis revealed a consistent upward trend in annual publications from 1994 to 2024, with China emerging as the most productive country in this research domain. Key thematic clusters identified through keyword analysis included \"acupuncture,\" \"stimulation,\" \"blood pressure regulation,\" and \"electroacupuncture.\" Co-citation analysis demonstrated significant research intensity for \"systemic hypertension\" (cluster strength: 6.94, 2015–2019), \"randomized controlled trials\" (4.31, 2022–2024), and \"neurons\" (3.9, 2012–2013). The study by Frank A Flachskampf et al. (burst strength = 8.48) showed the strongest citation burst.</div></div><div><h3>Conclusion</h3><div>Our bibliometric analysis reveals a marked surge in research output and scientific engagement, underscoring acupuncture’s expanding role as a therapeutic intervention for hypertension. The field exhibits robust growth potential, driven by intensifying global collaboration among leading institutions and interdisciplinary research teams.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"78 ","pages":"Article 102510"},"PeriodicalIF":1.9,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144522387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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