{"title":"X-linked hypophosphatemia in childhood: dental involvement, diagnosis, and treatment.","authors":"P Defabianis, N Bocca, R Ninivaggi","doi":"10.23804/ejpd.2025.2348","DOIUrl":"10.23804/ejpd.2025.2348","url":null,"abstract":"<p><strong>Aim: </strong>X-linked hypophosphatemia (XLH) is a rare genetic disorder that causes skeletal deformities, growth retardation and oral complications, being dental abscesses the most frequent reported problem. Patient management is often poor due to a lack of care pathways, particularly in pediatric settings, and this highlights the need for updated clinical protocols. This study emphasises the importance of the role of pediatric dentists in the early recognition of XLH and in the multidisciplinary management of these patients, including early diagnosis, personalised therapies, and prevention to improve oral health and overall well-being.</p><p><strong>Methods: </strong>A comprehensive search was conducted to identify studies focused on dental aspects in XLH pediatric patients published from 2020 and 2024. Databases such as the Cochrane Library and MEDLINE via PubMed databases were searched using terms and MeSH terms including X-linked hypophosphatemia, X-linked hypophosphatemic rickets, XLH, teeth, dental, child, oral health, and oral health-related quality of life. Only English-language articles were included.</p><p><strong>Conclusion: </strong>In the end the complexity and rarity of XLH often results in diagnostic delays, compromising either dental or general treatment. For these reasons, the need for early diagnosis and integrated care is evident; development of specific guidelines to improve outcomes and oral health-related quality of life in growing patients is strongly required.and nutritional disorders. The study emphasises the importance of including a dental evaluation in the follow-up of premature infants from the first months of life.</p>","PeriodicalId":11930,"journal":{"name":"European journal of paediatric dentistry","volume":" ","pages":"37-41"},"PeriodicalIF":2.2,"publicationDate":"2026-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145803619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N T Snigdha, M I Karobari, A Kamarudin, N A Samsudin, F Baharin, N Dziaruddin, A A Assiry, A M Luke, G A Scardina
{"title":"A Systematic Review and Meta-analysis of Regenerative Pulpotomy in the Treatment of Vital Primary Teeth.","authors":"N T Snigdha, M I Karobari, A Kamarudin, N A Samsudin, F Baharin, N Dziaruddin, A A Assiry, A M Luke, G A Scardina","doi":"10.23804/ejpd.2024.1981","DOIUrl":"10.23804/ejpd.2024.1981","url":null,"abstract":"<p><strong>Aim: </strong>To assess the clinical and radiographic success rates of regenerative pulpotomy compared to devitalising or preservative pulpotomy in treating vital pulp exposure in primary teeth.</p><p><strong>Methods: </strong>Comprehensive search with PubMed/MEDLINE, Cochrane Library, Web of Science, Google Scholar and Open Grey databases was done and two reviewers extracted the data after assessing the studies for eligibility criteria. The Cochrane Collaboration Tool and Minors Checklist assessed the quality of the selected studies. A meta-analysis was performed using RevMan (P<0.05).</p><p><strong>Conclusion: </strong>Within the limitations of the study, it can be concluded that MTA seemed to be the better alternative to FC and FS, showing a lower risk of failure and can be recommended for pulpotomy in primary teeth. BD also demonstrated promising results as a pulpotomy medicament.</p>","PeriodicalId":11930,"journal":{"name":"European journal of paediatric dentistry","volume":" ","pages":"105-120"},"PeriodicalIF":2.2,"publicationDate":"2026-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142282357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L Šimunović, B Špiljak, A Z Kovač, L Vranić, D Negovetic Vranic
{"title":"Bilateral root absence of permanent first molars: literature review and case report.","authors":"L Šimunović, B Špiljak, A Z Kovač, L Vranić, D Negovetic Vranic","doi":"10.23804/ejpd.2025.2333","DOIUrl":"10.23804/ejpd.2025.2333","url":null,"abstract":"<p><strong>Aim: </strong>This case report and literature review aim to elucidate the rare occurrence of bilateral root absence in permanent first molars, emphasizing its clinical implications, diagnostic challenges, management, and possible association with systemic conditions. A unique case involving a 13-year-old male diagnosed with atypical hemolytic uremic syndrome (aHUS) is presented to illustrate these points.</p><p><strong>Methods: </strong>A comprehensive review of existing literature was conducted to explore the etiology, diagnosis, and management strategies for root absence. In addition, the detailed case study of the patient with aHUS and root absence of all four permanent first molars complements the review, providing insights into systemic impacts on dental development.</p><p><strong>Conclusion: </strong>This report emphasizes the need for a multidisciplinary approach in diagnosing and managing dental anomalies associated with systemic diseases. Further research is recommended to understand the systemic influences on dental root development and improve patient outcomes.</p>","PeriodicalId":11930,"journal":{"name":"European journal of paediatric dentistry","volume":" ","pages":"31-36"},"PeriodicalIF":2.2,"publicationDate":"2026-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145803538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
E Boccalari, M Serafin, M Grandinetti, A Caprioglio
{"title":"Orthodontics meets otorhinolaryngology: a collaborative approach to otitis media prevention.","authors":"E Boccalari, M Serafin, M Grandinetti, A Caprioglio","doi":"10.23804/ejpd.2025.2413","DOIUrl":"10.23804/ejpd.2025.2413","url":null,"abstract":"<p><strong>Aim: </strong>To evaluate the role of orthodontic and craniofacial orthopaedic interventions in the prevention and management of otitis media with effusion (OME), focusing particularly on rapid maxillary expansion (RME) and its implications for Eustachian tube function.</p><p><strong>Methods: </strong>A comprehensive search was conducted in PubMed, Embase, and Web of Science using a structured combination of MeSH terms by two expert researchers from inception to December 2024. Randomised and non-randomised prospective studies involving pediatric patients (2-18 years) with chronic OME were included. The effectiveness of preventive measures was compared with alternative treatments or no interventions. Study quality was assessed using the ROBINS-I v2 tool.</p><p><strong>Conclusion: </strong>RME emerges as a promising preventive option for managing OME particularly in patients with orthodontic indications. By addressing structural contributors to Eustachian tube dysfunction, RME improves middle ear health and complements otolaryngological interventions. Integrating orthodontic and otolaryngological strategies represents an effective multidisciplinary approach to reducing OME incidence and recurrence. Further studies are needed to confirm the long-term stability and the generalisability of these observed benefits.</p>","PeriodicalId":11930,"journal":{"name":"European journal of paediatric dentistry","volume":" ","pages":"47-52"},"PeriodicalIF":2.2,"publicationDate":"2026-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145307157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K Awad, S Butt, E A Field, D Finn, K Hunter, B P Rajlawat, C E McCarthy
{"title":"Paediatric Oral Lichen Planus.","authors":"K Awad, S Butt, E A Field, D Finn, K Hunter, B P Rajlawat, C E McCarthy","doi":"10.23804/ejpd.2025.2379","DOIUrl":"10.23804/ejpd.2025.2379","url":null,"abstract":"<p><strong>Background: </strong>Lichen Planus is a chronic, mucocutaneous disease that may affect the oral mucosa, skin, genital mucosa, nails, and scalp. It occurs more frequently in adults than in children. Ten cases of Oral Lichen Planus (OLP), diagnosed in children presenting to the Liverpool University Dental Hospital (UK) Oral Medicine department are presented. The case series includes four male and six female patients, ranging in age from 10 to 17 years at diagnosis. A clinical diagnosis alone was made in five patients and five patients underwent an incisional biopsy, which confirmed a histological diagnosis consistent with OLP. In one case, moderate dysplasia was diagnosed, on a background of OLP. Five patients presented with asymptomatic disease. In symptomatic cases, treatments included topical anesthetic mouthwash and topical steroid preparations. OLP is classified as an oral potentially malignant disorder and approximately 1% of patients develop oral cancer, however no cases of malignant transformation have been reported in children. None of our paediatric patients with OLP have developed oral cancer during a mean follow up time of 2 years. However, ongoing clinical monitoring is required so that malignant change can be detected at the earliest possible stage when treatment is most successful.</p>","PeriodicalId":11930,"journal":{"name":"European journal of paediatric dentistry","volume":" ","pages":"42-46"},"PeriodicalIF":2.2,"publicationDate":"2026-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145430514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Assessment of the Neonatal/Natal Teeth in Children: A Retrospective Observational Study.","authors":"M Belevcikli, E Hazar Bodrumlu","doi":"10.23804/ejpd.2025.2434","DOIUrl":"10.23804/ejpd.2025.2434","url":null,"abstract":"<p><strong>Aim: </strong>It is rare for teeth to be visible in the mouth at birth or shortly after birth, whether they are additional teeth or primary teeth that have erupted early. If there is excessive mobility, the tooth must be extracted to avoid the risk of aspiration. The aim of this study was to evaluate the characteristics of these teeth and their effects on the developing dentition in children with natal/neonatal tooth extraction.</p><p><strong>Methods: </strong>Out of a total of 26 patients in the study, 22 were contacted by phone and 16 of them came for a follow-up visit. At the patients' follow-up appointments, the stage of dental development, amount of space and the presence of any dental anomalies were assessed.</p><p><strong>Conclusion: </strong>Knowing the characteristics of natal-neonatal teeth, their differential diagnosis, what should be considered in treatment options, and the problems that may arise after extraction of these teeth provides an advantage in the management of these teeth, which is a rare condition.</p>","PeriodicalId":11930,"journal":{"name":"European journal of paediatric dentistry","volume":" ","pages":"53-58"},"PeriodicalIF":2.2,"publicationDate":"2026-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145291535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Breastfeeding and craniofacial development: orthodontic prevention beginning at birth.","authors":"L Paglia","doi":"10.23804/ejpd.2026.27.01.01","DOIUrl":"10.23804/ejpd.2026.27.01.01","url":null,"abstract":"<p><p>Breastfeeding is universally recognised as the nutritional gold standard for the neonate, with well-established benefits on immunological, metabolic, and relational levels. However, in light of the evidence accumulated over recent years, limiting its value to the nutritional dimension alone is reductive. Breastfeeding also represents a powerful functional modulator of craniofacial growth and, consequently, an early potential determinant of orthodontic health. Suckling at the breast activates a complex neuromuscular pattern involving the tongue, lips, mandible, and perioral musculature in a coordinated and physiological manner. This functional pattern, which is more demanding and dynamic than artificial feeding, generates mechanical stimuli that are essential for the modelling of the hard palate, transverse expansion of the maxilla, and the correct maxillo-mandibular balance. In accordance with the functional matrix principle, bone growth is not an autonomous process but responds to the functional stimuli of the soft tissues: breastfeeding constitutes, during the first months of life, one of the principal biological inputs capable of directing such development. Epidemiological evidence reinforces this biological rationale. The meta-analysis by Peres et al. [2015] documented a significant reduction in the risk of malocclusion in breastfed children compared to those fed formula. Likewise, Boronat-Catalá et al. [2017] identified a dose-response association between duration of breastfeeding and lower prevalence of occlusal anomalies in the primary and mixed dentitions. Subsequent observational studies confirmed a reduced risk of anterior open bite and posterior crossbite in subjects breastfed for longer periods. The data pertaining to duration are particularly noteworthy: the protective effect appears to be more pronounced the longer breastfeeding is maintained. This suggests that the window of the first months of life represents a critical period of craniofacial plasticity, during which functional stimuli may exert a lasting influence on morphological development. Major health institutions have progressively incorporated these findings into their recommendations. The American Academy of Pediatrics, in the 2022 policy statement [Meek and Noble], highlights the contribution of breastfeeding to oro-facial functional development. Similarly, the Ministry of Health recommends exclusive breastfeeding for the first six months and its continuation until two years of age or beyond, acknowledging its impact on harmonious child development. Within the dental and orthodontic fields, these data warrant reflection: breastfeeding can no longer be regarded as an \"external\" factor with respect to dentofacial prevention. On the contrary, it represents the first natural functional orthodontic intervention, capable of reducing the incidence of malocclusions and oro-facial dysfunctions through the early modulation of muscular and respiratory stimuli. Methodological ","PeriodicalId":11930,"journal":{"name":"European journal of paediatric dentistry","volume":"27 1","pages":"2-3"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147347799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S Saccomanno, V Quinzi, D Adamo, L Coceani Paskay, R Fontanella, M Serenelli, G Marzo, L Memè
{"title":"Orthodontics and Myofunctional Therapy: A critical review of the best complementary treatments of orofacial dysfunctions (Part 1).","authors":"S Saccomanno, V Quinzi, D Adamo, L Coceani Paskay, R Fontanella, M Serenelli, G Marzo, L Memè","doi":"10.23804/ejpd.2026.27.01.03","DOIUrl":"10.23804/ejpd.2026.27.01.03","url":null,"abstract":"<p><strong>Aim: </strong>This critical review article illustrates the anatomo-physiological complexity of the orofacial district that makes orthodontic and myofunctional therapies naturally complementary.</p><p><strong>Methods: </strong>The evolution of the face and mouth's structures and functions intimately connects not just bones and muscles but several functions: breathing, sucking, swallowing, chewing, biting, protective mechanisms such as spitting or coughing, and parafunctions such as clenching or nocturnal bruxism. These functions (among others) are mediated by an extremely complex neural system that involves, affects, or is affected by relevant cranial nerves, the sensory-motor system, the sympathetic and parasympathetic systems, the enteric system, and the breathing system.</p><p><strong>Conclusion: </strong>This interdisciplinary approach promotes the lasting success of orthodontic treatment and supports overall body wellbeing.</p>","PeriodicalId":11930,"journal":{"name":"European journal of paediatric dentistry","volume":"27 1","pages":"78-83"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147347857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G Magalhães Cairo, M Cardoso Oliveira, V Meira Maia, I F Neves Oliveira, M J Neves Souza Gomes, C Augusto Casotti
{"title":"Effectiveness of chlorhexidine and xylitol varnish versus silver diamine fluoride in the control of initial dental caries lesions: a randomised clinical trial.","authors":"G Magalhães Cairo, M Cardoso Oliveira, V Meira Maia, I F Neves Oliveira, M J Neves Souza Gomes, C Augusto Casotti","doi":"10.23804/ejpd.2026.2361","DOIUrl":"https://doi.org/10.23804/ejpd.2026.2361","url":null,"abstract":"<p><strong>Aim: </strong>This study aims to compare the effectiveness of a chlorhexidine (2%) and xylitol (5%) varnish (VCX) versus a silver diamine fluoride (SDF) solution (30%) in controlling initial dental caries lesions in young children.</p><p><strong>Methods: </strong>A randomised clinical trial was conducted with children aged 5 and 6 from public schools in Jequié, Bahia. Participants were randomly assigned to three groups: one treated with VCX, another with SDF, and a control group that received no intervention. Carious lesions were classified using ICDAS-II criteria, and interventions were applied following standardised clinical protocols. Blinding was applied to participants, though not to researchers due to physical differences in treatment materials.</p><p><strong>Conclusion: </strong>Both VCX and SDF were effective in reducing initial dental caries lesions, with SDF showing superior efficacy. However, VCX may serve as a viable alternative for patients concerned with aesthetics, though further studies are required to confirm its long-term effectiveness and optimise treatment protocols.</p>","PeriodicalId":11930,"journal":{"name":"European journal of paediatric dentistry","volume":"27 ","pages":"1"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147503440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M Ferrillo, F Lerda, E Fani, F P De Luca, A De Rosa, M Rosa, G Marzo, V Quinzi
{"title":"The effect of serial extractions compared to enucleations on skeletal, dental, and soft tissues: a longitudinal evaluation.","authors":"M Ferrillo, F Lerda, E Fani, F P De Luca, A De Rosa, M Rosa, G Marzo, V Quinzi","doi":"10.23804/ejpd.2026.2747","DOIUrl":"https://doi.org/10.23804/ejpd.2026.2747","url":null,"abstract":"<p><strong>Background: </strong>Tooth size-arch length deficiencies (TSALD) malocclusions can be treated either with or without extractions in growing patients. The extraction treatments are usually recommended in severe crowding and involve the serial extractions (SEs) or the enucleation (EE) therapies. The aim of the present retrospective study was to compare the skeletal and dental effects of serial extraction and enucleation treatments in subjects with severe crowding in mixed dentition phase.</p><p><strong>Methods: </strong>Lateral cephalograms from patients who underwent orthodontic treatment involving serial extractions (SE group) or enucleations (EE group) were analysed. The matched control group (CG group) consisted of untreated subjects derived from the American Association of Orthodontists foundation (AAOF) Craniofacial Growth Legacy Collection Project. The initial lateral cephalograms were taken before the eruption of all the second molars (T0) and the second lateral cephalograms were taken after the completion of the extractions (T1). The primary outcome was the change of the vertical skeletal dimension evaluated using the SN to mandibular plane angle (SN-GoGn) angle from T0 to T1.</p><p><strong>Conclusion: </strong>Based on this longitudinal cephalometric analysis, significant reduction of SN-GoGn (about 2.3°), MMPA, and gonial angle were detected only in patients who underwent serial extractions, whereas no significant variations were detected in enucleation and control groups. IMPA, L1-Apo, and UIMx measurements did not significantly change at follow-up in all three groups, thus a lingual tipping of the incisor was not detected in both serial extraction and enucleation groups.</p>","PeriodicalId":11930,"journal":{"name":"European journal of paediatric dentistry","volume":"27 ","pages":"1"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147502950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}