European Journal of Clinical Nutrition最新文献

{"title":"Nutritional characterization of patients with oropharyngeal cancers: impact of human papillomavirus status.","authors":"Maryam Choulli, Catherine Kubrak, Francisca Morey, Jesús Brenes, Sara Tous, Beatriz Quirós, Xin Wang, Miquel Angel Pavón, Montserrat Gomà, Miren Taberna, Laia Alemany, Marc Oliva, Marisa Mena, Naresh Jha, Rufus Scrimger, Brock Debenham, Neil Chua, John Walker, Ricard Mesia, Vickie Baracos, Lorena Arribas","doi":"10.1038/s41430-024-01556-z","DOIUrl":"https://doi.org/10.1038/s41430-024-01556-z","url":null,"abstract":"<p><strong>Background: </strong>Oropharyngeal squamous cell carcinoma (OPSCC) of human papillomavirus (HPV)-positive status is increasing relative to HPV-negative disease. Nutritional features of OPSCC patients according to HPV status is unclear.</p><p><strong>Subjects/methods: </strong>Canadian and Spanish patients with OPSCC were assessed for body mass index (BMI), weight loss grade (WLG), and computed tomography-defined skeletal muscle index (SMI). Chi-square, t-test, Mann-Whitney-U, Kruskal-Wallis tests were conducted to compare HPV positive and negative groups. Overall survival (OS) was assessed by univariable Kaplan-Meier and Cox proportional hazard methods.</p><p><strong>Results: </strong>No differences in BMI, WLG, SMI, and adipose tissue index between the 308 (Canada) and 134 (Spain) patients according to HPV status; hence cohorts were pooled (n = 442). HPV-positive patients (n = 317) were overweight/obese (72.8%), had WLG of 0/1 (59.6%) and high SMI (83.4%) while HPV-negative patients were normal/underweight (61.5%), had high WLG 3/4 (50.8%), and moderate/severe SMI depletion (46.9%) (p < 0.003). These overall differences notwithstanding, there was crossover i.e. 35% of HPV-positive patients had high WLG and/or moderate/severe muscle depletion and 29% of HPV-negative patients had minimal weight loss and high SMI. HPV-negative patients had a higher risk of mortality (HR 3.78, 95% CI 2.70-5.29, P < 0.001) and this difference was retained after multivariable adjustment for WLG, SMI, age, disease stage, and planned treatment (HR 3.30, 95% CI 2.17-5.02, P < 0.001).</p><p><strong>Conclusion: </strong>Nutrition features of patients with OPSCC did not differ between Canada and Spain. Distinctive nutrition features exist in patients according to HPV status. The high heterogeneity of individual nutritional profiles invites an individualized approach to nutrition care.</p>","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142909590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of breastfeeding practices during the first 12 months and subsequent infant respiratory tract infections: a prospective cohort study.","authors":"Weiming Wang, Menghan Tu, Li Huang, Xu Zhang, Xi Chen, Lixia Lin, Xuefeng Yang, Liping Hao, Nianhong Yang","doi":"10.1038/s41430-024-01558-x","DOIUrl":"https://doi.org/10.1038/s41430-024-01558-x","url":null,"abstract":"<p><strong>Background: </strong>Breastfeeding and human milk are the normative standards for infant feeding and nutrition.</p><p><strong>Objectives: </strong>We aimed to examine the association of breastfeeding practices during the first year of life with subsequent infant respiratory tract infections (RTIs).</p><p><strong>Methods: </strong>The study was a secondary analysis embedded in the Tongji Maternal and Child Health Cohort study. Information on infant breastfeeding was collected at 3, 6, and 12 months of age. Pediatrician-diagnosed infant RTIs and hospitalization for RTIs during 12-24 months were obtained at 24 months postpartum. Robust log-Poisson regression models were applied to explore the association of breastfeeding practices with RTIs risk and hospitalization due to RTIs.</p><p><strong>Results: </strong>Among the 5242 infants studied, 13.1% (n = 435) of infants received full breastfeeding for six months and continued breastfeeding for at least one year (F6-L). When compared with infants in the F6-L group, those who were formula fed (FF) had a higher risk of RTIs, including upper RTIS and lower RTIS, the adjusted RRs (95%CIs) were 1.34 (1.17, 1.53), 1.31 (1.12, 1.52), 1.59 (1.10, 2.31), respectively. When compared with infants in the F6-L group, the adjusted RRs (95%CIs) for hospitalization from RTIs was 1.88 (1.20, 2.95) for the FF group.</p><p><strong>Conclusion: </strong>Full breastfeeding for six months and continued breastfeeding for at least one year was associated with a lower risk of subsequent infant RTIs and hospitalization from RTIs.</p>","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142871198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutraceuticals: a promising, yet unregulated Frontier in Healthcare.","authors":"Yoshiyasu Takefuji","doi":"10.1038/s41430-024-01557-y","DOIUrl":"https://doi.org/10.1038/s41430-024-01557-y","url":null,"abstract":"<p><p>Nutraceuticals, with their potential health benefits, are increasingly being used to manage a variety of health conditions. The global market for nutraceuticals, valued at USD 540 billion in 2022, is projected to reach USD 1025 billion by 2030. This paper delves into the beneficial impacts of emerging nutraceuticals on a spectrum of medical disorders, drawing from credible sources from the National Library of Medicine. We have scrutinized studies on the application of nutraceuticals in treating conditions like sleep disorders, migraines, oxidative stress, mental health issues, pain disorders, obesity, gastrointestinal disorders, and even COVID-19. Our analysis indicates that nutraceuticals hold promise for addressing various health issues. However, this paper also sheds light on the health risks associated with nutraceuticals. Despite their widespread use, the safety and efficacy of nutraceuticals are still uncertain due to the lack of stringent regulations, unlike pharmaceutical drugs. This raises concerns about potential health risks and misleading claims. Research indicates that some supplements can cause adverse effects and interact with medications. Therefore, to ensure safe usage, it is imperative to implement stricter regulations, enhance reporting systems, and boost consumer awareness.</p>","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142834826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Do cardiometabolic risk factors mediate the relationship between body composition and bone mineral content in South Indian children aged 5 to 16 years?","authors":"Sayeeda Arshiya Farheen,&nbsp;Poorvikha S,&nbsp;Sumithra Selvam,&nbsp;Deepa Puttaswamy,&nbsp;Jini V. Aravind,&nbsp;Rebecca Kuriyan","doi":"10.1038/s41430-024-01553-2","DOIUrl":"10.1038/s41430-024-01553-2","url":null,"abstract":"","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":"79 3","pages":"284-284"},"PeriodicalIF":3.6,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41430-024-01553-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142817164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The finger-ring test as an indicator of muscle mass estimated by dual-energy X-ray absorptiometry in an adult community-dwelling population.","authors":"Bruna Rosa, Rui Valdiviesso, Micaela Cunha-Rodrigues, Mónica Rodrigues, Maria Luisa Lucena, Rita S Guerra, Ana S Sousa, Joana Mendes, Ana Rita Sousa-Santos, Cláudia Silva, Nuno Borges, Teresa F Amaral","doi":"10.1038/s41430-024-01550-5","DOIUrl":"https://doi.org/10.1038/s41430-024-01550-5","url":null,"abstract":"<p><strong>Introduction: </strong>The finger-ring test (FRT) offers a simple method to screen older adults at increased risk of sarcopenia.</p><p><strong>Objective: </strong>To investigate the association between the FRT and lean soft tissue mass estimated by dual-energy X-ray absorptiometry (DXA), and to further elucidate the FRT as an indicator of muscle mass, while accounting for potential confounders, in a community-dwelling population.</p><p><strong>Materials and methods: </strong>Within this cross-sectional study 430 community-dwelling individuals aged 18 to 79 (286 women (66.5%) and 144 men (33.5%)) were enrolled. Data regarding FRT and anthropometric measurements were collected. Whole-body composition was estimated using DXA. Binary and ordinal logistic regressions were performed.</p><p><strong>Results: </strong>The frequency of smaller calf, just fits, and bigger calf was 17.7%, 33.7%, and 48.6%, respectively. Regardless of sex, higher appendicular lean soft tissue mass adjusted for height squared was observed for higher FRT categories (p < 0.001). For the ordinal logistic regression model, each unity of increment in appendicular lean soft tissue mass adjusted for height squared (kg/m²) was associated with a higher probability of being allocated to higher finger-ring test categories, in both genders. A higher cumulative adjusted odds ratio was found for women (7.53; 95% confidence interval: 4.58-12.38) than for men (2.99; 2.00-4.48).</p><p><strong>Conclusion: </strong>By demonstrating an association between the appendicular lean soft tissue mass estimated by DXA and the FRT, these results strengthen the utility of this simple self-test as an indicator of muscle mass, which can be used in the primary prevention of muscle mass decline and its recovery.</p>","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142779697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of sorghum flour-containing pasta on postprandial glycemia, appetite and energy intake in healthy individuals.","authors":"Imran Khan, Stuart K Johnson, Adel M Yousif, Shirani Gamlath, Jamil Ahmad, Ali Madi Almajwal","doi":"10.1038/s41430-024-01554-1","DOIUrl":"https://doi.org/10.1038/s41430-024-01554-1","url":null,"abstract":"<p><strong>Background/objectives: </strong>In vitro studies suggest that incorporating sorghum flour into staple foods including pasta reduces their starch digestibility and hence may suppress postprandial blood glucose levels, appetite and energy intake; however, these effects in humans have yet to be reported. Therefore, this study investigated the effect of red and white sorghum-containing pasta on blood glucose response, appetite and energy intake in humans.</p><p><strong>Subjects/methods: </strong>In a randomised crossover design, healthy individuals (n = 20) consumed the following three iso-caloric test meals (each providing 50 g available carbohydrates) as breakfast: control pasta (CP) made from100% durum wheat; 30% red sorghum pasta (RSP) and; 30% white sorghum pasta (WSP). Blood glucose and subjective appetite were measured postprandially for 2 and 3 h, respectively. Energy intakes from ad libitum lunch consumed 3 h after breakfast and for the remainder of the day were also measured. Incremental areas under or over the curves (iAUCs/iAOCs) for blood glucose and appetite parameters were calculated.</p><p><strong>Results: </strong>The RSP meal resulted in significantly lower blood glucose response (-0.35 ± 0.09 mmol/l; 95% CI: -0.61 ~ -0.09; P = 0.005) and glucose iAUC over 120 min (-36.11 ± 10.53 mmol/l × min; 95% CI: -67.11 ~ -5.11; P = 0.017) compared to CP meal. Compared to CP meal, the RSP meal resulted in significantly higher satiety iAUC (1219.46 ± 383.26 mm × min; 95% 91.18 ~ 2347.75; P = 0.029), lower hunger iAOC (-1410.47 ± 349.14 mm x min; 95% CI: -2438.30 ~ -382.63; P = 0.004) and lower prospective food intake iAOC (-1645.73 ± 324.14 mm x min; 95% CI: -2599.97 ~ -691.49; P < 0.001). Energy intake at ad libitum lunch was significantly lower after the RSP meal than after the CP meal (-794.17 ± 163.25 kJ; 95% CI: -1274.77 ~ -313.57; P = 0.001).</p><p><strong>Conclusion: </strong>The results indicate that red sorghum addition into pasta provides a product inducing reduced glycemia, favourably changed appetite parameters and decreased subsequent energy intake.</p>","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142767471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sociodemographic and clinical factors associated with low muscle mass and composition in people treated with (chemo)radiotherapy for lung cancer.","authors":"Nicole Kiss, Carla M Prado, Gavin Abbott, Lara Edbrooke, Linda Denehy, Annie R Curtis, Shankar Siva, David Ball, Nicholas Hardcastle, Anna Ugalde, Steve F Fraser, Andrew Wirth, Adeline Lim, Andrew Hui, Greg Wheeler, Robin M Daly","doi":"10.1038/s41430-024-01552-3","DOIUrl":"https://doi.org/10.1038/s41430-024-01552-3","url":null,"abstract":"<p><strong>Background: </strong>This study examined (1) associations between sociodemographic and clinical variables with low muscle mass and radiodensity and their loss relative to treatment commencement in patients with lung cancer; and (2) the magnitude of change in muscle mass and association with treatment outcomes and survival.</p><p><strong>Methods: </strong>Prospective study in patients planned for curative (chemo)radiotherapy for lung cancer. Low skeletal muscle mass and radiodensity and muscle loss were determined from pre- and post-treatment computed tomography images. Sociodemographic, clinical, functional, nutritional, physical activity and alternate body composition were assessed pre-treatment. Logistic and linear regression and Fisher's exact tests were used to assess associations between variables and study outcomes. Cox proportional hazards models were fitted to examine associations with survival.</p><p><strong>Results: </strong>Overall, 53 patients (62.3% male) with a mean age of 69 ± 9.3 years and 54.8% with stage III disease were included. Pre-treatment low calf circumference was associated with pre-treatment low muscle mass (p = 0.006). Higher comorbidity scores pre-treatment were associated with normal muscle radiodensity pre- and post-treatment (p = 0.015, p = 0.027, respectively). Pre-treatment low energy and protein intake were associated with low muscle radiodensity post-treatment. Muscle mass and radiodensity were not associated with survival or treatment outcomes.</p><p><strong>Conclusions: </strong>In patients with lung cancer, there is some evidence anthropometric measures of muscle mass are suggestive of low muscle mass pre-radiotherapy, while low energy intake pre-treatment may indicate low muscle radiodensity after treatment. However, these findings are limited by the small sample size and further prospective studies with larger samples are required.</p>","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142754897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of eating difficulties and gastrointestinal problems on the nutritional status of children and adolescents with cerebral palsy.","authors":"M E Cieri, M M Ruiz Brunner, A L Condinanzi, J Escobar, C Gil, E Cuestas","doi":"10.1038/s41430-024-01549-y","DOIUrl":"https://doi.org/10.1038/s41430-024-01549-y","url":null,"abstract":"<p><strong>Introduction: </strong>This study was to analyze the impact of dietary difficulties and gastrointestinal problems on the nutritional status of people with CP from 2-19 years old who attend rehabilitation centers in the province of Córdoba-Argentina.</p><p><strong>Methods: </strong>This was a retrospective observational-cohort study. Data from 105 people of both sexes with a CP. Motor compromise was assessed with GMFCS. Multiple logistic regression models with a binomial response were used, with a p < 0.05.</p><p><strong>Results: </strong>63.8% boys were collected. The mean age was 11 y 6 m (SD 4,4). The dependence on a caregiver at mealtime presents 4 (p = 0.027) times more chances of having undernutrition than those who feed independently. Requiring a change in food consistency was almost 7 (p = 0.021) times more likely to present undernutrition.</p><p><strong>Conclusion: </strong>A relationship was identified between dysphagia and constipation with a greater nutritional compromise. The food difficulties in those children with disorders highlights the need to implement specific and adapted nutritional strategies.</p>","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142727282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Continuous glucose monitoring in adults with short bowel syndrome receiving overnight infusions of home parenteral nutrition.","authors":"Priyasahi Saravana, Meghan Lau, Hassan S Dashti","doi":"10.1038/s41430-024-01548-z","DOIUrl":"https://doi.org/10.1038/s41430-024-01548-z","url":null,"abstract":"<p><strong>Background/objectives: </strong>Consumers of home parenteral nutrition (HPN) are susceptible to dysglycemia. The aim was to characterize 24-h glucose profiles of HPN consumers using continuous glucose monitors (CGM) and to identify factors that influence glucose.</p><p><strong>Subjects/methods: </strong>Glucose profiles of 20 adults with short bowel syndrome (SBS) without diabetes were assessed using the Freestyle Libre Pro CGM. Measures included mean 24-h glucose, coefficient of variation (%), % time in range (TIR 70-140 mg/dL), among others. HPN parameters and lifestyle behaviors were obtained from self-reports and validated surveys. Linear mixed-effects models were used to test associations with glycemic measures adjusted for age, sex, and BMI. Significance was considered at P < 0.05.</p><p><strong>Results: </strong>Participants (77% female, age = 52 years, BMI = 21.4 kg/m², 95% white) had a 24-h mean and CV for glucose of 94.69 (8.96) mg/dL and 20.27%, respectively, and a mean TIR of 87.73%. Among non-daily HPN-dependent patients, the mean glucose and TIR were higher on days receiving HPN. Tapering HPN was associated with -6.882 (95% confidence interval = -12.436, -1.329) % lower CV, and higher HPN dextrose content per gram was associated with 0.039 (95% confidence interval = 0.008, 0.07) % higher CV. Smoking, more depressive symptoms, and higher insomnia severity showed associations with glucose levels and variability.</p><p><strong>Conclusions: </strong>Metabolically stable HPN adult consumers have 24-h glucose measures comparable to healthy adults yet are notable for more time spent below range. The glucose profiles are influenced by HPN parameters such as tapering and dextrose and behaviors including smoking, depressive symptoms, and insomnia.</p>","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142695424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of individually tailored nutritional counseling on frailty status in older adults with protein-energy malnutrition or risk of it: an intervention study among home care clients.","authors":"Tarja Kaipainen, Sirpa Hartikainen, Miia Tiihonen, Irma Nykänen","doi":"10.1038/s41430-024-01547-0","DOIUrl":"https://doi.org/10.1038/s41430-024-01547-0","url":null,"abstract":"<p><strong>Background: </strong>Frailty and protein-energy malnutrition (PEM) are common in older home care clients. In this study, we evaluate the effect of individually tailored dietary counseling on frailty status among home care clients with PEM or its risk aged 75 or older with a follow-up of six months.</p><p><strong>Methods: </strong>This intervention study is part of the non-randomized population-based Nutrition, Oral Health and Medication (NutOrMed) study in Finland. The frailty was assessed using the abbreviated Comprehensive Geriatric Assessment (aCGA) and included 15 questions from three different domains: cognitive status (MMSE), functional status (ADL, IADL) and depression (GDS-15). The study population consisted of persons with PEM or its risk (intervention group n = 90, control group n = 55). PEM or its risk was defined by MNA score <24 and/or plasma albumin <35 g/l. Registered nutritionist gave individually tailored nutritional counseling for participants at the baseline and nutritional treatment included conventional food items.</p><p><strong>Results: </strong>The mean age was 83.9 in the intervention and 84.3 in the control group. At the baseline frailty prevalence was 74.4% (n = 67) and after six-month 61.1% (n = 55) in the intervention group and, respectively 74.5% (n = 41) and 80.0% (n = 44) in the control group. The intervention decreased significantly (p < 0.001) the prevalence of frailty in the intervention group, while it increased in the control group.</p><p><strong>Conclusions: </strong>Individually tailored nutritional counseling reduces the prevalence of frailty among vulnerable home care clients with PEM or its risk. In the nutritional treatment of frailty, adequate intake of protein and energy should be a cornerstone of treatment.</p>","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142695426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}