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Correlation of Depression, Anxiety and Stress with Quality of Life in COVID-19 Pandemic COVID-19大流行中抑郁、焦虑和压力与生活质量的相关性

Esculapio Pub Date : 2021-07-16 DOI: 10.51273/esc21.2517218

Aysha Rashid, Umair Mudassar, Ismail Tariq, Adil Zaheer, M. Iftikhar, N. Mazhar

{"title":"Correlation of Depression, Anxiety and Stress with Quality of Life in COVID-19 Pandemic","authors":"Aysha Rashid, Umair Mudassar, Ismail Tariq, Adil Zaheer, M. Iftikhar, N. Mazhar","doi":"10.51273/esc21.2517218","DOIUrl":"https://doi.org/10.51273/esc21.2517218","url":null,"abstract":"Due to Covid-19 pandemic the psychological health of individuals is disturbed globally. There is a dire need of looking into details about the effects of mental health issues on quality of life (QOL). Objectives: To determine correlation between depression, anxiety, stress, and quality of life among adults in Covid-19 and evaluate the impact of demographics on quality of life. Methods: It was a cross-sectional study carried out at a tertiary care hospital. Patients presenting in the psychiatry outdoor of age 18 to 60 years, of both genders and scoring ≥21 on Depression, Anxiety, and Stress Scale (DASS) were enrolled in the study and depression, anxiety and stress severity was assessed and Quality of Life Scale (QOLS) was applied on all to assess their quality of life. All findings were then subjected to statistical analysis. Results: The mean age of the patients was 21.78±3.204, mean depression score on DASS was 8.58±4.510, mean anxiety score on DASS was 11.68±4.160 and the mean stress score on DASS was 14.84±3.192. There were 63.5% males and 36.5% females. Depression, anxiety and stress had a negative correlation with quality of life. Depression and stress were significantly correlated negatively with quality of life (p=0.000). No demographical factor was significantly associated with poor quality of life. Conclusion: Depression, anxiety and stress were negatively correlated with poorer QOL and depression and stress had significant association with poor QOL. Key words: Anxiety, Depression, Covid-19, Quality of life How to cite: Rashid A., Mudassar U., Tariq I., Zaheer A., Iftikhar M., Mazhar N. Correlation of Depression, Anxiety and Stress with Quality of Life in COVID-19 Pandemic. Esculapio 2021;17(02):195-199.","PeriodicalId":11923,"journal":{"name":"Esculapio","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44773221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Induction of Labour with Isosorbide Mononitrate Versus Prostaglandin E2 (PGE2) in Primigravidas (PGs) at Term 单硝酸异山梨酯与前列腺素E2（PGE2）对妊娠期初产妇的引产作用

Esculapio Pub Date : 2021-07-16 DOI: 10.51273/esc21.2517211

Rubina Waheed, Nadia Ashraf, Nadia Sabeen, M. I. U Allah, Qaiser Javed, A. Khalid

{"title":"Induction of Labour with Isosorbide Mononitrate Versus Prostaglandin E2 (PGE2) in Primigravidas (PGs) at Term","authors":"Rubina Waheed, Nadia Ashraf, Nadia Sabeen, M. I. U Allah, Qaiser Javed, A. Khalid","doi":"10.51273/esc21.2517211","DOIUrl":"https://doi.org/10.51273/esc21.2517211","url":null,"abstract":"Objective: To compare the frequency of caesarean section due to fetal distress with Isosorbide mononitrate versus PGE2 for the induction of labour in primigravida at term. Methods: It was Randomized Control Trial conducted in Unit I, Department of Obstetrics & Gynaecology, Lahore General Hospital, Lahore from 11th April 2015 to 10th October 2015. 230 primigravida were randomized into two groups i.e. Prostaglandin E2 and Isosorbide mononitrate for induction of labour. The difference in the frequency of caesarean section due to fetal distress with Prostaglandin E2 and Isosorbide mononitrate for induction of labour in the primigravidas at term was calculated as outcome. Results: The mean age of 27.62 ± 3.909 ranging from 21 to 34 years. The frequency of cesarean section was 12.2%in Prostaglandin E2 group while 0% in Isosorbide mononitrate. There was no effect of gestational age, age of mother and number of doses on outcome. Conclusion: There is no difference in frequency of cesarean section in primigravida groups induced by either Isosorbide mononitrate versus prostaglandin E2. Wherever applicable and feasible we should opt for Isosorbide mononitrate for induction of labour. Keywords: Cesarean section, Prostaglandin E2, Isosorbide mononitrate, Dinoprostone, Induction of labour, Primigravida How to cite: Waheed R., Ashraf N., Sabeen N., U Allah I.M., Javed Q., Khalid A. Induction of Labour with Isosorbide Mononitrate Versus Prostaglandin E2 (PGE2) in Primigravidas (PGs) at term. Esculapio 2021;17(02):166-169","PeriodicalId":11923,"journal":{"name":"Esculapio","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48496844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Patient Denialism for COVID19 Pose Difficulty for Treating Physicians 新冠肺炎患者否认19给医生治疗带来困难

Esculapio Pub Date : 2021-07-16 DOI: 10.51273/esc21.2517215

R. p, Muhammad Asim Rana, Mohammad Ahad Qayyum, Ali H. Munawar, S. Tariq, Abdullah Ali Lashari

{"title":"Patient Denialism for COVID19 Pose Difficulty for Treating Physicians","authors":"R. p, Muhammad Asim Rana, Mohammad Ahad Qayyum, Ali H. Munawar, S. Tariq, Abdullah Ali Lashari","doi":"10.51273/esc21.2517215","DOIUrl":"https://doi.org/10.51273/esc21.2517215","url":null,"abstract":"Objective: As patients refusal has been a major issue in diagnosing the disease, we carried out this study to determine the magnitude of the refusal or denial of suspected COVID 19 cases. Methods: All patients seen with COVID 19 symptoms in medical out doors and emergency in Bahria International Hospital, Lahore in two weeks period from April 15, 2020 to April 30, 2020 were included in study. COVID 19 symptoms were ascertained on WHO guidelines labelling patients as COVID 19 suspected through laboratory tests. Depending upon results individual consultation with each patient was arranged to convince them to carry out nasopharyngeal swab for SARS Co-V-2 PCR. Some patients refused despite counselling for follow up regarding symptoms and advised tests. The public fear was the main barrier for the suspected cases to get tested. Each patient who refused PCR test was labelled as in denial. Results: Of the 40 cases diagnosed as suspected COVID 19. 21 refused to get tested. Majority (15) were male. Fever with chills was common among all with majority presented with shortness of breath (43%) followed by diarrhea (33%) and chest pain (9%). Conclusion: Patients who remain in denial pose a great threat to society as by spreading the virus or deteriorating themselves. An effective campaign on government level should be run to overcome the fear which has made this infection a social stigma to help contain this pandemic in a resource scarce country like Pakistan. Keywords: Coronavirus denial, COVID-19 denial, COVID in Pakistan, Public reaction to COVID 19 How to cite: Pervaiz R., Rana A.M., Qayyum A.M., Munawar A., Tariq S., Lashari A.A. Patient denialism for COVID19 pose difficulty for treating Physicians. Esculapio 2021;17(02):183-186.","PeriodicalId":11923,"journal":{"name":"Esculapio","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47650266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison Between Paracetamol Vs Voltral Suppositories For Post Operative Pain In Gynaecological Procedure 扑热息痛与伏特栓剂治疗妇科手术后疼痛的比较

Esculapio Pub Date : 2021-07-16 DOI: 10.51273/esc21.2517217

Zeeshan Khan, S. Khaleeq, A. ur Rehman, Aasam Maan, Umer Farooq, Amjad Nadeem

{"title":"Comparison Between Paracetamol Vs Voltral Suppositories For Post Operative Pain In Gynaecological Procedure","authors":"Zeeshan Khan, S. Khaleeq, A. ur Rehman, Aasam Maan, Umer Farooq, Amjad Nadeem","doi":"10.51273/esc21.2517217","DOIUrl":"https://doi.org/10.51273/esc21.2517217","url":null,"abstract":"Objective: To compare intravenous paracetamol vs Voltral (Diclofenac) suppositories for post operative pain in gynaecological procedures. Methods: This was a non randomized controlled trial that was carried out at Department of Anaesthesiology, Sheikh Zayed Hospital, Rahim Yar Khan during 01-07-2019 to 31-12-2019 in which all female cases with age range of 20 to 60 year undergoing any gynaecological surgery requiring general anaesthesia were included. The cases were divided into two equal groups and anesthesia was offered in standard doses. Just before reversal the cases in group Awere given intravenous paracetamol in a dose of 1 gm stat and then at 8-hour interval and those in group B were offered diclofenac suppositories in a dose of 50 mg twice a day, 12 hours apart. The pain was assessed at 4,8,12 and 24 hours and was labelled on visual analogue scale (VAS). Results: In this study there were 62 cases (31 in each group). The mean age in group A and B was 45.41±10.21 vs 48.12±11.13 years with p= 0.47. Mean duration of surgery in both groups was 57.51±15.23 vs53.11±14.79 minutes with p= 0.81. There was no significant difference in mean pain score at 4 and 8 hours with p= 0.91 and 0.81 respectively in group A and B. Mean pain score was 4.43±1.67 vs 3.21±1.09 with p= 0.01 at 12 and 4.57±1.71 vs 3.34±1.27 at 24 hours in group A and B with p values of 0.01 each. Mean time taken for rescue analgesia was 9.13±2.11 in group Aand 13.11±1.23 hours in group B with p= 0.001. Conclusion: Voltral (Diclofenac sodium) suppositories are better than paracetamol infusion in controlling pain after gynecological surgeries and this difference is significantly better at 12 and 24 hours. Key words: Gynaecological surgery, Pain, Paracetamol, Voltral suppository How to cite: Khan Z., Khaleeq S., Rehman Ur A., Maan A., Farooq U. Nadeem A. Comparison Between Paracetamol Vs Voltral Suppositories for Post-Operative Pain in Gynaecological Procedures. Esculapio 2021;17(02):191-194.","PeriodicalId":11923,"journal":{"name":"Esculapio","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44057913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of Alvarado Score and Paediatric Appendicitis Score for Diagnosing Appendicitis in Children Alvarado评分与小儿阑尾炎评分诊断儿童阑尾炎的比较

Esculapio Pub Date : 2021-07-16 DOI: 10.51273/esc21.2517213

Naeem Liaqat, A. Iqbal, Wajeeh Ur Reham, Zulfiqar Ahmed, Fozia Bashir, Sajid Hameed Dar

{"title":"Comparison of Alvarado Score and Paediatric Appendicitis Score for Diagnosing Appendicitis in Children","authors":"Naeem Liaqat, A. Iqbal, Wajeeh Ur Reham, Zulfiqar Ahmed, Fozia Bashir, Sajid Hameed Dar","doi":"10.51273/esc21.2517213","DOIUrl":"https://doi.org/10.51273/esc21.2517213","url":null,"abstract":"Objective: To compare diagnostic accuracy of Alvarado score (AS) and Paediatric Appendicitis Score (PAS) for diagnosis of acute appendicitis in children. Methods: This study was conducted at the department of Pediatric Surgery Children Hospital Lahore, over a period of 1 year. All the patients undergoing appendicectomy were included. Alvarado score and Pediatric Appendicitis score (PAS) was evaluated, compared and appendix specimen sent for histopa-thology. All findings were recorded in proforma. The collected data was analyzed by SPSS version 24. The mean Alvarado score and PAS was calculated, and stratified according to the histopathology reports. The sensitivity and specificity of both Alvarado score and PAS for three strata including score 3-5, 5-7 and 8-10 were also calculated. Results: A total of 177 patients were included in the study. The mean age of the patients was 9.16 ± 2.386 years. Among these 118 patients (67%) were male. The mean duration of pain was 21.42 ± 19.05 hours. Biopsy report showed that 18 patients (10.1%) had normal appendix with no signs of inflammations while 159 patients (89.9%) had inflammation on histopathology. We stratified the histopathology reports according to Alvarado score ≤7 and >7 and P-value was found significant. Similarly PAS ≤7 and >7 was stratified and P-value was not significant. The difference in mean Alvarado score between having acute appendicitis and those with normal histopathology was significant (P= 0.000) while this difference in mean PAS was not found significant (P= 0.325). Conclusions: None of the scoring system has adequate diagnostic accuracy and clinical judgment is preferred. Key Words: Alvarado Score; PAS; Appendicitis; Children How to cite: Liaqat N., Iqbal A., Rehman ur W., Ahmed Z., Bashir F., Dar H.S. Comparison of Alvarado score and Paediatric Appendicitis Score for diagnosing appendicitis in children” Esculapio 2021;17(02):175-178.","PeriodicalId":11923,"journal":{"name":"Esculapio","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47008684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Burnout in Postgraduate Trainees and Consultants working in Psychiatry Departments of Teaching Hospitals in Lahore, Pakistan 巴基斯坦拉合尔教学医院精神病学系研究生实习生和顾问的倦怠

Esculapio Pub Date : 2021-03-31 DOI: 10.51273/ESC21.2517117

A. Butt, S. Rehman, Minahil Rahman

{"title":"Burnout in Postgraduate Trainees and Consultants working in Psychiatry Departments of Teaching Hospitals in Lahore, Pakistan","authors":"A. Butt, S. Rehman, Minahil Rahman","doi":"10.51273/ESC21.2517117","DOIUrl":"https://doi.org/10.51273/ESC21.2517117","url":null,"abstract":"Objective: To gauge the prevalence of burnout among postgraduate trainees and consultants working in psychiatry department, Services Hospital Lahore, Pakistan. Methods: 31 trainee and consultant psychiatrists in Services Hospital Lahore, Pakistan participated in this cross-sectional study. Abbreviated Maslach Burnout Inventory (aMBI) measured burnout. It consisted of 9 items, relating to emotional exhaustion, depersonalization and personal accomplishment. Each item is scored on a seven-point Likert scale. For Emotional Exhaustion and Depersonalization, higher scores predicted greater burnout; Personal Accomplishment demonstrated the opposite, hence its scores were inverted. Participants with moderate scores in 2 or more dimensions were identified as suffering from burnout syndrome. Data was analyzed by SPSS 25.0. Result: Mean age of participants was 34.87 ± 8.06 years. 52% were female. 58% were consultants, with average experience of 7 years; 61% practiced in more than one place. 32.3% of participants had burnout syndrome. Emotional Exhaustion subscale showed the highest scores i.e. 7.06 ± 3.43. 71% of participants demonstrated moderate or high burnout in this scale. Average Depersonalization score was 2.94 ± 2.42, while that for Personal Accomplishment was 3.29 ± 2.25. Conclusion: A significant portion of the sample reported moderate and high level of emotional exhaustion. On the contrary, we found low levels of depersonalization in the sample. Most psychiatrists reported adequate levels of personal achievement. These results are reassuring because, despite the presence of emotional burnout, psychiatrists still have capacity to empathize and provide adequate patient care. Key Words: burnout, psychiatry, trainees, consultants, Lahore, Pakistan How to cite: But. A., Rahman S., Rahman Minahil. Burnout in Postgraduate Trainees and Consultants working in Psychiatry Departments of Teaching Hospitals in Lahore, Pakistan. Esculapio 2021;71(01):83-87","PeriodicalId":11923,"journal":{"name":"Esculapio","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48534617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hand's Functional Status of Children with Rheumatoid Arthritis in Everyday Activities: A Cross-Sectional Study 类风湿性关节炎儿童日常活动中手部功能状况的横断面研究

Esculapio Pub Date : 2021-03-31 DOI: 10.51273/ESC21.251712

Hafiza Ayesha Ikram, W. Ahad, Fazila Huma

{"title":"Hand's Functional Status of Children with Rheumatoid Arthritis in Everyday Activities: A Cross-Sectional Study","authors":"Hafiza Ayesha Ikram, W. Ahad, Fazila Huma","doi":"10.51273/ESC21.251712","DOIUrl":"https://doi.org/10.51273/ESC21.251712","url":null,"abstract":"Objective: Rheumatoid Arthritis [RA] is a chronic, systemic, autoimmune disease on an unknown aetiology. It leads to the progressive destruction of joints. It also warrants difficulties in performance of Activities of Daily Living(ADL). This study aimed at determine relationship between activities of daily living [ADL] and functional status of the hand. Methods: This Crossectional Study was conducted at Romatology Department Children Hospital and Sheikh Zayed Hospital Lahore from June 2018 to December 2018. Convenient sampling technique helped in the collection of data. A hand function questionnaire and the Barthel Index were the contributary data collection methods. Rheumatoid Arthritis [RA] patients selected were those experiencing functional impairment in hands, having difficulty in performing ADL. Results: The patients who were able to perform the hand function test were independent in their daily life activities. Whereas, those who were not able to perk the test were dependent on their daily life activities. Conclusion: It was found that children with RA had a significant association between performing the ADL and functional status of hand. Key Words: Activities of Daily Living [ADL], Rheumatoid Arthritis [RA] How to cite: Ikram A.H., Ahad A.W., Huma Fazlia. Hand's functional status of children with rheumatoid arthritis in everyday activities: a cross-sectional study Esculapio. 2021.17(01): 9-14","PeriodicalId":11923,"journal":{"name":"Esculapio","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44131536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Discontinuation of Tuberculosis Treatment in Co-Infected TB with HIV 艾滋病合并感染结核病患者停止结核病治疗

Esculapio Pub Date : 2021-03-31 DOI: 10.51273/ESC21.2517112

U. Usman, Muhammad Saqib, A. Chaudhary

引用次数: 0

Impact of COVID-19 Pandemic on Cancer Screening in the United States COVID-19大流行对美国癌症筛查的影响

Esculapio Pub Date : 2021-03-31 DOI: 10.51273/ESC21.2517123

Sonikpreet Aulakh, Asher Khan

{"title":"Impact of COVID-19 Pandemic on Cancer Screening in the United States","authors":"Sonikpreet Aulakh, Asher Khan","doi":"10.51273/ESC21.2517123","DOIUrl":"https://doi.org/10.51273/ESC21.2517123","url":null,"abstract":"COVID-19 pandemic has exposed vulnerabilities all across the global healthcare systems including those within the United States. A systematic evaluation of these soft spots has been crucial in order to reengineer the healthcare system for enhanced competences and superior quality of care. One area that has been undoubtedly affected is the diagnosis and management of neoplastic diseases. The healthcare system in the US witnessed an instantaneous implementation of a “social distancing” strategy, which was implemented in an effort to flatten the infectivity “curve”. This required an urgent modification in the general administration of healthcare delivery, independent of COVID-19 infection status of a patient. For the non-COVID patients, it meant a shift from in-person to a virtual administration platform.''(Royce et al., 2020) Neither the healthcare providers, nor the patients, or the hospital management were adequately prepared for this sudden transition. Various healthcare services offered through these healthcare systems were required to be triaged based upon patients' assessment of needs into either emergent, urgent or routine/non- urgent. Patients seeking services that fell in the non- urgent/routine clinical visits were encouraged to stay home until the pandemic simmered down/resolved. This strategy was erroneously predicated on a rather short anticipated duration of the pandemic. As expected, cancer screening visits were deemed non- urgent and thus most healthcare facilities in and outside the US suspended these services, inadvertently compromising the timely diagnosis of neoplastic disorders.","PeriodicalId":11923,"journal":{"name":"Esculapio","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41335583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Evaluation of Protective Effect of Ajwa Seed And Fruit on Renal Histopathological Changes in Diabetic Nephropathic Rats Ajwa种子和果实对糖尿病肾病大鼠肾脏组织病理变化的保护作用评价

Esculapio Pub Date : 2021-03-31 DOI: 10.51273/ESC21.2517121

I. Imran, Maryam Mansoor, F. Naqvi, M. Akhtar, W. Arshad, Faiza Khan

{"title":"Evaluation of Protective Effect of Ajwa Seed And Fruit on Renal Histopathological Changes in Diabetic Nephropathic Rats","authors":"I. Imran, Maryam Mansoor, F. Naqvi, M. Akhtar, W. Arshad, Faiza Khan","doi":"10.51273/ESC21.2517121","DOIUrl":"https://doi.org/10.51273/ESC21.2517121","url":null,"abstract":"Objective: To investigate the protective effect of Ajwa date seed and fruit on renal histological changes in alloxan induced diabetic rats. Methods: This was an experimental study and was conducted in Post Graduate Medical Institute. The duration of study was 6 weeks. In this study random allotment of 32 rats was done in four groups. Group 1 was treated as control. Diabetes was induced in the 2nd, 3rd and 4th group by alloxan injection intra peritoneally. Group 2 was diabetic non treated while group 3 and 4 were treated with Ajwa seed and flesh respectively. After six weeks, animals were anaesthetized and kidneys were then removed without delay and weighed. Kidney paraffin sections were prepared and stained with hematoxylin& eosin (H&E) and with Periodic acid Schiff (PAS) technique. Glomerular diameters were estimated. Glomerular volume determined by stage micrometer. Vascular, tubular injury and glomerular sclerosis were studied semi quantitatively. Results: The data showed that Ajwa date seed significantly reduced hyperglycemia but did not normalize the fasting blood glucose. We found exceedingly significant improvement in kidney weight, glomerular diameter, tubular and vascular injury with Ajwa date seed suggesting reduction in diabetic nephropathy. Ajwa seed diet found more effective in reducing nephropathy than Ajwa fruit diet. Current study displayed that the seed of Ajwa showed significant improvement in renal histological characteristics in diabetic rats. Conclusion: The findings showed that Ajwa date seed and flesh reduce loss of tubular and vascular damage in alloxan induced diabetes. Key Words: Oxidative stress, Kidney, Diabetes, Ajwa, Antioxidant, histopathology How to cite: Imran I., Mansoor M., Naqvi F., Akhtar M., Arshad W., Khan F. Evaluation of protective effect of Ajwa seed and fruit on renal histopathological changes in diabetic nephropathic rats. Esculapio 2021;17(01):104-109","PeriodicalId":11923,"journal":{"name":"Esculapio","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41886566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0