Induction of Labour with Isosorbide Mononitrate Versus Prostaglandin E2 (PGE2) in Primigravidas (PGs) at Term

Esculapio Pub Date : 2021-07-16 DOI:10.51273/esc21.2517211

Rubina Waheed, Nadia Ashraf, Nadia Sabeen, M. I. U Allah, Qaiser Javed, A. Khalid

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Abstract

Objective: To compare the frequency of caesarean section due to fetal distress with Isosorbide mononitrate versus PGE2 for the induction of labour in primigravida at term. Methods: It was Randomized Control Trial conducted in Unit I, Department of Obstetrics & Gynaecology, Lahore General Hospital, Lahore from 11th April 2015 to 10th October 2015. 230 primigravida were randomized into two groups i.e. Prostaglandin E2 and Isosorbide mononitrate for induction of labour. The difference in the frequency of caesarean section due to fetal distress with Prostaglandin E2 and Isosorbide mononitrate for induction of labour in the primigravidas at term was calculated as outcome. Results: The mean age of 27.62 ± 3.909 ranging from 21 to 34 years. The frequency of cesarean section was 12.2%in Prostaglandin E2 group while 0% in Isosorbide mononitrate. There was no effect of gestational age, age of mother and number of doses on outcome. Conclusion: There is no difference in frequency of cesarean section in primigravida groups induced by either Isosorbide mononitrate versus prostaglandin E2. Wherever applicable and feasible we should opt for Isosorbide mononitrate for induction of labour. Keywords: Cesarean section, Prostaglandin E2, Isosorbide mononitrate, Dinoprostone, Induction of labour, Primigravida How to cite: Waheed R., Ashraf N., Sabeen N., U Allah I.M., Javed Q., Khalid A. Induction of Labour with Isosorbide Mononitrate Versus Prostaglandin E2 (PGE2) in Primigravidas (PGs) at term. Esculapio 2021;17(02):166-169

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单硝酸异山梨酯与前列腺素E2（PGE2）对妊娠期初产妇的引产作用

目的：比较单硝酸异山梨酯与PGE2在初产妇足月引产中因胎儿窘迫而剖腹产的频率。方法：2015年4月11日至2015年10月10日在拉合尔市拉合尔总医院妇产科一单元进行随机对照试验。将230只初产妇随机分为两组，即前列腺素E2组和单硝酸异山梨酯组进行引产。结果计算了初产妇足月引产时因胎儿窘迫而使用前列腺素E2和单硝酸异山梨酯进行剖腹产的频率差异。结果：年龄21～34岁，平均27.62±3.909岁。前列腺素E2组剖宫产的发生率为12.2%，单硝酸异山梨酯组为0%。胎龄、母亲年龄和剂量对结果没有影响。结论：单硝酸异山梨酯和前列腺素E2对初产妇剖宫产的影响无统计学意义。在适用和可行的情况下，我们应选择单硝酸异山梨酯进行引产。关键词：剖宫产，前列腺素E2，单硝酸异山梨酯，地诺前列酮，引产，初产妇如何引用：Waheed R.，Ashraf N.，Sabeen N.，U Allah I.M.，Javed Q.，Khalid A.单硝酸异山梨醇酯引产与初产妇前列腺素E2（PGE2）的比较。Esculapio 2021；17（02）：166-169

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Esculapio

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12 weeks