European Journal of Anaesthesiology最新文献

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Neuromuscular blocking agent drug challenge: a literature review and protocol proposal with biological evaluation. 神经肌肉阻断剂药物挑战:文献综述和生物评估方案建议。
IF 4.2 2区 医学
European Journal of Anaesthesiology Pub Date : 2024-10-01 Epub Date: 2024-06-24 DOI: 10.1097/EJA.0000000000002033
Aurélie Gouel-Chéron, Catherine Neukirch, Sylvie Chollet-Martin, Arnaud Valent, Benoit Plaud, Dan Longrois, Pascale Nicaise-Roland, Philippe Montravers, Luc de Chaisemartin
{"title":"Neuromuscular blocking agent drug challenge: a literature review and protocol proposal with biological evaluation.","authors":"Aurélie Gouel-Chéron, Catherine Neukirch, Sylvie Chollet-Martin, Arnaud Valent, Benoit Plaud, Dan Longrois, Pascale Nicaise-Roland, Philippe Montravers, Luc de Chaisemartin","doi":"10.1097/EJA.0000000000002033","DOIUrl":"10.1097/EJA.0000000000002033","url":null,"abstract":"<p><strong>Background: </strong>Drug challenge is the gold standard for identifying causative agents of drug allergies. Although clinical guidelines have recently been published, they do not recommend neuromuscular blocking agent (NMBA) drug challenges. NMBA challenges are rendered difficult by the lack of homogeneity of routine allergy work-ups and the necessity of a specialised setting. Several scenarios support NMBA challenges, such as an ambiguous allergy work-up, a high suspicion of a false-positive skin test or identification of a well tolerated alternative NMBA strategy. Furthermore, routine allergy work-ups may not recognise non-IgE mechanisms, such as IgG or MRGPRX2, whereas drug challenges may reveal them. Finally, if the culprit NMBA is not identified, subsequent anaesthesia regimens will be challenging to implement, resulting in increased risk.</p><p><strong>Objectives: </strong>This literature review discusses the indications, strategies, doses, monitoring methods, limitations, and unresolved issues related to drug challenges for NMBAs.</p><p><strong>Design: </strong>The literature review included randomised controlled trials, observational studies, reviews, case reports, series, and comments on humans.</p><p><strong>Data sources: </strong>Studies were retrieved from databases (PubMed) and electronic libraries (OVID, EMBASE, Scopus, etc.).</p><p><strong>Eligibility criteria: </strong>All studies that referred to the NMBA challenge were included without publication date limitations.</p><p><strong>Results: </strong>NMBA challenge may be considered in NMBA anaphylaxis patients with inconclusive or ambivalent IgE diagnostic work-up under controlled conditions (presence of anaesthetists and allergists with continuous monitoring in a secured environment). To illustrate its utility, a case report of a double NMBA challenge in a patient with NMBA cross-reactivity is presented, along with biological explorations to detect subclinical cellular activation, a novel aspect of this procedure.</p><p><strong>Conclusion: </strong>Drug challenges could be implemented during the NMBA allergy work-up under strict safety conditions at specialised centres with close collaboration between anaesthetists and allergists. This could decrease uncertainty and contribute to defining a safer strategy for subsequent anaesthetic drug regimens.</p>","PeriodicalId":11920,"journal":{"name":"European Journal of Anaesthesiology","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141445913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of intravenous versus perineural dexamethasone as a local anaesthetic adjunct for peripheral nerve blocks in the lower limb: A meta-analysis and systematic review. 静脉注射地塞米松与硬膜外地塞米松作为下肢周围神经阻滞的局部麻醉辅助药物的比较:荟萃分析和系统综述。
IF 4.2 2区 医学
European Journal of Anaesthesiology Pub Date : 2024-10-01 Epub Date: 2024-07-10 DOI: 10.1097/EJA.0000000000002038
Neel Desai, Suji Pararajasingham, Desire Onwochei, Eric Albrecht
{"title":"Comparison of intravenous versus perineural dexamethasone as a local anaesthetic adjunct for peripheral nerve blocks in the lower limb: A meta-analysis and systematic review.","authors":"Neel Desai, Suji Pararajasingham, Desire Onwochei, Eric Albrecht","doi":"10.1097/EJA.0000000000002038","DOIUrl":"10.1097/EJA.0000000000002038","url":null,"abstract":"<p><strong>Background: </strong>As a local anaesthetic adjunct, the systemic absorption of perineural dexamethasone in the lower limb could be restricted because of decreased vascularity when compared with the upper limb.</p><p><strong>Objectives: </strong>To compare the pharmacodynamic characteristics of intravenous and perineural dexamethasone in the lower limb.</p><p><strong>Design: </strong>Systematic review of randomised controlled trials with meta-analysis.</p><p><strong>Data sources: </strong>Systematic search of Central, Google Scholar, Ovid Embase and Ovid Medline to 18 July 2023.</p><p><strong>Eligibility criteria: </strong>Randomised controlled trials, which compared the intravenous with perineural administration of dexamethasone as a local anaesthetic adjunct in peripheral nerve blocks for surgery of the lower limb.</p><p><strong>Results: </strong>The most common peripheral nerve blocks were femoral, sciatic and ankle block. The local anaesthetic was long acting in all trials and the dose of dexamethasone was 8 mg in most trials. The primary outcome, the duration of analgesia, was investigated by all nine trials ( n  = 546 patients). Overall, compared with intravenous dexamethasone, perineural dexamethasone increased the duration of analgesia from 19.54 to 22.27 h, a mean difference [95% confidence interval (CI) of 2.73 (1.07 to 4.38) h; P  = 0.001, I2  = 87]. The quality of evidence was moderate owing to serious inconsistency. However, analysis based on the location of the peripheral nerve block, the type of local anaesthetic or the use of perineural adrenaline showed no difference in duration between intravenous and perineural dexamethasone. No differences were shown for any of the secondary outcomes related to efficacy and side effects.</p><p><strong>Conclusion: </strong>In summary, moderate evidence supports the superiority of perineural dexamethasone over intravenous dexamethasone in prolonging the duration of analgesia. However, this difference is unlikely to be clinically relevant. Consideration of the perineural use of dexamethasone should recognise that this route of administration remains off label.</p>","PeriodicalId":11920,"journal":{"name":"European Journal of Anaesthesiology","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11377050/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141579280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The degree of respiratory depression according to the effect-site concentration in remimazolam target-controlled infusion: A randomised controlled trial. 根据雷马唑仑靶控输注的效应部位浓度确定呼吸抑制程度:随机对照试验。
IF 4.2 2区 医学
European Journal of Anaesthesiology Pub Date : 2024-10-01 Epub Date: 2024-07-29 DOI: 10.1097/EJA.0000000000002045
Soo Jung Park, Sang Kee Min, Gyubin Choi, Ji Eun Kim, Ha Yeon Kim
{"title":"The degree of respiratory depression according to the effect-site concentration in remimazolam target-controlled infusion: A randomised controlled trial.","authors":"Soo Jung Park, Sang Kee Min, Gyubin Choi, Ji Eun Kim, Ha Yeon Kim","doi":"10.1097/EJA.0000000000002045","DOIUrl":"10.1097/EJA.0000000000002045","url":null,"abstract":"<p><strong>Background: </strong>Remimazolam is not only associated with a lower incidence of respiratory depression than propofol but also in itself has the risk of respiratory depression.</p><p><strong>Objective: </strong>We investigated respiratory depression following remimazolam infusion, targeting different effect-site concentrations using target-controlled infusion.</p><p><strong>Design: </strong>A prospective, double-blind, randomised controlled study.</p><p><strong>Setting: </strong>Tertiary hospital, Suwon, South Korea, from April 2022 to November 2022.</p><p><strong>Participants: </strong>One hundred and seven patients scheduled for general anaesthesia were randomised into three groups targeting remimazolam effect-site concentrations of 500 (RMZ-500) ( n  = 36), 1000 (RMZ-1000) ( n  = 35) and 1500 ng ml -1 (RMZ-1500) ( n  = 36).</p><p><strong>Interventions: </strong>Remimazolam was solely infused for 10 min according to target effect-site concentrations. According to the degree of SpO 2 decrease, oxygen desaturations were managed with the following respiratory supports: jaw-thrust for SpO 2 less than 97%, 100% oxygen delivery for SpO 2 less than 93% and assisted ventilation for SpO 2 less than 90%.</p><p><strong>Main outcome measures: </strong>The incidence of each respiratory support, along with respiratory variables (at baseline, 5 min and 10 min after remimazolam infusion) and loss of consciousness were observed for 10 min after remimazolam target-controlled infusion.</p><p><strong>Results: </strong>Both RMZ-1000 and RMZ-1500 required more frequent respiratory support than RMZ-500 (both P  < 0.001), with nearly identical frequencies between RMZ-1000 and RMZ-1500. In terms of respiratory support, the incidence of assisted ventilation was significantly lower in RMZ-500 (2.8%) than RMZ-1000 (48.6%) and RMZ-1500 (50%) ( P  < 0.001). RMZ-1000 and RMZ-1500 achieved loss of consciousness in all patients; RMZ-500 only achieved loss of consciousness in 86.1% of patients ( P  = 0.010). In patients who maintained spontaneous respiration, tidal volume decreased by 41 to 48% and respiratory rate increased by 118 to 158% at 5 and 10 min, significantly compared to baseline in all groups ( P  < 0.001).</p><p><strong>Conclusions: </strong>Remimazolam infusion, like that of other benzodiazepines, led to respiratory depression, which was more prominent at higher target effect-site concentrations. Therefore, appropriate countermeasures should be developed to prevent oxygen desaturation.</p><p><strong>Trial registration: </strong>CRIS ( https://cris.nih.go.kr ), identifier: KCT0006952.</p>","PeriodicalId":11920,"journal":{"name":"European Journal of Anaesthesiology","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141792195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Positive impact of a nurse consultation on retention of information by outpatient after anaesthesia consultation: A randomised study. 护士咨询对门诊患者在麻醉咨询后保留信息的积极影响:随机研究。
IF 4.2 2区 医学
European Journal of Anaesthesiology Pub Date : 2024-10-01 Epub Date: 2024-09-11 DOI: 10.1097/EJA.0000000000002051
Vincent Compère, Etienne Allard, Quentin Robert, Thomas Clavier, Emmanuel Besnier, Julien Kallout, Jean Selim
{"title":"Positive impact of a nurse consultation on retention of information by outpatient after anaesthesia consultation: A randomised study.","authors":"Vincent Compère, Etienne Allard, Quentin Robert, Thomas Clavier, Emmanuel Besnier, Julien Kallout, Jean Selim","doi":"10.1097/EJA.0000000000002051","DOIUrl":"10.1097/EJA.0000000000002051","url":null,"abstract":"","PeriodicalId":11920,"journal":{"name":"European Journal of Anaesthesiology","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142125100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mild therapeutic hypothermia after cardiac arrest - effect on survival with good neurological outcome outside of randomised controlled trials: A registry-based analysis. 心脏骤停后的轻度治疗性低温--在随机对照试验之外对神经功能良好的存活率的影响:基于登记的分析。
IF 4.2 2区 医学
European Journal of Anaesthesiology Pub Date : 2024-10-01 Epub Date: 2024-05-27 DOI: 10.1097/EJA.0000000000002016
Jürgen Knapp, Richard Steffen, Markus Huber, Sandra Heilman, Stefan Rauch, Michael Bernhard, Matthias Fischer
{"title":"Mild therapeutic hypothermia after cardiac arrest - effect on survival with good neurological outcome outside of randomised controlled trials: A registry-based analysis.","authors":"Jürgen Knapp, Richard Steffen, Markus Huber, Sandra Heilman, Stefan Rauch, Michael Bernhard, Matthias Fischer","doi":"10.1097/EJA.0000000000002016","DOIUrl":"10.1097/EJA.0000000000002016","url":null,"abstract":"<p><strong>Background: </strong>For nearly 20 years, in international guidelines, mild therapeutic hypothermia (MTH) was an important component of postresuscitation care. However, recent randomised controlled trials have questioned its benefits. At present, international guidelines only recommend actively preventing fever, but there are ongoing discussions about whether the majority of cardiac arrest patients could benefit from MTH treatment.</p><p><strong>Objective: </strong>The aim of this study was to compare the outcome of adult patients treated with and without MTH after cardiac arrest.</p><p><strong>Design: </strong>Observational cohort study.</p><p><strong>Setting: </strong>German Resuscitation Registry covering more than 31 million inhabitants of Germany and Austria.</p><p><strong>Patients: </strong>All adult patients between 2006 and 2022 with out-of-hospital or in-hospital cardiac arrest and comatose on admission.</p><p><strong>Main outcome measures: </strong>Primary endpoint: hospital discharge with good neurological outcome [cerebral performance categories (CPC) 1 or 2]. Secondary endpoint: hospital discharge. We used a multivariate binary logistic regression analysis to identify the effects on outcome of all known influencing variables.</p><p><strong>Results: </strong>We analysed 33 933 patients (10 034 treated with MTH, 23 899 without MTH). The multivariate regression model revealed that MTH was an independent predictor of CPC 1/2 survival and of hospital discharge with odds ratio (95% confidence intervals) of 1.60 (1.49 to 1.72), P < 0.001 and 1.89 (1.76 to 2.02), P < 0.001, respectively.</p><p><strong>Conclusion: </strong>Our data indicate the existence of a positive association between MTH and a favourable neurological outcome after cardiac arrest. It therefore seems premature to refrain from giving MTH treatment for the entire spectrum of patients after cardiac arrest. Further prospective studies are needed.</p>","PeriodicalId":11920,"journal":{"name":"European Journal of Anaesthesiology","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11377051/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142125098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pre-operative anaemia in nonagenarians and centenarians undergoing hip fracture surgery: A retrospective cohort study. 接受髋部骨折手术的非长者和百岁老人术前贫血:一项回顾性队列研究。
IF 4.2 2区 医学
European Journal of Anaesthesiology Pub Date : 2024-09-26 DOI: 10.1097/EJA.0000000000002074
Jake V Hinton, Luke Fletcher, Cilla J Haywood, Laurence Weinberg
{"title":"Pre-operative anaemia in nonagenarians and centenarians undergoing hip fracture surgery: A retrospective cohort study.","authors":"Jake V Hinton, Luke Fletcher, Cilla J Haywood, Laurence Weinberg","doi":"10.1097/EJA.0000000000002074","DOIUrl":"https://doi.org/10.1097/EJA.0000000000002074","url":null,"abstract":"","PeriodicalId":11920,"journal":{"name":"European Journal of Anaesthesiology","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142344070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Positive end-expiratory pressure and emergence preoxygenation after bariatric surgery: A randomised controlled trial on postoperative oxygenation. 减肥手术后的呼气末正压和出现前吸氧:术后氧合的随机对照试验。
IF 4.2 2区 医学
European Journal of Anaesthesiology Pub Date : 2024-09-24 DOI: 10.1097/EJA.0000000000002071
Erland Östberg, Alexander Larsson, Philippe Wagner, Staffan Eriksson, Lennart Edmark
{"title":"Positive end-expiratory pressure and emergence preoxygenation after bariatric surgery: A randomised controlled trial on postoperative oxygenation.","authors":"Erland Östberg, Alexander Larsson, Philippe Wagner, Staffan Eriksson, Lennart Edmark","doi":"10.1097/EJA.0000000000002071","DOIUrl":"10.1097/EJA.0000000000002071","url":null,"abstract":"<p><strong>Background: </strong>Positive end-expiratory pressure (PEEP) is important to increase lung volume and counteract airway closure during anaesthesia, especially in obese patients. However, maintaining PEEP during emergence preoxygenation might increase postoperative atelectasis by allowing susceptible lung areas to be filled with highly absorbable oxygen that gets entrapped when small airways collapse due to the sudden loss of PEEP at extubation.</p><p><strong>Objective: </strong>This study aimed to test the hypothesis that withdrawing PEEP just before emergence preoxygenation would better maintain postoperative oxygenation.</p><p><strong>Design: </strong>Prospective, randomised controlled trial.</p><p><strong>Setting: </strong>Single centre secondary hospital in Sweden between December 2019 and January 2023.</p><p><strong>Patients: </strong>A total of 60 patients, with body mass index between 35 and 50 kg m -2 , undergoing laparoscopic bariatric surgery.</p><p><strong>Intervention: </strong>Intraoperative ventilation was the same for all patients with a fixed PEEP of 12 or 14 cmH 2 O depending on body mass index. No recruitment manoeuvres were used. After surgery, patients were allocated to maintained PEEP or zero PEEP during emergence preoxygenation.</p><p><strong>Main outcome measures: </strong>The primary outcome was change in oxygenation from before awakening to 45 min postoperatively as measured by estimated venous admixture calculated from arterial blood gases.</p><p><strong>Results: </strong>Both groups had impaired oxygenation postoperatively; in the group with PEEP maintained during awakening, estimated venous admixture increased by mean 9.1%, and for the group with zero PEEP during awakening, estimated venous admixture increased by mean 10.6%, difference -1.5% (95% confidence interval -4.6 to 1.7%), P  = 0.354. Throughout anaesthesia, both groups exhibited low driving pressures and superior oxygenation compared with the awake state.</p><p><strong>Conclusions: </strong>Withdrawing PEEP before emergence preoxygenation, did not alter early postoperative oxygenation in obese patients undergoing laparoscopic bariatric surgery. Intraoperative oxygenation was excellent despite using fixed PEEP and no recruitment manoeuvres, but deteriorated after extubation, indicating a need for future studies aimed at improving the emergence procedure.</p><p><strong>Clinical trial number and registry: </strong>www.clinicaltrials.gov , NCT04150276. Registration date: 4 November 2019. Principal investigator: Erland Östberg.</p>","PeriodicalId":11920,"journal":{"name":"European Journal of Anaesthesiology","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142344069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The burden of pre-operative anaemia and postoperative outcomes in 15 166 surgical patients from a public hospital in Brazil: A retrospective cohort study. 巴西一家公立医院 15 166 名手术患者的术前贫血负担和术后结果:一项回顾性队列研究。
IF 4.2 2区 医学
European Journal of Anaesthesiology Pub Date : 2024-09-24 DOI: 10.1097/EJA.0000000000002070
Clarissa Mendanha, Paulo C S Neto, Rogério B Borges, Isabela Sirtoli, Cleiton S Pando, Mariana Brandão, Alexandre Weber, Leo Sekini, Luciana Cadore Stefani
{"title":"The burden of pre-operative anaemia and postoperative outcomes in 15 166 surgical patients from a public hospital in Brazil: A retrospective cohort study.","authors":"Clarissa Mendanha, Paulo C S Neto, Rogério B Borges, Isabela Sirtoli, Cleiton S Pando, Mariana Brandão, Alexandre Weber, Leo Sekini, Luciana Cadore Stefani","doi":"10.1097/EJA.0000000000002070","DOIUrl":"https://doi.org/10.1097/EJA.0000000000002070","url":null,"abstract":"<p><strong>Background: </strong>Preoperative anaemia is associated with poor postoperative outcomes; however, few studies have reported its prevalence in developing countries and its association with significant postoperative outcomes.</p><p><strong>Objective: </strong>We aimed to identify the prevalence of anaemia and its association with postoperative outcomes in a major public hospital in Brazil.</p><p><strong>Design: </strong>Retrospective cohort study.</p><p><strong>Setting: </strong>Single-centre, 860-bed, quaternary university-affiliated teaching hospital in Southern Brazil.</p><p><strong>Patients: </strong>We included adult patients who had undergone surgery between 2015 and 2019. Main outcome measures: The main outcome was the in-hospital 30-day postoperative mortality. According to the World Health Organisation, we defined anaemia and its sub-classification (mild, moderate, and severe). We developed Poisson regression models to examine the association between preoperative anaemia and outcomes.</p><p><strong>Results: </strong>We included 15 166 patients, of whom 6387 (42.1%) were anaemic. After adjustment for confounding factors, patients with anaemia had an increased risk of in-hospital 30-day postoperative mortality (relative risk (RR) 1.69, 95% confidence interval (CI) 1.44 to 1.99, P < 0.001). Mild [relative risk (RR) 1.38, 95% CI 1.12 to 1.71, P = 0.003], moderate (RR 1.73, 95% CI 1.43 to 2.10, P < 0.001), and severe anaemia (RR 2.43, 95% CI 1.92 to 3.07, P < 0.001) were associated with the primary outcome. Anaemia increased the transfusion risk (RR 4.44, 95% CI 3.90 to 5.06, P < 0.001) and postoperative intensive care unit (ICU) admission (RR 1.09, 95% CI 1.04 to 1.16, P = 0.001).</p><p><strong>Conclusions: </strong>Four out of 10 patients had anaemia. These patients had an increased risk of adverse postoperative outcomes. Comprehension of the magnitude and impact of anaemia is essential to establish interventions in low-resource scenarios to optimise the patient's journey.</p><p><strong>Study registration: </strong>Institutional Review Board Registration number 40522820000005327 (Brazilian CEP/CONEP System, available in https://plataformabrasil.saude.gov.br/).</p>","PeriodicalId":11920,"journal":{"name":"European Journal of Anaesthesiology","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142344071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bacterial contamination and greenhouse gas emissions: A randomised study of reuse versus single-use of infusion-set components for intravenous anaesthesia. 细菌污染与温室气体排放:静脉麻醉输液器组件重复使用与一次性使用的随机研究。
IF 3.6 2区 医学
European Journal of Anaesthesiology Pub Date : 2024-09-17 DOI: 10.1097/eja.0000000000002067
Snorri Laxdal Karlsson,Jon Edman-Wallér,Magni Vidar Gudmundsson,Peter Bentzer,Per Werner Moller
{"title":"Bacterial contamination and greenhouse gas emissions: A randomised study of reuse versus single-use of infusion-set components for intravenous anaesthesia.","authors":"Snorri Laxdal Karlsson,Jon Edman-Wallér,Magni Vidar Gudmundsson,Peter Bentzer,Per Werner Moller","doi":"10.1097/eja.0000000000002067","DOIUrl":"https://doi.org/10.1097/eja.0000000000002067","url":null,"abstract":"BACKGROUNDReusing anaesthesia infusion-set components may reduce the climate impact from plastic waste and discarded medications. Infusion-set contents can be shielded from patient contact by single use of an infusion line fitted with dual antireflux valves, preventing retrograde entry of microorganisms, and eliminating the risk for patient-to-patient cross-contamination. However, infusion-set contamination from compromised aseptic handling could affect quality of care.INTERVENTIONSTo determine the prevalence of infusion-set bacterial contamination and compare the climate effects, we randomised operating rooms scheduled for total intravenous anaesthesia to handle procedures by infusion-set reuse or single-use. Both methods used dual single-use antireflux valves.OUTCOMESThe primary outcome was infusion-set bacterial contamination assessed by aerobic culture of infusion-set fluid collected after each procedure. The secondary outcome was CO 2 emissions (CO 2 -eq) estimated by life cycle assessment of component and medication use. To assess feasibility of detecting an inter-method difference in bacterial contamination, an interim analysis was planned after including at least 150 procedures per group.RESULTSAfter allocating 54 operating rooms per method, 189 and 159 procedures of reuse and single use were included. Reuse permitted a median of three procedures per infusion set (range 1 to 8). Positive cultures occurred in two procedures per method [mean (95% CI)]; prevalence 1.15% (0.03 to 2.27); relative risk of reuse versus single use 0.84 (0.12 to 5.93), P  = 0.861. As prespecified, inclusion was stopped due to futility. The median (95% CI) per-procedure climate emissions were 0.43 (0.41 to 0.47) and 1.39 (1.37 to 1.40) kg CO 2 -eq for reuse and single-use respectively; difference -0.96 (-0.99 to -0.93), P  < 0.0005. The main sources for climate emissions were production of infusion-set components and waste handling.CONCLUSIONSWe conclude that the prevalence of bacterial contamination was low for both methods. A much larger study would be needed to detect an inter-method difference. Reuse of infusion-set components allowed significantly reduced intravenous anaesthesia climate emissions.","PeriodicalId":11920,"journal":{"name":"European Journal of Anaesthesiology","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142248663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A survey and analysis of peri-operative quality indicators promoted by National Societies of Anaesthesiologists in Europe: The EQUIP project. 欧洲各国麻醉医师协会推广的围手术期质量指标调查与分析:EQUIP 项目。
IF 3.6 2区 医学
European Journal of Anaesthesiology Pub Date : 2024-09-12 DOI: 10.1097/eja.0000000000002054
Johannes Wacker,Guy Haller,Jan F A Hendrickx,Martin Ponschab
{"title":"A survey and analysis of peri-operative quality indicators promoted by National Societies of Anaesthesiologists in Europe: The EQUIP project.","authors":"Johannes Wacker,Guy Haller,Jan F A Hendrickx,Martin Ponschab","doi":"10.1097/eja.0000000000002054","DOIUrl":"https://doi.org/10.1097/eja.0000000000002054","url":null,"abstract":"BACKGROUNDTo capture preventable peri-operative patient harm and guide improvement initiatives, many quality indicators (QIs) have been developed. Several National Anaesthesiologist Societies (NAS) in Europe have implemented quality indicators. To date, the definitions, validity and dissemination of such quality indicators, and their comparability with validated published indicators are unknown.OBJECTIVESThe aim of this study was to identify all quality indicators promoted by NAS in Europe, to assess their characteristics and to compare them with published validated quality indicators.DESIGNA cross-sectional study with mixed methods analysis. Using a survey questionnaire, representatives of 37 NAS were asked if their society provided quality indicators to their members and, if so, to provide the list, definitions and details of quality indicators. Characteristics of reported quality indicators were analysed.SETTINGThe 37 NAS affiliated with the European Society of Anaesthesiology and Intensive Care (ESAIC) at the time. Data collection, translations: March 2018 to February 2020.PARTICIPANTSRepresentatives of all 37 NAS completed the survey.MAIN OUTCOME MEASURESQIs reported by NAS.RESULTSOnly 12 (32%) of the 37 NAS had made a set of quality indicators available to their members. Data collection was mandatory in six (16.2%) of the 37 countries. We identified 163 individual quality indicators, which were most commonly descriptive (60.1%), anaesthesia-specific (50.3%) and related to intra-operative care (21.5%). They often measured structures (41.7%) and aspects of safety (35.6%), appropriateness (20.9%) and prevention (16.6%). Patient-centred care (3.7%) was not well covered. Only 11.7% of QIs corresponded to published validated or well established quality indicator sets.CONCLUSIONSFew NAS in Europe promoted peri-operative quality indicators. Most of them differed from published sets of validated indicators and were often related to the structural dimension of quality. There is a need to establish a European-wide comprehensive core set of usable and validated quality indicators to monitor the quality of peri-operative care.TRIAL REGISTRATIONNo registration.","PeriodicalId":11920,"journal":{"name":"European Journal of Anaesthesiology","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142207593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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