European Journal of Anaesthesiology最新文献

{"title":"The effects of intraoperative low-dose dexmedetomidine on postoperative systemic inflammation and cognitive outcomes in elderly patients: Secondary analysis of a randomised controlled trial.","authors":"Luis I Cortinez, Gonzalo Boncompte, Karen Azagra, Víctor Contreras","doi":"10.1097/EJA.0000000000002299","DOIUrl":"https://doi.org/10.1097/EJA.0000000000002299","url":null,"abstract":"","PeriodicalId":11920,"journal":{"name":"European Journal of Anaesthesiology","volume":" ","pages":""},"PeriodicalIF":6.8,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145307234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Point-of-care visco-elastic testing for postpartum haemorrhage: A narrative review.","authors":"Hans Vandersmissen, Eva Roofthooft, Sarah Devroe, Steven Thiessen, Hendrik Stragier","doi":"10.1097/EJA.0000000000002293","DOIUrl":"https://doi.org/10.1097/EJA.0000000000002293","url":null,"abstract":"<p><p>Postpartum haemorrhage (PPH) remains a leading cause of maternal morbidity and mortality worldwide. While coagulation disorders are seldom the primary cause of PPH and are rare early in PPH, the incidence of coagulation abnormalities increases when blood loss escalates. Acute obstetric coagulopathy (AOC), with an incidence of one in 1000 deliveries, has emerged as a distinct coagulopathy in PPH, highlighting the need for timely coagulation testing and intervention. This narrative review examines the current evidence on the use of visco-elastic haemostatic assays (VHAs) to guide treatment in PPH, and further explores the prophylactic and therapeutic roles of fibrinogen and tranexamic acid (TXA). VHAs have shown potential in PPH management, with large prospective and retrospective cohort studies demonstrating reductions in transfusions and transfusion-related complications. However, these findings have not been consistently replicated, possibly due to variations in study design and statistical power. This review explores the benefits and limitations of VHAs in the context of PPH management. Until large, well designed studies suggest otherwise, women with PPH might benefit from access to VHAs, given their potential to improve clinical outcomes in large cohorts without evidence of associated harm. Fibrinogen replacement is essential in PPH management. VHAs have been shown to be as effective as the Clauss fibrinogen assay in guiding fibrinogen substitution during PPH. Recent updates to ROTEM Sigma cartridges have led to new FIBTEM A5 thresholds, with the Obstetric Bleeding Strategy (OBS) group of Wales proposing a FIBTEM A5 of 8 mm or less as the new trigger for fibrinogen replacement in PPH. Fibrinogen concentrate offers advantages over cryoprecipitate and may be preferred when both are available. Effective fibrinogen substitution not only corrects VHA results but also helps to control bleeding. TXA is a cornerstone in the treatment of PPH and should be administered promptly at a dose of 1 g as soon as PPH is diagnosed, regardless of VHA results, and always within three hours of onset. A second dose may be given if bleeding persists or recurs. However, high-quality randomised trials have consistently shown no benefit from prophylactic TXA in low-risk caesarean section or in vaginal births across all risk groups. Data on the prophylactic use of TXA in high-risk caesarean section are limited and its use in these cases should be based on clinical judgement and individual risk assessment.</p>","PeriodicalId":11920,"journal":{"name":"European Journal of Anaesthesiology","volume":" ","pages":""},"PeriodicalIF":6.8,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145285969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of the dopamine D2 receptor polymorphism rs1800497 with postoperative nausea and vomiting: Potential sex differences.","authors":"Hagen S Bachmann, Maike Stegen, Dominik Jung, Lea Weber, Thorsten Brenner, Stefanie Klenke","doi":"10.1097/EJA.0000000000002298","DOIUrl":"https://doi.org/10.1097/EJA.0000000000002298","url":null,"abstract":"","PeriodicalId":11920,"journal":{"name":"European Journal of Anaesthesiology","volume":" ","pages":""},"PeriodicalIF":6.8,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145279298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pain management for laparoscopic sleeve gastrectomy: An update of the systematic review and procedure-specific postoperative pain management (PROSPECT) recommendations.","authors":"Niels Debel, Eline Snijkers, Marc van de Velde, Girish P Joshi, Axel R Sauter, Stephan Freys, Esther Pogatzki-Zahn, Geertrui Dewinter","doi":"10.1097/EJA.0000000000002296","DOIUrl":"https://doi.org/10.1097/EJA.0000000000002296","url":null,"abstract":"<p><strong>Background: </strong>Bariatric surgery, particularly laparoscopic sleeve gastrectomy, is an effective and pivotal treatment for obesity. Patients undergoing laparoscopic sleeve gastrectomy commonly experience moderate pain in the immediate postoperative period. Therefore, optimal pain management is crucial.</p><p><strong>Objective: </strong>The aim of this review was to update the recommendations for pain management following laparoscopic sleeve gastrectomy, building upon the 2019 guidelines.</p><p><strong>Design: </strong>A systematic review was conducted using the PROSPECT methodology.</p><p><strong>Data sources: </strong>Randomised controlled clinical trials (RCTs) and systematic reviews concerning analgesic, anaesthetic and operative interventions, focusing on pain management for patients undergoing laparoscopic sleeve gastrectomy, were identified through searches in MEDLINE, EMBASE and Cochrane Databases from September 2018 until February 2024. Primary outcome included pain scores. We used the Rob 2 tool as our method to assess the risk of bias in the included studies.</p><p><strong>Results: </strong>The previous review included data from 18 RCTs. Since then, 188 eligible studies were identified, of which 39 RCTs and two meta-analyses met our inclusion criteria. In addition to paracetamol and NSAIDs or cyclooxygenase (COX)-2 specific inhibitors, ultrasound or laparoscopic-guided bilateral transversus abdominis plane (TAP) blocks and port-site local anaesthetic infiltration are recommended. In addition, intra-operative intravenous dexamethasone is recommended for analgesia and prevention of postoperative nausea and vomiting. Opioids are reserved for rescue treatment.</p><p><strong>Conclusions: </strong>This systematic review identified an evidence-based analgesic regimen for laparoscopic sleeve gastrectomy. Our current recommendations differ from the previous ones in that a TAP block is now recommended, and gabapentinoids are no longer advised.</p><p><strong>Prospero registration number: </strong>CRD42023487108.</p>","PeriodicalId":11920,"journal":{"name":"European Journal of Anaesthesiology","volume":" ","pages":""},"PeriodicalIF":6.8,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145279255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic pain after major breast surgery: A retrospective cohort study.","authors":"Victor Van Lishout, Steffen Rex, Steffen Fieuws, Sileny Han, An Teunkens","doi":"10.1097/EJA.0000000000002285","DOIUrl":"https://doi.org/10.1097/EJA.0000000000002285","url":null,"abstract":"<p><strong>Background: </strong>Breast surgery is a cornerstone in the treatment of breast cancer but can cause persistent or worsening pain lasting beyond 3 months. Perioperative risk factors for chronic pain remain an area of ongoing research.</p><p><strong>Objective: </strong>To assess the incidence of chronic pain following breast surgery and identify its associated factors.</p><p><strong>Design: </strong>A retrospective cohort study.</p><p><strong>Setting: </strong>A single high-volume tertiary medical centre.</p><p><strong>Patients: </strong>Women undergoing first-time unilateral breast surgery as part of breast cancer treatment, without pre-existing chronic pain, between January 2020 and September 2022.</p><p><strong>Main outcome measures: </strong>The incidence of chronic postoperative pain at 3 and 6 months, pain scores, perioperative and in-hospital analgesic use, and predictive factors related to anaesthetic and treatment modalities.</p><p><strong>Methods: </strong>Univariable and multivariable analysis of peri-operative data associated with chronic postoperative pain at 3 and 6 months. A multivariable model was constructed by stepwise selection of data.</p><p><strong>Results: </strong>Chronic pain was reported in 32% (95% confidence interval (CI), 28.8 to 35.4%) of patients at 3 months and in 39% (95% CI, 35.9 to 42.2%) at 6 months postoperatively. During postanaesthetic care, 31% of patients recorded a pain score above four on the numeric rating scale (NRS), while 3% reported a score above seven. On subsequent days, the mean pain score fell below one. The use of sufentanil and propofol during general anaesthesia was strongly associated with a lower incidence of pain at 3 months, odds ratio (OR) 0.548 (95% CI 0.381 to 0.788) P = 0.0012, as well as sentinel node biopsy, OR 0.520 (95% CI 0.274 to 0.988) P = 0.0459. Adjuvant radiotherapy, OR 3.294 (95% CI 1.610 to 6.741) P = 0.0011, and the presence of chronic pain at 3 months, OR 10.706 (95% CI 7.399 to 15.489) P < 0.0001, were the strongest predictors of persistent pain at 6 months. Mastectomy, OR 0.610 (95% CI 0.456 to 0.817) P = 0.0009, and age, OR 0.983 (95% CI 0.972 to 0.995) P = 0.0051, were significantly associated after model construction.</p><p><strong>Conclusions: </strong>Multiple factors are associated with chronic pain following breast surgery. While perioperative factors play a role, long-term treatment modalities also significantly influence its occurrence.</p>","PeriodicalId":11920,"journal":{"name":"European Journal of Anaesthesiology","volume":" ","pages":""},"PeriodicalIF":6.8,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145206011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"'The trachea heals but the hypoxia does not' an emergency front-of-neck access in a 4-year-old with foreign body airway obstruction.","authors":"Sigrun Asgeirsdottir, Elias K Karlsson, Theodor Sigurdsson","doi":"10.1097/EJA.0000000000002230","DOIUrl":"10.1097/EJA.0000000000002230","url":null,"abstract":"<p><p>'Can't Intubate Can't Oxygenate' (CICO) situation is a life-threatening emergency, and an uncommon event in the healthy paediatric population. In children without anatomical airway anomalies, this scenario is most often due to laryngospasm or airway obstruction and can in most cases, be reversed with appropriate medical treatment or removal of the foreign body. This case report describes an emergency front-of-neck surgical airway (eFONA) with a scalpel-bougie-tube method, during cardiopulmonary resuscitation in a 4-year-old child due to foreign body airway obstruction.</p>","PeriodicalId":11920,"journal":{"name":"European Journal of Anaesthesiology","volume":" ","pages":"945-947"},"PeriodicalIF":6.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144575104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of analgesic efficacy and safety of caudal dexmedetomidine versus intranasal dexmedetomidine in paediatric infraumbilical surgeries: A randomised controlled trial.","authors":"Ayushi Agarwal, Shreya B Shah, Renu Sinha, Ganga Prasad, Kelika Prakash, Prabudh Goel","doi":"10.1097/EJA.0000000000002228","DOIUrl":"10.1097/EJA.0000000000002228","url":null,"abstract":"<p><strong>Background: </strong>The established analgesic efficacy and safety of dexmedetomidine in children has demonstrated a rise in its use and various administration routes have been explored. However, clinical comparisons between caudal and intranasal dexmedetomidine are lacking.</p><p><strong>Objectives: </strong>We aimed to compare the analgesic efficacy, postanaesthesia recovery characteristics and side effects associated with caudal versus intranasal dexmedetomidine as an adjunct to a single-shot caudal block in paediatric infraumbilical surgeries.</p><p><strong>Design: </strong>A noninferiority randomised controlled trial.</p><p><strong>Setting: </strong>A tertiary care hospital from November 2022 to May 2024.</p><p><strong>Patients: </strong>Sixty-four children aged 1 to 8 years undergoing infraumbilical surgeries under general anaesthesia supplemented with caudal analgesia.</p><p><strong>Interventions: </strong>Patients were randomised to receive either caudal dexmedetomidine (1 ml kg -1 caudal 0.2% ropivacaine + 1 μg kg -1 caudal dexmedetomidine) or intranasal dexmedetomidine (1 ml kg -1 caudal 0.2% ropivacaine + 1 μg kg -1 intranasal dexmedetomidine).</p><p><strong>Main outcome measures: </strong>The primary outcome was the duration of postoperative analgesia. Other outcomes assessed included postoperative pain scores, peri-operative analgesic consumption, peri-operative haemodynamics, postoperative recovery profile and adverse events for 24 h postoperatively.</p><p><strong>Results: </strong>The duration of postoperative analgesia in caudal and intranasal group was 527 ± 83 and 545 ± 90 min, respectively ( P   =  0.422). There was a comparable decrease in the intra-operative heart rate. The greater number of episodes of intra-operative hypotension in the caudal group ( P   =  0.016) did not warrant vasopressors. Children in the caudal group were more sedated until 2 h postsurgery following which the sedation scores in both the groups were equivalent. Postoperative pain scores, peri-operative analgesic consumption and the incidence of emergence delirium was comparable. No adverse events were reported in either group.</p><p><strong>Conclusion: </strong>Intranasal dexmedetomidine can be considered a feasible analgesic adjunct to a single-injection caudal block in children undergoing infraumbilical surgeries associated with a smooth recovery profile and no associated adverse effects.</p><p><strong>Clinical trial registration: </strong>Clinical Trial Registry of India (CTRI/2022/09/045492; http://www.ctri.nic.in ).</p>","PeriodicalId":11920,"journal":{"name":"European Journal of Anaesthesiology","volume":" ","pages":"899-906"},"PeriodicalIF":6.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144505231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraoperative hypotension during robotic-assisted radical prostatectomy: A randomised controlled trial comparing standard goal-directed fluid therapy with hypotension prediction index-guided goal-directed fluid therapy.","authors":"Cotoia Antonella, Antonello Discenza, Michela Rauseo, Mario Matella, Girolamo Caggianelli, Rossana Ciaramelletti, Lucia Mirabella, Gilda Cinnella","doi":"10.1097/EJA.0000000000002211","DOIUrl":"10.1097/EJA.0000000000002211","url":null,"abstract":"<p><strong>Background: </strong>Robot-assisted radical prostatectomy (RARP) represents the leading application of robotic surgery in the treatment for prostate cancer with faster recovery and reduced invasiveness. Maintaining stable blood pressure during RARP is crucial to avoid complications. The approach used is goal-directed therapy (GDT); however, the Hypotension Prediction Index (HPI), a machine learning algorithm that analyses arterial waveforms, may provide additional benefits.</p><p><strong>Objective: </strong>To evaluate the cumulative amount, frequency and duration of intraoperative hypotension episodes in patients undergoing RARP, comparing those managed with a GDT protocol guided by the HPI algorithm versus those managed without it.</p><p><strong>Design: </strong>Prospective randomised study.</p><p><strong>Setting: </strong>Single-centre university hospital. Recruitment from January 2022 to April 2023.</p><p><strong>Participants: </strong>Eighty-two patients.</p><p><strong>Interventions: </strong>Patients undergoing RARP were randomly assigned to either a GDT protocol alone (control) or a GDT protocol guided by the HPI (HPI group). All patients received both general anaesthesia and a single-shot spinal technique.</p><p><strong>Mean outcome measures: </strong>Cumulative amount of intraoperative hypotension [measured using the time-weighted average (TWA) of mean arterial pressure (MAP) below 65 mmHg]; frequency of hypotensive events; duration of hypotensive events; postoperative complications; length of stay.</p><p><strong>Results: </strong>No differences were observed in TWA-MAP, or in the frequency and duration of hypotensive events between the groups. Both groups maintained stable haemodynamics with minimal hypotension, and had similar fluid infusion and vasoconstrictor administration. Additionally, there were no differences in postoperative complications or length of stay.</p><p><strong>Conclusions: </strong>In our study, HPI guidance did not reduce intraoperative hypotension during RARP. Interestingly, the control group experienced fewer hypotensive events than typically reported in the literature, likely because of the high standards of haemodynamic and anaesthesiologic management maintained across both groups.</p><p><strong>Trial registration: </strong>Clinicaltrials.gov identifier: NCT06535464.</p>","PeriodicalId":11920,"journal":{"name":"European Journal of Anaesthesiology","volume":" ","pages":"916-923"},"PeriodicalIF":6.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12422612/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial commitment to trust and integrity in science: Implications for pain and anaesthesiology research.","authors":"Tonya M Palermo, Didier Bouhassira, Karen D Davis, Hugh C Hemmings, Robert W Hurley, Joel Katz, Jaideep J Pandit, Theodore J Price, Michael E Schatman, Stephan K W Schwarz, Dennis C Turk, Marc Van de Velde, Matthew D Wiles, Tony L Yaksh, David Yarnitsky","doi":"10.1097/EJA.0000000000002237","DOIUrl":"10.1097/EJA.0000000000002237","url":null,"abstract":"","PeriodicalId":11920,"journal":{"name":"European Journal of Anaesthesiology","volume":" ","pages":"866-871"},"PeriodicalIF":6.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12422606/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144642144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential effects of propofol anaesthesia across three amplitude-defined electroencephalographic states in sedated critically ill term neonates: An observational study.","authors":"Gonzalo Boncompte, Luis I Cortínez, Alberto Toso, Ady Giordano, Francisco Cruzat, Ricardo Fuentes, Juan C Pedemonte, Victor Contreras, Daniela Biggs, Esteban Chiu, Mauricio Ibacache","doi":"10.1097/EJA.0000000000002208","DOIUrl":"10.1097/EJA.0000000000002208","url":null,"abstract":"<p><strong>Background: </strong>The developing neonatal brain displays different electroencephalographic (EEG) responses to GABAergic anaesthetics than adults. Evidence suggests the importance of isoelectric-like activity patterns. However, markers of hypnotic depth are currently lacking for this population.</p><p><strong>Objective: </strong>To explore potential EEG markers of propofol-induced hypnosis in sedated critically ill term neonates.</p><p><strong>Design: </strong>Observational exploratory cohort study.</p><p><strong>Patients: </strong>Twenty critically ill term neonates (postmenstrual age 37 to 44 weeks) undergoing intensive care and requiring anaesthesia for noncardiac surgery. Patients with perinatal asphyxia, neurological pathology, brain malformations and metabolic or haemodynamic instability were excluded.</p><p><strong>Interventions: </strong>Frontal EEG (Sedline) was recorded before induction and during a 20-min continuous rate propofol infusion.</p><p><strong>Main outcome measures: </strong>Depending on peak amplitude, segmented EEG signals (1 s epochs) were classified as either isoelectric (<10 μV), low-voltage 10 to 25 μV), or high-voltage (>25 μV). Propofol effects were evaluated in terms of time occupancy and spectral properties within these EEG states. Correlations between clinical variables and EEG states were explored.</p><p><strong>Results: </strong>The EEGs of 17 neonates were analysed. Most showed periods of low-voltage (16/17, 94%) and isoelectric states (2/17, 70.5%) before anaesthesia. The time spent in these EEG states increased significantly during propofol infusion; 17/17 (100%), P  < 0.001 and 16/17 (94.1%), P  = 0.016, respectively. Propofol increased the mean [95% confidence interval (CI)] time spent in the isoelectric state per patient: 12.4 (3.3 to 21.5)% versus 28.6 (14.4 to 42.8)%, P  < 0.002. A reduced spectral power was observed across all frequency bands during low-voltage states (all P  < 0.026). Gestational age was negatively correlated with time in the isoelectric state; rho, 95% CI, -0.539 (-0.11 to -0.87), P  = 0.031.</p><p><strong>Conclusion: </strong>Our results show that isoelectric periods are common before anaesthesia in our studied population and more frequent in patients born at earlier gestational ages. The data suggest that propofol anaesthesia increases isoelectric EEG states while also reducing the spectral power, specifically during low-voltage EEG states. Potentially, both of these EEG changes could be biomarkers of neonatal hypnosis depth in this particular critically ill subpopulation.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov identifier: NCT04904965.</p>","PeriodicalId":11920,"journal":{"name":"European Journal of Anaesthesiology","volume":" ","pages":"889-898"},"PeriodicalIF":6.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}