European Journal of Anaesthesiology最新文献

{"title":"Reply to: association between postoperative delirium in the postanaesthesia care unit and subsequent ward delirium: a retrospective cohort study.","authors":"Yotam Weiss, Shiri Zarour, Barak Cohen, Idit Matot","doi":"10.1097/EJA.0000000000002437","DOIUrl":"https://doi.org/10.1097/EJA.0000000000002437","url":null,"abstract":"","PeriodicalId":11920,"journal":{"name":"European Journal of Anaesthesiology","volume":"43 11","pages":"914-916"},"PeriodicalIF":7.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149106024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of peri-operative fluid balance and acute kidney injury in patients undergoing elective colorectal surgery: A preplanned secondary analysis of a multicentre prospective observational study.","authors":"Yasemin Burcu Ustun, Esra Turunc, Ersin Koksal, Burhan Dost","doi":"10.1097/EJA.0000000000002476","DOIUrl":"https://doi.org/10.1097/EJA.0000000000002476","url":null,"abstract":"","PeriodicalId":11920,"journal":{"name":"European Journal of Anaesthesiology","volume":"43 11","pages":"920"},"PeriodicalIF":7.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149105967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Remimazolam versus sevoflurane for general anaesthesia: A meta-analysis with trial sequential analysis of haemodynamic and clinical outcomes.","authors":"Lara Terumi Takayama, Kevlin de Souza, David Abraham Batista da Hora, Bezalel Hakkeem, Hiorrana Sousa Dias, Francisco José Lucena Bezerra","doi":"10.1097/EJA.0000000000002412","DOIUrl":"10.1097/EJA.0000000000002412","url":null,"abstract":"<p><strong>Background: </strong>Remimazolam is a novel ultra-short-acting intravenous benzodiazepine, while sevoflurane is a widely used inhalational anaesthetic for general anaesthesia (GA). Both agents are associated with risks of haemodynamic instability and postoperative nausea and vomiting (PONV), which can affect patient safety and recovery.</p><p><strong>Objective: </strong>To compare the efficacy and safety of remimazolam versus sevoflurane in terms of intraoperative haemodynamic stability during the maintenance phase of GA or deep sedation, and the incidence of PONV.</p><p><strong>Design: </strong>Systematic review of randomised controlled trials (RCTs) and meta-analysis, with trial sequential analysis (TSA).</p><p><strong>Data sources: </strong>PubMed/MEDLINE, Embase, Cochrane CENTRAL, Web of Science and Scopus were systematically searched from inception to April 2025.</p><p><strong>Eligibility criteria: </strong>RCTs comparing intraoperative use of remimazolam and sevoflurane with reported intraoperative or postoperative outcomes. Conference abstracts were excluded.</p><p><strong>Results: </strong>Twelve RCTs ( n  = 739 patients; mean age 61.6 years; 36.8% laparoscopic procedures) were included. Remimazolam significantly reduced the risk of intraoperative hypotension (as a binary event) compared with sevoflurane [risk ratio (RR) 0.38, 95% confidence interval (CI) 0.25 to 0.57; P  < 0.001]. Mean arterial pressure (MAP) was higher with remimazolam at 30 min after start of surgery (mean difference 6.05 mmHg, P  < 0.03). Heart rate (HR) was consistently higher with remimazolam at 30 min ( P  = 0.04), at the end of surgery ( P  < 0.01) and in the postanaesthesia care unit ( P  < 0.01). Analyses suggested a reduction in PONV incidence up to 24 h with remimazolam [RR 0.65 (95% CI, 0.47 to 0.90); P  = 0.01] and 72 h [RR 0.66 (95% CI, 0.50 to 0.89)]. TSA just confirmed favouring remimazolam in reducing intraoperative hypotension.</p><p><strong>Conclusions: </strong>Remimazolam was associated with a lower incidence of intraoperative hypotension compared with sevoflurane, while differences in MAP and HR were limited to specific time points. Sensitivity analyses suggested a potential reduction in PONV; however, these findings were not statistically significant in the primary analysis and should be interpreted with caution.</p>","PeriodicalId":11920,"journal":{"name":"European Journal of Anaesthesiology","volume":" ","pages":"901-912"},"PeriodicalIF":7.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148886645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revisiting the economic conclusions of TIVA versus sevoflurane: the critical impacts of BIS monitoring and propofol wastage in real-world practice.","authors":"Walter Swinnen, Tim De Grauwe, Matthias Quisquater, Johan Pauwels","doi":"10.1097/EJA.0000000000002484","DOIUrl":"https://doi.org/10.1097/EJA.0000000000002484","url":null,"abstract":"","PeriodicalId":11920,"journal":{"name":"European Journal of Anaesthesiology","volume":"43 11","pages":"927-928"},"PeriodicalIF":7.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149106050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Environmental and economic impacts of anaesthesia. A simulation study comparing total intravenous anaesthesia versus sevoflurane for maintenance of anaesthesia in 11 909 adult patients of a Belgian tertiary hospital.","authors":"Stefano Turi, Federico Mattia Oliva, Edoardo Mongardini, Rosa Labanca","doi":"10.1097/EJA.0000000000002479","DOIUrl":"https://doi.org/10.1097/EJA.0000000000002479","url":null,"abstract":"","PeriodicalId":11920,"journal":{"name":"European Journal of Anaesthesiology","volume":"43 11","pages":"921-922"},"PeriodicalIF":7.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149106038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of intraoperative low-dose dexmedetomidine on postoperative systemic inflammation and cognitive outcomes in elderly patients: Secondary analysis of a randomised controlled trial: Erratum.","authors":"","doi":"10.1097/EJA.0000000000002523","DOIUrl":"https://doi.org/10.1097/EJA.0000000000002523","url":null,"abstract":"","PeriodicalId":11920,"journal":{"name":"European Journal of Anaesthesiology","volume":"43 11","pages":"933"},"PeriodicalIF":7.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149106020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In reply: the inseparable pair: bleeding and thrombosis.","authors":"Carolina S Romero, Arash Afshari, Giammaria Cammarota, Armando Mena, Massimo Lamperti","doi":"10.1097/EJA.0000000000002480","DOIUrl":"https://doi.org/10.1097/EJA.0000000000002480","url":null,"abstract":"","PeriodicalId":11920,"journal":{"name":"European Journal of Anaesthesiology","volume":"43 11","pages":"922-924"},"PeriodicalIF":7.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149106106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The dichotomy of lipopolysaccharide mass and activity in the context of interpreting limulus amoebocyte lysate test results in clinical studies: A scientific commentary on the study 'Impaired endotoxin inactivation, rather than gut translocation, is associated with organ injury in cardiac surgery with cardiopulmonary bypass'.","authors":"Maxim A Babaev, German Yakovenko, Petr Ageev","doi":"10.1097/EJA.0000000000002473","DOIUrl":"https://doi.org/10.1097/EJA.0000000000002473","url":null,"abstract":"","PeriodicalId":11920,"journal":{"name":"European Journal of Anaesthesiology","volume":"43 11","pages":"918-920"},"PeriodicalIF":7.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149106081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trust without verification: generation Z, generative artificial intelligence and the calibration paradox in medical education.","authors":"Anupa Parajuli, Aimee Pak, Kenichi A Tanaka, Amir L Butt","doi":"10.1097/EJA.0000000000002481","DOIUrl":"https://doi.org/10.1097/EJA.0000000000002481","url":null,"abstract":"","PeriodicalId":11920,"journal":{"name":"European Journal of Anaesthesiology","volume":"43 11","pages":"924-926"},"PeriodicalIF":7.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149106064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospective clinical evaluation of the Eleveld pharmacokinetic and pharmacodynamic model of propofol for moderate-to-deep sedation in adults.","authors":"Mendy K Driesens, Clemens R M Barends, Douglas J Eleveld, Michel M R F Struys","doi":"10.1097/EJA.0000000000002408","DOIUrl":"10.1097/EJA.0000000000002408","url":null,"abstract":"<p><strong>Background: </strong>Target-controlled infusion (TCI) based on pharmacokinetic- and pharmacodynamic (PKPD) models is widely used for procedural moderate to deep sedation (MDS) outside of the operating room. Recently, PKPD models developed for broad populations such as the Eleveld model have become commercially available and are thought to be suitable for TCI during MDS. As clinical experience and guidelines are lacking, we aimed to evaluate the Eleveld propofol model for MDS and to find normative values of propofol effect-site target concentrations for MDS.</p><p><strong>Methods: </strong>We considered three patient groups: adult, elderly, and obese, with 25 patients for each group. Primary outcomes were maintaining adequate respiratory and haemodynamic parameters and successful completion of the planned procedures. Secondary outcomes were clinically relevant endpoints on the procedure timeline and the occurrence of adverse events.</p><p><strong>Results: </strong>We found that targets with the Eleveld propofol model are generally between 2-3 μg ml -1 for adults and nearer to 2 μg ml -1 for elderly and obese individuals, and do not require much adaptation during the procedure. Clinicians may observe slightly increased blood pressure and heart rate during the procedure and interpret this as a sign of patient stimulation, and in response increase target concentrations. Respiration rate and SpO 2 decrease slightly with increased predicted drug effect.</p><p><strong>Conclusion: </strong>The Eleveld propofol model can be used in TCI to achieve MDS while maintaining adequate respiratory and hemodynamic parameters, resulting in the safe completion of the planned procedures.</p>","PeriodicalId":11920,"journal":{"name":"European Journal of Anaesthesiology","volume":" ","pages":"892-900"},"PeriodicalIF":7.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147688978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}