Epilepsy Research最新文献

{"title":"Early-phase EEG power spectrum analysis may differentiate acute encephalopathy with biphasic seizures and late reduced diffusion from prolonged febrile seizures","authors":"Eri Ogawa ,&nbsp;Yuri Sakaguchi ,&nbsp;Tetsuji Kaneko ,&nbsp;Osamu Saito ,&nbsp;Sahoko Miyama","doi":"10.1016/j.eplepsyres.2025.107515","DOIUrl":"10.1016/j.eplepsyres.2025.107515","url":null,"abstract":"<div><h3>Background</h3><div>Acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) is clinically characterized by biphasic seizures associated with mild to severe neurological sequelae and is the most common subtype of acute encephalopathy in Japan, accounting for around 30 % of cases. The present study retrospectively analyzed the utility of electroencephalography (EEG) in determining the optimal method of diagnosing AESD at the early stage.</div></div><div><h3>Methods</h3><div>This study explores early power value differences to differentiate acute encephalopathy from prolonged febrile seizure (FS). The subjects were patients aged six months to four years who had received intensive care for febrile status epilepticus and had a continuous EEG record up to 24 h after seizure onset. Power spectrum analysis of consecutive, 30-minute recordings at two-hour intervals were conducted, and the power values (alpha, beta, delta, theta waves) were compared between AESD group and FS group.</div></div><div><h3>Results</h3><div>Eight patients with AESD and 69 patients with FS were identified retrospectively. The emergence of delta waves in the frontal region was significantly higher in the AESD group at six to ten hours after onset. The emergence of beta waves across all the regions was lower in the AESD group from six hours after seizure onset.</div></div><div><h3>Conclusions</h3><div>Frequency analysis of EEG in the early period after febrile status epilepticus onset demonstrated a significant difference between the AESD and FS groups. Delta wave power values in the frontal region at six to ten hours after onset might be useful for the early differentiation of AESD from FS.</div></div>","PeriodicalId":11914,"journal":{"name":"Epilepsy Research","volume":"210 ","pages":"Article 107515"},"PeriodicalIF":2.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143058518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuromodulation Strategies in Lennox‐Gastaut Syndrome: Practical Clinical Guidance from the Pediatric Epilepsy Research Consortium","authors":"Debopam Samanta ,&nbsp;Gewalin Aungaroon ,&nbsp;Anthony L. Fine ,&nbsp;Cemal Karakas ,&nbsp;Michelle Y. Chiu ,&nbsp;Puneet Jain ,&nbsp;Syndi Seinfeld ,&nbsp;Juliet K. Knowles ,&nbsp;Ismail S. Mohamed ,&nbsp;Carl E. Stafstrom ,&nbsp;Tracy Dixon-Salazar ,&nbsp;Anup D. Patel ,&nbsp;Sonam Bhalla ,&nbsp;Cynthia Guadalupe Keator ,&nbsp;Jorge Vidaurre ,&nbsp;Aaron E.L. Warren ,&nbsp;Renée A. Shellhaas ,&nbsp;M. Scott Perry","doi":"10.1016/j.eplepsyres.2024.107499","DOIUrl":"10.1016/j.eplepsyres.2024.107499","url":null,"abstract":"<div><div>Lennox-Gastaut syndrome (LGS) is a severe developmental and epileptic encephalopathy characterized by multiple drug-resistant seizure types, cognitive impairment, and distinctive electroencephalographic patterns. Neuromodulation techniques, including vagus nerve stimulation (VNS), deep brain stimulation (DBS), and responsive neurostimulation (RNS), have emerged as important treatment options for patients with LGS who do not respond adequately to antiseizure medications. This review, developed with input from the Pediatric Epilepsy Research Consortium (PERC) LGS Special Interest Group, provides practical guidance for clinicians on the use of these neuromodulation approaches in patients with LGS. We discuss patient selection criteria, expected seizure and non-seizure outcomes, potential complications, and device management considerations for each technique. The review also covers initiation and titration strategies, ongoing care requirements, and emerging data on combining multiple neuromodulation modalities. While all three approaches can reduce seizure frequency in patients with LGS, with commonly reported responder rates ranging from 50 % to 60 %, their impacts on cognition, behavior and quality of life are more variable. Careful patient selection, individualized programming, and long-term follow-up are essential to optimize outcomes with neuromodulation in this challenging patient population. Further research is needed to identify optimal candidates, determine the ideal timing during patients’ clinical course to consider neuromodulation, develop standardized outcome measures, and evaluate the comparative effectiveness and cost-effectiveness of different neuromodulation techniques for LGS.</div></div>","PeriodicalId":11914,"journal":{"name":"Epilepsy Research","volume":"210 ","pages":"Article 107499"},"PeriodicalIF":2.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142946967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Twenty-four-hour pattern of children with febrile seizures presenting to a United States Pediatric Emergency Department","authors":"Ami P. Shah ,&nbsp;Michael H. Smolensky ,&nbsp;Linda Sackett-Lundeen ,&nbsp;Shahab Haghayegh ,&nbsp;Aishah Najam ,&nbsp;David Slattery","doi":"10.1016/j.eplepsyres.2025.107508","DOIUrl":"10.1016/j.eplepsyres.2025.107508","url":null,"abstract":"<div><h3>Background</h3><div>Febrile seizure (FS) is the most common convulsive disorder in children. Understanding its time-of-day pattern can provide insight into mechanisms and prevention.</div></div><div><h3>Purpose</h3><div>We explored clock-time variation of FS presentations of children to a US pediatric emergency department (PED) in comparison to two control cohorts: one (<em>n</em> = 5719) like-aged children presenting solely with fever, i.e., temperature &gt; 100.4 °F/38°C, and one of children (<em>n</em> = 103,806) presenting for any medical emergency.</div></div><div><h3>Methods</h3><div>Electronic medical records covering a 58-month span were searched for clock time of arrivals to the PED, with data assessed either by chi-square or Cosinor analyses to test for temporal variation and derive descriptive parameters.</div></div><div><h3>Major findings</h3><div>Presentation of the 84 FS cases exhibited a time–of-day difference (<em>p</em> = .038), being 5-fold higher between 16:00–19:59 h than 08:00–11:59 h. Presentations of both control groups additionally exhibited such difference, with peak numbers between 16:00 and 19:59 h. Fever intensity of cases tended to be greater by 0.58 °F (<em>p</em> &gt; .10) in those attending the PED between 16:00–23:59 h than 00:00–07:59 h. The control group of children solely with fever showed (<em>p</em> &lt; .0001) time-of-day variation in body temperature, with the difference between presentations of highest and lowest temperature, respectively at ∼21:40 and ∼09:40 h, of 0.4 °F.</div></div><div><h3>Novelty of findings</h3><div>This is the first study to report time-of-day variation in FS of American children, which is like that reported in children of other countries. The peak number of presentations for FS corresponds in time both with that for fever without seizure and that for any medical emergency, and, additionally, fever intensity of fever controls.</div></div>","PeriodicalId":11914,"journal":{"name":"Epilepsy Research","volume":"210 ","pages":"Article 107508"},"PeriodicalIF":2.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of pediatric drug-resistant generalized epilepsy with responsive neurostimulation of the centromedian nucleus of the thalamus: A case series of seven patients","authors":"Mikaela E. Speakes ,&nbsp;Kiersten Reznik-Schaefer ,&nbsp;Ruba Al-Ramadhani ,&nbsp;Luis D. Fernandez ,&nbsp;Jasmine L. Hect ,&nbsp;Taylor J. Abel ,&nbsp;William P. Welch","doi":"10.1016/j.eplepsyres.2025.107516","DOIUrl":"10.1016/j.eplepsyres.2025.107516","url":null,"abstract":"<div><h3>Purpose</h3><div>Responsive neurostimulation of the centromedian nucleus of the thalamus (CM RNS) is being investigated for treatment of drug-resistant generalized epilepsy with promising results. The aim of this study is to report outcomes of seven patients with pediatric-onset drug-resistant generalized epilepsy, including both genetic generalized epilepsy (GGE) and Lennox-Gastaut syndrome (LGS), who underwent treatment with bilateral CM RNS.</div></div><div><h3>Methods</h3><div>A retrospective chart review was performed for patients with drug-resistant generalized epilepsy who underwent treatment with bilateral CM RNS at Children’s Hospital of Pittsburgh from 2020 to 2022. Improvement in seizure frequency was obtained through patient and/or caregiver reports on standardized patient questionnaires. The primary outcome measure was percent improvement in seizure frequency at time of last follow-up appointment compared to baseline seizure frequency.</div></div><div><h3>Results</h3><div>Five of the seven patients (71 %) had an average 50 % or greater improvement in seizure frequency among seizure types including four of the five patients (80 %) with GGE and one of the two patients (50 %) with LGS. There were no serious adverse events including post-operative infection, stroke, or device malfunction/migration.</div></div><div><h3>Conclusion</h3><div>This data, along with other recent studies, suggests that CM RNS can improve seizure frequency in pediatric-onset drug-resistant generalized epilepsy, but larger systematic studies with longer follow-up times and standardized outcome measures are needed to determine long-term effectiveness and optimal patient selection for thalamic RNS.</div></div>","PeriodicalId":11914,"journal":{"name":"Epilepsy Research","volume":"210 ","pages":"Article 107516"},"PeriodicalIF":2.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143046063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Action potential-dependent α4-containing GABAA receptors contribute to epileptogenicity in focal cortical dysplasia","authors":"Yogesh Aggarwal ,&nbsp;Aparna Banerjee Dixit ,&nbsp;Manjari Tripathi ,&nbsp;Ramesh Doddamani ,&nbsp;Meher Chand Sharma ,&nbsp;P.Sarat Chandra ,&nbsp;Jyotirmoy Banerjee","doi":"10.1016/j.eplepsyres.2025.107520","DOIUrl":"10.1016/j.eplepsyres.2025.107520","url":null,"abstract":"<div><div>FCD is a developmental disorder associated with drug-resistant seizures. Alterations in GABA_A receptor-mediated activity contribute to seizures in FCD. However, the exact mechanism of altered GABAergic synaptic activity is still unclear. Previously, we showed increased GABA_A receptor α4 subunit expression in FCD. In this study, we investigated whether changes in GABA_A receptor configuration at synaptic or extrasynaptic sites contribute to enhanced GABAergic activity in the resected samples of FCD patients. Results showed increase in the frequency and amplitude of spontaneous inhibitory postsynaptic currents on treatment with gaboxadol (agonist for α4δ-containing GABA_A receptors). In the presence of tetrodotoxin (voltage-gated Na⁺ channel inhibitor), frequency and amplitude of miniature inhibitory postsynaptic currents were also increased upon treatment with gaboxadol. However, higher magnitude of change was observed in spontaneous inhibitory postsynaptic currents compared to miniature inhibitory postsynaptic currents on gaboxadol treatment, suggesting action potential-dependent α4-containing GABA_A receptor activity may influence epileptogenicity in FCD.</div></div>","PeriodicalId":11914,"journal":{"name":"Epilepsy Research","volume":"210 ","pages":"Article 107520"},"PeriodicalIF":2.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143241673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epilepsy Arabic renaming to cerebroelectric disorder could minimize the stigma","authors":"Doaa A. Mekkawy ,&nbsp;Nirmeen kishk ,&nbsp;Noha T abokrysha ,&nbsp;Gihan M Ramzy ,&nbsp;Reham Mohamed Shamloul ,&nbsp;Rehab Magdy ,&nbsp;Alshimaa S. Othman ,&nbsp;Amr Mohamed Fouad ,&nbsp;Osama Yacoub ,&nbsp;Maged Abdel-Naseer ,&nbsp;Hatem S. Shehata ,&nbsp;Nevin M. Shalaby ,&nbsp;Amr Hassan ,&nbsp;Amal S. Ashour ,&nbsp;Ahmed Dahshan ,&nbsp;Mona Hussein ,&nbsp;Mohamed khodery ,&nbsp;Hazem Kamal Alhewag ,&nbsp;Dalia Abdelfatah ,&nbsp;Nesma Mounir","doi":"10.1016/j.eplepsyres.2024.107495","DOIUrl":"10.1016/j.eplepsyres.2024.107495","url":null,"abstract":"<div><h3>Background</h3><div>Naming is an important part of human communication. The precision of medical terms greatly influences the patients and their caregivers. \"Alsara’الصرع \" is the Arabic term defining epilepsy. However, it has a highly negative impact on patients, as reported by many caring physicians.</div></div><div><h3>Methods</h3><div>A multiple-choice face-to-face questionnaire was designed to assess stigma among patients with epilepsy (PwE), causes, impact on quality of life, impression of PwE about the Arabic terminology of epilepsy Alsara’, and their opinion regarding changing it to precise term \"itrab fi kahrabeit el mokh\" اضطراب في كهربية المخ” which means disturbance of the electrical brain activity. Stigma was assessed using a three-item stigma scale.The interviewed subjects were recruited from Cairo, Beni Suef, and Sohag University hospitals consecutively during a period from 15 August 2023 to 30 December 2023.</div></div><div><h3>Results</h3><div>Three hundred seventy-two PwE responded to the survey. Three hundred fifty-one (94.4 %) PwE felt a disease stigma. About 50 % of them attributed this stigma to the Arabic name of the disease. Eighty-four percent accepted changing the name Alsara’ into “itrab fi kahrabeit el mokh” and 77.2 % suspected a positive impact of this amendment on society. The occurrence of generalized tonic-clonic seizures was found to be an independent risk factor for epilepsy-associated stigma.</div></div><div><h3>Conclusion</h3><div>The Arabic nomenclature of epilepsy \"Alsara’\" is not an accurate term for epilepsy. In addition to being associated with many poor misconceptions and stigma. We hope this study will pave the way to replace it with a more appropriate and less defaming term.</div></div>","PeriodicalId":11914,"journal":{"name":"Epilepsy Research","volume":"210 ","pages":"Article 107495"},"PeriodicalIF":2.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142964275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term efficacy and tolerability of brivaracetam in pediatric patients with focal-onset seizures and cognitive or learning comorbidities: Post hoc analysis of an open-label trial","authors":"Dimitrios Bourikas ,&nbsp;Juliane Koch ,&nbsp;Christine de la Loge ,&nbsp;Svetlana Dimova ,&nbsp;Sami Elmoufti ,&nbsp;Brian Moseley ,&nbsp;Lieven Lagae","doi":"10.1016/j.eplepsyres.2024.107482","DOIUrl":"10.1016/j.eplepsyres.2024.107482","url":null,"abstract":"<div><h3>Objective</h3><div>Efficacy, tolerability, and behavioral/executive functioning during long-term adjunctive brivaracetam treatment were assessed in pediatric patients with focal-onset seizures (FOS) with/without cognitive/learning comorbidities (CLC).</div></div><div><h3>Methods</h3><div>Post hoc analysis of a phase 3 open-label follow-up trial (N01266/NCT01364597). Patients with FOS (&lt;16 years at core trial entry; direct enrollers ≥4–&lt;17 years) received ≤5 mg/kg/day brivaracetam (≤200 mg/day). Subgroup analyses were performed for patients with and without ongoing CLC at baseline.</div></div><div><h3>Results</h3><div>Patients with CLC (84/185 [45.4 %]) had longer epilepsy duration and higher number of prior antiseizure medications. Kaplan-Meier–estimated brivaracetam retention at 1, 3, and 5 years was 75.0 %/78.2 %, 61.9 %/61.9 %, and 52.2 %/53.3 % in patients with/without CLC. Efficacy assessments (patients &gt;2 years of age) showed numerically lower median percent reduction in FOS frequency/28 days (43.8 %/74.1 % [n = 63/60]), 50 % responder rates for FOS (46.0 %/61.7 % [n = 63/60]), and ≥12-month continuous freedom from all seizures (31.7 %/55.9 % [n = 60/68 patients with ≥12 months treatment]) in patients with/without CLC. Treatment-emergent adverse events were reported in 94.0 %/95.0 % of patients with/without CLC (serious: 33.3 %/27.7 %; drug-related: 31.0 %/33.7 %). From baseline to last evaluation, most patients with/without CLC had no shift in T-score category for each Achenbach Child Behavior Checklist (CBCL) 1.5–5 syndrome (≥50.0 %/≥72.2 %), CBCL 6–18 syndrome (≥66.0 %/≥69.1 %), and Behavior Rating Inventory of Executive Function scale (≥66.7 %/≥69.0 %).</div></div><div><h3>Conclusions</h3><div>These data indicate that brivaracetam could be an efficacious and well-tolerated treatment option for pediatric patients with FOS with and without CLC. Behavior and executive functioning were generally stable or slightly improved in patients with and without CLC.</div></div>","PeriodicalId":11914,"journal":{"name":"Epilepsy Research","volume":"209 ","pages":"Article 107482"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142784564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The characterization of psychosis and response to antipsychotic therapy in monogenic forms of familial focal epilepsy: A systematic review","authors":"Mark Ainsley Colijn","doi":"10.1016/j.eplepsyres.2024.107493","DOIUrl":"10.1016/j.eplepsyres.2024.107493","url":null,"abstract":"<div><div>While the genetic architecture of epilepsy is complex and presumably polygenic in many cases, pathogenic variants have increasingly been identified, and this is perhaps best exemplified by the monogenic familial focal epilepsies. Although individuals with epilepsy (particularly focal epilepsy) are at increased risk of developing psychosis, little has been written on this topic in relation to monogenic familial focal epilepsy, specifically. As such, this systematic review aimed to characterize the phenomenology of psychosis (and response to antipsychotic therapy) in affected individuals. Only eight articles were identified and minimal information with respect to psychiatric phenotyping was provided in most cases. As such, although no firm conclusions can be drawn, it is notable that none of the reports described a temporal relationship between seizure and psychosis onset; the typical convention used in epilepsy. As most reports also did not include primary psychotic disorder diagnoses, it remains unclear if the individuals’ presentations were understood to represent epileptic psychoses or schizophrenia, and to what degree (if at all) their genetic variants were thought to have contributed directly to psychosis risk. More robust case descriptions are needed to better characterize the nature of psychotic symptoms (and their response to treatment) in monogenic familial focal epilepsy.</div></div>","PeriodicalId":11914,"journal":{"name":"Epilepsy Research","volume":"209 ","pages":"Article 107493"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Late onset epilepsy findings in a developmental country, a report of first results","authors":"Hasan Saad Hosny,&nbsp;Mahmoud Salah Adly,&nbsp;Sarah Sherif Abdo,&nbsp;Sarah Khalil,&nbsp;Amr Mohamed Fouad","doi":"10.1016/j.eplepsyres.2024.107496","DOIUrl":"10.1016/j.eplepsyres.2024.107496","url":null,"abstract":"<div><h3>Introduction</h3><div>Older patients with Late onset epilepsy (LOE) provide a special set of difficulties for both the treating doctors and the patients.</div></div><div><h3>Objectives</h3><div>To address the characteristics and treatment outcomes of LOE in a cohort of Egyptian population at a tertiary center and to assess factors affecting seizure freedom in this age group.</div></div><div><h3>Methods</h3><div>From December 1, 1995, to November 30, 2020, we analysed all patients with newly diagnosed epilepsy above the age of 50 at Cairo University's neurology department. The term \"seizure freedom\" was used to refer to the absence of seizures or auras for at least 12 months. Patients were classified as either having achieved seizure freedom or not.</div></div><div><h3>Results</h3><div>One hundred and twenty-one patients were included. The median follow-up time was 24 months. 69.4 % attain seizure freedom. 52.1 % of our patients had symptomatic epilepsy. Among this group, 31.4 % (n = 38) had epilepsy caused by cerebrovascular disease (ischemic or hemorrhagic). Patients with epileptogenic lesions in neuroimaging, and those who are receiving ≥ 2 ASMs had significantly higher probability of not achieving seizure freedom for 12 months compared to those with normal or non-epileptogenic lesions in neuroimaging and receiving ≤ 1 ASMs with significant trends a trend toward lower seizure freedom in both.</div></div><div><h3>Conclusion</h3><div>Patients with Late- onset epilepsy have an excellent chance of achieving seizure freedom, especially those controlled on 1 ASM and those with normal neuroimaging.</div></div>","PeriodicalId":11914,"journal":{"name":"Epilepsy Research","volume":"209 ","pages":"Article 107496"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142893172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between disease self-management and internalized stigmatization in individuals with epilepsy: A sample in eastern Turkey","authors":"Eda Ay ,&nbsp;Emrah Ay ,&nbsp;Nuray Bingol","doi":"10.1016/j.eplepsyres.2024.107497","DOIUrl":"10.1016/j.eplepsyres.2024.107497","url":null,"abstract":"<div><h3>Background</h3><div>Epilepsy is often misunderstood, leading to fear, stigmatization of patients and the risk of social discrimination. For some patients, social stigma can be an even bigger problem than epilepsy itself.</div></div><div><h3>Aim</h3><div>This study examined the relationship between self-management and internalized stigma levels in individuals diagnosed with epilepsy.</div></div><div><h3>Methods</h3><div>This descriptive and cross-sectional study was conducted in the Neurology Outpatient Clinic of a Training and Research Hospital and 128 epilepsy patients were included in the sample based on various inclusion criteria such as having a diagnosis of epilepsy for at least six months, being over the age of 18, not having any psychiatric disorder that would prevent reading and comprehension.The Sociodemographic Data Form, Internalized Stigma in Epilepsy Scale, and Epilepsy Self-Management Scale were used to collect the data.</div></div><div><h3>Results</h3><div>The mean age at disease onset was 19.5 ± 11.7 years. In terms of the demographics of the patients, 55.5 % were female, 46 % were aged 18–22 years, 53.9 % were single, 30 % were at least university graduates, 85.2 % had income equal to their expenses, 75.8 % had a seizure frequency of more than one per year, 58.6 % had generalized onset seizures, and 73.4 % used one drug. The patients’ Self-Management Scale total score was 111.01 ± 13.22, and their Internalized Stigma Scale total score was 49.9 ± 12.9. The correlation analysis indicated a high significant negative correlation between the Self-Management Scale total score and the Internalized Stigma Scale total score (p &lt; 0.001).</div></div><div><h3>Conclusions</h3><div>The patients’ self-management levels were above average, and their internalized stigma levels were moderate. The patients were most stigmatized in the areas of isolation and discrimination. Generally, as the self-management skills of patients increased, their internalized stigma levels decreased. In this context, it is recommended that intervention studies be conducted to increase the self-management levels and reduce stigma for individuals diagnosed with epilepsy.</div></div>","PeriodicalId":11914,"journal":{"name":"Epilepsy Research","volume":"209 ","pages":"Article 107497"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143104392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}