Epilepsy Research最新文献

{"title":"Response to: \"Early benzodiazepine treatment and electrographic seizures after febrile status epilepticus\".","authors":"Kento Souma, Hiroshi Yamaguchi, Takuya Ueda, Shizuka Oikawa, Yusuke Ishida, Kandai Nozu, Azusa Maruyama, Hiroaki Nagase, Masahiro Nishiyama","doi":"10.1016/j.eplepsyres.2026.107931","DOIUrl":"https://doi.org/10.1016/j.eplepsyres.2026.107931","url":null,"abstract":"<p><p>We appreciate Inui et al.'s comments regarding the divergent prognostic outcomes of patients with electrographic seizures (ESz) between our studies. The poorer prognosis in their cohort compared to ours likely stems from three key differences. First, baseline disease severity significantly differed. Our cohort predominantly consisted of milder cases, such as febrile seizures, with only 17.2% requiring pediatric intensive care. Conversely, Inui et al. evaluated critically ill patients with acute encephalopathy, whose severe ESz EEG features-such as periodic discharges-inherently indicate a poorer prognosis. Second, the timing of EEG recordings varied. We evaluated EEGs during the hyperacute phase in the emergency department (median 77.5 min post-onset). In contrast, Inui et al. assessed patients 7-96 h post-onset, reflecting a substantially delayed timeframe. Third, diverging interpretations and treatments of evolving rhythmic delta activity (RDA) likely contributed to the prognostic gap. Our institution's protocol treats evolving RDA as a seizure equivalent, warranting immediate therapeutic intervention in the emergency setting. We have previously demonstrated that this early, RDA-targeted intervention yields better clinical outcomes. These discrepancies highlight the necessity for future studies incorporating comprehensive, early EEG evaluations. Further investigation is essential to clarify the precise prognostic implications of post-ictal evolving RDA and to establish a clinical consensus on the necessity of active therapeutic intervention.</p>","PeriodicalId":11914,"journal":{"name":"Epilepsy Research","volume":" ","pages":"107931"},"PeriodicalIF":2.3,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149105594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to “Comment on ‘Predictors of surgical outcome in frontal lobe epilepsy: Experience from a single-center cohort in Latin America’”","authors":"Diana Margoth Riaño-Carreño,&nbsp;Andrés Felipe Cardenas,&nbsp;Jacobo Ramirez-Triana,&nbsp;Carmela Fawcett Martínez,&nbsp;Santiago Martínez Corredor,&nbsp;Sergio Esteban Chacón,&nbsp;Oscar Zorro Guio,&nbsp;Juan Carlos Perez Poveda,&nbsp;Daniel Nariño González","doi":"10.1016/j.eplepsyres.2026.107863","DOIUrl":"10.1016/j.eplepsyres.2026.107863","url":null,"abstract":"","PeriodicalId":11914,"journal":{"name":"Epilepsy Research","volume":"226 ","pages":"Article 107863"},"PeriodicalIF":2.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148548269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on “Predictors of surgical outcome in frontal lobe epilepsy: Experience from a single-center cohort in Latin America”","authors":"Bhumesh Tyagi,&nbsp;Leelabati Toppo,&nbsp;Aishwarya Biradar","doi":"10.1016/j.eplepsyres.2026.107862","DOIUrl":"10.1016/j.eplepsyres.2026.107862","url":null,"abstract":"","PeriodicalId":11914,"journal":{"name":"Epilepsy Research","volume":"226 ","pages":"Article 107862"},"PeriodicalIF":2.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148359965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Refining risk stratification and understanding epilepsy severity in adults with profound intellectual and multiple disabilities: Author reply to commentary","authors":"Yuri Sakaguchi,&nbsp;Hiromi Seki,&nbsp;Yuji Iwasaki,&nbsp;Tomoki Kosho","doi":"10.1016/j.eplepsyres.2026.107854","DOIUrl":"10.1016/j.eplepsyres.2026.107854","url":null,"abstract":"","PeriodicalId":11914,"journal":{"name":"Epilepsy Research","volume":"226 ","pages":"Article 107854"},"PeriodicalIF":2.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148276354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on “Risk factors of epilepsy severity in institutionalized adults with profound intellectual and multiple disabilities from childhood”","authors":"Sangameshwar Manikya,&nbsp;Varshini Vadhithala,&nbsp;Rajnish Kumar,&nbsp;Pankaj Nainwal","doi":"10.1016/j.eplepsyres.2026.107853","DOIUrl":"10.1016/j.eplepsyres.2026.107853","url":null,"abstract":"","PeriodicalId":11914,"journal":{"name":"Epilepsy Research","volume":"226 ","pages":"Article 107853"},"PeriodicalIF":2.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148276372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to: \"A critical appraisal of principal component analysis of antiseizure medication-induced hostility/aggression and factor analysis of levetiracetam\".","authors":"Ryuichiro Hosoya, Kento Kitajima, Koushirou Sogawa, Daigo Ikegami, Tomoko Terajima, Hideaki Kato, Masahiko Funada, Hajime Kagaya, Yoshihiro Uesawa","doi":"10.1016/j.eplepsyres.2026.107860","DOIUrl":"https://doi.org/10.1016/j.eplepsyres.2026.107860","url":null,"abstract":"<p><p>We respond to the commentary by Aphale et al. on our study titled \"Principal Component Analysis of Antiseizure Medication-induced Hostility/Aggression and Factor Analysis of Levetiracetam\" using the Food and Drug Administration Adverse Event Reporting System (FAERS). The commentary raised four methodological points: (1) the interpretation of Component 2 as a \"behavioral axis\" in the principal component analysis and the classification of borderline personality disorder (BPD), (2) confounding by indication regarding risperidone, (3) the choice of the reporting odds ratio (ROR) over Bayesian methods such as the Empirical Bayes Geometric Mean, and (4) the absence of multivariate analysis in the pediatric group aged less than 12 years. We clarify that BPD was classified among the eight antiseizure medication-associated adverse effects primarily because of its high loading on Component 1 (PC1 = 0.816), the hostility/aggression risk axis, rather than on Component 2 (PC2 = 0.045), which was near-neutral. Component loadings for all 15 preferred terms are provided in Table 1. We acknowledge limitations related to confounding by indication inherent in spontaneous reporting databases, discuss the rationale for selecting the ROR as the primary signal-detection metric, and clarify data-driven constraints that precluded multivariate analysis in the pediatric subgroup. We propose that future studies use larger data sources, such as electronic health records and disease registries, including clinical indications and patient background to enable robust risk factor analyses in this population.</p>","PeriodicalId":11914,"journal":{"name":"Epilepsy Research","volume":" ","pages":"107860"},"PeriodicalIF":2.3,"publicationDate":"2026-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148359970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor: A critical appraisal of 'principal component analysis of antiseizure medication-induced hostility/aggression and factor analysis of levetiracetam.","authors":"Parth Aphale, Himanshu Shekhar, Shashank Dokania","doi":"10.1016/j.eplepsyres.2026.107859","DOIUrl":"https://doi.org/10.1016/j.eplepsyres.2026.107859","url":null,"abstract":"","PeriodicalId":11914,"journal":{"name":"Epilepsy Research","volume":" ","pages":"107859"},"PeriodicalIF":2.3,"publicationDate":"2026-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149079811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “A systematic review of highly purified cannabidiol in developmental and epileptic encephalopathies and complex treatment-resistant epilepsies: Changes in seizure frequency and adverse events” [Epilepsy Res. 220 (2026) 1–1/107731]","authors":"Antonietta Coppola ,&nbsp;Lisa Moore-Ramdin ,&nbsp;Marco Navetta ,&nbsp;Debopam Samanta","doi":"10.1016/j.eplepsyres.2026.107777","DOIUrl":"10.1016/j.eplepsyres.2026.107777","url":null,"abstract":"","PeriodicalId":11914,"journal":{"name":"Epilepsy Research","volume":"222 ","pages":"Article 107777"},"PeriodicalIF":2.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147443119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing an fMRI-guided titration paradigm for microburst VNS therapy","authors":"Kristl Vonck ,&nbsp;Ryan Verner ,&nbsp;Giovanni Ranuzzi ,&nbsp;Roshani Patel ,&nbsp;William O. Tatum ,&nbsp;Lesley Kaye ,&nbsp;Cornelia Drees ,&nbsp;Muhammad Zafar ,&nbsp;Rebecca O’Dwyer ,&nbsp;Jason Begnaud ,&nbsp;Jerzy P. Szaflarski ,&nbsp;on behalf of the Microburst Study Group","doi":"10.1016/j.eplepsyres.2026.107734","DOIUrl":"10.1016/j.eplepsyres.2026.107734","url":null,"abstract":"<div><h3>Rationale</h3><div>VNS is an efficacious therapy for people with epilepsy (PwE), but personalized implementation of VNS dosing and titration could be improved by measuring therapeutic engagement of cortical and subcortical physiology.</div></div><div><h3>Methods</h3><div>People with Drug-Resistant Epilepsy (DRE) were enrolled into a feasibility study using investigational microburst VNS (NCT03446664). An investigational VNS system with conditional approval for stimulation in the magnetic environment was titrated using an fMRI-guided titration approach to determine VNS therapy settings for each individual participant over 6 months. Stimulation parameter combinations that evoked the highest thalamic BOLD response were chosen in an individual participant as the preferred VNS therapy setting.</div></div><div><h3>Results</h3><div>Thirty-two participants were implanted and 31 participants attended the 6-month study visit and at least one prior fMRI study visit. In all participants, significant VNS-evoked thalamic BOLD responses were found. Participants who experienced significant thalamic BOLD signal among multiple stimulation parameter combinations over multiple visits were most likely to respond to µVNS. Participants responded to µVNS with a median reduction in seizure frequency of 42.6 % at 6 months. There were no MRI-related safety issues associated with active VNS during scanning.</div></div><div><h3>Conclusion</h3><div>Titration of VNS using an fMRI-guided approach is feasible and safe in PwE (when using appropriate investigational devices), but our specific biomarker, used in this specific study design, was ultimately too variable to be used for patient-specific titration. An increase in thalamic BOLD signal that occurred across multiple stimulation parameter combinations and multiple visits with microburst settings was associated with seizure response that could be visualized early in the titration process.</div></div>","PeriodicalId":11914,"journal":{"name":"Epilepsy Research","volume":"221 ","pages":"Article 107734"},"PeriodicalIF":2.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146060854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Challenges to epilepsy surgery referral in Mexico: Results from a nationwide survey of primary care physicians and specialists","authors":"Diego Pichardo-Rojas,&nbsp;Jorge Castro-Vega,&nbsp;María Fernanda Castelo-Pablos,&nbsp;Jonathan Ulises Macias-López,&nbsp;Karen Janely Camarena-Rubio,&nbsp;Irene Gómez-Oropeza,&nbsp;Valeria Isabel Bravo-Osorno,&nbsp;Manuel Alejandro Del Río Quiñones,&nbsp;Juan Carlos Reséndiz Aparicio,&nbsp;Mauricio Medina,&nbsp;Elma Paredes-Aragón,&nbsp;Sonia Iliana Mejía-Pérez,&nbsp;Laura E. Hernández-Vanegas","doi":"10.1016/j.eplepsyres.2026.107750","DOIUrl":"10.1016/j.eplepsyres.2026.107750","url":null,"abstract":"<div><h3>Background</h3><div>Epilepsy surgery is the most effective treatment for patients with drug-resistant epilepsy (DRE), yet remains critically underutilized. Physician perceptions and knowledge gaps are amongst the most consistently reported barriers to timely referral, with limited reports in low- and middle-income countries (LMICs). This study aimed to assess knowledge and perceptions regarding DRE and epilepsy surgery among Mexican physicians.</div></div><div><h3>Methods</h3><div>A 24-item survey was distributed nationally between August and November 2024. Eligible respondents were practicing general practitioners (GPs), neurologists, or neurosurgeons in Mexico. Items evaluated demographics, clinical experience with epilepsy, perceptions of surgery, and knowledge of International League Against Epilepsy (ILAE) recommendations. Intergroup comparisons were performed using chi-square and logistic regression analyses.</div></div><div><h3>Results</h3><div>Responses were obtained from 211 physicians across 27 states, including 140 GPs (66.4 %), 40 neurologists (19.0 %), and 31 neurosurgeons (14.6 %). Only 72 physicians (34.1 %) correctly identified the ILAE definition of DRE, including 55 % of neurologists (significant differences between groups p = 0.008). While 180 participants (85.3 %) recognized epilepsy surgery as a treatment option, only 107 (50.7 %) agreed that all DRE patients should be referred for surgical evaluation. Awareness of existing referral centers was low (n = 60, 28.4 %). Most respondents recognized EEG (n = 184, 87.2 %), and MRI (n = 125/211 59.2 %) as essential for initial evaluation. Notably, 82 physicians (38.9 %) perceived epilepsy surgery as a high-risk, last-resort option. Overall, neurologists had the highest knowledge of epilepsy.</div></div><div><h3>Conclusion</h3><div>Mexican physicians had significant knowledge gaps and referral barriers to epilepsy surgery in Mexico, including limited familiarity with DRE criteria, limited understanding of surgical outcomes, and low awareness of existing referral pathways. Addressing these gaps through targeted medical education and improved visibility of epilepsy care infrastructure is essential to improve outcomes for DRE patients in Mexico and other LMICs.</div></div>","PeriodicalId":11914,"journal":{"name":"Epilepsy Research","volume":"221 ","pages":"Article 107750"},"PeriodicalIF":2.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146141441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}