Epilepsy Research最新文献

{"title":"Principal component analysis of antiseizure medication-induced hostility/aggression and factor analysis of levetiracetam using the food and drug administration adverse event reporting system","authors":"Ryuichiro Hosoya ,&nbsp;Kento Kitajima ,&nbsp;Koushirou Sogawa ,&nbsp;Daigo Ikegami ,&nbsp;Tomoko Terajima ,&nbsp;Hideaki Kato ,&nbsp;Masahiko Funada ,&nbsp;Hajime Kagaya ,&nbsp;Yoshihiro Uesawa","doi":"10.1016/j.eplepsyres.2025.107626","DOIUrl":"10.1016/j.eplepsyres.2025.107626","url":null,"abstract":"<div><h3>Background</h3><div>Epilepsy affects approximately 50 million people worldwide. Antiseizure medications (ASMs) are essential for seizure control. However, adverse psychiatric effects, particularly hostility and aggression, affect treatment adherence and the quality of life. The risk factors and mechanisms underlying these adverse effects remain unclear.</div></div><div><h3>Objective</h3><div>This study aimed to classify ASM-induced hostility/aggression using the Food and Drug Administration Adverse Event Reporting System (FAERS), a global pharmacovigilance database, focusing on the risk factors and onset patterns of levetiracetam-induced hostility/aggression.</div></div><div><h3>Methods</h3><div>The FAERS database (2004 Q1–2022 Q1) was analyzed to calculate the reporting odds ratios for ASM-induced hostility/aggression, which were classified using a principal component analysis. Levetiracetam-induced adverse effects and the associated independent risk factors were examined. Weibull distribution analysis was used to assess the time-to-onset patterns</div></div><div><h3>Results</h3><div>Principal component analysis identified eight ASM-induced adverse effects, including \"aggression,\" \"anger,” “homicidal ideation,\" and \"hostility.\" In those taking levetiracetam aged ≥ 12 years, male sex, younger age, and specific concomitant medications were independent risk factors for levetiracetam-induced adverse effects. Levetiracetam-induced adverse effects exhibited an early failure pattern, with a median onset of 4.5 days in patients aged ≥ 12 years and 1.5 days in those &lt; 12 years.</div></div><div><h3>Conclusion</h3><div>In this study, we classified ASM-induced hostility/aggression and estimated the risk factors for levetiracetam-induced adverse effects. In particular, we identified early-onset patterns and high-risk patient profiles. These findings are consistent with clinical observations and provide insight into the mechanisms underlying these adverse effects, which will contribute to proactive risk management and personalized treatment strategies.</div></div>","PeriodicalId":11914,"journal":{"name":"Epilepsy Research","volume":"218 ","pages":"Article 107626"},"PeriodicalIF":2.0,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144679882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of in-vivo GABA+ and Glutamate levels in patients with drug resistant unilateral temporal lobe epilepsy using MEGA-PRESS and correlates with clinical semiology","authors":"N. Pradhan ,&nbsp;Manoj Kumar ,&nbsp;M. Sandhya ,&nbsp;P. Bairwa ,&nbsp;PV Prathyusha ,&nbsp;K. Raghavendra ,&nbsp;LG Viswanathan ,&nbsp;A. Asranna ,&nbsp;RC Mundlamuri ,&nbsp;DK Deelchand ,&nbsp;Jitender Saini ,&nbsp;Rose Dawn Bharath ,&nbsp;Sanjib Sinha","doi":"10.1016/j.eplepsyres.2025.107625","DOIUrl":"10.1016/j.eplepsyres.2025.107625","url":null,"abstract":"<div><h3>Background</h3><div>In this study, we used in vivo MEGA-PRESS spectroscopy to investigate GABA and Glu levels in patients with drug-resistant unilateral temporal lobe epilepsy (TLE) and also look for correlation between neurometabolites and clinical semiology assessed by other modalities.</div></div><div><h3>Materials and methods</h3><div>Twenty-five patients with TLE underwent MRS data acquisition on a 3.0 T MRI. Bilateral single-voxel MEGA-PRESS data was acquired from mesial temporal lobes, and data was post-processed using MRSpa and LC-Model for computing neurometabolites concentration. Tissue segmentation from spectroscopic voxel was performed for tissue metabolite and CSF correction. Statistical analysis was performed to analyze differences in neurometabolic between affected and normal-sides and clinical correlations.</div></div><div><h3>Results</h3><div>GABA, Glu, NAA, Cr, and Cho neurometabolites were computed. The group-wise statistical comparison revealed a significantly reduced NAA level from the affected compared to normal-side of the hippocampus (p-value=0.039). We observed reduced GABA (p-value=0.07) values and hippocampal volume (p-value&lt;0.001) were observed from the affected side. A significant negative correlation was noted between affected-side hippocampal volume and NAA concentration (rho=-0.497, p-value=0.05). Glu/NAA ratios from both affected (rho=-0.692, p-value=0.012) and normal-sides (rho=-0.608, p-value=0.016) of the hippocampus were negatively correlated with age. Concordance between neurometabolites with video-EEG for lateralization demonstrates correct classification percentage for GABA was 86.7 %, indicating that there is an 86.7 % chance that GABA will be able to lateralize the unaffected side as detected by VEEG.</div></div><div><h3>Conclusion</h3><div>A novel exploratory study demonstrates an alternation of <em>in-vivo</em> GABA and Glu levels and hippocampal volume. This study may provide a direction for utilizing MEGA-PRES as a presurgical tool for assessing <em>in-vivo</em> neurometabolic profiles and add to the knowledge of the role of GABA and Glu in epilepsy and its interplay.</div></div>","PeriodicalId":11914,"journal":{"name":"Epilepsy Research","volume":"218 ","pages":"Article 107625"},"PeriodicalIF":2.0,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144739530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and tolerability of magnesium sulfate in children with infantile epileptic spasms syndrome: A systematic review and meta-analysis","authors":"Indar Kumar Sharawat ,&nbsp;Ananthanarayanan Kasinathan ,&nbsp;Pragnya Panda ,&nbsp;Lesa Dawman ,&nbsp;Juhi Tiwari ,&nbsp;RC Pavan Kumar ,&nbsp;Prateek Kumar Panda","doi":"10.1016/j.eplepsyres.2025.107628","DOIUrl":"10.1016/j.eplepsyres.2025.107628","url":null,"abstract":"<div><h3>Background</h3><div>Several trials and clinical studies have explored the efficacy and safety of magnesium sulfate (MgSO₄) in children with infantile epileptic spasms syndrome (IESS). However, no systematic review has been conducted to synthesize the available evidence.</div></div><div><h3>Methods</h3><div>This systematic review aimed to assess the efficacy and safety of MgSO₄ in children with IESS. The primary outcomes included the proportion of patients achieving spasm freedom, a favorable response in the number of spasms (defined as at least a 50 % reduction in daily spasms), resolution of hypsarrhythmia, improvement in developmental quotient, and the nature and frequency of adverse events. Additionally, we compared these variables between the ACTH+MgSO₄ combination therapy and ACTH monotherapy at various time points. We included all controlled and uncontrolled trials, as well as prospective and retrospective cohort studies.</div></div><div><h3>Results</h3><div>A total of four studies involving 1334 IESS patients were identified. The proportion of patients achieving a favorable response in daily spasm frequency, spasm freedom, hypsarrhythmia resolution, and EEG normalization was higher in the adrenocorticotropic hormone (ACTH)+MgSO₄ group than in the ACTH monotherapy group (RR=1.22, 95 % CI: 1.09–1.36, I²=0 %, p = 0.0004; RR=1.44, 95 % CI: 1.24–1.67, I²=29 %, p &lt; 0.00001; RR=1.27, 95 % CI: 1.15–1.41, I²=0 %, p &lt; 0.00001; and RR=1.46, 95 % CI: 1.06–2.02, I²=0 %, p = 0.02, respectively). The proportion of patients experiencing treatment-emergent adverse events and serious adverse events was comparable between the ACTH+MgSO₄ and ACTH monotherapy groups (RR=0.55, 95 % CI: 0.28–1.07, I²=49 %, p = 0.08; and RR=1.15, 95 % CI: 0.74–1.79, I²=0 %, p = 0.54, respectively). However, the frequency of hypertension was significantly lower in the ACTH+MgSO₄ group compared to the ACTH monotherapy group (RR=0.11, 95 % CI: 0.03–0.34, I²=0 %, p = 0.0002).</div></div><div><h3>Conclusions</h3><div>The combination of ACTH and MgSO₄ is more effective than ACTH monotherapy in achieving seizure control in children with IESS. Additionally, it is associated with a reduced risk of certain adverse events, such as hypertension.</div></div>","PeriodicalId":11914,"journal":{"name":"Epilepsy Research","volume":"217 ","pages":"Article 107628"},"PeriodicalIF":2.0,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144653410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depressive symptoms in Chinese patients with epilepsy: Prevalence and clinical correlates","authors":"Yuwei Han ,&nbsp;Shun Gong ,&nbsp;Shimei Sun,&nbsp;Dan Yang,&nbsp;Bingying Zhang,&nbsp;Dandan Gao,&nbsp;Guanqian Yuan,&nbsp;Xiaoming Li,&nbsp;Guangzhi Hao,&nbsp;Guobiao Liang","doi":"10.1016/j.eplepsyres.2025.107624","DOIUrl":"10.1016/j.eplepsyres.2025.107624","url":null,"abstract":"<div><h3>Objective</h3><div>Depressive symptoms were a prevalent comorbidity among patients with epilepsy, significantly impacting their quality of life and treatment outcomes. This study aims to investigate the prevalence and clinical correlates of depressive symptoms in Chinese patients with epilepsy.</div></div><div><h3>Methods</h3><div>A descriptive cross-sectional study was conducted at the Department of Neurosurgery, General Hospital of Northern Theater Command, from January 2018 to June 2023. Patients diagnosed with epilepsy aged 16 years or older were included, excluding those with severe illnesses, substance abuse disorders, or severe cognitive impairments. Demographic and epilepsy-related information was collected using a standardized clinical data collection form. Depressive symptoms were assessed using the Beck Depression Inventory-II (BDI-II). Statistical analyses were performed using SPSS version 27.0.</div></div><div><h3>Results</h3><div>The study included 513 patients with epilepsy, with a mean age of 37.48 years (SD= 15.09). Among these, 65.9 % were male, and 62.6 % were aged 40 years or older. The majority of patients were single (50.9 %) and had formal education (57.1 %). The mean age of epilepsy onset was 21.96 years (SD = 12.83), and the mean duration of illness was 11.02 years (SD= 13.64). Generalized tonic-clonic seizures were the most common type (62.0 %), and 32.7 % of patients experienced very frequent seizures. Polytherapy was used by 63.5 % of patients. Depressive symptoms were present in 137 patients, representing a prevalence of 26.7 % (95 % CI: 20.51–31.89). The severity of depressive symptoms was categorized as mild in 62.0 %, mild to moderate in 18.2 %, moderate in 10.2 %, and severe in 9.5 %. The prevalence of depressive symptoms was higher among females, separated/widowed individuals, those with lower educational attainment, and unemployed patients. Significant associations were found between depressive symptoms and seizure frequency, duration of seizures, and polytherapy. Multivariate analysis identified seizure frequency, duration of seizures, and polytherapy as independent predictors of depressive symptoms.</div></div><div><h3>Conclusions</h3><div>Depressive symptoms were highly prevalent among Chinese patients with epilepsy, with significant associations found between depressive symptoms and several sociodemographic and clinical characteristics. Routine screening for depressive symptoms and tailored interventions are crucial for improving the quality of life and treatment outcomes in this population. Future research should focus on longitudinal studies to explore causal relationships and develop targeted interventions.</div></div>","PeriodicalId":11914,"journal":{"name":"Epilepsy Research","volume":"217 ","pages":"Article 107624"},"PeriodicalIF":2.0,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144653411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"White matter integrity and its correlation to seizures in diffuse glioma","authors":"Ludwig Klein ,&nbsp;Gordian Prasse ,&nbsp;Alim E. Basaran ,&nbsp;Jost-Julian Rumpf ,&nbsp;Martin Vychopen ,&nbsp;Johannes Wach ,&nbsp;Erdem Güresir ,&nbsp;Tim Wende","doi":"10.1016/j.eplepsyres.2025.107627","DOIUrl":"10.1016/j.eplepsyres.2025.107627","url":null,"abstract":"<div><h3>Introduction</h3><div>Seizures are one of the most common symptoms in patients with diffuse glioma, occurring in 30–80 % of cases. Although seizure control can be achieved in up to 90 %, seizures remain a significant burden and are hardly predictable. The aim of this analysis was, therefore, to investigate the association between white matter integrity and seizure occurrence in patients with diffuse glioma using diffusion tensor imaging (DTI).</div></div><div><h3>Methods</h3><div>Patients with first diagnosis of diffuse glioma (WHO-grade 2, 3, 4) who received preoperative DTI sequences for surgical planning were analyzed. Tractography of corpus callosum and cingulum was carried out, extracting mean FA values of the resulting volumes.</div></div><div><h3>Results</h3><div>50 patients (17 female) were included with a mean age of 59.5 ± 2.2 years. Glioma WHO grade 4 was most common (82 %), followed by grade 3 (10 %) and grade 2 (8 %). Most gliomas were located left temporal (32 %) and bilateral frontal (each hemisphere 16 %). 16 % presented with multifocal glioma. 48 % had suffered seizures prior to surgery, and were thus diagnosed with structural epilepsy. 22 % of all patients presented recurring seizures despite surgery and anti-seizure medication, and 6 % developed new seizures after surgery. After correction for multiple comparisons, increased FA in the left parahippocampal cingulum was significantly associated with preoperative seizures (0.30 ± 0.01 versus 0.27 ± 0.01, p_corr = 0.007), while increased FA in the forceps minor of the corpus callosum correlated with postoperative seizures (0.49 ± 0.01 versus 0.43 ± 0.01, p_corr = 0.014).</div></div><div><h3>Conclusion</h3><div>Higher preoperative white matter integrity was associated with increased risk for occurrence of seizures in diffuse glioma. Further research is warranted to investigate the relation with tumor pathology.</div></div>","PeriodicalId":11914,"journal":{"name":"Epilepsy Research","volume":"217 ","pages":"Article 107627"},"PeriodicalIF":2.0,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144632069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Childhood-onset epilepsy: Longitudinal seizure outcomes in a large single-center cohort","authors":"Hyun-Jin Kim,&nbsp;Min-Jee Kim,&nbsp;Eon Ah Kim,&nbsp;Ohcheol Kwon,&nbsp;Yun Sung Nam,&nbsp;Mi-Sun Yum ,&nbsp;Tae-Sung Ko","doi":"10.1016/j.eplepsyres.2025.107622","DOIUrl":"10.1016/j.eplepsyres.2025.107622","url":null,"abstract":"<div><h3>Objectives</h3><div>Epilepsy is the most common serious neurological disorder in children; however, previous long-term studies are often limited by small sample sizes or methodological variability. This study aimed to assess the epidemiology, seizure outcomes, and prognostic factors of childhood-onset epilepsy over &gt; 10 years of follow-up at a single tertiary center.</div></div><div><h3>Methods</h3><div>We retrospectively analyzed the medical records of 4248 patients diagnosed with epilepsy before age 19 between 1995 and 2017 at Asan Medical Center Children’s Hospital. All patients underwent at least one electroencephalogram (EEG) and received anti-seizure medications (ASMs) for &gt; 2 years.</div></div><div><h3>Results</h3><div>During a mean follow-up of 11.0 years, 43 patients (1.0 %) died. The median age at seizure onset was 7.2 years. Etiologies included unknown (52.5 %), structural (29.3 %), genetic/metabolic (23.4 %), and infectious/autoimmune (4.5 %). Focal epilepsy was the most common (63.4 %). Neurocognitive and psychological comorbidities were observed in 32.7 % and 20.6 % of patients, respectively. Seizure freedom for ≥ 2 years was achieved in 81.2 %, and terminal remission in 63.1 %. However, relapse occurred in 38.0 %, and 28.6 % developed intractable epilepsy. Prognostic factors included status epilepticus, intellectual disability, pretreatment seizure frequency, etiology, epilepsy syndromes, and EEG abnormalities.</div></div><div><h3>Conclusions</h3><div>This study reaffirms known risk factors while providing comprehensive insights into seizure trajectories, relapse patterns, and treatment responses in a large cohort. It highlights the clinical relevance of the 2-year seizure-free definition and underscores the need for early interventions in high-risk subgroups. Despite diagnostic advances, several cases remain etiologically unresolved, reinforcing the importance of expanding access to molecular and imaging tools in pediatric epilepsy care.</div></div>","PeriodicalId":11914,"journal":{"name":"Epilepsy Research","volume":"217 ","pages":"Article 107622"},"PeriodicalIF":2.0,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144604321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine learning models for predicting therapeutic response in drug-resistant epilepsy: A bivariate diagnostic meta-analysis","authors":"Anderson Matheus Pereira da Silva ,&nbsp;Victor Arthur Ohannesian ,&nbsp;Luciano Falcão ,&nbsp;Filipe Virgilio Ribeiro ,&nbsp;Isabelle Rodrigues Menezes ,&nbsp;Mariana Leticia de Bastos Maximiano ,&nbsp;Mariana Lee Han ,&nbsp;Lucas Silva Cabeça ,&nbsp;Pedro Lucas Machado Magalhães ,&nbsp;Gustavo Sousa Noleto ,&nbsp;Maria Bernadete de Sousa Maia ,&nbsp;Eryvelton de Souza Franco","doi":"10.1016/j.eplepsyres.2025.107623","DOIUrl":"10.1016/j.eplepsyres.2025.107623","url":null,"abstract":"<div><h3>Background</h3><div>Epilepsy affects approximately 6.4 per 1000 individuals worldwide. Despite advances in antiseizure medications (ASMs), nearly one-third of patients remain refractory to treatment, meeting criteria for drug-resistant epilepsy (DRE). This meta-analysis evaluated the performance of machine learning (ML) models in predicting therapeutic response in DRE based on ILAE-defined outcomes.</div></div><div><h3>Methods</h3><div>A systematic review and meta-analysis were conducted in accordance with PRISMA-DTA guidelines. Studies applying ML algorithms to predict treatment response in DRE were included. Eligible designs comprised retrospective or prospective observational studies. Outcomes included seizure remission (ILAE Class 1), ≥ 50 % reduction in seizure frequency, treatment failure, and diagnostic accuracy metrics. A bivariate random-effects model was used to pool sensitivity, specificity, and diagnostic odds ratio (DOR). Heterogeneity was assessed (I², χ²), and subgroup and meta-regression analyses were performed. Likelihood ratios, area under the curve (AUC), and Bayesian post-test probabilities were estimated. Publication bias was evaluated with Deeks’ test.</div></div><div><h3>Results</h3><div>Eight studies (n = 1887) met inclusion criteria (Kappa=0.98). Pooled sensitivity and specificity were both 0.84 (95 % CI: 0.76–0.89 and 0.77–0.89, respectively), with an AUC of 0.91. DOR was 27; LR+ , 5.2; LR−, 0.19. Heterogeneity was high (χ²=22.7; p &lt; 0.001). Sensitivity was lower in prospective studies, prognostic models, and ASMs users, and higher with long-term follow-up. Meta-regression identified model type, study design, ASM exposure, and sample adequacy as key moderators.</div></div><div><h3>Conclusion</h3><div>ML models demonstrate high diagnostic accuracy in predicting therapeutic response in DRE. Findings support their potential clinical utility, provided external validation and methodological standardisation.</div></div><div><h3>Registration PROSPERO protocol number</h3><div>CRD 42024628323</div></div>","PeriodicalId":11914,"journal":{"name":"Epilepsy Research","volume":"217 ","pages":"Article 107623"},"PeriodicalIF":2.0,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144595496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Oxidative stress, metalloproteinase and LDH in children with intractable and non-intractable epilepsy as reflected in salivary analysis” [Epilepsy Res. 108 (1) (2014) 117–124]","authors":"Eli Shahar ,&nbsp;Uri Attias ,&nbsp;Dana Savulescu ,&nbsp;Jacob Genizin ,&nbsp;Moshe Gavish ,&nbsp;Rafael Nagler","doi":"10.1016/j.eplepsyres.2025.107612","DOIUrl":"10.1016/j.eplepsyres.2025.107612","url":null,"abstract":"","PeriodicalId":11914,"journal":{"name":"Epilepsy Research","volume":"215 ","pages":"Article 107612"},"PeriodicalIF":2.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144552704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Theta functional connectivity alterations related to executive control in refractory temporal lobe epilepsy","authors":"Changqing Zhan ,&nbsp;Qiao Wang ,&nbsp;Wenyu Wang ,&nbsp;Xueping Lu ,&nbsp;Shizao Fei ,&nbsp;Zongsheng Chen ,&nbsp;Yingnian Chen","doi":"10.1016/j.eplepsyres.2025.107620","DOIUrl":"10.1016/j.eplepsyres.2025.107620","url":null,"abstract":"<div><h3>Aims</h3><div>Using the attention network test (ANT) with simultaneous electroencephalography (EEG) recordings, this study investigated the neural mechanisms underlying executive control (EC) dysfunction in patients with temporal lobe refractory epilepsy.</div></div><div><h3>Methods</h3><div>Participants comprised three demographically matched groups (n = 20 each): refractory temporal lobe epilepsy (RE), drug-sensitive temporal lobe epilepsy (DSE), and healthy controls (Ctrl). Participants were instructed to perform the ANT while scalp EEG signals were simultaneously recorded. Theta-band functional connectivity was computed from EEG data acquired during ANT task execution.</div></div><div><h3>Results</h3><div>The RE group exhibited significant impairment in EC performance. Theta-band functional connectivity strength in the whole-brain and frontal regions of the EC network was significantly reduced in both patient groups (RE/DSE) versus healthy controls. Notably, the RE group demonstrated reduced whole-brain and frontal theta connectivity within the EC network relative to the DSE group. Furthermore, frontal theta connectivity strength positively correlated with EC_effect in both Ctrl and DSE groups (r = -0.658, p = 0.002; r = -0.540, p = 0.014). In contrast, no significant association was observed between EC network theta connectivity and behavioral performance in the RE group (p &gt; 0.05).</div></div><div><h3>Conclusion</h3><div>Patients with refractory epilepsy exhibited impaired EC behavioral performance, concomitant with reduced theta-band functional connectivity strength in frontal regions. This diminished frontal theta connectivity may underlie EC dysfunction in this patient population.</div></div>","PeriodicalId":11914,"journal":{"name":"Epilepsy Research","volume":"217 ","pages":"Article 107620"},"PeriodicalIF":2.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144534978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phenylbutyrate for monogenetic epilepsy: Literature review","authors":"Amelia Stone ,&nbsp;Jacqueline Burré ,&nbsp;Natalie Wayland ,&nbsp;Zachary M. Grinspan","doi":"10.1016/j.eplepsyres.2025.107621","DOIUrl":"10.1016/j.eplepsyres.2025.107621","url":null,"abstract":"<div><div>Monogenetic epilepsies are seizure disorders with a single-gene etiology. More than 500 genes are linked to epilepsy. As many as 40 % of epilepsies are caused by variants in one of these genes. Single gene-linked epilepsies have a wide phenotypic spectrum and may be accompanied by comorbidities such as developmental and motor delays. Epilepsy is often pharmacoresistant and does not respond to existing drug therapies. Preclinical data suggests that 4-phenylbutyrate (PBA) may produce an anti-seizure effect in individuals with genetic epilepsies, including STXBP1, SLC6A1, SLC6A8, GABA(A) disorders, Dravet Syndrome (SCN1A), and LGI1 variants. Clinical data also suggests that PBA may have a therapeutic effect for SYNGAP1. This literature review describes the clinical profiles of several monogenetic epilepsies and the pathogenesis of seizure activity in these disorders. We focus on gene-linked epilepsy syndromes that may benefit from treatment with PBA according to several proposed theories of the drug’s mechanism and functional impact.</div></div>","PeriodicalId":11914,"journal":{"name":"Epilepsy Research","volume":"217 ","pages":"Article 107621"},"PeriodicalIF":2.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144579869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}