European Heart Journal: Case Reports最新文献

{"title":"First demonstration of implication of hereditary alpha-tryptasaemia in vasospastic angina: a case report.","authors":"Benoit Caullery, Alexis Bocquet, Laurent Riou, Gilles Barone-Rochette","doi":"10.1093/ehjcr/ytaf130","DOIUrl":"10.1093/ehjcr/ytaf130","url":null,"abstract":"<p><strong>Background: </strong>Vasospastic angina is a common condition. In cases of poor therapeutic response, less common causes should be explored.</p><p><strong>Case summary: </strong>A 50-year-old woman with vasospastic angina was diagnosed with significant fluctuation in response to treatment without explanation that led to the suspicion of an allergic phenomenon. A diagnosis of hereditary alpha-tryptasaemia was made, and introduction of a second-generation H1-antihistamine has enabled effective control of previously treatment-resistant vasospastic coronary disease.</p><p><strong>Discussion: </strong>The case shows the first time the involvement of hereditary alpha-tryptasaemia in vasospastic angina. Future pathophysiological investigations will be needed to further explore the connection between these two pathologies.</p>","PeriodicalId":11910,"journal":{"name":"European Heart Journal: Case Reports","volume":"9 3","pages":"ytaf130"},"PeriodicalIF":0.8,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11941469/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143717983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful percutaneous closure of an iatrogenic right ventricular perforation utilizing an Angio-Seal device: a case report.","authors":"Abdulrahman Arabi, Amr A Ashour, Mawahib El Hassan, Bassam Shoman, Abdulwahid Al Mulla","doi":"10.1093/ehjcr/ytaf128","DOIUrl":"10.1093/ehjcr/ytaf128","url":null,"abstract":"<p><strong>Background: </strong>Pericardiocentesis, a procedure with potential life-saving implications, can lead to complications such as cardiac perforation. Emergency open cardiac surgery, the conventional approach for addressing iatrogenic or traumatic cardiac perforations, is associated with unfavourable outcomes in high-risk patients. This report explores a case of accidental iatrogenic right ventricular (RV) puncture, which was effectively managed using a percutaneous closure device.</p><p><strong>Case summary: </strong>A 42-year-old male was hospitalized due to a persistent cough, dyspnoea, and fever, raising suspicion of tuberculosis. He was found to have a large pericardial effusion with signs of impending cardiac tamponade. During an attempted pericardiocentesis at an outside facility, his right ventricle was inadvertently perforated by a catheter. He was transferred to a specialized hospital to be assessed by a cardiac surgeon, where the heart team performed a percutaneous closure of the perforation using an Angio-Seal device, which was successful. A subsequent pericardiectomy was performed to address the effusion and confirm the absence of tuberculosis or malignancy. The patient recovered well, and follow-up imaging showed no worsening of the pericardial effusion. He was discharged in stable condition.</p><p><strong>Discussion: </strong>Pericardiocentesis, while crucial for treating large pericardial effusions, carries a small risk of complications such as ventricular perforation. Although surgery is a cornerstone in management, the Angio-Seal device has been used successfully in some cases to repair these tears. In this case, an Angio-Seal device effectively closed a RV rupture, with no further complication seen in follow-up exams. This suggests Angio-Seal as a potentially useful, less invasive option for treating such complications.</p>","PeriodicalId":11910,"journal":{"name":"European Heart Journal: Case Reports","volume":"9 4","pages":"ytaf128"},"PeriodicalIF":0.8,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11971473/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A unique presentation of systolic anterior motion of the mitral valve in a patient with obstructive hypertrophic cardiomyopathy and recurrent syncope: a case report.","authors":"Wenxia Li, Jing Ping Sun, Chao Han, Shengjun Ta, Liwen Liu","doi":"10.1093/ehjcr/ytaf103","DOIUrl":"10.1093/ehjcr/ytaf103","url":null,"abstract":"<p><strong>Background: </strong>Systolic anterior motion (SAM) of the mitral valve is a hallmark feature of hypertrophic obstructive cardiomyopathy (HOCM) and a primary cause of dynamic left ventricular outflow tract obstruction. This case report highlights an unusual presentation of SAM associated with acute haemodynamic collapse.</p><p><strong>Case summary: </strong>A 36-year-old male with HOCM presented with recurrent episodes of syncope. After a multidisciplinary evaluation, he underwent percutaneous intramyocardial septal radiofrequency ablation (PIMSRA). Approximately 1-h post-procedure, the patient developed severe haemodynamic collapse. Transthoracic echocardiography revealed abnormal proximal displacement of the anterior mitral valve leaflet, bringing it into close proximity with the septum. The patient was treated emergently with high-dose intravenous norepinephrine, stabilizing his condition. At the 18-month follow-up, the patient reported no recurrence of syncope.</p><p><strong>Discussion: </strong>Proximal displacement of the anterior mitral leaflet, a rare and severe form of SAM, is an uncommon yet critical complication associated with haemodynamic collapse and syncope. This phenomenon warrants heightened attention during PIMSRA for the treatment of HOCM.</p>","PeriodicalId":11910,"journal":{"name":"European Heart Journal: Case Reports","volume":"9 3","pages":"ytaf103"},"PeriodicalIF":0.8,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11905931/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary cardiac lymphoma presenting with wide QRS tachycardia: a case report.","authors":"Ömer Şahin, Halime Tanriverdi, Turgut Seber, Arzu Taşdemir","doi":"10.1093/ehjcr/ytaf065","DOIUrl":"10.1093/ehjcr/ytaf065","url":null,"abstract":"<p><strong>Background: </strong>Lymphomas, which originate from the haematopoietic system, are seldom found in the heart due to the absence of a lymphoid system. Primary cardiac lymphoma is quite rare. Cardiac lymphomas can present with dyspnoea, heart failure, pericardial effusion, and arrhythmia. Given the high mortality rates associated with cardiac masses, swift diagnosis is crucial.</p><p><strong>Case summary: </strong>A 46-year-old male patient presented to the emergency department of our hospital with complaints of dyspnoea and palpitations. The patient's electrocardiogram revealed a tachycardia characterized by a wide QRS complex and a heart rate of 234 beats per minute, and an intravenous infusion of amiodarone was immediately started. In the cardiac MRI performed, a mass lesion was observed, which was ∼63 ∗ 30 ∗ 79 mm in size, extending from the right atrium to the superior vena cava and right atrial appendage, infiltrating the free wall of the right ventricle, pericardium, and right atrial wall, and showing distinct diffusion restriction in places. The patient's cardiac MRI was documented with a suspicion for cardiac lymphoma. The patient was referred to haematology clinic and started on rituximab-cyclophosphamide, doxorubicin, vincristine, and prednisone chemotherapy.</p><p><strong>Discussion: </strong>The diagnosis of primary cardiac lymphoma is uncommon. Even a mass exceeding 7 cm in size may not be visible on transthoracic echocardiography. The use of cardiac MRI to identify intracardiac masses should be incorporated into the diagnostic process to expedite diagnosis and the initiation of life-saving treatment.</p>","PeriodicalId":11910,"journal":{"name":"European Heart Journal: Case Reports","volume":"9 3","pages":"ytaf065"},"PeriodicalIF":0.8,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11894249/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143604498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acurate Neo2 for valve-in-valve treatment of degenerated 3F Enable sutureless bioprosthetic valve in nonagenarian patient: a case report.","authors":"Andres Agustin Vecchia, Giuseppe Migliaro, Paolo Cioffi, Dario Calderone, Giuseppe Verolino","doi":"10.1093/ehjcr/ytaf073","DOIUrl":"10.1093/ehjcr/ytaf073","url":null,"abstract":"<p><strong>Background: </strong>Sutureless bioprosthetic valves (SBVs) are engineered to enable a less invasive surgical valve replacement procedure in patients at high surgical risk. Valve degeneration is a relatively common occurrence across all types of surgical valves, including SBVs. Valve-in-valve (ViV) procedures are increasingly becoming the preferred treatment for many cases of valve degeneration due to their minimally invasive nature and favourable long-term outcomes. However, the specific structural characteristics of SBVs present challenges for ViV procedures, and the evidence on this subject remains limited.</p><p><strong>Case summary: </strong>A 91-year-old man was admitted to our hospital presenting with dyspnoea due to severe aortic regurgitation in a degenerated 3F Enable sutureless valve. Valve-in-valve transcatheter aortic valve implantation (ViV-TAVI) was successfully performed using a self-expanding Acurate Neo2 valve, yielding good haemodynamic results without overt interaction between the prosthesis. A 6-month follow-up echocardiogram confirmed excellent valve performance.</p><p><strong>Discussion: </strong>ViV-TAVI is a well-established treatment for bioprosthetic valve failure in high-risk patients. However, sutureless valve degeneration presents a challenging scenario for ViV procedures, with only a limited number of cases performed using the Acurate platform. In this case, we demonstrated the technical feasibility of ViV using the Acurate system in a less explored surgical sutureless bioprosthesis.</p>","PeriodicalId":11910,"journal":{"name":"European Heart Journal: Case Reports","volume":"9 3","pages":"ytaf073"},"PeriodicalIF":0.8,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11895507/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143604482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful percutaneous retrieval of a detached MitraClip® in the left atrium via maintained gripper line: a case report.","authors":"Hiroto Yagasaki, Takeki Suzuki, Ryota Watanabe, Keitaro Watanabe, Toshiyuki Noda","doi":"10.1093/ehjcr/ytaf124","DOIUrl":"10.1093/ehjcr/ytaf124","url":null,"abstract":"<p><strong>Background: </strong>Mitral valve transcatheter edge-to-edge repair (M-TEER) with MitraClip® has become an established treatment for high-risk patients with mitral regurgitation (MR). While device-related complications are known, they typically occur during leaflet grasping or after deployment, with most issues arising from device-tissue interaction.</p><p><strong>Case summary: </strong>A 67-year-old woman with dilated cardiomyopathy underwent M-TEER for severe functional MR. Although resistance was noted during initial device preparation and loading, limited functional testing appeared normal and the procedure was continued. During clip manipulation in the left atrium, mechanical resistance in the arm positioner led to unexpected detachment of the MitraClip, connected only by the gripper line. Through careful traction under echocardiographic and fluoroscopic guidance, we successfully retrieved the clip percutaneously. The procedure was completed with new MitraClip systems, achieving mild residual MR. The patient's symptoms improved from New York Heart Association Classes II and III to I, with sustained improvement during 4.5 years of follow-up.</p><p><strong>Discussion: </strong>This case reveals a novel mechanism of MitraClip detachment through mechanical failure during preparation, where introducer damage led to harness deformation and subsequent clip detachment. Among available retrieval options, we demonstrated the feasibility of direct traction retrieval under specific conditions, offering a less invasive solution when gripper line connection is maintained. This case emphasizes the importance of meticulous device inspection and preparation, while providing insights into both failure mechanisms and retrieval strategies in M-TEER complications.</p>","PeriodicalId":11910,"journal":{"name":"European Heart Journal: Case Reports","volume":"9 3","pages":"ytaf124"},"PeriodicalIF":0.8,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11926327/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bachmann's bundle and upper septal inter-atrial connections as key paths for a biatrial macro re-entrant circle: a case report.","authors":"Heber Ivan Condori Leandro, Dmitry S Lebedev, Lubov B Mitrofanova, Evgeny N Mikhaylov","doi":"10.1093/ehjcr/ytaf119","DOIUrl":"10.1093/ehjcr/ytaf119","url":null,"abstract":"<p><strong>Background: </strong>The Bachmann's bundle has been described as a key route for re-entrant circuits in biatrial tachycardias. Septal inter-atrial muscular connections were discovered a while ago, but evidence on their potential role in re-entrant tachycardias is lacking.</p><p><strong>Case summary: </strong>We describe an atrial macro re-entrant circuit presented as a wide complex tachycardia that utilized the Bachmann's bundle, septal inter-atrial connections, and a limited area of the anterior left atrial myocardium in a patient with previous multiple atrial fibrillation ablation procedures. This tachycardia was diagnosed by using a combination of electrophysiological visualization modalities and was terminated by a single radiofrequency application.</p><p><strong>Discussion: </strong>The inter-atrial muscular connections can pose a major contribution to the mechanism of biatrial tachycardias, especially in patients after extensive left atrial ablation. Thorough mapping modalities, including entrainment stimulation, facilitate a correct diagnosis. Understanding inter-atrial connection anatomy is crucial for the detection and successful ablation of such tachycardia.</p>","PeriodicalId":11910,"journal":{"name":"European Heart Journal: Case Reports","volume":"9 3","pages":"ytaf119"},"PeriodicalIF":0.8,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11925846/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reflex syncope due to exaggerated cardioinhibitory vagal response to photic stimulation: a case report.","authors":"Rebecca Lewis, Christopher E D Saunderson, Muzahir H Tayebjee, Sam Fairclough, Ben N Mercer","doi":"10.1093/ehjcr/ytaf123","DOIUrl":"10.1093/ehjcr/ytaf123","url":null,"abstract":"<p><strong>Background: </strong>Transient loss of consciousness is a common presentation to emergency departments, medical assessment units, and cardiology and neurology outpatients. It is a presentation frequently resulting in hospital admission, or multiple presentations to health services and in up to a third of cases a specific aetiology is not identified. [D'Ascenzo F, Biondi-Zoccai G, Reed MJ, Gabayan GZ, Suzuki M, Costantino G, et al. Incidence, etiology and predictors of adverse outcomes in 43,315 patients presenting to the Emergency Department with syncope: an international meta-analysis. <i>Int J Cardiol</i> 2013;167:57-62.].</p><p><strong>Case summary: </strong>A 68-year-old female presented with an unexplained episode of collapse with amnesia. Initial cardiac and neurological investigations were normal. A sleep deprived electroencephalogram (EEG) with intermittent photic stimulation triggered a profound bradycardic response with a 12 second period of asystole interspersed with a single junctional beat. The EEG demonstrated slow delta and theta activity frequency waves without epileptiform spikes or sharp waves during the period of bradycardia consistent with decreased cerebral perfusion. A dual chamber pacemaker was implanted and the patient has remained asymptomatic since implantation.</p><p><strong>Discussion: </strong>This case highlights an unusually pronounced cardioinhibitory response to photic stimulation successfully treated with pacemaker implantation. 'Trigeminocardiac' reflex mechanisms are described which may explain this phenomenon in association with sinus node dysfunction.</p>","PeriodicalId":11910,"journal":{"name":"European Heart Journal: Case Reports","volume":"9 4","pages":"ytaf123"},"PeriodicalIF":0.8,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11952998/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case report of procedural management of an adult with morquio syndrome undergoing transcatheter aortic valve implantation.","authors":"Agustin Oneto, Rahul Sakhuja, Asishana Osho, Nathaniel B Langer, Matthew J Eagleton, Michael G Fitzsimons","doi":"10.1093/ehjcr/ytaf117","DOIUrl":"10.1093/ehjcr/ytaf117","url":null,"abstract":"<p><strong>Background: </strong>Morquio syndrome is an autosomal recessive deficiency of <i>N</i>-acetylgalactosamine-6-sulphate, causing an accumulation of glycosaminoglycans that leads to musculoskeletal and cardiopulmonary abnormalities. We describe the management of aortic stenosis via a transcatheter aortic valve implantation (TAVI) in a patient with Morquio syndrome.</p><p><strong>Case summary: </strong>A 73-year-old woman with Morquio syndrome presented with one year of progressive dyspnoea and was found to have severe aortic stenosis on transthoracic echocardiogram. She previously underwent an attempted TAVI via transfemoral approach, which was aborted due to iliac artery dissection and occlusion. A multidisciplinary team opted for TAVI via a surgical femoral artery cut-down approach. She was last seen and recovering well three months post-procedure.</p><p><strong>Discussion: </strong>Musculoskeletal and cardiopulmonary manifestations of Morquio syndrome place patients at higher risk for procedural complications. As medical techniques improve and patients survive later into adulthood, increasing numbers will require aortic valve replacements to improve quality of life. This case highlights the challenges of aortic valve disease management in patients with Morquio syndrome, and suggests that TAVI can be safely performed using a surgical femoral cut-down approach.</p>","PeriodicalId":11910,"journal":{"name":"European Heart Journal: Case Reports","volume":"9 3","pages":"ytaf117"},"PeriodicalIF":0.8,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11945293/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143729453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Midostaurin-associated perimyocarditis: a case report of severe cardiotoxicity of novel targeted treatments for acute myeloid leukaemia and review of the literature.","authors":"Alev Kalkan, Lenhard Pennig, Roman Pfister, Oliver A Cornely, Jannik Stemler","doi":"10.1093/ehjcr/ytaf044","DOIUrl":"10.1093/ehjcr/ytaf044","url":null,"abstract":"<p><strong>Background: </strong>Midostaurin is a multikinase inhibitor for the treatment of Fms-like tyrosine 3 (<i>FLT3</i>)-mutated acute myeloid leukaemia (AML). Cardiac adverse events like QTc-prolongation, pericardial effusion, and congestive heart failure have been described. Inflammatory diseases associated with midostaurin are rarely reported.</p><p><strong>Case summary: </strong>A 24-year-old man with newly diagnosed AML and <i>FLT3-ITD</i> mutation was treated with intensive remission-induction chemotherapy and midostaurin. After 5 days of midostaurin, the patient reported severe focal chest pain. Due to laboratory evidence of acute myocardial cell damage, coronary macroangiopathy and pulmonary artery embolism were ruled out via computed tomography. Cardiovascular magnetic resonance showed evidence for active perimyocarditis with myocardial oedema and late gadolinium of the basal, midventricular, and apical lateral wall of the left ventricle. Therapeutic drug monitoring did not reveal excessive midostaurin plasma levels, and hence, initially suspected drug interaction with posaconazole administered for antifungal prophylaxis was considered less likely to be causative. After discontinuing midostaurin, clinical signs of perimyocarditis improved. During continued high-dose cytarabine therapy, no further cardiac events occurred. It was concluded that perimyocarditis was an adverse effect of midostaurin since the inhibition of <i>FTL3</i> may have led to a loss of cardiomyocyte protective capacity against oxidative stress-induced apoptosis, as previously described <i>in vitro</i>.</p><p><strong>Discussion: </strong>In addition to the most frequently reported non-cardiac adverse effects of midostaurin, serious cardiotoxic complications appear to occur and may require discontinuation of therapy. This case highlights the importance of interdisciplinary work-up of a cardio-oncology pathway even in presumably low-risk patients and particularly in the context of rare cases of cardiotoxicity in novel cancer treatments.</p>","PeriodicalId":11910,"journal":{"name":"European Heart Journal: Case Reports","volume":"9 3","pages":"ytaf044"},"PeriodicalIF":0.8,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11886857/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}