European Journal of Nuclear Medicine and Molecular Imaging最新文献

{"title":"Prognostic impact of metabolic tumor volume using the SUV4.0 segmentation threshold in 1,960 lymphoma patients from prospective LYSA trials","authors":"Solène Malmon, Mad-Helenie Elsensohn, Catherine Thieblemont, Franck Morschhauser, Olivier Casasnovas, Marc André, Steven Le Gouill, Yassine Al Tabaa, Paul Bland Durand, Clement Bailly, Veronique Edeline, Lavinia Vija, Laetitia Vercellino, Romain Ricci, Salim Kanoun, Anne-Ségolène Cottereau","doi":"10.1007/s00259-025-07176-4","DOIUrl":"https://doi.org/10.1007/s00259-025-07176-4","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose</h3><p>This study compared the prognostic value of total metabolic tumor volume (TMTV) in lymphoma measured with the recently proposed SUV4.0 segmentation threshold versus the 41% SUVmax across LYSA trials and its impact on intensity and dissemination PET features.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>A total of 1960 baseline PET/CT scans of Diffuse Large B cell lymphoma (DLBCL), follicular lymphoma (FL) and Hodgkin lymphoma (HL) patients were collected. After a semi-automatic preselection of region of interest, two different segmentation threshold were applied: 41% SUVmax (TMTV_41%) and SUV &gt; 4.0 (TMTV_4.0).</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>The correlation between TMTV_4.0 and TMTV_41% was ρ = 0.90 for DLBCL, ρ = 0.65 for FL and ρ = 0.60 for HL. For SUVmax, SUVpeak, Dmax and Dbulk features, a strong correlation was observed with ρ &gt; 0.95 whatever the lymphoma subtypes. The predictability of TMTV was high and comparable for the two methods with superimposable confidence intervals for the three subtypes. At the 90th percentile TMTV value, the predicted 7-year PFS was 51.13% with TMTV_4.0 vs. 49.7% with TMTV_41% for DLBCL patients, 45.5% vs. 39.8% for FL patients, and 82.6% vs. 80.5% for HL patients. A minority of patients showed a predicted PFS deviation &gt; 10% between the two methods: 2.33% in DLBCL, 6.51% in FL and 1% in HL.</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>TMTV measured with the SUV4.0 threshold provides a comparable PFS prediction than the 41%SUVmax method supporting its routine adoption particularly in the diffuse large B cell lymphoma subtype.</p>","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":"16 1","pages":""},"PeriodicalIF":9.1,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143661334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Takayasu’s arteritis imaged by a LAFOV PET/CT system: better resolution leads to greater diagnostic certainty","authors":"Sofie Rytter, André Henrique Dias, Ole Lajord Munk, Lars Christian Gormsen","doi":"10.1007/s00259-025-07192-4","DOIUrl":"https://doi.org/10.1007/s00259-025-07192-4","url":null,"abstract":"","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":"24 1","pages":""},"PeriodicalIF":9.1,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143661335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visualization of tuberculosis and interstitial lung disease in dermatomyositis using [68Ga]Ga-FAPI‐04 PET/CT","authors":"Qian Zhao, Xinlin Shao, Hua Cao, Jiajia Hu","doi":"10.1007/s00259-025-07189-z","DOIUrl":"https://doi.org/10.1007/s00259-025-07189-z","url":null,"abstract":"","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":"69 1","pages":""},"PeriodicalIF":9.1,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143653424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The utility of [¹⁸F] FDG PET/CT in staging hidradenocarcinoma","authors":"Gokce Belge Bilgin, Cem Bilgin, Matthew A. Frick, Doris E. Wenger, Matthew P. Thorpe, Stephen M. Broski","doi":"10.1007/s00259-025-07213-2","DOIUrl":"https://doi.org/10.1007/s00259-025-07213-2","url":null,"abstract":"<p>Hidradenocarcinoma is a rare and aggressive malignant cutaneous adnexal tumor that originates from the intradermal ducts of eccrine sweat glands. Herein, we report a case of hidradenocarcinoma that had transformed from a previously excised benign hidradenoma. [¹⁸F] FDG PET/CT revealed an FDG-avid mass in the left calf, and extensive metastatic disease, including soft tissue, pulmonary, osseous, and extensive nodal metastases. This case underscores the potential for malignant transformation of hidradenoma and highlights the utility of [¹⁸F] FDG PET/CT in staging hidradenocarcinoma.</p>","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":"67 1","pages":""},"PeriodicalIF":9.1,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143653422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Functional biomarkers derived from computed tomography and magnetic resonance imaging differentiate PDAC subgroups and reveal gemcitabine‑induced hypo‑vascularization.","authors":"Irina Heid, Marija Trajkovic-Arsic, Fabian Lohöfer, Georgios Kaissis, Felix N Harder, Moritz Mayer, Geoffrey J Topping, Friderike Jungmann, Barbara Crone, Moritz Wildgruber, Uwe Karst, Lucia Liotta, Hana Algül, Hsi-Yu Yen, Katja Steiger, Wilko Weichert, Jens T Siveke, Marcus R Makowski, Rickmer F Braren","doi":"10.1007/s00259-025-07195-1","DOIUrl":"https://doi.org/10.1007/s00259-025-07195-1","url":null,"abstract":"","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":" ","pages":""},"PeriodicalIF":8.6,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the origins of frequent tau-PET signal in vermal and adjacent regions","authors":"Agnes Kling, Julia Kusche-Palenga, Carla Palleis, Alexander Jäck, Alexander M. Bernhardt, Lukas Frontzkowski, Sebastian N. Roemer, Luna Slemann, Mirlind Zaganjori, Maximilian Scheifele, Lars Paeger, Gérard N. Bischof, Thilo van Eimeren, Alexander Drzezga, Osama Sabri, Michael Rullmann, Henryk Barthel, Johannes Levin, Jochen Herms, Nicolai Franzmeier, Günter Höglinger, Sigrun Roeber, Matthias Brendel, Johannes Gnörich","doi":"10.1007/s00259-025-07199-x","DOIUrl":"https://doi.org/10.1007/s00259-025-07199-x","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose</h3><p>Off-target binding remains a significant challenge in tau-PET neuroimaging. While off-targets including monoamine oxidase enzymes and neuromelanin-containing cells have been identified, recent studies indicated a relevant binding of novel tau tracers to melanin-containing structures. To date, little is known about the effect of melanocytes in the meninges on tracer signals in brain PET data. Thus, we aimed to identify the target structure causal for the frequently observed [¹⁸F]PI-2620 PET signal in the vermis and adjacent cerebellar regions.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>274 participants underwent dynamic [¹⁸F]PI-2620 tau-PET: 3/4R-tauopathies (n = 85), 4R-tauopathies (n = 147), tau-negative disease controls (n = 24), and healthy controls (n = 18). Standardized uptake value ratio (SUVR) and kinetic parameters including the distribution volume ratio (DVR), tracer clearance (k2) and relative perfusion (R1), were compared among the cohorts and sexes using the Automated Anatomical Labelling (AAL) atlas. Age and p-Tau levels in cerebrospinal fluid (CSF) were assessed for their relationship with vermal tau-PET signal. Furthermore, we combined autoradiographic and histochemical experiments on post-mortem brain tissue of deceased patients (n = 9).</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>Male participants revealed higher mean vermal [¹⁸F]PI-2620 DVR (0.95 ± 0.13; vs. females 0.88 ± 0.10, p &lt; 0.0001). Sex-related differences were most pronounced in the 3/4R-tauopathy cohort (p &lt; 0.0001). Mean SUVR_Ver/Cbl, k2 and correlation analyses of kinetic parameters did not differ among groups. Histological assessments revealed co-localization of leptomeningeal pigmented cells with strong autoradiography signal spots within the vermal fissures. Tau-related autoradiography signals, age or p-Tau levels did not correlate significantly with tau-PET signals. Iron deposits did not cause relevant autoradiography signals in the vermis.</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>Leptomeningeal melanocytes are the primary target structure for [¹⁸F]PI-2620 PET binding in anterior vermis, whereas iron and tau deposits do not contribute significantly.\u0000</p>","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":"10 1","pages":""},"PeriodicalIF":9.1,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143640554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"131I SPECT/CT provides prognostic information in patients with differentiated thyroid cancer","authors":"Marieke Heinrich, Elias Blickle, Philipp E. Hartrampf, Natalie Hasenauer, Aleksander Kosmala, Alexander Kerscher, Nicolas Schlegel, Frederik A. Verburg, Andreas K. Buck, Kerstin Michalski","doi":"10.1007/s00259-025-07187-1","DOIUrl":"https://doi.org/10.1007/s00259-025-07187-1","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose</h3><p>The aim of this study is to investigate the impact of lymph node metastases (LNM) detected on cervical ¹³¹I single photon emission computed tomography/computed tomography (SPECT/CT) after the first radioiodine therapy (RAI) on complete response (CR) and progression-free survival (PFS) in patients with differentiated thyroid cancer (DTC).</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>This retrospective study included 942 DTC patients who underwent cervical ¹³¹I SPECT/CT after their first RAI. LNM were categorized based on CT (enlarged ≥ 1 cm, small &lt; 1 cm) and ¹³¹I uptake. CR and PFS were analysed using Kaplan–Meier curves and Cox regression.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>Patients with no LNM had a shorter median time to CR (9.4 months) than those with LNM (44 months, HR 2.2; <i>p</i> &lt; 0.01) and a lower risk of progression (median PFS not reached, HR 0.46; <i>p</i> &lt; 0.01). Among patients with LNM, those with enlarged ¹³¹I negative LNM had the longest time to CR (24 months, HR 0.36; <i>p</i> &lt; 0.01). Patients with small LNM had a PFS similar to patients without LNM (median PFS not reached, HR 1.22; <i>p</i> = 0.54). Reoperation after first RAI (13.5 months) led to earlier CR than second RAI (median not reached) in patients with enlarged LNM. For small LNM, second RAI was associated with longer PFS than reoperation (38.4 months vs. not reached, HR 4.0; <i>p</i> = 0.02).</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>Patients without LNM on post-therapy ¹³¹I SPECT/CT have better chances for early CR and longer PFS. Patients with LNM benefit from early reoperations but treatment strategies should be tailored based on LNM characteristics.</p>","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":"92 1","pages":""},"PeriodicalIF":9.1,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143627494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myocardial blood flow reference values for 13N-ammonia PET myocardial perfusion imaging in patients without flow-limiting coronary artery disease","authors":"Rita Pingree, Susanne Markendorf, Dimitrios Moysidis, Christoph Ryffel, Magdalena Stuetz, Raffael Ghenzi, Marko Gajic, Dominik C. Benz, Aju P. Pazhenkottil, Andreas A. Giannopoulos, Philipp A. Kaufmann, Simon Winther, Ronny R. Buechel","doi":"10.1007/s00259-025-07196-0","DOIUrl":"https://doi.org/10.1007/s00259-025-07196-0","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose</h3><p>To determine the most important patient factors influencing quantitative MBF and to report the lower (LRL) and upper (URL) reference limits for 13N-ammonia positron emission tomography (PET) myocardial perfusion imaging (MPI).</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>Patients who underwent 13N-ammonia PET-MPI were screened, and those with evidence of myocardial ischemia or scar, known cardiomyopathy, impaired left ventricular function, non-response to vasodilators, and those who underwent a stress-rest protocol were excluded. Multiple linear regression analyses were performed to identify independent predictors of rest MBF (rMBF), stress MBF (sMBF), and myocardial flow reserve (MFR), and predictor importance was calculated. Finally, median, LRL, and URL for rMBF, sMBF, and MFR were calculated based on the presence of predictors.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>Among 784 patients with a median coronary artery calcium score (CACS) of 69, median rMBF was 0.75mL∙min^− 1∙g^− 1 (LRL = 0.49 mL∙min^− 1∙g^− 1; URL = 1.33 mL∙min^− 1∙g^− 1), median sMBF was 2.41mL∙min^− 1∙g^− 1 (LRL = 1.42 mL∙min^− 1∙g^− 1; URL = 3.73 mL∙min^− 1∙g^− 1), and median MFR was 3.09 (LRL = 2.11; URL = 4.65). The body mass index (BMI) was the single most important independent predictor of rMBF, sMBF, and MFR (predictor importance of 72%, 87%, and 41%, respectively; standardized β=-0.434, -0.566 and − 0.174, respectively). Additional predictors were sex and hypertension for rMBF, sex for sMBF, and hypertension and CACS for MFR.</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>In patients without flow-limiting CAD, MBF is strongly influenced by the patient’s habitus, whereby median and reference limits for sMBF and rMBF decrease with increasing BMI. Consequently, MFR exhibits stable lower reference limits across a wide range of BMI and may be considered the most robust quantitative parameter derived from 13N-ammonia PET-MPI.</p>","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":"213 1","pages":""},"PeriodicalIF":9.1,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143618412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"68Ga-Trivehexin PET/CT uptake in malignant and fibrotic lung tissue: refining diagnostic applications","authors":"Serkan Kuyumcu, Dilara Denizmen Zorba, Zeynep Gözde Özkan","doi":"10.1007/s00259-025-07193-3","DOIUrl":"https://doi.org/10.1007/s00259-025-07193-3","url":null,"abstract":"","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":"87 1","pages":""},"PeriodicalIF":9.1,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143618385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CT-free attenuation and Monte-Carlo based scatter correction-guided quantitative 90Y-SPECT imaging for improved dose calculation using deep learning","authors":"Zahra Mansouri, Yazdan Salimi, Nicola Bianchetto Wolf, Ismini Mainta, Habib Zaidi","doi":"10.1007/s00259-025-07191-5","DOIUrl":"https://doi.org/10.1007/s00259-025-07191-5","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Background</h3><p>This work aimed to develop deep learning (DL) models for CT-free attenuation and Monte Carlo-based scatter correction (AC, SC) in quantitative ⁹⁰Y SPECT imaging for improved dose calculation.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>Data of 190 patients who underwent ⁹⁰Y selective internal radiation therapy (SIRT) with glass microspheres was studied. Voxel-level dosimetry was performed on uncorrected and corrected SPECT images using the local energy deposition method. Three deep learning models were trained individually for AC, SC, and joint ASC using a modified 3D shifted-window UNet Transformer (Swin UNETR) architecture. Corrected and unorrected dose maps served as reference and as inputs, respectively. The data was split into train set (~ 80%) and unseen test set (~ 20%). Training was conducted in a five-fold cross-validation scheme. The trained models were tested on the unseen test set. The model’s performance was thoroughly evaluated by comparing organ- and voxel-level dosimetry results between the reference and DL-generated dose maps on the unseen test dataset. The voxel and organ-level evaluations also included Gamma analysis with three different distances to agreement (DTA (mm)) and dose difference (DD (%)) criteria to explore suitable criteria in SIRT dosimetry using SPECT.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>The average ± SD of the voxel-level quantitative metrics for AC task, are mean error (ME (Gy)): -0.026 ± 0.06, structural similarity index (SSIM (%)): 99.5 ± 0.25, and peak signal to noise ratio (PSNR (dB)): 47.28 ± 3.31. These values for SC task are − 0.014 ± 0.05, 99.88 ± 0.099, 55.9 ± 4, respectively. For ASC task, these values are as follows: -0.04 ± 0.06, 99.57 ± 0.33, 47.97 ± 3.6, respectively. The results of voxel level gamma evaluations with three different criteria, namely “DTA: 4.79, DD: 1%”, “DTA:10 mm, DD: 5%”, and “DTA: 15 mm, DD:10%” were around 98%. The mean absolute error (MAE (Gy)) for tumor and whole normal liver across tasks are as follows: 7.22 ± 5.9 and 1.09 ± 0.86 for AC, 8 ± 9.3 and 0.9 ± 0.8 for SC, and 11.8 ± 12.02 and 1.3 ± 0.98 for ASC, respectively.</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>We developed multiple models for three different clinically scenarios, namely AC, SC, and ASC using the patient-specific Monte Carlo scatter corrected and CT-based attenuation corrected images. These task-specific models could be beneficial to perform the essential corrections where the CT images are either not available or not reliable due to misalignment, after training with a larger dataset.</p>","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":"8 1","pages":""},"PeriodicalIF":9.1,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143607944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}