European Journal of Nuclear Medicine and Molecular Imaging最新文献

{"title":"Kinetic modelling of [⁶⁸Ga]Ga-FAPI-46 PET in pancreaticobiliary lesions: distinguishing cancer from pancreatitis.","authors":"Ted Nilsson, Pawel Rasinski, Ernesto Sparrelid, Antonios Tzortzakakis, Thuy A Tran, Örjan Smedby, Rimma Axelsson, Mark Lubberink, Maria Holstensson","doi":"10.1007/s00259-026-07906-2","DOIUrl":"https://doi.org/10.1007/s00259-026-07906-2","url":null,"abstract":"<p><strong>Purpose: </strong>Fibroblast activation protein (FAP)-targeted PET using [⁶⁸Ga]Ga-FAPI-46 visualizes fibroblasts abundant in pancreatic cancer (PC) but also present in pancreatitis, complicating interpretation of static images. Dynamic imaging and kinetic modeling may provide additional insight, but their diagnostic value remains unclear. This study evaluated whether kinetic parameters from dynamic [⁶⁸Ga]Ga-FAPI-46 PET can differentiate PC from pancreatitis and their relationship with standardized uptake value (SUV) and tumor-to-blood ratio (TBR).</p><p><strong>Methods: </strong>Sixty-one patients with suspected pancreaticobiliary cancer underwent a 45-min dynamic [⁶⁸Ga]Ga-FAPI-46 PET scan, followed by static scans at 60 and 180 min. Time-activity curves were generated for 51 malignant and 53 benign lesions. Compartment models and Logan analysis yielded kinetic parameters (K₁, k₂, k₃, k₄, V_T, V_NS, V_S). SUV and TBR were correlated with V_T, and group comparisons and ROC analyses assessed discriminatory performance.</p><p><strong>Results: </strong>Reversible models best described the tracer kinetics. V_T and V_S were significantly higher in PC than pancreatitis, and k₂ and k₄ were lower, indicating higher [⁶⁸Ga]Ga-FAPI-46 binding respectively slower washout in malignant lesions. SUV correlated strongly with V_T (r ≥ 0.784)​, and TBR showed very strong correlations (r ≥ 0.902)​ for the 0-60 min interval, with strong correlations observed across all models and time points. ROC analyses demonstrated comparable differentiation between V_T, SUV_max, and TBR_max.</p><p><strong>Conclusions: </strong>Kinetic parameters showed strong correlations with simplified methods and similar ability to differentiate PC from pancreatitis. SUV and TBR measures thus represent practical alternatives to kinetic modelling for lesion characterization.</p><p><strong>Clinicaltrials: </strong>gov ID: NCT05172310.</p>","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147835617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pyomyositis, a rare complication of a urinary tract infection on FDG PET/CT.","authors":"Elizabeth Celine, Ivana Mulyanto, Febby Hutomo, Rian Hidayatullah, Marcel P M Stokkel","doi":"10.1007/s00259-026-07908-0","DOIUrl":"https://doi.org/10.1007/s00259-026-07908-0","url":null,"abstract":"","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147835577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term relative survival with and without radioiodine in patients with low-risk thyroid cancer: a SEER based analysis of histologic subtypes and risk factors.","authors":"Henning Weis, Katharina Schmidt, Jan Heilinger, Jasmin Weindler, Martin Hellmich, Alexander Drzezga, Matthias Schmidt","doi":"10.1007/s00259-026-07888-1","DOIUrl":"https://doi.org/10.1007/s00259-026-07888-1","url":null,"abstract":"","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147812173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"¹⁸F-FDG PET/CT finding of isolated tracheal langerhans cell histiocytosis.","authors":"Wenshan Huang, Nawa Xie, Jiangkun Yu, Jiequn Yu, Jiehua Xu","doi":"10.1007/s00259-026-07907-1","DOIUrl":"https://doi.org/10.1007/s00259-026-07907-1","url":null,"abstract":"","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147812212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bridging the gaps in fibroblast activation protein targeted radionuclide therapy: a translational perspective.","authors":"Chunhui Wu, Ahmad Kurniawan, Zihe Ming, Ines F Antunes, Walter Noordzij, Andor Glaudemans, Bart Cornelissen","doi":"10.1007/s00259-025-07711-3","DOIUrl":"10.1007/s00259-025-07711-3","url":null,"abstract":"","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":" ","pages":"4270-4296"},"PeriodicalIF":7.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13121195/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146100159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond nigrostriatal dopamine transporter loss: whole-brain DAT depletion patterns discriminate PD phenotypes.","authors":"Jian Li, Xuan Guo, Yaqin Xiang, Juanjuan Huang, Wenna Mu, Qiaoke Ma, Yongxiang Tang, Beisha Tang, Jifeng Guo, Shuo Hu","doi":"10.1007/s00259-026-07779-5","DOIUrl":"10.1007/s00259-026-07779-5","url":null,"abstract":"","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":" ","pages":"3985-3998"},"PeriodicalIF":7.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146141059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of stress on myocardial perfusion and left ventricular synchrony in patients undergoing left bundle branch area pacing.","authors":"Zijun Zhao, Miao Liu, Yushi Luo, Jie Li, Saifullah Syed, Wen Yang, Xiujuan Zhou, Qijun Shan, Zhongqiang Zhao, Zhixin Jiang","doi":"10.1007/s00259-026-07801-w","DOIUrl":"10.1007/s00259-026-07801-w","url":null,"abstract":"","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":" ","pages":"4050-4058"},"PeriodicalIF":7.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146178526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hemoglobin levels and myocardial blood flow in patients undergoing positron emission tomography.","authors":"Ahmed Sayed, Mahmoud Al Rifai, Maria Alwan, Ahmad El Yaman, Mouaz Al-Mallah","doi":"10.1007/s00259-026-07805-6","DOIUrl":"10.1007/s00259-026-07805-6","url":null,"abstract":"","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":" ","pages":"4069-4077"},"PeriodicalIF":7.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146194309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[⁶⁸Ga]Ga-NY104 PET/CT and [¹⁸F]FDG PET/CT in patients with metastatic clear cell renal cell carcinoma (NYCRM): A prospective, single-center, single-arm, comparative imaging trial.","authors":"Xinchun Yan, Xiaoyuan Li, Guoyang Zheng, Mingwei Ma, Meixi Liu, Jingnan Wang, Yushi Zhang, Yi Ba, Xianshu Gao, Wenjia Zhu, Li Huo","doi":"10.1007/s00259-025-07755-5","DOIUrl":"10.1007/s00259-025-07755-5","url":null,"abstract":"","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":" ","pages":"3711-3719"},"PeriodicalIF":7.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146141717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time-robust myocardial [⁶⁸Ga]Ga-FAPI PET biomarker reflects aortic stenosis severity and predicts post-TAVI outcomes.","authors":"Song Xue, Qianling Ye, Aleksa Lazarević, Kevin Hamzaraj, Patrick Binder, Christian Nitsche, Attila Kiss, Bruno K Podesser, Marcus Hacker, Xiang Li, Raffaella Calabretta","doi":"10.1007/s00259-026-07815-4","DOIUrl":"10.1007/s00259-026-07815-4","url":null,"abstract":"<p><strong>Background: </strong>Aortic stenosis (AS) induces myocardial remodeling and fibroblast activation, yet modifiable biomarkers capable of capturing active fibrogenesis and predicting post-transcatheter aortic valve implantation (TAVI) recovery are currently scarce. Fibroblast activation protein (FAP)-targeted PET serves as a noninvasive tool to visualize activated fibroblasts in vivo. We evaluated a time-robust, blood-pool-normalized myocardial [⁶⁸Ga]Ga-FAPI PET imaging biomarker that reflects AS burden and predicts outcomes after TAVI.</p><p><strong>Methods: </strong>Nineteen patients with severe symptomatic AS underwent [⁶⁸Ga]Ga-FAPI-04 PET/CT at 60, 70, and 120 min. Using an in-house semi-automatic pipeline, the left ventricular (LV) myocardium was segmented, and regions of elevated fibroblast activity (EFM) were delineated using a blood-pool-anchored, time-point-specific threshold. We quantified myocardial SUV_mean, blood-pool SUV_mean, and a normalized myocardium-to-blood index, TBR(EFM), and assessed associations with N-terminal pro-brain natriuretic peptide (NT-proBNP) and left-ventricular ejection fraction (LVEF). One-year outcomes (n = 11) were assessed using a predefined composite clinical response.</p><p><strong>Results: </strong>Blood-pool SUV_mean declined from 60 to 120 min, whereas myocardial SUV_mean decreased less, yielding stable TBR(EFM) across time points (60/70/120 min: 2.2 ± 0.8, 2.1 ± 0.9, 2.3 ± 0.9; ANOVA p = 0.596). By contrast, myocardial SUV_mean fell from 3.8 ± 0.7 (60 min) to 2.1 ± 0.9 (120 min; p < 0.001). TBR(EFM) correlated with NT-proBNP at all time-points (60 min r = 0.65, p = 0.007; 120 min r = 0.72, p = 0.003), whereas SUV_mean did not (60 min p = 0.576; 120 min p = 0.109). Baseline TBR(EFM) was significantly lower in one-year responders than non-responders (1.7 ± 0.2 vs. 2.9 ± 0.9; p = 0.013), with separation present at each time point (p < 0.05). Higher baseline TBR(EFM) associated with lower reductions in NT-proBNP at one year (p < 0.05).</p><p><strong>Conclusions: </strong>Myocardial [⁶⁸Ga]Ga-FAPI TBR may provide a time-robust index of active fibroblast signaling that relates to myocardial hemodynamic stress and stratifies one-year clinical response after TAVI. A single 60-minute acquisition with TBR quantification may be sufficient for myocardial [⁶⁸Ga]Ga-FAPI assessment. These hypothesis-generating findings require validation in larger, multicenter cohorts.</p>","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":" ","pages":"4078-4087"},"PeriodicalIF":7.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13121330/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146200580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}