European Journal of Nuclear Medicine and Molecular Imaging最新文献

{"title":"Bellmunt risk score enables survival prediction in men with metastatic castration resistant prostate cancer (mCRPC) undergoing PSMA-targeted radioligand therapy (LUMEN).","authors":"Thomas Büttner,Milka Marinova,Florian C Gaertner,Barbara Kreppel,Leander Fritsche,Christian Immanuel,Gerd Geraths,Stefan Kürpig,Jim Küppers,Ingo G H Schmidt-Wolf,Markus Essler,Manuel Ritter,Philipp Krausewitz","doi":"10.1007/s00259-025-07492-9","DOIUrl":"https://doi.org/10.1007/s00259-025-07492-9","url":null,"abstract":"PURPOSE[177Lu]Lu-PSMA-617 therapy has emerged as a promising radioligand treatment for metastatic castration-resistant prostate cancer (mCRPC). Given the overall poor prognosis of mCRPC, accurately predicting the key endpoint overall survival (OS) remains an ongoing challenge, crucial for optimizing risk/benefit assessment prior to treatment. This study investigates the prognostic utility of the simple designed Bellmunt Risk Score (BRS) in mCRPC patients treated with [177Lu]Lu-PSMA-617.METHODSWe retrospectively evaluated data from 386 mCRPC patients who had received [177Lu]Lu-PSMA-617 therapy at our center. BRS was constructed by attributing one point for each of the following risk factors: ECOG performance status (ECOG PS) > 0, hemoglobin < 10 g/dL, and the presence of liver metastases. Additionally, an enhanced version of the score including C-reactive protein (CRP) > 30 mg/dL and a modified version utilizing a semi-quantitative ECOG PS were developed. Statistical analysis included Cox regression, Kaplan-Meier estimates, concordance indices and time-dependent area under the curve (tAUC).RESULTSThe BRS served as an independent predictor of OS in multivariable analysis. The estimated median OS was 17.6, 10.9, 6.6, and 2.7 months for patients with scores of 0, 1, 2 and 3, respectively (Log-Rank P < 0.001). The tAUC values for predicting 1-year and 2-year OS were 71.6% and 74.4%, respectively. The CRP-enhanced score further improved prognostic accuracy, achieving tAUCs of 75.7% for 1-year OS and 78.1% for 2-year OS.CONCLUSIONThe Bellmunt Risk Score effectively stratifies mCRPC patients undergoing [177Lu]Lu-PSMA-617 therapy. Its straightforward design, based on readily accessible clinical parameters, ensures practicality and utility in real-world clinical settings.","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":"88 1","pages":""},"PeriodicalIF":9.1,"publicationDate":"2025-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144766028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Functional biomarkers derived from computed tomography and magnetic resonance imaging differentiate PDAC subgroups and reveal gemcitabine‑induced hypo‑vascularization.","authors":"Irina Heid, Marija Trajkovic-Arsic, Fabian Lohöfer, Georgios Kaissis, Felix N Harder, Moritz Mayer, Geoffrey J Topping, Friderike Jungmann, Barbara Crone, Moritz Wildgruber, Uwe Karst, Lucia Liotta, Hana Algül, Hsi-Yu Yen, Katja Steiger, Wilko Weichert, Jens T Siveke, Marcus R Makowski, Rickmer F Braren","doi":"10.1007/s00259-025-07195-1","DOIUrl":"10.1007/s00259-025-07195-1","url":null,"abstract":"","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":" ","pages":"3916-3917"},"PeriodicalIF":7.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[¹⁸F]NaF PET/CT to assess bone healing capacity in orthopaedic trauma surgery: a feasibility study.","authors":"N D van Rijsewijk, M Wouthuyzen-Bakker, J H van Snick, J van Sluis, K Ten Duis, A W J M Glaudemans, F F A IJpma","doi":"10.1007/s00259-025-07209-y","DOIUrl":"10.1007/s00259-025-07209-y","url":null,"abstract":"<p><strong>Objective: </strong>Evaluation of bone healing potential in cases of delayed union or non-union remains a challenge. This study evaluated the use of [¹⁸F]NaF PET/CT to assess bone healing and its role in guiding clinical decision-making in orthopaedic trauma surgery.</p><p><strong>Methods: </strong>From June 2019 to December 2024, a prospective study was conducted in a level 1 trauma center. The study included 18 patients (20 fractures: 15 non-unions, 5 bone defects) all showing impaired bone healing after initial surgical fracture treatment, who were eligible for revision surgery. Dynamic (first 10 min post-tracer injection) and static (1-hour post-injection) [¹⁸F]NaF PET/CT scans were performed to assess bone healing capacity through qualitative and quantitative analysis. The relationship between scan results and treatment outcome was evaluated.</p><p><strong>Results: </strong>Increased [¹⁸F]NaF uptake, suggestive for bone healing capacity, was observed in all fractures (20/20). Based on the positive [¹⁸F]NaF PET/CT results, watchful waiting was recommended for all fractures, with two patients preferring surgery. After prolonged watchful waiting, 72% (13/18) showed bone healing progression. Notably, atrophic fractures displayed biological activity, and non-unions demonstrated sustained metabolic activity even beyond 12 months. Most fractures requiring revision surgery (80%, 4/5) needed additional stabilization. Ultimately, [¹⁸F]NaF PET/CT imaging helped to avoid revision surgery in 65% of all fractures (13/20). Uptake pattern analysis suggest that whole-bone uptake could potentially indicate surgical need (χ² = 5.62, p = 0.018). Quantitative assessment provided no additional information.</p><p><strong>Conclusion: </strong>[¹⁸F]NaF PET/CT imaging provides valuable insights into bone healing potential, especially in non-unions, helping guide clinical decisions and reducing unnecessary surgeries. This study challenges traditional non-union definitions by highlighting the biological activity of both atrophic and hypertrophic fractures.</p>","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":" ","pages":"3903-3914"},"PeriodicalIF":7.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143990544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preoperative localization of metastatic axillary lymph nodes using radioactive iodine seed before neoadjuvant chemotherapy. A one-step marking method for targeted axillary dissection.","authors":"Miguel Macedo,Eduard Agustí,Sergi Ganau,Belén Úbeda,Carla Sitges,Jordi Ribera-Perianes,Gabriela Oses,Tomás Pascual,Eduard Mension,Sergi Vidal-Sicart,Xavi Bargalló","doi":"10.1007/s00259-025-07481-y","DOIUrl":"https://doi.org/10.1007/s00259-025-07481-y","url":null,"abstract":"OBJECTIVETo evaluate the reliability and effectiveness of using the radioactive iodine seed (RIS) as one-step target axillary dissection (TAD) procedure in breast cancer patients.MATERIALS AND METHODSThis was a non-randomized, single-center, prospective study. Consecutive patients between May-2022 and November-2023 with breast cancer and axillary involvement (cN1) planned to receive NAC and TAD surgery were marked with RIS in the pathologically proven ALN. Radiation levels emitted by the patient were measured. On the day of surgery, the marked lymph node (MLN) and sentinel lymph node (SLN) were removed. We studied the identification rate (IR) and the concordance rate (CR) between the MLN and SLN.RESULTSForty patients participated in the study (39 females, 1 male; mean age 53). Most of the patients included were diagnosed with invasive ductal carcinoma (92.5%). Half of the patients were hormone receptor positive and HER2 negative, and the other half were triple negative or HER2 positive. There was one suspicious ALN in the majority of breast cancer cases (72.5%). Average time from RIS placement to surgery was 157 days. IR of RIS were 100% and IR of SLN was 95%. CR between SLN and MLN was 52.5%. No complications in RIS placement and carriage were reported. No breast or axillary relapse were reported in a 16-34 month follow-up period. The radiation levels were low at distances greater than 0.5 m.CONCLUSIONSThe use of RIS for TAD as a one-step procedure for axillary staging of cN1 breast cancer patients in a pre-NAC context is a reliable and effective radiologic marker placement procedure.","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":"15 1","pages":""},"PeriodicalIF":9.1,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144747873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The superiority of [68Ga]Ga-FAPI PET/CT over MRI and [18F]FDG PET/CT in delineating a rare case of pituitary fibrosarcoma.","authors":"Yiting Cai,Meixi Liu,Yuwei Zhang,Hanze Du,Li Huo,Hongli Jing","doi":"10.1007/s00259-025-07467-w","DOIUrl":"https://doi.org/10.1007/s00259-025-07467-w","url":null,"abstract":"","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":"285 1","pages":""},"PeriodicalIF":9.1,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144747877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac mechanical synchrony couples with myocardial sympathetic innervation. A retrospective study with novel echocardiographic assessment in patients with 123I-mIBG imaging.","authors":"Laura Petraglia,Dario Leosco,Valentina Parisi,Maddalena Conte,Leonardo Bencivenga,Laura Andreea Ceparano,Paola Gargiulo,Roberta Assante,Roberta Modica,Pierluigi Incarnato,Letizia Spinelli,Alberto Cuocolo,Pasquale Perrone Filardi,Giuseppe Rengo,Dino Franco Vitale","doi":"10.1007/s00259-025-07472-z","DOIUrl":"https://doi.org/10.1007/s00259-025-07472-z","url":null,"abstract":"PURPOSELeft ventricular (LV) mechanical synchrony is essential for efficient cardiac function, and its disruption (dyssynchrony) negatively impacts outcomes, particularly in heart failure. Although sympathetic innervation modulates electrical activation and contraction timing, its relationship with mechanical synchrony is underexplored. This study aimed to assess their association using echocardiographic synchrony indices and 123I-mIBG scintigraphy, introducing a novel index (AMP-sync).METHODSWe retrospectively analyzed 208 patients who underwent both 123I-mIBG imaging and echocardiography suitable for synchrony assessment within two weeks. Standard deviation of time-to-peak longitudinal strain across 18 LV segments defined the standard synchrony index (SD-sync). AMP-sync was calculated using the sum of the first two harmonics of a two-dimensional Fourier transform of the strain polar map. Sympathetic innervation was assessed by early and late heart-to-mediastinum ratios (H/Mr) and washout rate. Multivariable regression adjusted for age, sex, BMI, and ejection fraction (EF). Patients with QRS > 120 ms were excluded.RESULTSBoth synchrony indices significantly associated with late H/Mr, with AMP-sync showing superior model performance. The relationship followed a robust inverse-square pattern, independent of age, EF, and BMI. AMP-sync explained approximately 30% of the variance in late H/Mr, comparable to EF. Bootstrap validation confirmed the stability of the findings. No significant associations were found with early H/Mr or washout rate.CONCLUSIONLV mechanical dyssynchrony is independently associated with reduced myocardial sympathetic innervation. The novel AMP-sync index outperformed SD-sync in predicting late H/Mr and may offer added value for patient stratification. External validation of AMP-sync in independent cohorts is warranted before routine clinical adoption.","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":"45 1","pages":""},"PeriodicalIF":9.1,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144747820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vasculature cast sign on 18F-FDG PET/CT: a specific imaging marker for pediatric T-lymphoblastic lymphoma.","authors":"Haoyu Zhang,Chao Li,Yuxuan Chen,Yafu Yin,Hongliang Fu,Hui Wang,Suyun Chen","doi":"10.1007/s00259-025-07488-5","DOIUrl":"https://doi.org/10.1007/s00259-025-07488-5","url":null,"abstract":"PURPOSETo evaluate the diagnostic performance of 18F-FDG PET/CT parameters for T-lymphoblastic lymphoma (T-LBL), with particular emphasis on the \"vasculature cast\" sign, for distinguishing T-LBL from other pediatric anterior mediastinal malignancies.METHODSPretreatment 18F-FDG PET/CT scan of 60 patients (≤ 21 years) with anterior mediastinal tumors were retrospectively analyzed. Diagnostic performance of the imaging parameters was compared between T-LBL and nonT-LBL groups. Intra- and interobserver agreement for vasculature cast sign was assessed.RESULTSThe vasculature cast sign was present in 15/24 T-LBL cases, with high specificity (97.2%) and positive predictive value (93.8%) but moderate sensitivity (62.5%). Intra- and interobserver agreement were 0.91 and 0.83, respectively. T-LBL had significantly larger tumor dimension (Dmax), lower SUVmax of the tumor or the spleen, higher total or mediastinal tumor metabolic tumor volume with a threshold of 41% of SUVmax and more frequent aortic arch encasement compared to nonT-LBL. Multivariable logistic regression identified the vasculature cast sign (odds ratio [OR], 37.45, 95% CI: 1.83-767.64, p = 0.019), tumor SUVmax (OR, 0.82, 95% CI: 0.69-0.97, p = 0.023) and Dmax > 6.85 cm (OR, 16.67; 95% CI: 1.76-158.21, p = 0.014) as independent imaging markers for T-LBL. Model combining these parameters yielded an area under the curve of 0.943 (p < 0.001), and a simplified scoring system was developed based on the three parameters, yielding the diagnostic rates of 0% (0/8), 14.3% (3/21), 40% (6/15), and 100% (15/15) for scores of 0, 1, 2, and 3, respectively.CONCLUSIONThe vasculature cast sign is a specific and reproducible PET/CT marker of T-LBL.","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":"13 1","pages":""},"PeriodicalIF":9.1,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144737225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Translocator protein (TSPO) positron emission tomography imaging and expression in patients with brain metastases.","authors":"Paolo Zanotti-Fregonara,Monika Vishnoi,Quentin Finn,John D Patterson,Aboud Tahanis,David R Beers,Oluwaseun B Ogunbona,Belen Pascual,Joseph C Masdeu,Steve H Fung,Nafiseh Ghazanfari,Kanayo Ikeneme,Suzanne Powell,Zheng Yin,Robert C Rostomily","doi":"10.1007/s00259-025-07477-8","DOIUrl":"https://doi.org/10.1007/s00259-025-07477-8","url":null,"abstract":"PURPOSE18 kDa translocator protein (TSPO) is a biomarker for inflammatory conditions. However, full kinetic positron emission tomography (PET) modeling has rarely been used to quantify brain tumors, and it has never been used in brain metastases (BMs). This proof-of-principle study quantified TSPO expression using full kinetic modeling in patients with BMs from various types of peripheral primary tumors.METHODSNine adult patients with BMs and 12 healthy volunteers (HVs) took part in the study. The total distribution volume (VT) of 11C-ER176 was calculated with a two-tissue compartment model (2TCM) and metabolite-corrected arterial input function in the BMs and in the rest of the brain. Immunohistochemistry (IHC) and single-cell RNAseq database were used to quantify TSPO expression in vitro. The VT values of the hemisphere contralateral to the BMs were compared to the cortical values of HVs.RESULTS11C-ER176 uptake was increased in BMs compared with the rest of the brain of each participant. The BM time-activity curves were well-fitted by the 2TCM, and the resulting VT (range 3.2-13 mL/cm3) was identified with precision (standard error generally < 5%). The rate constant mostly affected by the integrity of the blood-brain barrier (BBB) (K1) was similar between the BMs and the contralateral hemisphere. TSPO expression was detected by IHC in tumor regions and variably in microglia/macrophages, a finding largely corroborated by single-cell RNAseq database. The average VT of the rest of the brain in BM patients was significantly lower than in HVs, which may have been due to immunosuppressive therapy.CONCLUSIONIn this pilot study, full kinetic modeling quantified TSPO expression in BMs with good fit and precision. The kinetic modeling outcome parameters and the TSPO expression levels in vitro suggest that 11C-ER176 binding was largely specific and not significantly affected by disruption of the BBB.","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":"43 1","pages":""},"PeriodicalIF":9.1,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144737228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular imaging of stem cell therapies in ischemic stroke.","authors":"Peili Cen,Xiaoyun Luo,Jing Wang,Hetian Chen,Mei Tian,Hong Zhang","doi":"10.1007/s00259-025-07466-x","DOIUrl":"https://doi.org/10.1007/s00259-025-07466-x","url":null,"abstract":"Ischemic stroke is a leading cause of mortality and morbidity worldwide, lacking effective approaches to restore neurological functions in clinical practice. Stem cell therapies for ischemic stroke show great potential in neural regeneration, neuroprotection, microenvironment regulation, and neural network reconstruction. Stem cells including mesenchymal stem cells (MSCs), embryogenic stem cells (ESCs), induced pluripotential stem cells (iPSCs), neural stem cells (NSCs), et al., have been widely investigated in preclinical and clinical research, to treat ischemic stroke through different pathways. Benefiting from various imaging agents with specificity and sensitivity to the target, molecular imaging can facilitate the exploration of underling in vivo mechanisms of stem cell therapies for ischemic stroke, with multiple imaging modalities and techniques. Both direct in vitro labeling with imaging agents and indirect labeling through imaging reporter genes have been developed to label grafted stem cells and tracking their behaviors in vivo. And molecular imaging can further evaluate the therapeutic efficacy of stem cells in ischemic stroke from molecular level, providing comprehensive information combined with structural and functional imaging. With the advantages and contribution of molecular imaging, stem cell therapies for ischemic stroke can be greatly promoted for clinical translation from the laboratory to clinical practice.","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":"25 1","pages":""},"PeriodicalIF":9.1,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144737299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Value of [18F]flurpiridaz PET/CT for preoperative localization of atypical parathyroid tumors in primary hyperparathyroidism.","authors":"Thorsten Derlin,Frank M Bengel,Dennis Kleine-Döpke,Moritz Schmelzle,Bastian P Ringe","doi":"10.1007/s00259-025-07487-6","DOIUrl":"https://doi.org/10.1007/s00259-025-07487-6","url":null,"abstract":"","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":"144 1","pages":""},"PeriodicalIF":9.1,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144720143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}