European Journal of Nuclear Medicine and Molecular Imaging最新文献

{"title":"Differentiation of axial spondyloarthritis-related lesions from degenerative lesions on Na[18F]Fluoride PET/CT in a longitudinal dataset of patients with radiographic axial spondyloarthritis","authors":"Jerney de Jongh, Sam Groothuizen, Gerben J.C. Zwezerijnen, Robert Hemke, Tom Doorschodt, Ralph Paul Maguire, Tom Vaux, Conny J. van der Laken","doi":"10.1007/s00259-026-08178-6","DOIUrl":"https://doi.org/10.1007/s00259-026-08178-6","url":null,"abstract":"Purpose To investigate longitudinal changes of Na[ <jats:sup>18</jats:sup> F]Fluoride uptake in the axial skeleton of patients with radiographic axial spondyloarthritis (r-axSpA) during biological treatment, focusing on r-axSpA and degenerative (D) lesions. Methods 20 active r-axSpA patients were included. Na[ <jats:sup>18</jats:sup> F]Fluoride Positron Emission Tomography / Computed Tomography (PET/CT) scans were performed prior to, as well as 12 and 52 weeks after starting biological therapy. PET-positive lesions in the axial skeleton were scored and classified by two blinded readers. Quantitative Na[ <jats:sup>18</jats:sup> F]Fluoride uptake was assessed by determination of standardized uptake values (SUV) corrected for individual integrated whole blood activity concentration (SUV <jats:sup>AUC</jats:sup> ). Results A total of 276 lesions with visual Na[ <jats:sup>18</jats:sup> F]Fluoride uptake were detected, of which 98 (36%) were defined as r-axSpA and 46 (17%) as D. The total number of r-axSpA lesions decreased from 98 at baseline to 67 at week 12 (-32%) and to 55 at week 52 (-18%), while the number of D lesions remained stable over time. The majority of r-axSpA lesions were observed in the thoracic spine (84%), while the majority of D lesions were observed in the lumbar spine (48%). Quantitatively, 84% and 88% of the r-axSpA lesions showed a decrease of Na[ <jats:sup>18</jats:sup> F]Fluoride uptake between baseline and 12 and 52 weeks, respectively. In contrast, most D lesions either showed an increase or mild decrease between baseline and follow-up. Conclusion Na[ <jats:sup>18</jats:sup> F]Fluoride uptake in visually classified r-axSpA and D lesions in r-axSpA patients on PET/CT demonstrated a striking different change in both the number of r-axSpA lesions and quantitative tracer uptake herein versus D lesions while on biological treatment.","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":"27 1","pages":""},"PeriodicalIF":9.1,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149130347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"¹⁸F-sodium fluoride PET/CT as a complementary measure of osteoblastic disease burden in axial spondyloarthritis: a prospective exploratory study","authors":"Hung-Yi Chen,Yu-Li Chiu,Sin-Yi Lyu,Chun-Hao Kao,Li-Fan Lin,En Chao,Yu-Hsiang Chiu,Shi-Jye Chu,Feng-Cheng Liu,Fu-Chiang Yeh,Ya-Chi Li,Hsiang-Cheng Chen,Deh-Ming Chang,Chun-Chi Lu","doi":"10.1007/s00259-026-08190-w","DOIUrl":"https://doi.org/10.1007/s00259-026-08190-w","url":null,"abstract":"","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":"1 1","pages":""},"PeriodicalIF":9.1,"publicationDate":"2026-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149088755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First-in-human dosimetry and biodistribution of [89Zr]Zr-oxine-labeled autologous leukocytes using PET/CT","authors":"Kadir Gultekin,Jennifer L. Bartels,Carlos E. Cardenas,Yogesh Kumar,Grayson R. Gimblet,Chloe L. Jones,Christina Bankston,Charlotte D. Jeffers,Sharon L. White,Suzanne E. Lapi,Jarred W. Younger,Jonathan E. McConathy","doi":"10.1007/s00259-026-08158-w","DOIUrl":"https://doi.org/10.1007/s00259-026-08158-w","url":null,"abstract":"Abstract Purpose Cell tracking with zirconium-89 PET has the potential for widespread clinical and research applications, including imaging infection and inflammation and tracking cell-based therapies. This prospective first-in-human clinical trial assessed the dosimetry and safety profile of [ 89 Zr]Zr-oxine-labeled autologous leukocytes in healthy female participants. Methods Four healthy adult female participants (ages 37–53) received 10.9 ± 2.9 MBq of [ 89 Zr]Zr-oxine-labeled autologous leukocytes and underwent whole-body PET/CT imaging at five time points (0, 4, 24, 48, and 72 h). Regions of interest were automatically segmented on CT using a machine learning-based approach and manually refined. Time-integrated activity coefficients were calculated using Simpson’s rule, with physical decay assumed beyond the final time point. Mean absorbed-dose and effective-dose coefficients were estimated using OLINDA 2.1. Results Administration was well-tolerated among all participants. The highest mean absorbed-dose coefficients (mGy/MBq) with standard deviation were observed in the spleen (3.52 ± 1.38), liver (2.1 ± 0.45), adrenals (1.62 ± 0.24), uterus (1.48 ± 0.98), and kidneys (1.36 ± 0.12). The mean effective-dose coefficient was 0.92 ± 0.06 mSv/MBq, numerically lower than the predicted value of 1.14 mSv/MBq based on the distribution of [ 111 In]In-oxine-labeled leukocytes in adult females ( P  = 0.006, one-sample t-test). The use of [ 89 Zr]Zr-oxine-labeled leukocytes enabled the visualization of leukocyte distribution and temporal dynamics. Conclusion This study demonstrates the safety and favorable dosimetry of [ 89 Zr]Zr-oxine-labeled leukocytes in healthy humans. These results support the further use of this approach for imaging autologous leukocytes using PET in a range of clinical and research settings. Trial registration ClinicalTrials.gov NCT03807973. Registered January 16, 2019.","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":"36 1","pages":""},"PeriodicalIF":9.1,"publicationDate":"2026-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149088756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Whole-brain metabolic activity on pretreatment [18 F]FDG PET/CT provides prognostic information beyond metabolic tumour burden in patients with breast cancer.","authors":"Mehmet Tarık Tatoğlu, Burak Canıtez, Hatice Uslu, Ebru İbişoğlu, Ferda Yerdelen Tatoğlu","doi":"10.1007/s00259-026-08046-3","DOIUrl":"10.1007/s00259-026-08046-3","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate whether whole-brain (WB) metabolic activity measured on pretreatment [18 F]FDG PET/CT provides prognostic information beyond global metabolic tumour burden in patients with breast cancer.</p><p><strong>Methods: </strong>This single-centre retrospective cohort included 358 patients with biopsy-confirmed breast cancer who underwent pretreatment [18 F]FDG PET/CT for staging. WB SUVmean, WB SULmean, and total metabolic tumour volume (TMTV) were measured using a semi-automated PET/CT analysis workflow. The primary endpoint was overall survival (OS). Sequential Cox models evaluated the incremental prognostic value of WB SUVmean beyond clinical variables and TMTV; WB SULmean was assessed in sensitivity analysis.</p><p><strong>Results: </strong>Complete-case data were available for 354 patients. In univariable analysis, higher TMTV was associated with worse OS (HR 1.167 per 100 mL; P < 0.001), whereas higher WB SUVmean (HR 0.785; P < 0.001) and WB SULmean (HR 0.733; P < 0.001) were associated with better OS. After adjustment for age, body mass index, disease extent, fasting glucose, and TMTV, WB SUVmean remained independently associated with OS (HR 0.810, 95% CI 0.679-0.967; P = 0.019), while TMTV retained prognostic value (HR 1.104, 95% CI 1.053-1.157; P < 0.001). WB SULmean showed similar results in sensitivity analysis (HR 0.764, 95% CI 0.586-0.997; P = 0.047). Combined TMTV/WB SUVmean stratification identified three prognostic groups (global log-rank P = 2.14 × 10⁻¹⁰).</p><p><strong>Conclusion: </strong>Pretreatment WB metabolic activity provides prognostic information beyond global metabolic tumour burden in breast cancer and may represent a complementary host-related prognostic signal, although the underlying biological mechanisms require further validation.</p>","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":" ","pages":"6909-6919"},"PeriodicalIF":7.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148359979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From image reconstruction to clinical prognosis: A comprehensive analysis of centiloid-based amyloid PET assessment.","authors":"Katharina C E Hirschmüller, Elena Prieto, Edgar F Guillén, Beatriz Echeveste, Fernando Mínguez, Marta Romera, Félix Pareja, Rachid Fahmi, Mario Riverol, Javier Arbizu","doi":"10.1007/s00259-026-07943-x","DOIUrl":"10.1007/s00259-026-07943-x","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the sources of variability in Centiloid (CL) calculations, particularly the influence of image reconstruction and reference region selection, and to examine the relationship between baseline CL scores, visual interpretation and subsequent disease progression.</p><p><strong>Methods: </strong>162 aMCI patients who underwent amyloid PET at a single center were retrospectively analyzed. Visual assessment was performed by two nuclear medicine physicians and Centiloid scoring was determined using syngo.MI Neurology Cortical Analysis, using different reference regions (RR) and image reconstruction settings. The CL values were compared against visual interpretation, using a ROC analysis. The value of CL in predicting the onset of Alzheimer's dementia was assessed.</p><p><strong>Results: </strong>The use of the whole cerebellum as RR provided the most robust and consistent CL values across reconstruction methods. The RR was critical in the case of flutemetamol, as CL varied in more than 20 units between pons and whole cerebellum. Visual classifications and CL values showed strong concordance (area under the ROC curve: 0.9786) and the CL cut-off value that maximized agreement with visual reading was 28 CL. During follow-up, 49% of patients progressed to AD dementia and CL-based amyloid positivity was a significant predictor of progression.</p><p><strong>Conclusion: </strong>Standardized CL quantification using the whole cerebellum as RR enhances the reliability of amyloid PET interpretation across tracers and reconstruction settings. CL values strongly correlate with visual assessment and are predictive of clinical progression. These findings suggest the potential utility of CL quantification in both clinical and research settings.</p>","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":" ","pages":"7538-7547"},"PeriodicalIF":7.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13633294/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148653056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Automated Deauville Score computation from baseline [¹⁸F]FDG PET/CT predicts progression-free survival in multiple myeloma: a radiogenomic framework.","authors":"Sara Peluso, Stefano Polizzi, Lisa Pagnini, Martina Tarozzi, Ettore Rocchi, Valentino Dragonetti, Vincenza Solli, Daniele Dall'Olio, Marco Talarico, Carolina Terragna, Claudia Sala, Elena Zamagni, Stefano Fanti, Cristina Nanni, Gastone Castellani","doi":"10.1007/s00259-026-08103-x","DOIUrl":"10.1007/s00259-026-08103-x","url":null,"abstract":"<p><strong>Purpose: </strong>Deauville Score (DS) assessment from [¹⁸F]FDG PET/CT in multiple myeloma (MM) relies on visual interpretation, limiting reproducibility. This study aimed to develop an automated pipeline for standardised DS computation, evaluate the prognostic value of DS at five anatomical sites, and predict progression-free survival (PFS) by integrating DS with copy number alterations (CNA) and clinical variables.</p><p><strong>Methods: </strong>A retrospective cohort of 165 newly diagnosed MM patients with baseline FDG PET/CT, CNA profiling, and blood tests was analysed. An automated pipeline computed DS fully automatically for vertebral bone marrow (BM) and long bones (LB), and semi-automatically for focal (FL), paramedullary (PM), and extramedullary (EM) lesions. DS were subdivided into absent (1), low (2-3), and high (4-5) groups and compared via log-rank test. A penalised Cox model with 12 covariates (five DS, three CNAs, haemoglobin, platelet count, age, sex) was evaluated via nested cross-validation for PFS prediction. For inference on individual prognostic contributions, an unpenalised multivariable Cox model was fitted on the full cohort.</p><p><strong>Results: </strong>In univariate analyses, high LB, PM and EM DS were significantly associated with shorter PFS. The penalised Cox model achieved a C-index of 0.710 [95% CI: 0.689-0.732] in predicting the risk of progression. In the multivariable analysis, age, haemoglobin, BM DS, PM DS and amp(1q) were identified as independent prognostic factors.</p><p><strong>Conclusion: </strong>Automated DS computation from baseline FDG PET/CT is feasible and, combined with genomic and clinical data, enables a reproducible multimodal approach to prognostic stratification in MM. The pipeline for DS computation is publicly available as an open-source tool (autoDS-PET) at https://github.com/Sara-Peluso/autoDS-PET .</p>","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":" ","pages":"7336-7349"},"PeriodicalIF":7.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13633357/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148619052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic performance of multiparametric model integrating ¹⁸F-MFBG PET/CT imaging parameters and clinical factors for differentiating neuroblastoma from ganglioneuroblastoma: a preliminary study","authors":"Xiaoya Wang,Keyu Zhang,Ying Kan,Wei Wang,Jigang Yang","doi":"10.1007/s00259-026-08185-7","DOIUrl":"https://doi.org/10.1007/s00259-026-08185-7","url":null,"abstract":"","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":"17 1","pages":""},"PeriodicalIF":9.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149088777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Inter- and intra-quartile comparison of multi-tracer PET/CT and liquid biopsy molecular markers in cancer: a futuristic perspective on evolving a \"stepped care\" model for individualized precision theranostics through AI/ML.","authors":"Sandip Basu, Shyam Kumar Ravada, Rahul V Parghane, Aadil Adnan, Mahesh K Padwal, Bhakti Basu","doi":"10.1007/s00259-026-08069-w","DOIUrl":"10.1007/s00259-026-08069-w","url":null,"abstract":"","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":" ","pages":"7665-7667"},"PeriodicalIF":7.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148419896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic value of volume-based metabolic parameters of [¹⁸F]FDG PET/CT in anaplastic thyroid carcinoma.","authors":"H I Coerts, O P Smit, J F Lin, P van Houten, T P Links, A H Brouwers, C C D van der Rijt, T M van Ginhoven, R T Netea-Maier, M J C van Treijen, M Medici, B de Keizer, S Kruijff, F A Verburg","doi":"10.1007/s00259-026-08100-0","DOIUrl":"10.1007/s00259-026-08100-0","url":null,"abstract":"<p><strong>Introduction: </strong>Anaplastic thyroid carcinoma (ATC) is a rare and aggressive malignancy with a median overall survival (OS) of approximately 2 months. The prognostic value of ¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography ([¹⁸F]FDG PET/CT) in ATC remains unclear. This study aims to evaluate the prognostic significance of [¹⁸F]FDG PET/CT parameters in ATC patients.</p><p><strong>Methods: </strong>This retrospective study analyzed 34 patients diagnosed with ATC between January 2010 and October 2024 who underwent initial staging with [¹⁸F]FDG PET/CT. Data collected included standardized uptake value (SUV), metabolic tumor volume (MTV), and total lesion glycolysis (TLG), along with patient and tumor characteristics. The relationships between these parameters and survival were assessed.</p><p><strong>Results: </strong>OS was 48 days (IQR: 27-134). In univariate analysis, MTV (HR = 1.44, p = 0.009) was significantly associated with poorer OS. Surgery was associated with a significantly decreased hazard of mortality (HR, 0.418; 95% CI, 0.188-0.929; P = 0.032), as was radiotherapy (HR, 0.423; 95% CI, 0.220-0.977; P = 0.026).</p><p><strong>Conclusion: </strong>This study identifies MTV as a significant prognostic markers in univariate analysis for patients with ATC, highlighting the utility of [¹⁸F]FDG PET/CT in predicting patient outcomes.</p>","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":" ","pages":"7327-7335"},"PeriodicalIF":7.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13633364/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148618993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[¹⁸F]FAPI PET/MR imaging in a patient with liver metastasis of breast cancer complicated by hepatic sinusoidal obstruction syndrome.","authors":"Ye Li, Bingxin Gu, Ming Qi, Xiaoping Xu, Shaoli Song","doi":"10.1007/s00259-026-07942-y","DOIUrl":"10.1007/s00259-026-07942-y","url":null,"abstract":"","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":" ","pages":"6720-6721"},"PeriodicalIF":7.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148013578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}