European Journal of Nuclear Medicine and Molecular Imaging最新文献

{"title":"New compartment model for hepatic blood flow quantification in humans from 15O-water PET images","authors":"Oona Rainio, Juhani Knuuti, Riku Klén","doi":"10.1007/s00259-025-07210-5","DOIUrl":"https://doi.org/10.1007/s00259-025-07210-5","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Background</h3><p>Different compartment models are commonly used to derive crucial information about blood flow, metabolism, and oxygenation from the results of a dynamic positron emission tomography (PET) scan. However, compared to blood flow in many other organs of interest, the hepatic blood flow (HBF) quantification is challenging due to the dual blood supply of liver from both the hepatic artery and the portal vein (PV). Here, we introduce a new model that can be used to estimate the HBF in combination with an automatic volume of interest selection method.</p><h3 data-test=\"abstract-sub-heading\">Materials and methods</h3><p>By using the <span>(^{15})</span>O-water PET data of 57 patients, we extract the mean time-activity curves (TACs) from aorta, hepatic PV, liver, and spleen with help of an automated computer tomography-based segmentation tool and systematically fit our new compartment model and three earlier compartment models from literature to the TACs. After this, we compare the model performance with mean relative error (MRE), mean squared error, and Akaike’s information criteria with one-sided Wilcoxon signed-rank tests. After determining the best model, we study possible HBF differences caused by age, sex, and weight with Mann-Whitney U test and Pearson’s correlations coefficient.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>We obtained the mean arterial HBF of 0.299±0.168 mL/min/mL, the mean portal HBF of 0.930±0.520 mL/min/mL, and the total HBF of 1.229±0.612 mL/min/mL with our new model. Based on earlier research, both these estimates and also the results of two earlier versions of the original dual-input model are realistic. Out of these three models, our proposed model performed the best in terms of MRE (p-values<span>(le )</span>0.001). According to our results, there are no significant sex- or age-based differences but there is moderate positive correlation between the arterial and portal HBFs and negative correlation between the total HBF and the weight of patients.</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>The HBF can effectively be estimated from <span>(^{15})</span>O-water PET data with our new model in combination with robust segmentation by TotalSegmentator. Due to the fact that potential underestimation of the PV concentration caused by the small size of this vessel might lead to overestimation of the HBF, more research would be beneficial to validate these methods further. Our results suggests that there is a negative trend between the HBF and the weight, though this might be related to the underlying conditions of the patients.</p>","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":"88 1","pages":""},"PeriodicalIF":9.1,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic value of [18F]FDG- and PSMA-PET in patients evaluated for [177Lu]Lu-PSMA therapy of mCRPC","authors":"Tugce Telli, Leonor Lopes, Madeleine Karpinski, Kim M. Pabst, Viktor Grünwald, Kuangyu Shi, Boris Hadaschik, Claudia Kesch, Lale Umutlu, Ken Herrmann, Robert Seifert, Wolfgang P. Fendler","doi":"10.1007/s00259-025-07198-y","DOIUrl":"https://doi.org/10.1007/s00259-025-07198-y","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose</h3><p>To improve [¹⁷⁷Lu]Lu-Prostate-specific membrane antigen therapy (LuPSMA) selection, this study investigates the prognostic value of PSMA and 2-[¹⁸F]fluoro-2-deoxy-D-glucose ([¹⁸F]FDG)-PET in metastatic castration-resistant prostate cancer (mCRPC) patients considered for LuPSMA therapy.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>We conducted a retrospective analysis in 152 mCRPC patients referred for LuPSMA therapy who underwent PSMA and [¹⁸F]FDG-PET/CT. Of these, 104 patients (68.4%) underwent LuPSMA therapy, while 48 (31.6%) received other standard of care (SOC). PET/CT analyses included visual assessment and semiquantitative measurements. Clinical and laboratory parameters were recorded. Overall survival (OS) and PSA response (decline &gt; 50%) were primary and secondary endpoints, respectively.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>Baseline [¹⁸F]FDG-derived total tumor volume was the only independent predictor of overall survival both in patients subsequently treated with LuPSMA (HR 1.28 [95%CI 1.02—1.61]; p = 0.03) or in those under other SOC (HR 1.61 [95%CI 1.02—2.56]; p = 0.04), respectively. In other SOC patients, additional independent predictors of OS were total lesion PSMA uptake (PSMA-TL; HR 1.14 [95%CI 1.03–1.26]; p = 0.01), [¹⁸F]FDG mean SUV (HR 20.88 [95%CI 1.2–364.74]; p = 0.04), and [¹⁸F]FDG total lesion glycolysis (HR 1.61 [95%CI 1.02–2.56]; p = 0.04). In LuPSMA patients, PSMA-PET SUVmean was a significant independent predictor of PSA decline ≥ 50% (OR 2.97 [95%CI 1.27–8.16]; p = 0.02).</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>PSMA-PET and [¹⁸F]FDG-PET provide imaging biomarkers of outcome in candidates for LuPSMA. FDG-PET total tumor volume was an independent predictor of overall survival in candidates for LuPSMA therapy, irrespective of subsequent treatment decision. PSMA-PET SUVmean was associated with biochemical response to LuPSMA. Dual tracer imaging should further be assessed in prospective trials for mCRPC treatment guidance.\u0000</p>","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":"10 1","pages":""},"PeriodicalIF":9.1,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between PD-L1 expression and [18F]FAPI versus [18F]FDG uptake on PET/CT in lung cancer","authors":"Jingjie Qin, Chao Han, Haoqian Li, Zhendan Wang, Xudong Hu, Lanping Liu, Shouhui Zhu, Jingjing Zhao, Yuhong Sun, Yuchun Wei","doi":"10.1007/s00259-025-07201-6","DOIUrl":"https://doi.org/10.1007/s00259-025-07201-6","url":null,"abstract":"&lt;h3 data-test=\"abstract-sub-heading\"&gt;Purpose&lt;/h3&gt;&lt;p&gt;To investigate the correlation between [&lt;sup&gt;18&lt;/sup&gt;F] labeled fibroblast activation protein inhibitor (FAPI) positron emission tomography (PET)/computed tomography (CT) uptake and programmed death ligand 1 (PD-L1) expression in lung cancer and evaluate the predictive value of [&lt;sup&gt;18&lt;/sup&gt;F]FAPI PET/CT for PD-L1 expression compared with [&lt;sup&gt;18&lt;/sup&gt;F]fluorodeoxyglucose ([&lt;sup&gt;18&lt;/sup&gt;F]FDG) PET/CT.&lt;/p&gt;&lt;h3 data-test=\"abstract-sub-heading\"&gt;Methods&lt;/h3&gt;&lt;p&gt;This single-center retrospective study consecutively enrolled patients with pathologically confirmed lung cancer who underwent [&lt;sup&gt;18&lt;/sup&gt;F]FAPI and [&lt;sup&gt;18&lt;/sup&gt;F]FDG PET/CT scans within 2 weeks, with a minimum interval of 20 h. PD-L1 expression was assessed using immunohistochemistry and stratified into three groups. PET/CT uptake parameters included the maximum standard uptake value (SUV&lt;sub&gt;max&lt;/sub&gt;) in the biopsy tumor or mediastinal metastasis lymph nodes area and the mean SUV&lt;sub&gt;s&lt;/sub&gt; (SUV&lt;sub&gt;mean&lt;/sub&gt;) of normal tissue (lung and blood). The ratios of SUV&lt;sub&gt;max&lt;/sub&gt; to the SUV&lt;sub&gt;mean&lt;/sub&gt; for each normal tissue were denoted as the tumor-to-background ratios (TBR&lt;sub&gt;lung&lt;/sub&gt; and TBR&lt;sub&gt;blood&lt;/sub&gt;). All statistical analyses were conducted using IBM SPSS Statistics. Normality was assessed, and for non-normally distributed data, the Kruskal-Wallis and Mann-Whitney U tests were applied. Associations between variables were evaluated using Spearman’s rank correlation. All tests were two-sided, with a &lt;i&gt;P&lt;/i&gt;-value &lt; 0.05 considered statistically significant.&lt;/p&gt;&lt;h3 data-test=\"abstract-sub-heading\"&gt;Results&lt;/h3&gt;&lt;p&gt;Among the 75 cases included on the final analysis, the TBR&lt;sub&gt;blood&lt;/sub&gt; and TBR&lt;sub&gt;lung&lt;/sub&gt; derived from [&lt;sup&gt;18&lt;/sup&gt;F]FAPI PET/CT were significantly positively correlated with PD-L1 expression (&lt;i&gt;r&lt;/i&gt; = 0.32, &lt;i&gt;P&lt;/i&gt; &lt; 0.01; &lt;i&gt;r&lt;/i&gt; = 0.26, &lt;i&gt;P&lt;/i&gt; &lt; 0.05). Additionally, cases with high PD-L1 expression showed significantly higher [&lt;sup&gt;18&lt;/sup&gt;F]FAPI uptake values (mean TBR&lt;sub&gt;lung&lt;/sub&gt;=36.16; mean TBR&lt;sub&gt;blood&lt;/sub&gt;=10.75) compared with those with low PD-L1 expression (mean TBR&lt;sub&gt;lung&lt;/sub&gt;=25.10; mean TBR&lt;sub&gt;blood&lt;/sub&gt;=8.04). No statistically significant correlation was observed between [&lt;sup&gt;18&lt;/sup&gt;F]FDG uptake values and PD-L1 expression level. Receiver operating characteristic analysis identified TBR&lt;sub&gt;blood&lt;/sub&gt; on [&lt;sup&gt;18&lt;/sup&gt;F]FAPI PET/CT with a cutoff value of 7.76 (area under the curve = 0.68, &lt;i&gt;P&lt;/i&gt; &lt; 0.01, sensitivity = 75%, and specificity = 53.49%) as a significant predictor of the level of PD-L1 expression.&lt;/p&gt;&lt;h3 data-test=\"abstract-sub-heading\"&gt;Conclusion&lt;/h3&gt;&lt;p&gt;[&lt;sup&gt;18&lt;/sup&gt;F]FAPI uptake was positively correlated with PD-L1 expression in lung cancer. The combination of [&lt;sup&gt;18&lt;/sup&gt;F]FAPI PET/CT and PD-L1 expression may offer a more comprehensive approach to assessing the response of lung cancer to immunotherapy.&lt;/p&gt;&lt;h3 data-test=\"abstract-sub-heading\"","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":"37 1","pages":""},"PeriodicalIF":9.1,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic impact of metabolic tumor volume using the SUV4.0 segmentation threshold in 1,960 lymphoma patients from prospective LYSA trials","authors":"Solène Malmon, Mad-Helenie Elsensohn, Catherine Thieblemont, Franck Morschhauser, Olivier Casasnovas, Marc André, Steven Le Gouill, Yassine Al Tabaa, Paul Bland Durand, Clement Bailly, Veronique Edeline, Lavinia Vija, Laetitia Vercellino, Romain Ricci, Salim Kanoun, Anne-Ségolène Cottereau","doi":"10.1007/s00259-025-07176-4","DOIUrl":"https://doi.org/10.1007/s00259-025-07176-4","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose</h3><p>This study compared the prognostic value of total metabolic tumor volume (TMTV) in lymphoma measured with the recently proposed SUV4.0 segmentation threshold versus the 41% SUVmax across LYSA trials and its impact on intensity and dissemination PET features.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>A total of 1960 baseline PET/CT scans of Diffuse Large B cell lymphoma (DLBCL), follicular lymphoma (FL) and Hodgkin lymphoma (HL) patients were collected. After a semi-automatic preselection of region of interest, two different segmentation threshold were applied: 41% SUVmax (TMTV_41%) and SUV &gt; 4.0 (TMTV_4.0).</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>The correlation between TMTV_4.0 and TMTV_41% was ρ = 0.90 for DLBCL, ρ = 0.65 for FL and ρ = 0.60 for HL. For SUVmax, SUVpeak, Dmax and Dbulk features, a strong correlation was observed with ρ &gt; 0.95 whatever the lymphoma subtypes. The predictability of TMTV was high and comparable for the two methods with superimposable confidence intervals for the three subtypes. At the 90th percentile TMTV value, the predicted 7-year PFS was 51.13% with TMTV_4.0 vs. 49.7% with TMTV_41% for DLBCL patients, 45.5% vs. 39.8% for FL patients, and 82.6% vs. 80.5% for HL patients. A minority of patients showed a predicted PFS deviation &gt; 10% between the two methods: 2.33% in DLBCL, 6.51% in FL and 1% in HL.</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>TMTV measured with the SUV4.0 threshold provides a comparable PFS prediction than the 41%SUVmax method supporting its routine adoption particularly in the diffuse large B cell lymphoma subtype.</p>","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":"16 1","pages":""},"PeriodicalIF":9.1,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143661334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Takayasu’s arteritis imaged by a LAFOV PET/CT system: better resolution leads to greater diagnostic certainty","authors":"Sofie Rytter, André Henrique Dias, Ole Lajord Munk, Lars Christian Gormsen","doi":"10.1007/s00259-025-07192-4","DOIUrl":"https://doi.org/10.1007/s00259-025-07192-4","url":null,"abstract":"","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":"24 1","pages":""},"PeriodicalIF":9.1,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143661335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visualization of tuberculosis and interstitial lung disease in dermatomyositis using [68Ga]Ga-FAPI‐04 PET/CT","authors":"Qian Zhao, Xinlin Shao, Hua Cao, Jiajia Hu","doi":"10.1007/s00259-025-07189-z","DOIUrl":"https://doi.org/10.1007/s00259-025-07189-z","url":null,"abstract":"","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":"69 1","pages":""},"PeriodicalIF":9.1,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143653424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The utility of [¹⁸F] FDG PET/CT in staging hidradenocarcinoma","authors":"Gokce Belge Bilgin, Cem Bilgin, Matthew A. Frick, Doris E. Wenger, Matthew P. Thorpe, Stephen M. Broski","doi":"10.1007/s00259-025-07213-2","DOIUrl":"https://doi.org/10.1007/s00259-025-07213-2","url":null,"abstract":"<p>Hidradenocarcinoma is a rare and aggressive malignant cutaneous adnexal tumor that originates from the intradermal ducts of eccrine sweat glands. Herein, we report a case of hidradenocarcinoma that had transformed from a previously excised benign hidradenoma. [¹⁸F] FDG PET/CT revealed an FDG-avid mass in the left calf, and extensive metastatic disease, including soft tissue, pulmonary, osseous, and extensive nodal metastases. This case underscores the potential for malignant transformation of hidradenoma and highlights the utility of [¹⁸F] FDG PET/CT in staging hidradenocarcinoma.</p>","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":"67 1","pages":""},"PeriodicalIF":9.1,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143653422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Functional biomarkers derived from computed tomography and magnetic resonance imaging differentiate PDAC subgroups and reveal gemcitabine‑induced hypo‑vascularization.","authors":"Irina Heid, Marija Trajkovic-Arsic, Fabian Lohöfer, Georgios Kaissis, Felix N Harder, Moritz Mayer, Geoffrey J Topping, Friderike Jungmann, Barbara Crone, Moritz Wildgruber, Uwe Karst, Lucia Liotta, Hana Algül, Hsi-Yu Yen, Katja Steiger, Wilko Weichert, Jens T Siveke, Marcus R Makowski, Rickmer F Braren","doi":"10.1007/s00259-025-07195-1","DOIUrl":"https://doi.org/10.1007/s00259-025-07195-1","url":null,"abstract":"","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":" ","pages":""},"PeriodicalIF":8.6,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the origins of frequent tau-PET signal in vermal and adjacent regions","authors":"Agnes Kling, Julia Kusche-Palenga, Carla Palleis, Alexander Jäck, Alexander M. Bernhardt, Lukas Frontzkowski, Sebastian N. Roemer, Luna Slemann, Mirlind Zaganjori, Maximilian Scheifele, Lars Paeger, Gérard N. Bischof, Thilo van Eimeren, Alexander Drzezga, Osama Sabri, Michael Rullmann, Henryk Barthel, Johannes Levin, Jochen Herms, Nicolai Franzmeier, Günter Höglinger, Sigrun Roeber, Matthias Brendel, Johannes Gnörich","doi":"10.1007/s00259-025-07199-x","DOIUrl":"https://doi.org/10.1007/s00259-025-07199-x","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose</h3><p>Off-target binding remains a significant challenge in tau-PET neuroimaging. While off-targets including monoamine oxidase enzymes and neuromelanin-containing cells have been identified, recent studies indicated a relevant binding of novel tau tracers to melanin-containing structures. To date, little is known about the effect of melanocytes in the meninges on tracer signals in brain PET data. Thus, we aimed to identify the target structure causal for the frequently observed [¹⁸F]PI-2620 PET signal in the vermis and adjacent cerebellar regions.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>274 participants underwent dynamic [¹⁸F]PI-2620 tau-PET: 3/4R-tauopathies (n = 85), 4R-tauopathies (n = 147), tau-negative disease controls (n = 24), and healthy controls (n = 18). Standardized uptake value ratio (SUVR) and kinetic parameters including the distribution volume ratio (DVR), tracer clearance (k2) and relative perfusion (R1), were compared among the cohorts and sexes using the Automated Anatomical Labelling (AAL) atlas. Age and p-Tau levels in cerebrospinal fluid (CSF) were assessed for their relationship with vermal tau-PET signal. Furthermore, we combined autoradiographic and histochemical experiments on post-mortem brain tissue of deceased patients (n = 9).</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>Male participants revealed higher mean vermal [¹⁸F]PI-2620 DVR (0.95 ± 0.13; vs. females 0.88 ± 0.10, p &lt; 0.0001). Sex-related differences were most pronounced in the 3/4R-tauopathy cohort (p &lt; 0.0001). Mean SUVR_Ver/Cbl, k2 and correlation analyses of kinetic parameters did not differ among groups. Histological assessments revealed co-localization of leptomeningeal pigmented cells with strong autoradiography signal spots within the vermal fissures. Tau-related autoradiography signals, age or p-Tau levels did not correlate significantly with tau-PET signals. Iron deposits did not cause relevant autoradiography signals in the vermis.</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>Leptomeningeal melanocytes are the primary target structure for [¹⁸F]PI-2620 PET binding in anterior vermis, whereas iron and tau deposits do not contribute significantly.\u0000</p>","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":"10 1","pages":""},"PeriodicalIF":9.1,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143640554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"131I SPECT/CT provides prognostic information in patients with differentiated thyroid cancer","authors":"Marieke Heinrich, Elias Blickle, Philipp E. Hartrampf, Natalie Hasenauer, Aleksander Kosmala, Alexander Kerscher, Nicolas Schlegel, Frederik A. Verburg, Andreas K. Buck, Kerstin Michalski","doi":"10.1007/s00259-025-07187-1","DOIUrl":"https://doi.org/10.1007/s00259-025-07187-1","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose</h3><p>The aim of this study is to investigate the impact of lymph node metastases (LNM) detected on cervical ¹³¹I single photon emission computed tomography/computed tomography (SPECT/CT) after the first radioiodine therapy (RAI) on complete response (CR) and progression-free survival (PFS) in patients with differentiated thyroid cancer (DTC).</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>This retrospective study included 942 DTC patients who underwent cervical ¹³¹I SPECT/CT after their first RAI. LNM were categorized based on CT (enlarged ≥ 1 cm, small &lt; 1 cm) and ¹³¹I uptake. CR and PFS were analysed using Kaplan–Meier curves and Cox regression.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>Patients with no LNM had a shorter median time to CR (9.4 months) than those with LNM (44 months, HR 2.2; <i>p</i> &lt; 0.01) and a lower risk of progression (median PFS not reached, HR 0.46; <i>p</i> &lt; 0.01). Among patients with LNM, those with enlarged ¹³¹I negative LNM had the longest time to CR (24 months, HR 0.36; <i>p</i> &lt; 0.01). Patients with small LNM had a PFS similar to patients without LNM (median PFS not reached, HR 1.22; <i>p</i> = 0.54). Reoperation after first RAI (13.5 months) led to earlier CR than second RAI (median not reached) in patients with enlarged LNM. For small LNM, second RAI was associated with longer PFS than reoperation (38.4 months vs. not reached, HR 4.0; <i>p</i> = 0.02).</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>Patients without LNM on post-therapy ¹³¹I SPECT/CT have better chances for early CR and longer PFS. Patients with LNM benefit from early reoperations but treatment strategies should be tailored based on LNM characteristics.</p>","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":"92 1","pages":""},"PeriodicalIF":9.1,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143627494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}