Kamran Abbasi, Parveen Ali, Virginia Barbour, Marion Birch, Inga Blum, Peter Doherty, Andy Haines, Ira Helfand, Richard Horton, Kati Juva, Jose F Lapena, Robert Mash, Olga Mironova, Arun Mitra, Carlos Monteiro, Elena N Naumova, David Onazi, Tilman Ruff, Peush Sahni, James Tumwine, Carlos Umaña, Paul Yonga, Chris Zielinski
{"title":"Ending nuclear weapons, before they end us.","authors":"Kamran Abbasi, Parveen Ali, Virginia Barbour, Marion Birch, Inga Blum, Peter Doherty, Andy Haines, Ira Helfand, Richard Horton, Kati Juva, Jose F Lapena, Robert Mash, Olga Mironova, Arun Mitra, Carlos Monteiro, Elena N Naumova, David Onazi, Tilman Ruff, Peush Sahni, James Tumwine, Carlos Umaña, Paul Yonga, Chris Zielinski","doi":"10.1007/s00259-025-07365-1","DOIUrl":"https://doi.org/10.1007/s00259-025-07365-1","url":null,"abstract":"","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":" ","pages":""},"PeriodicalIF":8.6,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144283055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Qiao Yang, Song Xue, Chao Ren, Xue Lin, Marcus Hacker, Wei Chen, Na Niu, Xiang Li, Li Huo
{"title":"Fibroblast activation protein-targeted PET/CT in multiple non-ischemic cardiomyopathies.","authors":"Qiao Yang, Song Xue, Chao Ren, Xue Lin, Marcus Hacker, Wei Chen, Na Niu, Xiang Li, Li Huo","doi":"10.1007/s00259-025-07385-x","DOIUrl":"https://doi.org/10.1007/s00259-025-07385-x","url":null,"abstract":"","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":" ","pages":""},"PeriodicalIF":8.6,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Michael Rullmann, Philipp M Meyer, Andreas Schildan, Karl-Titus Hoffmann, Osama Sabri, Solveig Tiepolt
{"title":"Impact of white matter hyperintensities on α4β2 nicotinic acetylcholine receptor binding in the human brain.","authors":"Michael Rullmann, Philipp M Meyer, Andreas Schildan, Karl-Titus Hoffmann, Osama Sabri, Solveig Tiepolt","doi":"10.1007/s00259-025-07383-z","DOIUrl":"https://doi.org/10.1007/s00259-025-07383-z","url":null,"abstract":"<p><strong>Purpose: </strong>White matter hyperintensities (WMHs) are commonly observed in aging and neurodegenerative diseases, but their impact on the α4β2 nicotinic acetylcholine receptor (α4β2-nAChR) system remains unclear. This study investigates the relationship between WMHs and gray matter nicotinic signaling, aiming to elucidate potential pathways contributing to neurodegeneration.</p><p><strong>Methods: </strong>Multimodal imaging data using PET and MR imaging from 39 participants, including 19 healthy controls and 20 patients with Alzheimer's disease dementia (AD), were analyzed. WMHs were identified on T1-weighted MPRAGE and T2-weighted TSE MR images using advanced segmentation algorithms. Probabilistic fiber tracking was applied to determine WMH-connected gray matter. PET-based total distribution volume (V<sub>T</sub>) values of the α4β2-nAChR tracer (-)-[<sup>18</sup>F]Flubatine were compared between WMH-affected and unaffected gray matter regions.</p><p><strong>Results: </strong>WMH volumes were significantly correlated with age, Fazekas and MMSE scores, but no differences in absolute or relative WMH volumes were observed between healthy controls and patients with AD. PET-based V<sub>T</sub> values in WMH-connected gray matter showed no significant difference from contralateral unaffected regions, regardless of disease status or WMH burden. However, intra-individual differences in V<sub>T</sub> values correlated with Fazekas scores, presumably driven by patients with AD. Pathway-based analyses revealed decreased V<sub>T</sub> values in the medial cholinergic pathway of patients with AD but no significant differences in lateral pathways.</p><p><strong>Conclusion: </strong>This study shows that WMHs do not significantly alter gray matter nicotinic signaling in directly connected regions. However, the results suggest subtle associations between WMH severity and specific cholinergic pathways, particularly in AD.</p>","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":" ","pages":""},"PeriodicalIF":8.6,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144265659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maria Fala, Eleni Josephides, Sweni Shah, Hemal Ariyaratne, Anant Patel, Gary J R Cook, Sugama Chicklore, Thomas Wagner
{"title":"The utility of [<sup>18</sup>F]FDG PET in discriminating between local recurrence and inflammatory changes following SABR in primary lung cancer patients.","authors":"Maria Fala, Eleni Josephides, Sweni Shah, Hemal Ariyaratne, Anant Patel, Gary J R Cook, Sugama Chicklore, Thomas Wagner","doi":"10.1007/s00259-025-07400-1","DOIUrl":"https://doi.org/10.1007/s00259-025-07400-1","url":null,"abstract":"<p><strong>Purpose: </strong>Stereotactic ablative radiotherapy (SABR) is used in patients with early-stage primary lung cancer who are not fit for surgery or who refuse surgery. Post-treatment, patients are monitored with surveillance CT, with [<sup>18</sup>F]FDG PET-CT often used for further investigation if there is suspicion of recurrence on CT. This study investigated the utility of [<sup>18</sup>F]FDG PET-CT in detecting recurrence in patients with suspicious CT findings.</p><p><strong>Methods: </strong>This is a dual-centre retrospective study of 754 consecutive patients who received SABR for lung lesions in our institutions between 2012 and 2023. Seventy-four FDG PET-CT scans from 65 patients, performed at a median of 585 days after SABR were included. SUVmax and subjective score of likelihood of recurrence were recorded. Follow-up imaging, biopsy and resection histology, where available, were used to ascertain the patients' outcome.</p><p><strong>Results: </strong>Out of 74 included FDG PET-CT scans, there were 11 local recurrences and 63 non-recurrences by reference standard. The SUVmax of the lesion post-SABR was significantly higher in patients who had recurrent tumour (median 4.3, range 2.2-16.1) compared to those who did not (median 3.3, range 1.4-6.4) (p = 0.011). Subjective scores of likelihood of recurrence performed better than SUVmax readings alone with positive and negative predictive values of 0.45 and 0.96, respectively, which are significantly improved to 0.94 and 1.00 when only including tumours with baseline SUVmax > 5.0.</p><p><strong>Conclusion: </strong>FDG PET is useful in guiding management of patients with suspected recurrence after SABR, particularly in cases where the tumour is FDG avid pre-treatment.</p>","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":" ","pages":""},"PeriodicalIF":8.6,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144265662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zhiling Song, Jiajia Zhang, Shanshan Qin, Xiaohui Luan, Han Zhang, Mengdie Yang, Yao Jin, Gang Yang, Fei Yu
{"title":"Targeted alpha therapy: a comprehensive analysis of the biological effects from \"local-regional-systemic\" dimensions.","authors":"Zhiling Song, Jiajia Zhang, Shanshan Qin, Xiaohui Luan, Han Zhang, Mengdie Yang, Yao Jin, Gang Yang, Fei Yu","doi":"10.1007/s00259-025-07390-0","DOIUrl":"https://doi.org/10.1007/s00259-025-07390-0","url":null,"abstract":"<p><p>Targeted alpha therapy (TAT) has emerged as a promising radiopharmaceutical modality in precision oncology. Compared to beta-emitters, alpha-emitters exhibit superior properties, including higher linear energy transfer, shorter penetration range, enhanced resistance to hypoxic conditions, and convenient radiation protection. Notably, alpha-emitters also demonstrate therapeutic efficacy against a subset of tumors exhibiting resistance to beta-radiotherapy. In 2013, the first α-particle therapeutic agent, ²²³RaCl₂ (Xofigo<sup>®</sup>), was approved by the FDA for treating bone metastases in advanced castration-resistant prostate cancer, marking a milestone in clinical translation of alpha-emitters. However, the biological mechanisms underlying alpha-particle-mediated therapeutic effects remain incompletely elucidated, which has hindered the optimization of precision treatment strategies. This review systematically analyzes TAT's tripartite antitumor mechanisms-targeted effects, bystander effects and abscopal effects-thereby constructing a \"local-regional-systemic\" multidimensional antitumor network. This framework not only clarifies the radiobiological principles of α-emitters but also provides innovative perspectives for advancing TAT applications in tumor precision therapy.</p>","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":" ","pages":""},"PeriodicalIF":8.6,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144265661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Predicting aggressive disease and poor outcome in endometrial cancer using preoperative [<sup>18</sup>F]FDG PET primary tumor radiomics.","authors":"Kristine Eldevik Fasmer, Ankush Gulati, Sunniva Lindås, Camilla Krakstad, Ingfrid Salvesen Haldorsen","doi":"10.1007/s00259-025-07335-7","DOIUrl":"https://doi.org/10.1007/s00259-025-07335-7","url":null,"abstract":"<p><strong>Purpose: </strong>To develop a [<sup>18</sup>F]fluorodeoxyglucose ([<sup>18</sup>F]FDG) positron emission tomography (PET) primary tumor radiomic model for predicting disease-specific survival (DSS), and compare it with conventional PET markers in a large endometrial cancer cohort.</p><p><strong>Methods: </strong>Radiomic features were extracted from preoperative [<sup>18</sup>F]FDG PET scans of 489 endometrial cancer patients using a standardized uptake value (SUV) threshold > 2.5 to define primary metabolic tumor volumes (MTVs). A second reader extracted features in 154/489 patients, in which intraclass correlation coefficients (ICCs) were calculated. Radiomic features with ICCs > 0.75 were retained and ComBat harmonization was applied to reduce scanner/protocol effects on the extracted features. Patients were divided into training (n = 343) and test (n = 146) sets. A radiomic DSS score (R<sub>dss</sub>) was developed in the training set using least absolute shrinkage and selection operator (LASSO) Cox regression. A combined model (C<sub>dss</sub>), incorporating R<sub>dss</sub>, PET positive lymph nodes (LN<sub>PET</sub>) and preoperative histology risk was constructed using multivariable Cox hazard analyses. Prediction performances were assessed by comparing areas under time-dependent receiver operating characteristic curves (tdROCs AUCs) for R<sub>dss</sub>, C<sub>dss</sub>, and conventional PET markers: SUV<sub>max</sub>, SUV<sub>mean</sub>, MTV, tumor lesion glycolysis (TLG) and LN<sub>PET</sub>.</p><p><strong>Results: </strong>In the test set, AUCs for 2- and 5-year DSS were higher for R<sub>dss</sub> (0.855, 0.720) compared to SUV<sub>max</sub> (0.548, 0.572) and SUV<sub>mean</sub> (0.549, 0.554) (p ≤ 0.04 for all), while similar to MTV (0.863, 0.696), TLG (0.814, 0.672) and LN<sub>PET</sub> (0.802, 0.626) (p ≥ 0.12 for all). C<sub>dss</sub> predicted 2-year DSS with AUC of 0.909 in the test set, outperforming all conventional imaging markers (p ≤ 0.04 for all) except MTV (p = 0.29). For 5-year DSS, C<sub>dss</sub> (AUC: 0.817) outperformed all conventional imaging markers, including MTV (AUC ≤ 0.696, p ≤ 0.05, for all).</p><p><strong>Conclusion: </strong>R<sub>dss</sub> predicts short-term survival with high accuracy, outperforming tumor SUV<sub>max/mean</sub>, but not MTV, TLG and LN<sub>PET</sub>. The combined C<sub>dss</sub> model yields high accuracy for predicting both short- and long-term survival, outperforming all conventional PET imaging markers.</p>","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":" ","pages":""},"PeriodicalIF":8.6,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144265660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lukas Frontzkowski, Johannes Gnörich, Mattes Gross, Amir Dehsarvi, Sebastian N Roemer-Cassiano, Carla Palleis, Sabrina Katzdobler, Anna Dewenter, Anna Steward, Davina Biel, Fabian Hirsch, Zeyu Zhu, Johannes Levin, Andrew W Stephens, Andre Müller, Norman Koglin, Gérard N Bischof, Gabor G Kovacs, Günter U Höglinger, Matthias Brendel, Nicolai Franzmeier
{"title":"Developing a novel reference region for [<sup>18</sup>F]PI-2620-PET imaging to facilitate the assessment of 4-repeat tauopathies.","authors":"Lukas Frontzkowski, Johannes Gnörich, Mattes Gross, Amir Dehsarvi, Sebastian N Roemer-Cassiano, Carla Palleis, Sabrina Katzdobler, Anna Dewenter, Anna Steward, Davina Biel, Fabian Hirsch, Zeyu Zhu, Johannes Levin, Andrew W Stephens, Andre Müller, Norman Koglin, Gérard N Bischof, Gabor G Kovacs, Günter U Höglinger, Matthias Brendel, Nicolai Franzmeier","doi":"10.1007/s00259-025-07396-8","DOIUrl":"https://doi.org/10.1007/s00259-025-07396-8","url":null,"abstract":"","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":" ","pages":""},"PeriodicalIF":8.6,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bianca Dagmar Berndorfler, James Mathew Warwick, Patrick Dupont, Riette du Toit, Amori Engelbrecht, Thabiet Jardine, Prabash Sadhai, Tholakele Sabela, Vivian Anopuechi-Clarkson, Alex Govert George Doruyter
{"title":"Distinct metabolic patterns of neuropsychiatric systemic lupus erythematosus on hierarchical cluster analysis.","authors":"Bianca Dagmar Berndorfler, James Mathew Warwick, Patrick Dupont, Riette du Toit, Amori Engelbrecht, Thabiet Jardine, Prabash Sadhai, Tholakele Sabela, Vivian Anopuechi-Clarkson, Alex Govert George Doruyter","doi":"10.1007/s00259-025-07391-z","DOIUrl":"https://doi.org/10.1007/s00259-025-07391-z","url":null,"abstract":"","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":" ","pages":""},"PeriodicalIF":8.6,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"RhTSH in aiding dynamic assessment in patients with differentiated thyroid Cancer.","authors":"YanSong Lin, Qiang Wen, Wei Fu, Hui Yang, YongJu Gao, ZhiYong Li, JinXiong Huang, ZaiRong Gao, Jing Wu, ZhongWei Lv, KeYi Lu, Yue Chen, AiMin Yang, Wei OuYang, ShuiXing Zhang, HaiZhong Zhou, ZhiYong Deng, ZhiJun Chen, Yong Ding, Chao Yuan, LinFa Li, ChengHe Lin, ShiBiao Sang, ZhiFeng Cheng, YiZhuang Cheng","doi":"10.1007/s00259-025-07349-1","DOIUrl":"https://doi.org/10.1007/s00259-025-07349-1","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the efficacy of a novel recombinant human thyroid-stimulating hormone (ZGrhTSH) as an alternative to thyroid hormone withdrawal (THW) in dynamic assessment of DTC patients.</p><p><strong>Methods: </strong>This phase 3, open-label, multicenter trial, conducted across 27 sites in China, employed a self-controlled design to enroll patients. Eligible patients had previously undergone total or near-total thyroidectomy, with or without RAI therapy. During both the ZGrhTSH-stimulated phase and the THW phase, Dx-WBS and serum Tg measurements were performed on all participants. The study focused on the concordance of Dx-WBS results, stimulated Tg levels, and their combination in patients across the two phases. Additionally, the safety and immunogenicity profiles of ZGrhTSH were assessed as well.</p><p><strong>Results: </strong>In the assessment of radioiodine uptake and stimulated Tg levels, ZGrhTSH demonstrated efficacy comparable to that of THW. The concordance rate for scans between the two phases was 88.2% (95% CI: 83.7-92.7%). When setting stimulated Tg levels with a cutoff of 1 ng/mL, the concordance rate was 90.4% (95% CI: 86.1-94.6%), and the concordance of scans combined with stimulated Tg was 93.6% (95% CI: 90.1-97.1%). Adverse events associated with ZGrhTSH were reported in 22 patients (10.9%), all of which were mild and transient, graded as 1 or 2.</p><p><strong>Conclusion: </strong>ZGrhTSH showed non-inferior performance in detecting radioiodine uptake and serum Tg, and could be an effective and safe alternative for the dynamic evaluation of DTC patients.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov, NCT04971473. Registered July 7, 2021.</p>","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":" ","pages":""},"PeriodicalIF":8.6,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144247027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}