European Journal of Nuclear Medicine and Molecular Imaging最新文献

{"title":"Systemic effects of 177Lu-DOTATATE therapy to patients with metastatic neuroendocrine tumors: mechanistic insights and role of exosome","authors":"Swati, Preetam Basak, B. R. Mittal, Jaya Shukla, Vijayta Dani Chadha","doi":"10.1007/s00259-025-07291-2","DOIUrl":"https://doi.org/10.1007/s00259-025-07291-2","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose</h3><p>The present study aimed to evaluate the systemic redox status in metastatic neuroendocrine tumor (NET) patients following ¹⁷⁷Lu-DOTATATE therapy and to explore the role of exosomes in communicating the redox signals in-vitro.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>Levels of reactive oxygen species (ROS), enzymes associated with oxidative stress and lipid peroxidation, gene expression of oxidative stress markers (COX2, iNOS, NF-κB and SOD) were determined in peripheral blood mononuclear cells (PBMCs) and serum isolated from a total of 30 NET subjects at three time points viz.: before, 4 weeks after first and fourth cycle of ¹⁷⁷Lu-DOTATATE therapy. Serum cytokine levels (IL-2, IL-6, IFN-γ, TNF-α, IL-4, IL-10 and TGF-β) were measured by ELISA. DNA damage was assessed by checking the expression of γH2AX and DNA repair genes (ATM: Ataxia-Telangiectasia Mutated and ATR: Ataxia-Telangiectasia and Rad3-related). Plasma-derived exosomes were characterized, their uptake by PBMCs was visualized and consequent ROS generation was assessed in in-vitro co-culture.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>The study exhibits a significant increase in ROS level and relatively higher expression of COX2 and iNOS in PBMCs of NET patients post therapy. Serum inflammatory cytokines including IL-2, IL-6 and TNF-α were found elevated. The study did not find any change in the expression of genes associated with DNA damage. In-vitro co-culture of PBMCs (isolated before therapy) with exosomes derived after therapy exhibited significant increase in ROS as compared to control cells.</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>The study concludes that ¹⁷⁷Lu-DOTATATE therapy alters redox status, however it does not cause DNA damage, suggestive of its safety. Further, the study demonstrates the role of exosomes in spreading of oxidative stress systemically.</p>","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":"17 1","pages":""},"PeriodicalIF":9.1,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143862956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Harmonizing Aβ deposition threshold for 18F-florbetaben PET imaging: Addressing discrepancies and calibration between PET/CT and PET/MRI","authors":"Huamei Lin, Quanling Jiang, Yunhao Yang, Qi Huang, Ying Zhang, Zhengwei Zhang, Yuhua Zhu, Jiaying Lu, Jing Wang, Min Wang, Jianwei Men, Yufeng Yang, Huiwei Zhang, Yihui Guan, Jingjie Ge, Jie Lu, Jiehui Jiang, Chuantao Zuo","doi":"10.1007/s00259-025-07279-y","DOIUrl":"https://doi.org/10.1007/s00259-025-07279-y","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose</h3><p>Discrepancies between PET/CT and PET/MRI scanners can affect the determination of amyloid beta (Aβ) deposition thresholds in patients with cognitive impairment. This study aimed to identify these differences and propose a calibration method to standardize Aβ quantification across imaging modalities.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>A total of 133 patients with cognitive impairment underwent Aβ PET imaging and were divided into four groups: a head-to-head PET/CT and PET/MRI cohort (group A, <i>n</i> = 6), an independent PET/CT cohort (group B, <i>n</i> = 48), an independent PET/MRI cohort (group C, <i>n</i> = 79), and another independent PET/MRI cohort (group D, <i>n</i> = 10). Standardized uptake value ratios (SUVR) of global cortical target (CTXsuvr) and centiloid (CL) values were compared within group A and between groups B and C. A whole cerebellum (WC)-referenced SUVR method was used to calibrate CL values in group C, with verification in group D.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>CTXsuvr values were significantly higher in PET/MRI than in PET/CT in both group A (<i>P</i> &lt; 0.05) and group C versus group B (<i>P</i> &lt; 0.001). Aβ-negative/positive cases showed mean ± variance of CTXsuvr as 1.023 ± 0.104/1.479 ± 0.203 in group B and 1.146 ± 0.100/1.743 ± 0.254 in group C, with cutoffs of 1.140 (CL = 20) and 1.401 (CL = 60), respectively. WC-referenced calibration adjusted PET/MRI cutoff to 1.132 (CL = 19) in group C, aligning it with PET/CT thresholds and validated in group D.</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>WC-referenced SUVR calibration effectively mitigates differences in Aβ thresholds between PET/CT and PET/MRI, enhancing Aβ quantification standardization in multi-modal imaging.</p>","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":"7 1","pages":""},"PeriodicalIF":9.1,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143862957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genomic instability is associated with response to [¹⁷⁷Lu]Lu-PSMA-I&T radioligand therapy: an exploratory, preliminary liquid biopsy analysis","authors":"Kilian Kluge, David Haberl, Alexander Haug, Lukas Kenner, Gero Kramer, Shahrokh Shariat, Katarina Kumpf, Marcus Hacker","doi":"10.1007/s00259-025-07280-5","DOIUrl":"https://doi.org/10.1007/s00259-025-07280-5","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Background</h3><p>PSMA-targeted radioligand therapies (PSMA RLT) are an effective and safe option for metastatic castration-resistant prostate cancer, but responsive subtypes and their biomarkers are not fully defined.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>Plasma samples for cell-free DNA (cfDNA) analysis were collected from 17 patients undergoing [¹⁷⁷Lu]Lu-PSMA-I&amp;T. CfDNA underwent whole-genome sequencing to establish copy number variation (CNV) profiles and circulating-tumor DNA (ctDNA) levels and compared between prostate-specific antigen (PSA) response- and 1-year overall survival (1YOS) groups.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>Non-responders exhibited higher degrees of cfDNA CNV burden (<i>P</i> = 0.048) and higher ctDNA levels (<i>P =</i> 0.036) than responders. Both markers allowed for the differentiation of responses (AUC: 0.792, 0.806) and 1YOS (AUC: 0.778, 0.847).</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>Unresponsive patients exhibited higher levels of cfDNA genomic instability and ctDNA levels, warranting genome-wide CNV profiling studies next to targeted approaches for mechanistic radiobiological insights and their value as response biomarkers for PSMA RLTs.</p><h3 data-test=\"abstract-sub-heading\">Graphical Abstract</h3>","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":"17 1","pages":""},"PeriodicalIF":9.1,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143857552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of PET/CT using 68Ga-NOTA-Exendin-4 with 68Ga-DOTATATE, 18F-FDG, and conventional imaging in the localization of insulinomas","authors":"Haonan Yu, Xiangyuan Bao, Yian Gu, Meijie Pan, Qing He, Dong Li, Qiusong Chen, Shaobo Yao","doi":"10.1007/s00259-025-07288-x","DOIUrl":"https://doi.org/10.1007/s00259-025-07288-x","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose</h3><p>Accurate preoperative localization is particularly important for surgical treatment of insulinomas. Current imaging methods, including ¹⁸F-FDG (FDG) PET/CT, ⁶⁸Ga-DOTATATE (TATE) PET/CT, CE-CT, and CE-MRI, have limitations. This prospective study provides a direct comparison of ⁶⁸Ga-NOTA-Exendin-4 (Ex4) PET/CT with other imaging techniques.</p><h3 data-test=\"abstract-sub-heading\">Method</h3><p>47 patients with biochemically proven endogenous hyperinsulinemic hypoglycemia underwent Ex4 PET/CT and other imaging methods. Sensitivity and accuracy of all imaging procedures for localizing insulinoma were calculated at the patient level and lesion level. Both clinical (&gt;10 years experience) and junior (&lt; 2 years experience) nuclear medicine physician readings were used to assess the diagnostic efficacy. We compared the SUV_max and tumor-to-background ratio (TBR) of three tracers and analyzed the values with Ki-67, maximum tumor diameter, and glucose metabolism indicators.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>In patient level, the sensitivity and accuracy of Ex4 PET/CT (94.11% and 95.74%) were higher than TATE PET/CT (70.59%, <i>p</i> = 0.026; 78.72%, <i>p</i> = 0.030), FDG PET/CT (50.00%, <i>p</i> &lt; 0.001; 63.83%, <i>p</i> &lt; 0.001), CE-CT (77.77%, <i>p</i> = 0.135; 72.22%, <i>p</i> = 0.007), and CE-MRI (63.64%, <i>p</i> = 0.135; 43.75%, <i>p</i> &lt; 0.001), respectively. Interobserver agreement was higher for Ex4 PET/CT than TATE PET/CT and FDG PET/CT (Cohen κ, 0.839 vs. 0.707 and 0.784, respectively). SUV_max and TBR of Ex4 and TATE PET/CT were significantly higher than FDG PET/CT (<i>p</i> &lt; 0.01). Negative correlations of tumor Ki-67 with TATE PET/CT were observed with SUV_max (<i>r</i> = -0.637, <i>p</i> &lt; 0.001). SUV_max and TBR of three molecular imaging methods had positive correlations with the maximum tumor diameter (<i>p</i> &lt; 0.05), except TBR of FDG PET/CT. Semi-quantitative values of the three tracers showed no correlation with the lowest blood glucose level, corresponding insulin, and C-peptide level. TBR of TATE PET/CT showed a positive correlation with C-peptide (<i>r</i> = 0.393, <i>p</i> = 0.043).</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>Ex4 PET/CT showed superior characteristics in localization compared to routine imaging modalities in benign insulinomas. Ex4 PET/CT demonstrates better imaging quality and interpretability than FDG PET/CT and TATE PET/CT. Combined Ex4 and TATE PET/CT could provide a comprehensive evaluation/localization of insulinoma.</p><h3 data-test=\"abstract-sub-heading\">Trial registration</h3><p>The trial was retrospectively registered at ClinitalTrial.gov (NCT06690957 and NCT06725693) on November 14, 2024 and December 5, 2024.</p>","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":"16 1","pages":""},"PeriodicalIF":9.1,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143857545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The eye-black sign of lower eyelids related to R-CHOP therapy: a rare imaging pitfall","authors":"Ivana Dewi Mulyanto, Elizabeth Celine, Ryan Yudistiro, Febby Hutomo, Hapsari Indrawati, Marcel P.M. Stokkel","doi":"10.1007/s00259-025-07284-1","DOIUrl":"https://doi.org/10.1007/s00259-025-07284-1","url":null,"abstract":"","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":"14 1","pages":""},"PeriodicalIF":9.1,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143853454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A pilot study of [18F]F-fluciclovine positron emission tomography/computed tomography for staging muscle invasive bladder cancer preceding radical cystectomy","authors":"Thomas S. C. Ng, Mofei Liu, Matthew Robertson, Arda Könik, Su Chun Cheng, Martin K. Bakht, Kristen Harrington, Andrew Wolanski, Lauren Gilbert, Mark Preston, Matthew Mossanen, Himisha Beltran, Michelle S. Hirsch, Guru Sonpavde, Heather A. Jacene","doi":"10.1007/s00259-025-07287-y","DOIUrl":"https://doi.org/10.1007/s00259-025-07287-y","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Aim</h3><p>To assess the ability of [¹⁸F]F-fluciclovine-PET/CT to stage muscle invasive bladder cancer (MIBC) before radical cystectomy.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>This single-site prospective pilot study enrolled patients with MIBC and T2-T4, N0 disease on CT/MRI slated to undergo radical cystectomy (RC). Dynamic and static [¹⁸F]F-fluciclovine-PET/CT images were acquired. Clinical readers assessed for confirmation of the primary bladder lesion on imaging and the presence of pelvic nodal metastases. Findings were compared to pathology at RC. Kinetic parameters from dynamic PET/CT were compared across bladder lesions of different clinical stages.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>The study enrolled sixteen patients (median age: 73 years, range: 57–88 years, 11 males, 5 females), twelve receiving neoadjuvant chemotherapy before RC. There was high specificity amongst all three readers for detecting lymph node metastases (overall specificity: 0.91, 95%CI: 0.81–1.00) with good overall agreement rate with pathology (0.67, 95%CI: 0.44–0.83). The overall PPV for all readers for identifying node-positive disease was 0.4 (95%CI: 0–1.00), and the overall sensitivity was 0.13 (95%CI: 0–0.44). The overall PPV for detecting the primary tumor was 0.69 (95%CI: 0.47–0.88), and the sensitivity was 0.89 (95%CI: 0.78–1.00), with NPV and specificity being 0.70 (95%CI: 0.33, 1.00) and 0.39 (95%CI: 0.33, 0.50), respectively. Compartmental analysis of the primary bladder tumor revealed that k₁ and v_b parameters significantly differentiated between low (pT0-pT1) and high (pT2-pT4) risk disease (<i>p</i> &lt; 0.05). Immunohistochemical assessment showed no significant correlation of tumor [¹⁸F]F-fluciclovine uptake nor kinetic parameter with amino acid transporter expression.</p><h3 data-test=\"abstract-sub-heading\">Conclusions</h3><p>[¹⁸F]F-fluciclovine demonstrates good specificity and agreement rate for MIBC staging, with sensitivity like CT/MRI. Kinetic parameters such as k₁ was able to delineate higher-stage ( ≥ = pT2) primary lesions. Heterogeneous amino acid transporter expression can be seen across lesions. Further studies are warranted to understand [¹⁸F]F-fluciclovine PET/CT use in the context of other imaging modalities in this disease.</p><h3 data-test=\"abstract-sub-heading\">Clinical trial registration</h3><p>NCT04018053 Registered 2/26/2020.</p>","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":"108 1","pages":""},"PeriodicalIF":9.1,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143853451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How to improve the availability of radiosynoviorthesis in Europe.","authors":"Knut Liepe","doi":"10.1007/s00259-025-07261-8","DOIUrl":"https://doi.org/10.1007/s00259-025-07261-8","url":null,"abstract":"","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":"19 1","pages":""},"PeriodicalIF":9.1,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143857350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combination of amyloid and FDG PET for the prediction of short-term conversion from MCI to Alzheimer´s disease in the clinical practice","authors":"Beatriz Echeveste, Elena Prieto, Edgar Fernando Guillén, Adolfo Jimenez, Genoveva Montoya, Rafael Villino, Mario Riverol, Javier Arbizu","doi":"10.1007/s00259-025-07275-2","DOIUrl":"https://doi.org/10.1007/s00259-025-07275-2","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose</h3><p>Amnestic mild cognitive impairment (aMCI) is considered a precursor to Alzheimer’s disease (AD). Since cerebral amyloid aggregation and neurodegeneration can be detected at an early stage, it can serve as a diagnostic aid. This study aimed to determine the predictive value of Amyloid-PET and FDG-PET in determining progression to AD among patients with aMCI.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>This study recruited 145 patients with aMCI from October 2013 to March 2021. The patients were classified into four groups based on whether Amyloid-PET (A) and FDG-PET (N) were positive (+) or negative (-). The patients were then clinically followed to establish progression to dementia due to AD.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>Amyloid-PET demonstrated high sensitivity (100% in year 1, 94.67% in year 4) and a high negative predictive value (100% in year 1, 88.24% in year 4). FDG-PET exhibited a high negative predictive value initially (94.59% in year 1), and during follow-up, both specificity (85%) and positive predictive value (88%) increased. The conversion from aMCI to AD had a global mean time of 39.95 months. However, progression to AD was slower in amyloid-negative patients versus amyloid-positive patients (75.07 [CI 56.54–81] vs. 32.59 months [CI 20.56–40.74] months). Taking both tests together, the time to conversion was faster in A+/N + versus A+/N- patients (27.79 [CI 20.40–33.21] vs. 37.38 [CI 20.73–48.26] months).</p><h3 data-test=\"abstract-sub-heading\">Conclusions</h3><p>Among patients with aMCI, those with a positive Amyloid-PET and an AD pattern on FDG-PET progressed to dementia significantly earlier versus those with a positive Amyloid-PET only. Using both biomarkers during the initial diagnosis enhances the prediction of short-term conversion.</p><h3 data-test=\"abstract-sub-heading\">Clinical trial number</h3><p>Not applicable. It is not a clinical trial.</p>","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":"65 1","pages":""},"PeriodicalIF":9.1,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143853457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fast 4D-PET parametric imaging computation at the whole field of view level: Reliability under simulated conditions of PET KinetiX, a dedicated software solution","authors":"Sylvain Faure, Adrien Paillet, Claude Comtat, Florent L. Besson","doi":"10.1007/s00259-025-07285-0","DOIUrl":"https://doi.org/10.1007/s00259-025-07285-0","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose</h3><p>The reliability of a new academic software, PET KinetiX, designed for fast parametric 4D-PET imaging computation, is assessed under simulated conditions.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>4D-PET data were simulated using the XCAT digital phantom and realistic time-activity curves (ground truth). Four hundred analytical simulations were reconstructed using CASToR, an open-source software for tomographic reconstruction, replicating the clinical characteristics of two available PET systems with short and long axial fields of view (SAFOV and LAFOV). A total of 2,800 Patlak and 2TCM kinetic parametric maps of ¹⁸F-FDG were generated using PET KinetiX. The mean biases and standard deviations of the kinetic parametric maps were computed for each tissue label and compared to the biases of unprocessed SUV data. Additionally, the mean absolute ratio of kinetic-to-SUV contrast-to-noise ratio (CNR) was estimated for each tissue structure, along with the corresponding standard deviations.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>The K_i and v_b parametric maps produced by PET KinetiX faithfully reproduced the predefined multi-tissue structures of the XCAT digital phantom for both Patlak and 2TCM models. Image definition was influenced by the 4D-PET input data: a higher number of iterations resulted in sharper rendering and higher standard deviations in PET signal characteristics. Biases relative to the ground truth varied across tissue structures and hardware configurations, similarly to unprocessed SUV data. In most tissue structures, Patlak kinetic-to-SUV CNR ratios exceeded 1 for both SAFOV and LAFOV configurations. The highest kinetic-to-SUV CNR ratio was observed in 2TCM k₃ maps within tumor regions.</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>PET KinetiX currently generates K_i and v_b parametric maps that are qualitatively comparable to unprocessed SUV data, with improved CNR in most cases. The 2TCM k₃ parametric maps for tumor structures exhibited the highest CNR enhancement, warranting further evaluation across different anatomical regions and radiotracer applications.</p>","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":"219 1","pages":""},"PeriodicalIF":9.1,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143853452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diffuse pleural and pulmonary involvement with intense 18F-FDG uptake: a rare extramedullary manifestation of multiple myeloma","authors":"Jia Guo, Xianping Huang","doi":"10.1007/s00259-025-07283-2","DOIUrl":"https://doi.org/10.1007/s00259-025-07283-2","url":null,"abstract":"","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":"25 1","pages":""},"PeriodicalIF":9.1,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143853458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}