European Journal of Nuclear Medicine and Molecular Imaging最新文献

{"title":"Long-term trends in total administered radiation dose from brain [¹⁸F]FDG-PET in children with drug-resistant epilepsy.","authors":"Antonio G Gennari, Stephan Waelti, Moritz Schwyzer, Valerie Treyer, Alexia Rossi, Thomas Sartoretti, Alexander Maurer, Georgia Ramantani, Ruth Tuura O'Gorman, Christian J Kellenberger, Martin W Hüllner, Michael Messerli","doi":"10.1007/s00259-024-06902-8","DOIUrl":"https://doi.org/10.1007/s00259-024-06902-8","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the trends in administered 2-[¹⁸F]fluoro-2-deoxy-D-glucose ([¹⁸F]FDG) doses, computed tomography (CT) radiation doses, and image quality over the last 15 years in children with drug-resistant epilepsy (DRE) undergoing hybrid positron emission tomography (PET) brain scans.</p><p><strong>Methods: </strong>We retrospectively analyzed data from children with DRE who had [¹⁸F]FDG-PET/CT or magnetic resonance scans for presurgical evaluation between 2005 and 2021. We evaluated changes in injected [¹⁸F]FDG doses, administered activity per body weight, CT dose index volume (CTDIvol), and dose length product (DLP). PET image quality was assessed visually by four trained raters. Conversely, CT image quality was measured using region-of-interest analysis, normalized by signal-to-noise (SNR) and contrast-to-noise ratio (CNR).</p><p><strong>Results: </strong>We included 55 children (30 male, mean age: 9 ± 6 years) who underwent 61 [¹⁸F]FDG-PET scans (71% as PET/CT). Annually, the injected [¹⁸F]FDG dose decreased by ~ 1% (95% CI: 0.92%-0.98%, p < 0.001), with no significant changes in administered activity per body weight (p = 0.51). CTDIvol and DLP decreased annually by 16% (95% CI: 9%-23%) and 15% (95% CI: 8%-21%, both p < 0.001), respectively. PET image quality improved by 9% year-over-year (95% CI: 6%-13%, p < 0.001), while CT-associated SNR and CNR decreased annually by 7% (95% CI: 3%-11%, p = 0.001) and 6% (95% CI: 2%-10%, p = 0.008), respectively.</p><p><strong>Conclusion: </strong>Our findings indicate stability in [¹⁸F]FDG administered activity per body weight alongside improvements in PET image quality. Conversely, CT-associated radiation doses reduced. These results reaffirm [¹⁸F]FDG-PET as an increasingly safer and higher-resolution auxiliary imaging modality for children with DRE. These improvements, driven by technological advancements, may enhance the diagnostic precision and patient outcomes in pediatric epilepsy surgery.</p>","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":null,"pages":null},"PeriodicalIF":8.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142344051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comments on the letter to the editor: \"Rate of unspecific bone uptake on PSMA PET is determined by the Scaffold - not the Radionuclide\".","authors":"Cristiano Pini, Gaia Ninatti","doi":"10.1007/s00259-024-06908-2","DOIUrl":"10.1007/s00259-024-06908-2","url":null,"abstract":"","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":null,"pages":null},"PeriodicalIF":8.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142105639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive value of C-X-C motif chemokine receptor 4-directed molecular imaging in patients with advanced adrenocortical carcinoma.","authors":"Wiebke Schloetelburg, Philipp E Hartrampf, Aleksander Kosmala, Sebastian E Serfling, Niklas Dreher, Andreas Schirbel, Martin Fassnacht, Andreas K Buck, Rudolf A Werner, Stefanie Hahner","doi":"10.1007/s00259-024-06800-z","DOIUrl":"10.1007/s00259-024-06800-z","url":null,"abstract":"<p><strong>Background: </strong>In patients affected with adrenocortical carcinoma (ACC), C-X-C motif chemokine receptor 4 (CXCR4) is highly expressed in sites of disease in an ex-vivo setting. We aimed to determine the predictive value of CXCR4-targeting [⁶⁸Ga]Ga-PentixaFor PET/CT for outcome when compared to clinical parameters.</p><p><strong>Methods: </strong>We identified 41 metastasized ACC patients imaged with [⁶⁸Ga]Ga-PentixaFor PET/CT. Scans were assessed visually and on a quantitative level by manually segmenting the tumor burden (providing tumor volume [TV], peak/mean/maximum standardized uptake values [SUV] and tumor chemokine receptor binding on the cell surface [TRB], defined as SUV_mean multiplied by tumor volume). Clinical parameters included sex, previous therapies, age, Weiss-Score, and Ki67 index. Following imaging, overall survival (OS) was recorded.</p><p><strong>Results: </strong>After [⁶⁸Ga]Ga-PentixaFor PET/CT, median OS was 9 months (range, 1-96 months). On univariable analysis, only higher TRB (per 10 ml, HR 1.004, 95%CI: 1.0001-1.007, P = 0.005) and presence of CXCR4-positive peritoneal metastases (PM) were associated with shorter OS (HR 2.03, 95%CI: 1.03-4.02, P = 0.04). Presence of CXCR4-positive liver metastases (LM) trended towards significance (HR 1.85, 0.9-4.1, P = 0.11), while all other parameters failed to predict survival. On multivariable analysis, only TRB was an independent predictor for OS (HR 1.0, 95%CI: 1.00-1.001, P = 0.02). On Kaplan-Meier analysis, TRB above median (13.3 months vs. below median, 6.4 months) and presence of CXCR4-positive PM (6.4 months, vs. no PM, 11.4 months) were associated with shorter survival (P < 0.05, respectively). Presence of LM, however, was also linked to less favorable outcome (8.5 months vs. no LM, 18.1 months), without reaching significance (P = 0.07).</p><p><strong>Conclusions: </strong>In advanced ACC, elevated tumor chemokine receptor binding on the tumor cell surface detected through [⁶⁸Ga]Ga-PentixaFor PET/CT is an independent predictor for OS, while other imaging and clinical parameters failed to provide relevant prognostic information.</p>","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":null,"pages":null},"PeriodicalIF":8.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11445370/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141418442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cost-effectiveness of one-stop-shop [¹⁸F]Fluorocholine PET/CT to localise parathyroid adenomas in patients suffering from primary hyperparathyroidism.","authors":"Sietse van Mossel, Sopany Saing, Natasha Appelman-Dijkstra, Elske Quak, Abbey Schepers, Frits Smit, Lioe-Fee de Geus-Oei, Dennis Vriens","doi":"10.1007/s00259-024-06771-1","DOIUrl":"10.1007/s00259-024-06771-1","url":null,"abstract":"<p><strong>Purpose: </strong>We conducted a cost-effectiveness analysis in which we compared a preoperative [¹⁸F]Fluorocholine PET/CT-based one-stop-shop imaging strategy with current best practice in which [¹⁸F]Fluorocholine PET/CT is only recommended after negative or inconclusive [^99mTc]Tc-methoxy isobutyl isonitrile SPECT/CT for patients suffering from primary hyperparathyroidism. We investigated whether the one-stop-shop strategy performs as well as current best practice but at lower costs.</p><p><strong>Methods: </strong>We developed a cohort-level state transition model to evaluate both imaging strategies respecting an intraoperative parathyroid hormone monitored treatment setting as well as a traditional treatment setting. The model reflects patients' hospital journeys after biochemically diagnosed primary hyperparathyroidism. A cycle length of twelve months and a lifetime horizon were used. We conducted probabilistic analyses simulating 50,000 cohorts to assess joint parameter uncertainty. The incremental net monetary benefit and cost for each quality-adjusted life year were estimated. Furthermore, threshold analyses regarding the tariff of [¹⁸F]Fluorocholine PET/CT and the sensitivity of [^99mTc]Tc-methoxy isobutyl isonitrile SPECT/CT were performed.</p><p><strong>Results: </strong>The simulated long-term health effects and costs were similar for both imaging strategies. Accordingly, there was no incremental net monetary benefit and the one-stop-shop strategy did not result in lower costs. These results applied to both treatment settings. The threshold analysis indicated that a tariff of €885 for [¹⁸F]Fluorocholine PET/CT was required to be cost-effective compared to current best practice.</p><p><strong>Conclusion: </strong>Both preoperative imaging strategies can be used interchangeably. Daily clinical practice grounds such as available local resources and patient preferences should inform policy-making on whether a hospital should implement the one-stop-shop imaging strategy.</p>","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":null,"pages":null},"PeriodicalIF":8.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11457719/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141246955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Refining salvage radiotherapy strategies for pelvic node recurrence in prostate cancer: insights from salvage lymph node dissection.","authors":"Gaetan Devos, Alexander Giesen, Steven Joniau","doi":"10.1007/s00259-024-06900-w","DOIUrl":"10.1007/s00259-024-06900-w","url":null,"abstract":"","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":null,"pages":null},"PeriodicalIF":8.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142132191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[¹⁸F]Fluorocholine PET/CT as First-Line vs. Second-Line Imaging Method to localize parathyroid adenomas in primary hyperparathyroidism: \"Game, Set, and Match\".","authors":"Giorgio Treglia, Arnoldo Piccardo, Gaetano Paone, Pierpaolo Trimboli, Alessio Imperiale","doi":"10.1007/s00259-024-06772-0","DOIUrl":"10.1007/s00259-024-06772-0","url":null,"abstract":"","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":null,"pages":null},"PeriodicalIF":8.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141160782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: B-Glycine as a marker for β cell imaging and β cell mass evaluation.","authors":"Yuxiang Han, Hui Liu, Yimin Li, Zhibo Liu","doi":"10.1007/s00259-024-06884-7","DOIUrl":"10.1007/s00259-024-06884-7","url":null,"abstract":"","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":null,"pages":null},"PeriodicalIF":8.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142035505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A deep learning model for generating [¹⁸F]FDG PET Images from early-phase [¹⁸F]Florbetapir and [¹⁸F]Flutemetamol PET images.","authors":"Amirhossein Sanaat, Cecilia Boccalini, Gregory Mathoux, Daniela Perani, Giovanni B Frisoni, Sven Haller, Marie-Louise Montandon, Cristelle Rodriguez, Panteleimon Giannakopoulos, Valentina Garibotto, Habib Zaidi","doi":"10.1007/s00259-024-06755-1","DOIUrl":"10.1007/s00259-024-06755-1","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Amyloid-β (Aβ) plaques is a significant hallmark of Alzheimer's disease (AD), detectable via amyloid-PET imaging. The Fluorine-18-Fluorodeoxyglucose ([&lt;sup&gt;18&lt;/sup&gt;F]FDG) PET scan tracks cerebral glucose metabolism, correlated with synaptic dysfunction and disease progression and is complementary for AD diagnosis. Dual-scan acquisitions of amyloid PET allows the possibility to use early-phase amyloid-PET as a biomarker for neurodegeneration, proven to have a good correlation to [&lt;sup&gt;18&lt;/sup&gt;F]FDG PET. The aim of this study was to evaluate the added value of synthesizing the later from the former through deep learning (DL), aiming at reducing the number of PET scans, radiation dose, and discomfort to patients.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A total of 166 subjects including cognitively unimpaired individuals (N = 72), subjects with mild cognitive impairment (N = 73) and dementia (N = 21) were included in this study. All underwent T1-weighted MRI, dual-phase amyloid PET scans using either Fluorine-18 Florbetapir ([&lt;sup&gt;18&lt;/sup&gt;F]FBP) or Fluorine-18 Flutemetamol ([&lt;sup&gt;18&lt;/sup&gt;F]FMM), and an [&lt;sup&gt;18&lt;/sup&gt;F]FDG PET scan. Two transformer-based DL models called SwinUNETR were trained separately to synthesize the [&lt;sup&gt;18&lt;/sup&gt;F]FDG from early phase [&lt;sup&gt;18&lt;/sup&gt;F]FBP and [&lt;sup&gt;18&lt;/sup&gt;F]FMM (eFBP/eFMM). A clinical similarity score (1: no similarity to 3: similar) was assessed to compare the imaging information obtained by synthesized [&lt;sup&gt;18&lt;/sup&gt;F]FDG as well as eFBP/eFMM to actual [&lt;sup&gt;18&lt;/sup&gt;F]FDG. Quantitative evaluations include region wise correlation and single-subject voxel-wise analyses in comparison with a reference [&lt;sup&gt;18&lt;/sup&gt;F]FDG PET healthy control database. Dice coefficients were calculated to quantify the whole-brain spatial overlap between hypometabolic ([&lt;sup&gt;18&lt;/sup&gt;F]FDG PET) and hypoperfused (eFBP/eFMM) binary maps at the single-subject level as well as between [&lt;sup&gt;18&lt;/sup&gt;F]FDG PET and synthetic [&lt;sup&gt;18&lt;/sup&gt;F]FDG PET hypometabolic binary maps.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The clinical evaluation showed that, in comparison to eFBP/eFMM (average of clinical similarity score (CSS) = 1.53), the synthetic [&lt;sup&gt;18&lt;/sup&gt;F]FDG images are quite similar to the actual [&lt;sup&gt;18&lt;/sup&gt;F]FDG images (average of CSS = 2.7) in terms of preserving clinically relevant uptake patterns. The single-subject voxel-wise analyses showed that at the group level, the Dice scores improved by around 13% and 5% when using the DL approach for eFBP and eFMM, respectively. The correlation analysis results indicated a relatively strong correlation between eFBP/eFMM and [&lt;sup&gt;18&lt;/sup&gt;F]FDG (eFBP: slope = 0.77, R&lt;sup&gt;2&lt;/sup&gt; = 0.61, P-value &lt; 0.0001); eFMM: slope = 0.77, R&lt;sup&gt;2&lt;/sup&gt; = 0.61, P-value &lt; 0.0001). This correlation improved for synthetic [&lt;sup&gt;18&lt;/sup&gt;F]FDG (synthetic [&lt;sup&gt;18&lt;/sup&gt;F]FDG generated from eFBP (slope = 1.00, R&lt;sup&gt;2&lt;/sup&gt; = 0.68, P-value &lt; 0.0001), eFMM (slope = 0.93, R&lt;sup&gt;2&lt;/sup&gt; = 0.72, ","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":null,"pages":null},"PeriodicalIF":8.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11445334/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141300319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Connectivity based on glucose dynamics reveals exaggerated sensorimotor network coupling on subject-level in Parkinson's disease.","authors":"Marina C Ruppert-Junck, Vanessa Heinecke, Damiano Librizzi, Kenan Steidel, Maya Beckersjürgen, Frederik A Verburg, Tino Schurrat, Markus Luster, Hans-Helge Müller, Lars Timmermann, Carsten Eggers, David Pedrosa","doi":"10.1007/s00259-024-06796-6","DOIUrl":"10.1007/s00259-024-06796-6","url":null,"abstract":"<p><strong>Purpose: </strong>While fMRI provides information on the temporal changes in blood oxygenation, 2- [18F]fluoro-2-deoxy-D-glucose ([¹⁸F]FDG)-PET has traditionally offered a static snapshot of brain glucose consumption. As a result, studies investigating metabolic brain networks as potential biomarkers for neurodegeneration have primarily been conducted at the group level. However, recent pioneering studies introduced time-resolved [¹⁸F]FDG-PET with constant infusion, which enables metabolic connectivity studies at the individual level.</p><p><strong>Methods: </strong>In the current study, this technique was employed to explore Parkinson's disease (PD)-related alterations in individual metabolic connectivity, in comparison to inter-subject measures and hemodynamic connectivity. Fifteen PD patients and 14 healthy controls with comparable cognition underwent sequential resting-state dynamic PET with constant infusion and functional MRI. Intrinsic networks were identified by independent component analysis and interregional connectivity calculated for summed static PET images, PET time series and functional MRI.</p><p><strong>Results: </strong>Our findings revealed an intrinsic sensorimotor network in PD patients that has not been previously observed to this extent. In PD, a significantly higher number of connections in cortical motor areas was observed compared to elderly control subjects, as indicated by both static PET and functional MRI (p_{Bonferroni-Holm} = 0.027), as well as constant infusion PET and functional MRI connectomes (p_{Bonferroni-Holm} = 0.012). This intensified coupling was associated with disease severity (ρ = 0.56, p = 0.036).</p><p><strong>Conclusion: </strong>Metabolic connectivity, as revealed by both static and dynamic PET, provides unique information on metabolic network activity. Subject-level metabolic connectivity based on constant infusion PET may serve as a potential marker for the metabolic network signature in neurodegeneration.</p>","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":null,"pages":null},"PeriodicalIF":8.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11445336/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141330561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cinematic rendering of [¹⁸F]FDG-PET/MR.","authors":"Martin W Huellner, Klaus Engel, Grégoire B Morand, Bernd Stadlinger","doi":"10.1007/s00259-024-06812-9","DOIUrl":"10.1007/s00259-024-06812-9","url":null,"abstract":"","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":null,"pages":null},"PeriodicalIF":8.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11445327/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141476239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}