European Addiction Research最新文献

{"title":"Front & Back Matter","authors":"","doi":"10.1159/000533225","DOIUrl":"https://doi.org/10.1159/000533225","url":null,"abstract":"","PeriodicalId":11902,"journal":{"name":"European Addiction Research","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46711761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pattern and Socio-demographic characteristics of Drug Users at the National Drug Law Enforcement Agency (NDLEA) Rehabilitation Facility, Port Harcourt","authors":"Nkporbu Ak, Stanley Pc","doi":"10.33425/2639-8451.1035","DOIUrl":"https://doi.org/10.33425/2639-8451.1035","url":null,"abstract":"Background: Substance abuse particularly among young people has become a large phenomenon globally affecting all segments of society. The abuse of alcohol, tobacco, cannabis and other psychoactive drugs among young people has become an issue of public health concern with untold negative consequences on human existence. Aim: This study sought to examine the sociodemographic profiles and patterns of drug use among drug users at the NDLEA Rehabilitation Facility, Port Harcourt. Materials and Methods: This was a descriptive cross-sectional study conducted among inmates of the National Drug Law Enforcement Agency (NDLEA), Port Harcourt. A structured questionnaire covering socio-demographic characteristics and other factors were self-administered to inmates of the facility, who have been brought by their relative for addiction care over a period of 3 years (2017 to 2020). Ethical approval was obtained from the ethical committee of the University of Port Harcourt Teaching Hospital and approval was obtained from the NDLEA Authority. All other ethical provisions were followed. Descriptive statistics was used to analyzed the data. Data were analyzed with number count, percentage, and then Chi-square of independence. Results: Majority of the drug users were male (98,8%), single (72.5%), unemployed (27.5%) and apprentice (40.0%), between the ages of 15 and 35 (67.5%) and with tertiary education. Cannabis was the most consumed drug (75.7%), followed by nicotine (30.8%) alcohol (28.3%), cocaine (27.4%) and heroine (25.8%). Majority of the users were introduced to drug by friends and family members and referred to the feeling they got on the first day of use as high and happy. Majority had 15 to 25 years as age of onset of drug use and there were no family history of psychoactive substance use or mental illness. Conclusion: Substance use is common among young people between the ages of 26 and 30, single, with higher level of education and low-income earners. Majority use illicit drugs, which they started at early age of 15 to 25 and introduced to by friends and family members. Improvement in socio-economic status of adolescents and sustained public health enlightenment will help to reduce the rising prevalence of drug use.","PeriodicalId":11902,"journal":{"name":"European Addiction Research","volume":"7 1","pages":""},"PeriodicalIF":3.9,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81235767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pattern and Prevalence of Drug Use among a Population of Mentally Ill Patients attending the University of Port Harcourt Teaching Hospital","authors":"Nkporbu Ak, Ojule In","doi":"10.33425/2639-8451.1034","DOIUrl":"https://doi.org/10.33425/2639-8451.1034","url":null,"abstract":"Background: People with mental illness are at increased risk for substance use and individuals who experience a substance use disorder (SUD) during their lives may experience a co-occurring mental disorder and vice versa. The dual diagnosis often affects the illness course, worsens prognosis and presents a management difficulty. Aim: This study aimed to look at the prevalence of psychoactive use among mentally ill patients at the University of Port Harcourt Teaching Hospital. Materials and Methods: This was a descriptive cross-sectional study conducted among attendees of Neuropsychiatric Outpatient Clinic of the University of Port Harcourt Teaching Hospital (UPTH). A structured questionnaire covering socio-demographic characteristics and other factors were self-administered to 75 patients diagnosed with various psychiatric disorders by consultants Psychiatrists and attending the out-patient clinic via a systematic random sampling. Ethical approval was obtained from the ethical committee of the University of Port Harcourt Teaching Hospital and all other ethical provisions were followed. Descriptive statistics was used to analyze the data. Results: Majority of the respondents were male (81%), single (76.0%), unemployed (36.0%), low income earners (73.4%) and between the ages of 21 and 30 (44%).. Majority had tertiary education (58.7%) followed by respondents with secondary education (33.3%). The prevalence of psychoactive substance use was 48% with Cannabis being the most reported consumed drug (24%), cocaine 16%, nicotine 14.7%, heroine 10.7%, alcohol 6.7%, then volatile substance and hypno-sedation 2.7% and 1.3% respectively. Majority of the Respondents had use drugs between 1- 10 years. Conclusion: Drug use is common among the persons suffering from mental disorders in UPTH. Better evaluation for and proper management of this dual diagnosis will help to improve their mental well-being and quality of life.","PeriodicalId":11902,"journal":{"name":"European Addiction Research","volume":"83 1","pages":""},"PeriodicalIF":3.9,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79987751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Traumatic Events on Substance Use among Internally Displaced People in Selected Flood and War Impacted Areas in Rivers State","authors":"Nkporbu Ak, Oti Ik, Stanley Pc","doi":"10.33425/2639-8451.1033","DOIUrl":"https://doi.org/10.33425/2639-8451.1033","url":null,"abstract":"Background: Different individuals react differently to emotionally traumatic events just as there are varying degrees of coping mechanisms. One of the common maladaptive coping mechanisms of victims of internal displacement is increased predisposition to substance use. Aim: This study determined the relationship between stressful life events and substance use among victims of flood and wars in selected parts of Rivers State. Methods: A cross-sectional study was conducted in 4 different flood and war impacted areas where 357 respondents were investigated. Ethical procedures were followed including consent from participants. Respondents of between the ages 10-75 years were included in the study and their socio-demographic characteristics determined. The Impact of Event Scale –Revised (IES-R) was used to assess posttraumatic symptomatology of the flood victims, while the CAGE and a semi-structured questionnaire were used to assess alcohol and other psychoactive substances. Rapid urine drug toxicology was done for the respondents. Data was analysed using the SPSS version 20. p≤0.05 was considered statistically significant. Results: Two hundred and eighty (79.6%) respondents had IES-R score of 22 and above while 65.3% (n=233) scored 33 and above. Prevalence of substance use was 34.4% (n=123) from self-report and 41.7% (n=149) from urine toxicology. Of the 149 respondents, 138 was among those who scored IES-R 22 and above while 11 was among those who scored below 22 (p=0.001). Alcohol was the most consumed drug with 22.65 (n=81), followed by cannabis with 18.8% (n=67), tramadol 16.5% (n=59), codeine 15.7% (n=56), Nicotine 14.8% (n=53), kolanut and khatchewing 6.4% (n=23), and benzodiazepam 12.8% (n=64). Polysubstance use was 34.17% (n=122). Three respondents use drug intravenously. Substance use significantly correlated with IES-R scores (p=0.002). Conclusion: Stressful and traumatic events may increase vulnerability to substance use, therefore Internally Displaced People (IDP) may require substance use disorder services and psychological care.","PeriodicalId":11902,"journal":{"name":"European Addiction Research","volume":"54 1","pages":""},"PeriodicalIF":3.9,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87623189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Metabotropic Glutamate Receptor Subtype 5 in Mouse Models of Cocaine Addiction","authors":"Marion Nicole, Briggs Lily, Donar Andrew, Godin Brandon, LaCrosse Amber","doi":"10.33425/2639-8451.1036","DOIUrl":"https://doi.org/10.33425/2639-8451.1036","url":null,"abstract":"Cocaine is a psychostimulant that is one of the most widely used illicit drugs, particularly in America. Cocaine addiction is a chronic relapsing disease that is characterized by drug craving and loss of inhibitory control. Animal models of psychiatric diseases are essential to identify underlying neural circuitry and to test the effectiveness of novel pharmacotherapies to prevent relapse. Current research using animal models indicates that type 5 metabotropic glutamate receptors may be of particular importance to the onset and maintenance of cocaine addiction. This literature review provides a general overview of the glutamate system, and the animal models frequently used in the study of addiction and summarizes peer-reviewed research focused on cocaine-induced adaptations to the type 5 metabotropic glutamate receptors in mice. Cocaine administration in mouse models induces a range of neural changes in the brain, reflecting the neuroadaptations associated with cocaine addiction. Cocaine-induced adaptations to type 5 metabotropic glutamate receptor vary by brain region and by methodological constraints. Key neural changes that occur in the mouse brain following cocaine administration include adaptations in the dopaminergic and glutamatergic systems. The interplay between mGluR5 and the dopamine system plays a significant role in the neurobiological adaptations that drive cocaine addiction. Lastly, we cover the potential efficacy of targeting this receptor as a novel therapeutic option to prevent cocaine relapse. Selective antagonists of this receptor have been studied for their potential therapeutic effects in mouse models of cocaine addiction. These compounds reduce the conditioned responses to drug-associated cues and reduce the motivation to seek cocaine, thereby inhibiting relapse-like behavior, and have been found to modulate synaptic plasticity in brain regions involved in addiction, such as the nucleus accumbens and prefrontal cortex. Overall, these compounds demonstrate promising effects in mouse models of cocaine addiction.","PeriodicalId":11902,"journal":{"name":"European Addiction Research","volume":"50 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136300590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Front & Back Matter","authors":"","doi":"10.1159/000531384","DOIUrl":"https://doi.org/10.1159/000531384","url":null,"abstract":"","PeriodicalId":11902,"journal":{"name":"European Addiction Research","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42715543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patients' Perspectives on the Development of Prescription Opioid Use Disorder in Patients with Chronic Non-Cancer Pain.","authors":"Lisa E M Davies,&nbsp;Ellen S Koster,&nbsp;Katinka F M Damen,&nbsp;Harmen Beurmanjer,&nbsp;Arnt F A Schellekens,&nbsp;Marcel L Bouvy","doi":"10.1159/000529926","DOIUrl":"https://doi.org/10.1159/000529926","url":null,"abstract":"<p><strong>Introduction: </strong>In the past decade, prescription opioid use increased exponentially and concomitantly opioid use disorders (OUD) are becoming more common. Several risk factors for developing OUD have been identified, but little is known regarding the patients' perspective on developing a prescription OUD.</p><p><strong>Methods: </strong>We recruited 25 adults undergoing treatment for prescription OUD. In-depth, semi-structured interviews focussed on experiences with long-term opioid use, knowledge and attitudes regarding opioids, and access to opioids. A directed content analysis was conducted on the transcribed interviews using NVivo.</p><p><strong>Results: </strong>Participants showed that the development of an OUD is affected by various factors which could be grouped into three themes: (1) experiences driving initiation, (2) experiences driving continuation, and (3) experiences with prescription OUD. Besides the need for pain management, the dynamics of patient-provider communication, care coordination, provider vigilance, and environmental support all contributed to the way patients used their opioids.</p><p><strong>Conclusion: </strong>Patients' experiences illustrate that the first stage of the development of prescription OUD differs from the development of other substance addictions. Negative reinforcement might play a more prominent role in the early phase of prescription opioid use. Patients expressed a lack of guidance, both at the start of use and long-term use, easy access to new prescriptions and a lack of monitoring as main drivers of the development. Poorly controlled pain and subjective stress fuelled continuous opioid use.</p>","PeriodicalId":11902,"journal":{"name":"European Addiction Research","volume":"29 2","pages":"141-149"},"PeriodicalIF":3.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9562779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence and Determinants of COVID-19 in Patients Seeking Treatment for Substance Use Disorder: A Patient-Based Linkage Study.","authors":"Irene Lana-Lander,&nbsp;Regina Muñoz-Galán,&nbsp;Jorge Palacio-Vieira,&nbsp;Xavier Majo-Roca,&nbsp;Elisenda Martínez-Carbonell,&nbsp;Robert Muga,&nbsp;Joan Colom","doi":"10.1159/000528647","DOIUrl":"10.1159/000528647","url":null,"abstract":"<p><strong>Introduction: </strong>People with substance use disorder (SUD) may be at increased risk of COVID-19 infection. However, there is little evidence regarding the incidence of and determinants associated with infection in this group. The aims of the study were to determine the cumulative incidence of COVID-19 among people who sought treatment for heroin, cocaine, cannabis, and alcohol use disorder in Catalonia; to identify sociodemographic, substance, and clinical determinants associated with COVID-19 infection among SUD patients; and to compare the cumulative incidence of COVID-19 infection in the population with SUD with that of the general population.</p><p><strong>Methods: </strong>A patient-based retrospective observational study was conducted. The study population comprised people who sought treatment for heroin, cocaine, cannabis, or alcohol use disorder in Catalonia in 2018 and 2019. We analysed cumulative incidence of COVID-19 (confirmed by PCR test) from 25 February to 31 December 2020. Additionally, we used a log-link binomial generalized linear model for COVID-19 infection, using the substance as the exposition, adjusting for sociodemographic and clinical variables.</p><p><strong>Results: </strong>Of the 23,092 individuals who sought treatment for SUD, 38.15% were considered suspected cases of COVID-19, and 2.60% (95% CI = 2.41-2.82) were confirmed positive for COVID-19 by PCR test during the study period. Those who sought treatment for alcohol use (cumulative incidence of COVID-19 of 3% [95% CI = 2.70-3.34]) had a higher risk ratio than, those who sought treatment for heroin use (cumulative incidence of 1.94% [95% CI = 1.47-2.56]). Being born outside of Spain, living in an institutionalized residence, having HIV, and being in a high morbidity group were associated with higher risk of COVID-19 infection. Meanwhile, the cumulative incidence of COVID-19 in the general population, according to public COVID-19 test data, was 3.86% (95% CI = 3.85-3.87).</p><p><strong>Conclusion: </strong>This study did not find higher cumulative incidence of COVID-19 infection among people with SUD in Catalonia in 2020, despite the clinical vulnerability of this population and their social disadvantage. However, differences were seen in the cumulative incidence of COVID-19 according to the substance for which treatment was sought. For example, those with alcohol dependence had a higher rate than those dependent on heroin. Further studies are needed to determine the factors contributing to these differences.</p>","PeriodicalId":11902,"journal":{"name":"European Addiction Research","volume":" ","pages":"333-343"},"PeriodicalIF":3.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10614235/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10389317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Legal Approaches to New Psychoactive Substances: First Empirical Findings.","authors":"Jan van Amsterdam,&nbsp;Nicholas Burgess,&nbsp;Wim van den Brink","doi":"10.1159/000531503","DOIUrl":"10.1159/000531503","url":null,"abstract":"<p><strong>Background: </strong>Generic drug legislation, i.e., simultaneously banning groups of drugs, has been introduced worldwide to counteract the trade and use of emerging \"new psychoactive substances\" (NPSs) more effectively.</p><p><strong>Summary: </strong>The potential and de facto positive and negative effects of generic drug legislation have been described using an analysis based on documented evaluations of the experiences in the UK and Germany, supplemented with data from other publicly available sources. In particular, the effects of generic drug legislation on availability, use, sales, and overall health harms of NPS, and switches from NPS to traditional (classical) drugs are addressed. The results show that the introduction of generic drug legislation in the UK and Germany has enabled stricter regulation of NPS but has also led to some major harms within the domain of public health. Depending on the population considered, the rate of NPS use remained stable, slightly declined, or increased following the banning of NPS. Once banned, NPSs were more often purchased on the black market, often together with other (more harmful) drugs. Moreover, NPS-related harms did not reduce following the ban, and in some cases even increased. Finally, when harmful NPS, like potent synthetic opioids and cannabinoids, become substantially used and endanger public health, legislators already have the legal means to ban the problem drug, thus overruling the need for a generic ban.</p><p><strong>Key messages: </strong>Generic drug legislation may facilitate drug law enforcement, but it is not (very) effective in counteracting NPS use and it may increase NPS-related public health problems. It is concluded that, overall, the advantages of generic drug legislation are overshadowed by its serious disadvantages.</p>","PeriodicalId":11902,"journal":{"name":"European Addiction Research","volume":" ","pages":"363-372"},"PeriodicalIF":3.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10020472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using Direct and Indirect Estimates for Alcohol-Attributable Mortality: A Modelling Study Using the Example of Lithuania.","authors":"Jürgen Rehm,&nbsp;Huan Jiang,&nbsp;Kawon Victoria Kim,&nbsp;Robin Room,&nbsp;Pol Rovira,&nbsp;Kevin David Shield,&nbsp;Alexander Tran,&nbsp;Shannon Lange,&nbsp;Mindaugas Štelemėkas","doi":"10.1159/000529200","DOIUrl":"https://doi.org/10.1159/000529200","url":null,"abstract":"<p><strong>Introduction: </strong>Comparative risk assessments (CRAs) for alcohol use are based on indirect estimates of attributable harm, and usually combine country-specific exposure estimates and global risk relations derived from meta-analyses. CRAs for Eastern European countries, such as Lithuania, base their risk relations not on global risk relations, but on a large Russian cohort study. The availability of a direct estimate of alcohol-attributable mortality following the 2017 implementation of a large increase in alcohol excise taxes in Lithuania has allowed a comparison of these indirect estimates with a country-specific gold standard.</p><p><strong>Methods: </strong>A statistical modelling study compared direct (predictions based on a time-series methodology) and indirect (predictions based on an attributable-fraction methodology) estimates of alcohol-attributable mortality before and after a large increase in alcohol excise taxes in Lithuania. Specifically, Russia-specific versus global relative risks were compared against the gold standard of time-series based predictions.</p><p><strong>Results: </strong>Compared to direct estimates, indirect estimates markedly underestimated the reduction of alcohol-attributable mortality 12 months post intervention by at least 63%. While both of the indirect estimates differed markedly from the direct estimates, the Russia-specific estimates were closer to the direct estimates, primarily due to higher estimates for alcohol-attributable cardiovascular mortality.</p><p><strong>Discussion: </strong>As all indirect estimates were markedly lower than direct estimates, current overall relative risks and price elasticities should be re-evaluated. In particular, global estimates should be replaced by new regional estimates based on cohort studies.</p>","PeriodicalId":11902,"journal":{"name":"European Addiction Research","volume":"29 2","pages":"119-126"},"PeriodicalIF":3.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10238643/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10020691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}