European Addiction Research最新文献

{"title":"Emerging Detection of Hexahydrocannabinol in Driver Saliva: Preliminary Data.","authors":"Anne-Sophie Derne, Jean-Yves Jouzeau, Elise Pape, Allan Kolodziej, Valérie Gibaja, Elodie Marchand, Nicolas Gambier, Julien Scala-Bertola","doi":"10.1159/000541760","DOIUrl":"https://doi.org/10.1159/000541760","url":null,"abstract":"<p><strong>Introduction: </strong>Hexahydrocannabinol or HHC has recently appeared on the Internet and in cannabidiol (CBD) stores in various forms. Although the abuse and dependence potential of HHC consumption has not yet been established, HHC has been reported by consumers to have effects similar to delta-9-tetrahydrocannabinol (THC) and has been classified as narcotics in France since June 12, 2023.</p><p><strong>Methods: </strong>We conducted a retrospective study of all cases of oral fluid samples collected from drivers by traffic police officers and sent to our laboratory to confirm the presence of illicit substances between June 12, 2023 and December 31, 2023. The presence of 33 psychoactive substances, including HHC, THC, and CBD, in the oral fluid samples was assessed by an ultra-high performance liquid chromatography system coupled to a triple quadrupole mass spectrometer.</p><p><strong>Results: </strong>Of the 867 oral fluid samples analyzed, 16 were positive for HHC and involved only male drivers aged between 19 and 58. The mean and median HHC concentrations found in oral fluid were 35 ± 69 ng/mL and 10 ng/mL, respectively. In these preliminary data, HHC was always associated with THC, but the THC/HHC and CBD/HHC ratios were very broad. Although the kinetics of HHC and THC in saliva are different, the 11 cases with the highest THC/HHC ratios (>300) support that impaired alertness in drivers may be mainly due to THC. In these 11 cases, a linear correlation was found between THC and HHC concentrations in oral fluid.</p><p><strong>Conclusion: </strong>Further large-scale studies are required to extend these preliminary data, but the emerging detection of HHC in oral fluid of drivers may illustrate its spreading use in the general population.</p>","PeriodicalId":11902,"journal":{"name":"European Addiction Research","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142647090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychometric Evaluation of the Dutch version of the Substance Use Recovery Evaluator (SURE-NL).","authors":"Charlotte Migchels, Wim van den Brink, Amine Zerrouk, Frieda I A Matthys, Clara De Ruysscher, Dries Debeer, Wouter Vanderplasschen, Cleo Lina Crunelle","doi":"10.1159/000541584","DOIUrl":"https://doi.org/10.1159/000541584","url":null,"abstract":"<p><p>Introduction Patient-Reported Outcome Measures (PROMs) are an important source of information that allow for a patient-centered assessment. Outcome measurement of substance use disorder (SUD) treatment traditionally focuses on drug use and deficits in functioning, overlooking other aspects of the personal and dynamic process of recovery. The Substance Use Recovery Evaluator (SURE) is a PROM developed with service user input to monitor the recovery journey and assess treatment outcomes in people with SUD. The objective of this study was to examine the validity and reliability of the Dutch translation of the SURE, the SURE-NL, for measuring indicators of recovery in Dutch-speaking patients with SUD. Methods The original SURE questionnaire was translated from English to Dutch using forward-backward translation. A total of N=171 participants were recruited as part of a naturalistic multicenter study in inpatient (N=149) and outpatient (N=22) SUD treatment centers. We examined the factorial structure, reliability, and concurrent and discriminant validity of the SURE-NL. Results The original 5-factor structure of the SURE showed acceptable fit for the SURE-NL, and internal consistencies of the subscales ranged from .61 to .76 and internal consistency of the total score was .83. Concurrent validity was confirmed through positive correlations of the SURE-NL total and subscale scores with the WHOQoL-BREF subscales, but correlations varied depending on subscale and treatment setting, with higher correlations for the outpatient compared to the inpatient subgroup. Discriminant validity was confirmed through low, mostly non-significant correlations between the SURE-NL and the DASS-21. Conclusions Although the SURE was originally designed for outpatient settings, our findings in a predominantly inpatient sample indicate that the SURE-NL is suitable for assessing personal recovery and recovery capital in Dutch-speaking Belgian patients with SUD. However, subscales should be used and interpreted with caution. Further research is needed with larger Dutch-speaking outpatient samples and the development of a tailored SURE for inpatient settings should be considered.</p>","PeriodicalId":11902,"journal":{"name":"European Addiction Research","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142616914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}