European Child & Adolescent Psychiatry最新文献

{"title":"The possible effect of inflammation on non-suicidal self-injury in adolescents with depression: a mediator of connectivity within corticostriatal reward circuitry.","authors":"Dan Qiao, Yirun Qi, Xiaoyu Zhang, Yujiao Wen, Yangxi Huang, Yiran Li, Penghong Liu, Gaizhi Li, Zhifen Liu","doi":"10.1007/s00787-025-02709-6","DOIUrl":"10.1007/s00787-025-02709-6","url":null,"abstract":"<p><p>Non-suicidal self-injury (NSSI) in adolescent depression is a prevalent and clinically significant behavior linked to dysregulated peripheral inflammation and corticostriatal circuitry dysfunction. However, the neuroimmune mechanisms bridging these systems remain poorly understood. Here, we combined peripheral cytokine profiling with static/dynamic functional connectivity (sFC/dFC) analysis to investigate the potential influence of inflammaton on corticostriatal circuit related to NSSI. A set of peripheral blood inflammatory markers and resting-state functional magnetic resonance imaging (rs-fMRI) were collected in depression with NSSI (NSSI+), depression without NSSI (NSSI-), and healthy controls (HC). We first ascertain group differences in level of pro- and anti-inflammatory cytokines. And using ventral/dorsal striatal seeds, we compared whole-brain, voxel-wise sFC and dFC differences across three groups. Further, we tested the mediation effects of connectivity in the association between inflammatory markers and NSSI frequency. NSSI+ group exhibited elevated pro-inflammatory cytokines (C-reactive protein (CRP), interleukin (IL)-1, and IL-6) whereas reduced anti-inflammatory cytokines (IL-10), compared to NSSI- and HC. Neuroimaging analysis revealed corticostriatal dysconnectivity mainly characterized by static hyperconnectivity between dorsal striatum and thalamus, dynamic instability in dorsal striatum-lingual pathways, and dynamic rigidity in ventral striatum-prefrontal/temporal/occipital gyrus circuits. Critically, sFC of dorsal striatum-thalamus and dFC of dorsal striatum-lingual gyrus mediated the prospective association between altered CRP and NSSI frequency, establishing corticostriatal circuits as conduits for inflammatory effects on NSSI. By bridging molecular psychiatry with circuit neuroscience, this work advances precision management of NSSI in adolescent depression, prioritizing biomarker-driven strategies to disrupt neuroimmune maladaptation.</p>","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":"2871-2885"},"PeriodicalIF":4.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12508009/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic syndrome in youth with bipolar spectrum disorders treated with second-generation antipsychotics: baseline results from the community-based pragmatic MOBILITY Trial.","authors":"Claudine Higdon, Jeffrey A Welge, Nancy A Crimmins, Christina C Klein, Victor M Fornari, Michael T Sorter, Thomas J Blom, Brian P Kurtz, Christoph U Correll, Melissa P DelBello","doi":"10.1007/s00787-025-02680-2","DOIUrl":"10.1007/s00787-025-02680-2","url":null,"abstract":"<p><p>Metabolic syndrome (MetS) in obese youth in the general population is about 29%. The aim of this study is to identify the baseline prevalence and clinical characteristics of MetS in a sample of overweight/obese youth with bipolar spectrum disorders treated with second-generation antipsychotics (SGAs). The MOBILITY trial enrolled overweight/obese youth 8-19 years of age with a lifetime diagnosis of a bipolar spectrum disorder who were continuing or starting treatment with an SGA (November/2015-December/2022). Baseline height, weight, body mass index (BMI), blood pressure, fasting lipid profile, glucose, hemoglobin A1c, and insulin were collected. Logistic regression was used to estimate the odds of MetS and each of its component criteria and correlations with demographic factors. Of 1565 randomized patients mean age = 13.9 ± 2.8 years, males = 53%, White = 65.4%, Black/African American = 18.5%, multiracial = 9.6%, obese = 65.7%, overweight = 34.3%, MetS status could be determined for 996 patients (63.6%). The overall prevalence of MetS was 32.8% (males = 49.5%, females = 26.0%, p < 0.001), being higher in obese than overweight youth (41.1% vs 4.1%, p < 0.001). The odds of MetS increased rapidly with age in boys (p < 0.001); no association with age was evident among girls. White patients having significantly higher frequency of MetS than Black/African American patients (35.5% vs 24.9%, OR = 1.75, p = 0.003). The prevalence of MetS in this enriched sample was about one-third higher than the MetS prevalence in the general population of obese youth. Over one third of participants had missing metabolic data. These data highlight the need for increased identification and targeted interventions for MetS in youth. Clinical Trial Registration: NCT02515773, https://clinicaltrials.gov/study/NCT02515773.</p>","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":"2917-2929"},"PeriodicalIF":4.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12507931/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143990349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The distribution of frequent perceived loneliness and its association with suicidal behaviors in adolescents: a school-based study across 93 countries/territories.","authors":"Wanting Hu, Boyu Li, Xinger Li, Shengyu Luo, Zhongzhi Xu, Jinghua Li, Weiqing Chen, Vivian Yawei Guo","doi":"10.1007/s00787-025-02698-6","DOIUrl":"10.1007/s00787-025-02698-6","url":null,"abstract":"<p><p>Adolescent loneliness is prevalent and poses a significant risk for youth mental health. This study aimed to estimate the global prevalence and distribution of frequent perceived loneliness in adolescents and its associations with suicidal ideation, planning, and attempts. We analyzed data from the Global School-based Student Health Survey (GSHS) across 93 countries/territories (2003-2021) for adolescents aged 11-18. Weighted prevalence of frequent perceived loneliness was estimated for each country/territory, with pooled prevalence calculated by sex, age, WHO regions, and economic groups. Binary logistic regressions were employed to assess the associations between loneliness perception and suicidal behaviors in each country/territory, with overall estimates derived by random-effects meta-analysis. Among 388,093 adolescents included, 13.2% (95% CI 12.2-14.3%) reported frequent perceived loneliness, with the lowest observed in Europe (North Macedonia and Tajikistan) at 4.6% (95% CI 1.1-8.1%) and the highest in the Eastern Mediterranean at 16.1% (95% CI 14.7-17.6%). Girls and older adolescents had higher prevalence of frequent perceived loneliness. Frequent perceived loneliness was significantly associated with increased odds of suicidal ideation (overall OR: 2.41, 95% CI 2.25-2.58), planning (overall OR: 2.06, 95% CI 1.92-2.21), and attempts (overall OR: 2.08, 95% CI 1.95-2.20). These associations were consistent across most countries/territories, sexes, age, regions, and economic groups. These findings highlight frequent perceived loneliness in adolescents as a global public health concern strongly linked to suicidal behaviors, underscoring the urgent need for targeted interventions to address loneliness and its mental health consequences.</p>","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":"2779-2789"},"PeriodicalIF":4.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence trends and clinical management of self-harm in adolescents and young adults in catalonia: primary care cohort study (2013-2022).","authors":"Enric Aragonès, Ana Lozano-Sánchez, Tomàs López-Jiménez, Matthew Bennett, Stella Evangelidou, Esther Francisco, Myriam García, Estel Malgosa, Núria Codern-Bové, Claudia Guzmán-Molina, Constanza Jacques-Aviñó","doi":"10.1007/s00787-025-02840-4","DOIUrl":"https://doi.org/10.1007/s00787-025-02840-4","url":null,"abstract":"<p><p>This study investigates trends in the incidence and clinical management of self-harm among adolescents and young adults in Catalonia from 2013 to 2022, using data from the Information System for Research in Primary Care (SIDIAP). A population-based cohort analysis was conducted to examine temporal trends, demographic inequalities, and clinical care patterns. The study population comprised 1,707,471 eligible individuals aged 10 to 24, contributing 8,868,472 person-years of observation. The incidence of self-harm increased significantly over the study period (Incidence Rate Ratio [IRR] 2022 vs. 2013 for the total cohort: 2.67; 95% CI: 2.31-3.10), particularly during the COVID-19 pandemic (IRR 2022 vs. 2019: 2.06; 95 CI: 1.81-2.35), with rates in girls approximately three times higher than in boys. Socioeconomic deprivation emerged as a major risk factor, with individuals from deprived areas demonstrating elevated self-harm rates. Comorbid mental health disorders, notably anxiety and depression, were highly prevalent among individuals engaging in self-harm. Clinical management strategies differed by age and sex; girls were more frequently referred to mental health services, while psychotropic medication was commonly prescribed for both sexes. The incidence of self-harm has steadily increased reaching unprecedented levels during the pandemic, with significant disparities by sex, age, and socioeconomic status. The findings underscore the need for an appropriate healthcare response addressing the social determinants of health. Monitoring incidence trends and implementing targeted strategies are essential to support youth mental health in the post-pandemic context.</p>","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144947439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Effectiveness of a cognitive-behavioral sleep hygiene intervention for adolescents with ADHD: a randomized controlled trial.","authors":"Lena Keuppens, Finja Marten, Dieter Baeyens, Bianca Boyer, Annelore Roose, Stephen Becker, Marina Danckaerts, Saskia Van der Oord","doi":"10.1007/s00787-025-02825-3","DOIUrl":"https://doi.org/10.1007/s00787-025-02825-3","url":null,"abstract":"","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144947419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Change in vital parameters at first methylphenidate administration as a predictor of treatment response at six-month follow-up.","authors":"Barbara D'Aiello, Deny Menghini, Giorgia Cordaro, Stefano Vicari, Pietro De Rossi","doi":"10.1007/s00787-025-02845-z","DOIUrl":"https://doi.org/10.1007/s00787-025-02845-z","url":null,"abstract":"<p><p>Methylphenidate is the primary pharmacological treatment for attention-deficit/hyperactivity disorder (ADHD), yet approximately 30% of patients show a poor clinical response. Currently, no reliable biomarkers exist to predict which patients will benefit from treatment. Emerging evidence suggests that methylphenidate-induced increases in blood pressure are associated with improvements in attention and underlying neurobiological mechanisms. Blood pressure could thus serve as a low-cost, accessible predictor of methylphenidate response. The aim of this study was to explore whether acute changes in vital signs-specifically blood pressure and heart rate-after a single methylphenidate dose can predict clinical response after six months of treatment in children and adolescents with ADHD. The final sample consisted of N = 171 children and adolescents (M:F = 148:23; mean age = 9.83 ± 2.61 years, range = 5.27-16.17) diagnosed with ADHD, and ADHD symptoms were assessed using the SNAP-IV. In this context, data on vital parameters and severity of symptoms made during the first single-dose methylphenidate administration and at 6-month methylphenidate monotherapy were retrieved from patients' medical records. Our findings showed that greater increases in blood pressure during the first methylphenidate administration were associated with greater symptom reduction over time (Inattention: β = 0.202, t = 2.452, p = 0.015; Hyperactivity/Impulsivity: β = 0.225, t = 2.743, p = 0.007; Combined: β = 0.233, t = 2.837, p = 0.005). These results suggest that early cardiovascular response may serve as a low-cost, accessible predictor of treatment efficacy, supporting more individualized approaches to ADHD pharmacotherapy.</p>","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144947449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient characteristics' moderation of multinutrients treatment response in school-age children with attention deficit hyperactivity disorder.","authors":"Brenda My Leung, Cindy Feng, Anupam Roy, Yang S Liu, Jeanette M Johnstone, Irene E Hatsu, L Eugene Arnold","doi":"10.1007/s00787-025-02851-1","DOIUrl":"https://doi.org/10.1007/s00787-025-02851-1","url":null,"abstract":"<p><strong>Objective: </strong>This study analyzed data from the Micronutrients for ADHD in Youth (MADDY) 8-week RCT to identify moderators of treatment response to multinutrients, i.e., patient characteristics likely to predict optimal benefit based on the Clinical Global Impression-Improvement (CGI-I)- scale.</p><p><strong>Methods: </strong>Classification tree analysis investigated demographic and clinical history variables as potential moderators of treatment response. Effect sizes (ES) with confidence intervals (CI) were generated using bivariate analysis of risk difference of proportions derived from the classification tree between-treatment effects stratified by the moderator variable.</p><p><strong>Results: </strong>The classification tree showed a higher response rate among multinutrient-treated children (n = 70) with university-educated parents compared to those with parents with less than a university education (64% vs. 36%); a finding also supported by the bivariate analysis (ES = 0.35, 95% CI = 0.03-0.67). Within university-educated parents, a larger percentage of children with past ADHD medication use were responders compared to no past ADHD medication use (83% vs. 52%). Classification tree also revealed that among multinutrient-treated children with university-educated parents without past ADHD medication, higher baseline CGI-Severity score was responders compared to lower baseline score (67% vs. 33%). Bivariate analysis predicted higher response in participants whose parents reported alcohol use disorder (ES = 0.43, 95% CI = 0.10-0.76), or illegal drug use (ES = 0.68, 95% CI = 0.52-0.84), or learning problems (ES = 0.44, 95% CI = 0.13-0.75).</p><p><strong>Conclusions: </strong>Parent education level, substance use disorder or learning problems, and child's previous medication use moderated multinutrient response in children with ADHD. These findings have implications for future research and clinical practice.</p>","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144947384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immigration detention of children: a systematic review and meta-analysis of physical and mental health impacts.","authors":"Bafreen Sherif, Debbie C Hocking, Mohammad Asghari-Jafarabadi, Susan Rees, Letizia M Affaticati, Suresh Sundram","doi":"10.1007/s00787-025-02832-4","DOIUrl":"https://doi.org/10.1007/s00787-025-02832-4","url":null,"abstract":"&lt;p&gt;&lt;p&gt;Upper-middle and high income countries employ immigration detention for asylum-seeking/refugee (ASR) children despite documented health risks. We sought to assess the physical and mental health impacts of detention on ASR children in these settings. A systematic review of 15 studies (N = 4,890 children) from 2,512 screened records was undertaken. Relevant databases were searched from 1808 to October 2024 for papers using the search terms 'unaccompanied/separated/children/minors/adolescents,' and 'war/trauma/asylum/refugee,' and 'mental illness/ PTSD/depression/ distress, depressive symptoms/ anxiety/physical health/ health/risk factors,' as well as 'detention/detain/imprison/incarcerate'. Joanna Briggs Institute tools assessed quality. Strengths and Difficulties Questionnaire (SDQ) data from three studies (n = 239) underwent random-effects meta-analysis as the primary measure of social-emotional and behavioural issues. Duration of detention ranged from 2 weeks to 36 months. Prevalence of PTSD ranged from 6.5% (brief detention &lt; 30 days) to 100% (prolonged detention ≥ 12 months). MDD was reported in 44-95% of children, and suicidal ideation/self-harm in 25-57%. Developmental delays were observed in 75% of children detained ≥ 12 months. Anxiety disorders (45-50%) included separation anxiety and generalised anxiety. The mixed model meta-analysis revealed severe mental health burdens with detained children exhibiting total difficulties scores twice the normative population mean (16.63 vs. 7.1-8.4, 95% CI: 11.19-22.07) with elevated subscale scores for emotional symptoms (5.40 vs. 1.6-2.1, 95% CI: 3.79-7.01), conduct problems (2.93 vs. 1.3-1.6, 95% CI: 1.53-4.32), and peer problems (3.34 vs. 1.4-1.6, 95% CI: 2.17-4.51) (I² &gt;75% for all mental health outcomes). Physical health impacts included malnutrition (24-56%), dental caries (21-54%), vitamin D deficiency (51%), and somatic complaints (e.g., headaches, enuresis). Systemic risk factors-detention duration, family separation, and cumulative trauma-exacerbated harm, with parental mental illness (54%) and dehumanising conditions (e.g., numeric identification) amplifying risks. Comparative data highlight resettled children's recovery trajectories when provided stability and community support. Most studies were cross-sectional, limiting the ability to assess causality. This review consolidates evidence that establishes a connection between immigration detention and the manifestation of mental disorders, categorising it as an instance of early-life adversity. All fifteen studies identified detrimental consequences, and a meta-analysis of three studies revealed significant emotional distress and behavioural issues. These findings underscore the urgent need for policy reforms to abolish prolonged detention, prioritise family unity, and implement trauma-informed care to mitigate irreversible health consequences for ASR children. Policymakers must recognise these impacts and refrain from detaining and s","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144947452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond hostility: exploring facial emotion recognition biases in youths with conduct disorder.","authors":"Janine Bacher, Beryll von Planta, Anka Bernhard, Graeme Fairchild, Lucres Jansen, Stephane A De Brito, Christine M Freitag, Kerstin Konrad, Christina Stadler, Gregor Kohls, Eva Unternaehrer","doi":"10.1007/s00787-025-02846-y","DOIUrl":"https://doi.org/10.1007/s00787-025-02846-y","url":null,"abstract":"<p><p>Facial emotion recognition (FER) biases refer to systematic tendencies to recognize specific emotions when processing facial expressions. In youths with conduct disorder (CD), who are characterized by highly impairing antisocial behavior, research on FER biases has focused on hostile attribution biases. This work has shown that youths with CD perceive ambiguous social cues as angry. However, youths with CD may not only show biases towards anger, which is why we investigated FER biases in youths with CD towards the six basic emotions. Within the European FemNAT-CD study, we analyzed data from 610 youths with CD (60% female) and 818 typically developing controls (TDCs; 68% female), aged 9 to 18 years (M = 14.1, SD = 2.41 years). FER biases were assessed using the Emotion Hexagon Task by showing morphed emotional expressions and asking participants to choose the predominant emotion. Biases were calculated as tendency towards an emotion shown at 0%, 10%, 30%, or 50% intensity. Our findings from hierarchical linear modelling indicate that youths with CD exhibited stronger FER biases than TDCs across all emotions, meaning that they misclassified each emotion more often. However, this difference varied by intensity, with youths with CD displaying weaker biases at higher intensity levels and a smaller increase in bias with increasing intensity level. Our findings indicate that youths with CD not only show a hostile attribution bias but rather misclassify emotions as predominant when they are present at low intensity, regardless of type of emotion.</p>","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144947406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kidstime workshops: the evaluation of a multi-family intervention for children of parents with mental illness.","authors":"Esther Strittmatter, Niklas Helsper, Jens Joas, Alan Cooklin, Eva Möhler, Klaus Henner Spierling","doi":"10.1007/s00787-025-02853-z","DOIUrl":"https://doi.org/10.1007/s00787-025-02853-z","url":null,"abstract":"<p><strong>Background: </strong>Kidstime workshops were conceptualized as a low-threshold intervention for children of parents with mental illness (COPMI).</p><p><strong>Methods: </strong>Kidstime workshops were set up at eleven locations throughout Germany. The multi-center eligibility study employed a pre-post-design. In addition to selected capability items, clinical scales were analyzed.</p><p><strong>Results: </strong>The preliminary results demonstrated significant improvements in the children's distress and impairment as well as improvements in parental psychopathology and psychosocial functioning. There were also improvements in capability-based measures of psychological integrity and resilience, participation, life motivation and satisfaction in both children and parents. Our analysis suggests that Kidstime workshops can be more effective at improving capabilities, with better resource-benefit ratio compared with nationwide data of general child support interventions.</p><p><strong>Conclusion: </strong>The preliminary results suggest that Kidstime workshops show therapeutic potential by improving wellbeing and participation for both COPMI and their parents. The Kidstime workshops address an important gap in support for COPMI by implementing a multi-family-based approach in the families' social environment and providing cross-system delivery with low costs and few hours of investment.</p>","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144947478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}