European Child & Adolescent Psychiatry最新文献

{"title":"Identifying high-risk groups for self-harm in adolescents using the Avon Longitudinal Study of Parents and Children (ALSPAC): a cross-cohort comparison latent class analysis study.","authors":"David McEvoy, Ross Brannigan, Colm Healy, David Mongan, Mary Clarke","doi":"10.1007/s00787-025-02702-z","DOIUrl":"10.1007/s00787-025-02702-z","url":null,"abstract":"<p><p>Young people who self-harm are at an increased risk of suicide. Furthering our understanding of the risk factors for self-harm is essential for identifying high-risk groups, which can be used to inform the design of preventative interventions. This study used the Avon Longitudinal Study of Parents and Children (ALSPAC) and applied latent class analysis to the risk factors for self-harm at ages 13 and 17. Longitudinal associations between the latent classes and self-harm at ages 17 and 20 were examined. Cross-cohort comparisons were conducted between this study and a previous study using Irish data. At age 13 there was a low risk group, a peer problems group, and substance use group, similar for the two cohort studies, and a family conflict group, which was the least similar group to its matching group in the Irish study. All of these age 13 high-risk groups had approximately twice the relative risk (between 1.3 and 2.5) for self-harm at age 17 compared to the low risk group. The age 17 models were very similar across the two cohorts, each with a low risk group, a depression and high substance use group, a depression and low substance use group, and a substance use group. The relative risk of self-harm at age 20 for these high-risk groups compared the low risk group ranged from 3.6 to 8.0. These groups could help identify those at risk of self-harm and inform the design of prevention programmes to reduce self-harm behaviour in young people.</p>","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":"2843-2857"},"PeriodicalIF":4.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12507929/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal attitudes and child mental health across cultures: a European /Chinese comparison.","authors":"Viviane Kovess-Masfety, Nathalie Touma, Guoli Yan, Huifang Yin, Dietmar Goelitz, Adina Bitfoi, Sigita Lesinskiene, Zlatka Mihova, Roy Otten, Guangming Xu","doi":"10.1007/s00787-025-02699-5","DOIUrl":"10.1007/s00787-025-02699-5","url":null,"abstract":"<p><p>This study sought to identify factors associated with parenting across Western Europe, Eastern Europe and China countries, and determine whether the associations between parental attitudes and child's mental health differ across countries. This cross-sectional study included mothers and their children. European data were drawn from the School Child Mental Health in Europe study, conducted in the Netherlands, Germany, Lithuania, Bulgaria and Romania, including 4104 dyads. Chinese data were collected from the Dongli District of Tianjin, including 1000 dyads. Parental attitudes were auto reported using Parenting Scale and Parent Behavior and Attitude Questionnaire. Children's mental health was auto reported using the Dominic Interactive. Parenting vary across cultures and impact children's mental health differently. Whatever the parental attitudes, the main determinants were related to family configuration, parental well-being and place of residence. Some associations were culture-specific: parent's distress associated with laxness, over-reactivity and low autonomy-promoting attitudes in Europe. Single parenting correlated with low autonomy-promoting attitudes in China but low caring in Western Europe. Urban parents exhibited less laxness and low caring in Eastern Europe. The impact on children's mental health also varied: over-reactivity was linked to internalized and externalized disorders in Western Europe, verbosity associated with internalized and externalized disorders in China, and low caring was linked to externalized disorders in Eastern Europe. Parental diverse attitudes are associated with different children mental health problems; these associations are not identical in the different regions emphasizing the need to tailor existing supporting parental interventions with a culturally sensitive approach.</p>","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":"2791-2803"},"PeriodicalIF":4.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Addiction profile is associated with suicidal behavior and repetition of non-suicidal self injury: a latent profile analysis study in a schooled adolescents.","authors":"María Arqueros, Iván Perez-Diez, Adriana Garcia-Ramos, Wala Ayad-Ahmed, Alberto Sanchez, Alejandro de la Torre-Luque","doi":"10.1007/s00787-025-02712-x","DOIUrl":"10.1007/s00787-025-02712-x","url":null,"abstract":"<p><p>Adolescence is a critical period for the development of self-regulatory behaviors, with emotional dysregulation, impulsivity, and substance use emerging as significant factors associated with self-injury and suicidal thoughts and behaviors. This study aims to investigate the prevalence and patterns of non-suicidal self-injury (NSSI), suicidal ideation, and suicide attempts in a community-based sample of adolescents. A sample of 1526 adolescents aged 12-16 was analyzed using Latent Profile Analysis (LPA), identifying two distinct behavioral profiles: the Substance Use with Non-Problematic Gaming (37.4%) profile, characterized by alcohol, cannabis, and nicotine use, and the Moderate Problematic Gaming with Minimal Substance Use (62.6%) profile, associated with problematic video game use and minimal substance use. Overall, 36% of participants reported engaging in NSSI, 27.2% reported suicidal ideation, and 3.21% reported suicide attempts within the past year. Ordinal regression analysis indicated that adolescents in the SUP group exhibited higher levels of emotional dysregulation, impulsivity, and behavioral difficulties, significantly increasing their odds of suicide attempts (OR 2.24, p < 0.02). Additionally, emotional dysregulation independently doubled the risk of suicide attempts (OR 2.01, p < 0.001). This study provides a detailed risk profile for adolescent self-injury and suicide-related behaviors in school settings. Despite the limitations of a non-clinical sample, the findings underscore the importance of early prevention efforts targeting emotional dysregulation and impulsivity. Future research should consider longitudinal approaches to better understand the developmental trajectories of NSSI and suicidal behaviors in adolescents, particularly in high-risk, marginalized populations.</p>","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":"2931-2941"},"PeriodicalIF":4.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12507973/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143964081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neural activation during processing of emotional faces as a function of resilience in adolescents.","authors":"Steve Eaton, Harriet Cornwell, Jack Rogers, Stephane De Brito, Nicola Toschi, Christina Stadler, Nora Raschle, Kerstin Konrad, Gregor Kohls, Areti Smaragdi, Karen Gonzalez-Madruga, Maaike Oosterling, Anne Martinelli, Anka Bernhard, Christine M Freitag, Catherine Hamilton-Giachritsis, Graeme Fairchild","doi":"10.1007/s00787-025-02703-y","DOIUrl":"10.1007/s00787-025-02703-y","url":null,"abstract":"<p><p>Neuroimaging studies suggest that resilience to adversity is linked to reduced emotional reactivity or enhanced emotion regulation. However, such studies are scarce and mainly use adult samples and categorical definitions of resilience. Using a novel, data-driven approach to define resilience dimensionally, based on cumulative adversity exposure across childhood and psychopathology, we investigated associations between resilience and brain activation during facial emotion processing in youth. We also tested for sex differences in the relationship between resilience and brain activation. fMRI data were acquired from 208 youths (aged 9-18 years; Mean age = 13.28), while viewing angry, fearful, and neutral faces. Whole-brain analyses were performed, followed by region-of-interest analyses focusing on the amygdala, hippocampus, and prefrontal cortex. Resilience was positively correlated with bilateral inferior frontal gyrus responses to fearful (versus neutral) faces, and negatively correlated with right superior temporal gyrus, left hippocampal, and right inferior frontal gyrus responses to neutral faces (versus fixation). Sex-by-resilience interactions were observed in the medial prefrontal cortex: males showed positive, while females showed negative, associations between resilience and brain activation, though these results did not survive correction for multiple comparisons. These findings provide further evidence that resilience in youth is associated with enhanced emotion regulation at a neural level.</p>","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":"2943-2955"},"PeriodicalIF":4.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12507940/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143996375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Barriers and facilitators to using standardised diagnostic assessments in child and adolescent mental health services: a qualitative process evaluation of the STADIA trial.","authors":"Louise Thomson, Kristina Newman, Colleen Ewart, Anupam Bhardwaj, Bernadka Dubicka, Tamsin Marshall, Julia Gledhill, Alexandra Lang, Kirsty Sprange, Kapil Sayal","doi":"10.1007/s00787-025-02678-w","DOIUrl":"10.1007/s00787-025-02678-w","url":null,"abstract":"<p><p>The STADIA trial aimed to assess the effectiveness of a standardised diagnostic assessment tool (Development and Wellbeing Assessment, DAWBA) in aiding clinician-made diagnosis decisions in Child and Adolescent Mental Health Services (CAMHS). This study reports the qualitative process evaluation of the STADIA trial, which aimed to identify barriers and facilitators to using the online-completed DAWBA in CAMHS. Qualitative data were collected through 109 semi-structured interviews with young people, parents/carers, healthcare professionals and service commissioners/funders in 8 CAMHS sites across England. Deductive thematic analysis was guided by the domains of the Consolidated Framework for Implementation Research. Young people and parents/carers showed high levels of engagement with the DAWBA. They perceived a validation of symptoms from the generated DAWBA report, which they actively used as 'evidence' when seeking help from other services. Clinicians involved in determining referral acceptance/rejection decisions were positive about its use and saw benefits in aiding decision-making. In contrast, however, barriers to clinicians engaging with the DAWBA report during the assessment stage arose from limited awareness and accessibility to the report, a context of high workload and pressure, and general concerns about the value of a diagnosis. The DAWBA was not widely used by clinicians in the expected way to aid diagnostic decision-making. However, it may offer children and young people much-needed engagement during long waiting times for initial assessment in CAMHS. The DAWBA may be more acceptable to clinical teams in triaging referrals to help with timely decisions about the most suitable services.Trial registration ISRCTN15748675 (29/05/2019).</p>","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":"2763-2777"},"PeriodicalIF":4.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12507920/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional connectivity of the precuneus and posterior cingulate cortex moderates the relationship between tic symptoms and premonitory urge in tourette syndrome.","authors":"Xianbin Wang, Wenyan Zhang, Weiwei Men, Xu Hong, Yonghua Cui, Tianyuan Lei","doi":"10.1007/s00787-025-02685-x","DOIUrl":"10.1007/s00787-025-02685-x","url":null,"abstract":"<p><p>This study explores the roles of the precuneus and posterior cingulate cortex (pCunPCC) in the relationship between premonitory urge (PU) and tic severity in Tourette syndrome (TS). We recruited 58 children diagnosed with TS (age mean ± SD = 11.12 ± 2.56, F/M = 11/47). Tic and PU severity were measured using the Yale Global Tic Severity Scale (YGTSS) and the Premonitory Urge for Tics Scale (PUTS), respectively. We constructed brain functional networks for each subject based on resting-state fMRI and further calculated the degree centrality (DC), global efficiency (GE), and local efficiency (LE) of each pCunPCC region. A significant positive correlation was found between PUTS and YGTSS scores (t = 4.75, p < 0.001). The DC and GE of the right pCunPCC ROI 3 (Schaefer Atlas) showed significant negative correlations with YGTSS (t = -2.63, FDR-corrected p = 0.03 for DC; t = -2.85, FDR-corrected p = 0.04 for GE) and PUTS scores (t = -3.35, FDR-corrected p = 0.01 for DC; t = -2.95, FDR-corrected p = 0.03 for GE). Moderation analysis indicated that higher DC in the right pCunPCC ROI 3 reduced the effect of PU on tic severity. These moderation effects were also observed with PU and vocal tics, but not motor tics. The right pCunPCC serves as critical moderator in the relationship between PU and tic severity. This study highlighted the potential neural mechanisms underlying the relationship between PU and tic severity, providing potential targets for future intervention and treatment of TS.</p>","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":"2717-2726"},"PeriodicalIF":4.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in antipsychotic treatment of children and adolescents in Israel from post-mental health reform to post-COVID19 pandemic (2015-2023).","authors":"Rachel Nega, Ron Walfisch, Michal Taler, Martin Efron, Nurit El Bar, Revital Perlov Gavze, Liat Lev-Shalem, Gilad Bodenheimer, Yonatan Bilu, Doron Gothelf","doi":"10.1007/s00787-025-02691-z","DOIUrl":"10.1007/s00787-025-02691-z","url":null,"abstract":"<p><p>This study investigates the patterns of antipsychotic drug dispensations among children and adolescents from 2015 to 2023, with a focus on the impact of introducing national health reform (2015) and the COVID-19 pandemic. Data from Maccabi Healthcare Services, encompassing 1,105,439 individuals aged 6-18 years, were analyzed using a retrospective cohort study. We investigated the incidence rates of antipsychotic prescriptions by age, sex, socioeconomic status, and geographical region. During the study period, there was a 15% overall increase in antipsychotics prescriptions. Higher prescription rates were observed among boys aged 6-11 years and girls aged 14-18 years. Significant increases in prescriptions were observed in the year immediately following the mental health reform and the COVID-19 pandemic. Low socioeconomic status and peripheral regions exhibited higher and increasing prescription rates. Seasonal patterns revealed peaks in the fourth quarter of each year. The study highlights an overall increase in antipsychotic prescriptions, influenced by policy changes and the pandemic. Inequality in prescription rates by socioeconomic status and geographical location underscores the need for targeted mental health interventions. The findings also suggest enduring changes in the utilization of antipsychotic medications among youth, which may reflect broader impacts of the COVID-19 pandemic on mental health care needs.</p>","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":"2825-2832"},"PeriodicalIF":4.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Whose sleep matters? Untangling the relationships between maternal sleep, child sleep, and maternal depressive symptoms in the first two years of life.","authors":"Bethany Kotlar, Alex Kotlar, Ekaterina Sadikova, Monik Jimenez, Aisha Yousafzai, Mioko Sudo, Yena Kyeong, Peipei Setoh, Gwendolyn Ngoh, Anne Rifkin-Graboi, Michael J Meaney, Helen Chen, Birit F P Brockman, Daniel Y T Goh, Fabian Yap, Yung Seng Lee, Shirong Cai, Henning Tiemeier","doi":"10.1007/s00787-025-02689-7","DOIUrl":"10.1007/s00787-025-02689-7","url":null,"abstract":"<p><strong>Background: </strong>Infants frequently experience sleep problems in early childhood. Poor infant sleep can impact not only infants' cognitive development but also maternal sleep and maternal mental health. Studies have reported associations between infant sleep and maternal sleep and between infant sleep and maternal depression. However, methods utilized in these studies are unable to disentangle the directionality of these relationships. The purpose of this study was to assess the bi-directional relationships between child sleep, maternal sleep, and maternal depression in the first two years of life in a multi-ethnic Asian cohort. Data were drawn from the Growing Up in Singapore Towards healthy Outcomes (GUSTO) cohort. Child nighttime sleep duration, maternal sleep (PSQI), and maternal depression scores (BDI) were assessed at 26 weeks gestational age, and when the child was 3, 12, and 24 months old in 1,131 children. We used autoregressive latent trajectory modeling with structured residuals (ALT-SR) to assess associations. Higher maternal depression scores at 3 months were predictive of longer nighttime sleep duration when the child was 12 months (BDI_3mo → ChildSleep_12mo:Ѱ_Standardized = 0.04, p = .01), but at other timepoints this cross-lagged relationship was not significant, (BDI_prenatal → ChildSleep_3mo: Ѱ_Standardized = 0.02, p = .49; BDI_12mo → ChildSleep_24mo: Ѱ_Standardized = 0.03, p = .07). In addition, better maternal sleep at 3 months predicted longer nighttime child sleep duration at 12 months (PSQI_3mo → ChildSleep_12mo: Ѱ_Standardized = - 0.08, p = 0.01), but not at other timepoints (PSQI_prenatal → BISQ_3mo: Ѱ_Standardized = -0.06, p = .29; PSQI_12mo → ChildSleep_24mo: Ѱ_Standardized = -0.05, p = 0.18). When using methods that properly differentiate between-person and within-person effects, we found that higher maternal depression scores were protective of infant sleep, but infant sleep did not affect maternal sleep or depression scores.</p>","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":"2727-2738"},"PeriodicalIF":4.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143604507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experimental investigations of social exclusion among adolescents with psychiatric disorders: a systematic review.","authors":"Lior Weinreich, Kristina Moll, Matthias F J Sperl, Gerd Schulte-Körne, Bert Timmermans","doi":"10.1007/s00787-025-02687-9","DOIUrl":"10.1007/s00787-025-02687-9","url":null,"abstract":"<p><p>Social exclusion is a form of bullying that can lead to various negative consequences, and even extreme forms of violence. Certain groups, such as people with poor mental health and adolescents, are particularly vulnerable. This paper features a systematic review of experiments that investigated the impact of social exclusion on adolescents with psychiatric disorders. Experiments were searched via: PubMed, Web of Science, PsycInfo, ERIC, Cochrane, and a manual search. The search yielded 174 experiments, and 12 remained after screening. These met the inclusion criteria, which included: having an empirical design, participants aged 10-19, and a clinical sample with at least one psychiatric disorder. Among the clinical samples, the most common disorder was depression, featured in seven experiments. The most common paradigm was Cyberball. Results showed that social exclusion impacts adolescents with psychiatric disorders differently than inclusion (e.g., leading to a more negative mood). However, the difference in the impact of social exclusion on adolescents with vs. without psychiatric disorders was only conclusive via fMRI measurements. Compared to healthy controls, adolescents with psychiatric disorders seem to display altered neural reactivity during social exclusion. Based on identified research gaps, future studies are needed to explore the impact of social exclusion on adolescents with a wider range of psychiatric disorders. Other recommendations are included, such as a brain region checklist for future experiments using fMRI.</p>","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":"2631-2648"},"PeriodicalIF":4.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12508016/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143959866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Replicating and extending the reliability, criterion validity, and treatment sensitivity of the shortened PANSS for pediatric trials.","authors":"Joan Busner, Eric A Youngstrom, Joshua A Langfus, David G Daniel, Robert L Findling","doi":"10.1007/s00787-025-02681-1","DOIUrl":"10.1007/s00787-025-02681-1","url":null,"abstract":"<p><p>Do the shortened Positive and Negative Syndrome Scale (PANSS) (Kay et al., J Clin Psychiatry 58:538-546, 1987) versions recently developed from a National Institute of Mental Health (NIMH) pediatric dataset continue to perform well in a third independent randomized double-blind clinical trial of adolescents with schizophrenia? Secondary analysis of the double-blind, placebo-controlled aripiprazole pivotal trial data (N = 302) found that the 10-item (and 20-item) PANSS versions on which we have previously reported (Findling et al., J Am Acad Child Adolesc Psychiatry, https://doi.org/10.1016/j.jaac.2022.07.864 , 2023) continued to provide high reliability, strong convergent correlation with expected measures, and treatment effects that equaled those found in the 30-item adult PANSS. Our shortened PANSS, derived originally from the randomized non-placebo controlled NIMH Treatment of Early Onset Schizophrenia Spectrum study (TEOSS) (Sikich et al., Am J Psychiatry 165(11):1420-1431, 2008), and independently replicated in both the placebo-controlled paliperidone pivotal trial for adolescents with schizophrenia (Youngstrom et al., PsyArxiv, https://doi.org/10.31234/osf.io/zb695 , 2023), and now the placebo-controlled aripiprazole pivotal trial for adolescents with schizophrenia, has again performed as well as the full 30 item adult-patient derived PANSS. The findings suggest it is possible to reduce the PANSS interview by 2 thirds, thus reducing burden on families and pediatric patients as well as administration and training costs, while maintaining high reliability, validity, and sensitivity to treatment equal to that of the 30-item version.</p>","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":"2707-2716"},"PeriodicalIF":4.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12507937/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}