European Child & Adolescent Psychiatry最新文献

{"title":"Prevalence and risk factors of suicidal ideation amongst unaccompanied young refugees: a machine learning approach.","authors":"Jacob Keller, Jenny Eglinsky, Maike Garbade, Elisa Pfeiffer, Paul L Plener, Rita Rosner, Thorsten Sukale, Cedric Sachser","doi":"10.1007/s00787-025-02828-0","DOIUrl":"https://doi.org/10.1007/s00787-025-02828-0","url":null,"abstract":"<p><strong>Background: </strong>Suicidality is a major public health concern worldwide. Evidence on the prevalence and risk factors of suicidality amongst unaccompanied young refugees (UYRs), a population already at risk for mental health disorders, is scarce.</p><p><strong>Methods: </strong>Given the complexity of individual risk factor constellations influencing suicidality, machine learning (ML) methods offer a statistical approach that can detect complex relations within the data. Four ML classifiers, (logistic regression (LR), random forest (RF), support vector machines (SVM), and extreme gradient boosting (XGB)) were trained on a dataset of n = 623 UYRs (M_age=16.77, SD = 1.34, range: 12-21), retrieved from the large-scale randomized controlled trial Better Care to predict suicidal ideation. Features used in the classifiers were age, gender, asylum status, having contact with the family, and whether parents are alive as well as clinically elevated post-traumatic stress symptoms (PTSS), depressive symptoms and past suicide attempts. The classifiers were then tested on the independent dataset of n = 94 UYRs (M_age=16.31, SD = 2.03, range: 5-21) retrieved from the screening tool porta project to examine their predictive performance.</p><p><strong>Results: </strong>The prevalence of past-week suicidal ideation in the combined sample of N = 717 was 18.13%. All classifiers yielded good predictive performance (accuracy 0.734-0.840, sensitivity 0.857, AUC 0.853-0.880). The most relevant features were past suicide attempts, PTSS and depressive symptoms as risk factors, and having a living mother as protective factor.</p><p><strong>Conclusions: </strong>Suicidal ideation is prevalent amongst UYRs, and using ML approaches, the classifiers were able to classify roughly 85% of the cases with suicidal ideation in the past week correctly as suicidal. Building on the findings of this study, screening for suicidality could be further improved by implementing ML classifiers in the assessment to highlight potential at risk cases early, and suitable interventions be developed.</p>","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145039474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: \"Maternal nut and fish consumption during pregnancy and child risky decision-making at 11 years old\".","authors":"Aysegul Tonyali","doi":"10.1007/s00787-025-02857-9","DOIUrl":"https://doi.org/10.1007/s00787-025-02857-9","url":null,"abstract":"","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145029133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of maternal stress and COVID-19 exposure during pregnancy on offspring neurodevelopment: signature cohort 12 month follow-up.","authors":"Nathalia Garrido-Torres, Andrés Román-Jarrín, Julia Rider, María Alemany-Navarro, Blake A Gibson, Bea de-Felipe, Alberto Pérez-Gómez, Lucas Cerrillos, Cristina Duque-Sánchez, Luis Alameda, Ezequiel Ruiz-Mateos, Miguel Ruiz-Veguilla, Benedicto Crespo-Facorro","doi":"10.1007/s00787-025-02848-w","DOIUrl":"https://doi.org/10.1007/s00787-025-02848-w","url":null,"abstract":"<p><p>The COVID-19 pandemic brought unprecedented global challenges. Amid the crisis, the potential impact of COVID-19 exposure on the neurodevelopment of offspring born to infected mothers emerged as a critical concern. This is a prospective cohort study of pregnant women and their offspring enrolled in the Signature project at Hospital Universitario Virgen del Rocio in Seville, Spain, between 01/01/2024 and 08/31/2022. Participants were subsequently classified into SARS-CoV-2 exposed (mild or severe COVID-19) and non-exposed groups. Maternal stress was assessed through the Perceived Stress Scale; offspring neurodevelopment was screened through Ages & Stages Questionnaire, 3rd Edition (ASQ-3) at 6 months and 12 months. Association between COVID-19 severity and neurodevelopmental outcomes were analyzed with univariate and multivariate analysis. The cohort included 689 women categorized into three distinct groups based on COVID-19 severity: non-infected mothers (N = 277), mothers with mild COVID-19 (N = 358), and mothers with severe COVID-19 (N = 54). The reference category for the odds ratio (OR) analyses was the non-infected group. In utero exposure to mild or severe COVID-19, as well as maternal stress, was not significantly associated with risk of developmental concern in any ASQ-3 subdomain at 12-month follow-up. This study highlights the need for further research with longer follow-up periods to better understand the potential long-term impact of prenatal COVID-19 exposure on offspring neurodevelopment.</p>","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145029119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The hidden pandemic: changes in outpatient mental health care among French children and adolescents.","authors":"Zaba Valtuille, Vincent Trebossen, Naim Ouldali, Michael Huguet, Hugo Peyre, Richard Delorme, Florentia Kaguelidou","doi":"10.1007/s00787-025-02847-x","DOIUrl":"https://doi.org/10.1007/s00787-025-02847-x","url":null,"abstract":"<p><p>The COVID-19 pandemic significantly worsened mental health (MH) challenges among young people. We aimed to assess changes in mental health-related outpatient care before and after the onset of the pandemic. In this nationwide cross-sectional study, we retrieved visits to general practitioners (GP) resulting in the coding of a MH disorder and/or the prescribing of any psychotropic medication for children aged 6 to 17 years, from January 1, 2016 to May 31, 2022 in France. Interrupted time series analysis of monthly rates of MH-related outpatient visits (per 100,000) was conducted to assess changes in trends overall and by age and sex group (girls/boys- 6 to 11 years; girls/boys- 12 to 17 years). Rate ratios (RR) were also calculated to compare estimated rates after the pandemic onset with expected rates. In total, 5,271,958 MH-related outpatient visits were analyzed. We noted an immediate decrease of the outpatient visit rate by 30.8% in the initial pandemic period (March-May 2020). Hereafter, visit rates increased by 0.4% per month, eventually exceeding expected levels by 6% overall. Notably, outpatient visit rates for adolescent girls (12-17 years) rose 20% above expected levels, while rates for younger girls (6-11 years) declined by 6%. Trends remained stable for other age-sex groups. These findings indicate a persistent increase in outpatient mental healthcare use in children, especially adolescent girls, more than two years after the pandemic onset. Future research should explore the factors contributing to the increased mental health burden in adolescent girls and the potential resilience observed in boys.</p>","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145023040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Duration effects of micronutrients in children with ADHD: Randomised controlled trial vs. Open-Label extension.","authors":"Adarsh Chand, Kathryn Darling, Julia J Rucklidge","doi":"10.1007/s00787-025-02841-3","DOIUrl":"10.1007/s00787-025-02841-3","url":null,"abstract":"<p><p>A 10-week randomised controlled trial (RCT) showed efficacy of micronutrients in improving symptoms associated with Attention-Deficit/Hyperactivity Disorder (ADHD). This study investigated duration effects of micronutrient treatment through the open label (OL) phase and document the micronutrient effect on those initially allocated to placebo. Children aged 7-12 years randomized to micronutrients or placebo for 10 weeks (RCT), then received 10 weeks OL, creating two groups: placebo first then micronutrients (P-M) or micronutrients in both phases (M-M). Assessments included measures of ADHD, emotional dysregulation and Clinical-Global-Impression-Improvement (CGI-I). Of the 93 children enrolled in RCT, 78 (83.9%) completed OL; 37 in P-M and 41 in M-M. For those initially assigned to placebo, CGI-I responders significantly increased from 32.4% in the RCT to 64.9% in OL (p = .002); those who took micronutrients for 20 weeks increased from 46.3% (end-of-RCT) to 63.4% responders (end-of-OL) but this was not significant (p = .065). Over half of children were treatment responders at end-of-OL, based on 30% reduction in ADHD symptoms from baseline, both from parent (61.5%) and clinician (53.8%) report. Pre-post effect sizes within both groups were significant and very large for all measures, with no significant group differences at end of OL. There were no differences in side effects. Both groups showed significant increases in height over time. This study supports micronutrients as a viable treatment option for ADHD with acute changes maintained and improved over a further 10-week period, with the placebo group catching up to those exposed to micronutrients for full trial duration.</p>","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144947396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Indirect associations between adolescent ADHD and/or oppositional defiant disorder symptoms and adult incomes: the mediating roles of education and co-occurring psychiatric disorders.","authors":"Sampo Seppä, Sanna Huikari, Marko Korhonen, Tanja Nordström, Tuula Hurtig, Anu-Helmi Halt","doi":"10.1007/s00787-025-02842-2","DOIUrl":"https://doi.org/10.1007/s00787-025-02842-2","url":null,"abstract":"<p><p>This longitudinal, population-based cohort study examines the direct and indirect associations between adolescent Attention-Deficit/Hyperactivity Disorder (ADHD) and/or Oppositional Defiant Disorder (ODD) symptoms and adult incomes. Moving beyond a simple direct link, our model explores how ADHD and/or ODD symptoms indirectly affect the accumulation of human, social, and health capital, which in turn may affect productivity and income. The population was drawn from members of the Northern Finland Birth Cohort 1986 (NFBC1986) who had ADHD and ODD symptoms assessed at age 16 using the Strengths and Weaknesses of ADHD Symptoms and Normal Behaviours (SWAN) scale. The results indicate a significant indirect negative effect of adolescent ADHD and ADHD + ODD symptoms on adult incomes. This effect was most pronounced in males with ADHD + ODD, who experienced a 25% income reduction via human capital (education) and an 18% reduction via health capital (presence of psychiatric disorders other than ADHD or ODD). Social capital did not mediate the association. The model was adjusted for work experience, white-collar status, marital status, parenthood, self-rated health, educational attainments of the participants' parents and family type during adolescence. Notably, no direct effect of adolescent ADHD and/or ODD symptoms on adult incomes was observed. These findings highlight the potential of educational and healthcare investments to reduce the income disparities associated with ADHD and ODD symptoms in the general population.</p>","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144947469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experience of compassionate care in mental health and community-based services for children and young people: facilitators of, and barriers to compassionate care- a systematic review.","authors":"Frane Vusio, Kathryn Odentz, Charlene Plunkett","doi":"10.1007/s00787-025-02711-y","DOIUrl":"10.1007/s00787-025-02711-y","url":null,"abstract":"<p><p>Compassion and compassionate care for children and young people (CYP) encompass a variety of emotions, including sympathy, empathy, and sadness for their suffering, alongside actions intended to alleviate their distress. While compassion is a well-recognised concept in health and social care, literature has identified various barriers and facilitators that affect the delivery of compassionate care. These include compassion fatigue, time limitations, organisational and clinical culture, insufficient resources or support, technological advancements, and burdensome administrative tasks. Despite being viewed as essential in health care, the concept of compassionate care remains poorly defined and expressed, particularly in the context of mental health services for CYP. This review explored the perspectives of CYPs, their parents, and staff regarding the compassionate care provided in community services. Additionally, it aimed to identify factors that facilitate or obstruct compassionate care for CYPs in both mental health and community settings services. From June to August 2024, a search was carried out for peer-reviewed articles and grey literature, with additional searches conducted in October 2024. The initial search produced 7,461 articles, with 23 selected for this review. A thematic synthesis organised the studies based on the main themes identified: 'Compassionate care is all about humanity' and 'the complex interplay of facilitators and barriers to compassionate care'. The identified articles highlighted the increasing need for compassionate care in community-based services for CYP, along with the range of facilitators and barriers to providing this care. Lastly, we propose an alternative definition of compassionate care tailored to these services.</p>","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":"2899-2916"},"PeriodicalIF":4.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12507948/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of low vitamin B₁₂ levels with depressive and schizophrenia spectrum disorders in child and adolescent psychiatric inpatients.","authors":"Gerard Anmella, Eva Varela, Nuria Prades, Anna Giménez-Palomo, Laura Espinosa, Clara de Castro, Ramon Deulofeu, Mireia Solerdelcoll, Ástrid Morer, Inmaculada Baeza","doi":"10.1007/s00787-025-02662-4","DOIUrl":"10.1007/s00787-025-02662-4","url":null,"abstract":"<p><p>Folate and vitamin B₁₂ are associated with neurodevelopment and neurotransmitter synthesis and insufficiencies of these nutrients could be linked to psychiatric disorders in children and adolescents. To assess serum levels of folate and B₁₂ in child and adolescent psychiatric inpatients and examine possible links between these levels and different psychiatric disorders. Child and adolescent psychiatric inpatients admitted in a general hospital during a 3-year period were included for analysis. Folate and B₁₂ levels were measured when the subjects were admitted. Psychiatric diagnoses were made following DSM-5 criteria and grouped into categories. Logistic regression analysis was used to study the effects of socio-demographic variables as well as folate and B₁₂ levels, insufficiencies and deficits as possible predictors of outcome (psychiatric diagnostic category). 729 inpatients (60.6% female, mean age: 15.1 ± 2 years) were included. A total of 42.9% presented insufficient folate levels and 19.4% insufficient B₁₂ levels. Insufficient B₁₂ levels were associated with depressive disorders in the multivariate model (OR = 0.82, p = 0.002) as was female sex (OR = 1.65, p = 0.007). Moreover, low vitamin B₁₂ levels were linked to schizophrenia spectrum disorders (SSD, OR = 0.9982, p = 0.024). In contrast, higher folate (OR = 1.15, p < 0.001) and vitamin B₁₂ levels (1.0024, p = 0.002) as well as female sex (OR = 7.86, p < 0.001) were associated with eating disorders. Insufficient or low B₁₂ levels could help predict depressive and SSD respectively in child and adolescent psychiatric inpatients. Further study could help us better understand the impact of this insufficiency during the neurodevelopmental period and the potential benefits of nutritional interventions.</p>","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":"2753-2762"},"PeriodicalIF":4.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12507942/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From child sexual abuse to psychiatric diagnoses and complex trauma in adolescence.","authors":"Marine Rousset, Aziz Essadek, Maurice Corcos, Marion Robin","doi":"10.1007/s00787-025-02682-0","DOIUrl":"10.1007/s00787-025-02682-0","url":null,"abstract":"<p><p>CSA (Childhood Sexual Abuse) represents a major health issue, however its detection in daily psychiatric practice is remains challenging. In adolescents, CSA often takes a back seat to diagnostic and behavioral issues such as suicide attempts and BPD (Borderline Personality Disorder), with which it is frequently associated. Additionally, confusion persists between the perspective of complex trauma and conventional psychiatric diagnoses. This study aimed to compare clinical features of hospitalized adolescents with a history of CSA, to a control group, in order to identify clinical predictors of CSA and of suicidal attempts. The secondary objective was to describe the overlap between PTSD (Post Traumatic Stress Disorder) and BPD, according to cumulative adversity. This study included 425 adolescents aged 13 to 19 years, who were hospitalized in a psychiatric unit. Among these adolescents, 107 had a history of CSA. The findings indicate that CSA plays a significant role in the psychopathology of adolescents. CSA was found to be associated with PTSD, BPD (OR = 1.9, p < 0.01), self-harm (OR = 1.8, p < 0.05), addictive disorders (OR = 1.87, p < 0.05), and parental neglect (p < 0,001). Suicide attempts were also significantly correlated with sexual abuse (OR = 1.78, p < 0.05). Moreover, the combination of factors such as female gender, the presence of BPD, and substance dependence was found to increase the likelihood of a history of sexual abuse in these adolescents by 14.8 times. These findings contribute to the early detection of sexual violence and its consequences, providing valuable insights for healthcare professionals. Additionally, they support the reinforcement of preventive initiatives.</p>","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":"2805-2814"},"PeriodicalIF":4.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143735887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prefrontal-hippocampal pathways underlying adolescent resilience.","authors":"Luqing Wei, Zhengdong Wu, Qi Xia, Chris Baeken, Guo-Rong Wu","doi":"10.1007/s00787-025-02704-x","DOIUrl":"10.1007/s00787-025-02704-x","url":null,"abstract":"<p><p>The prefrontal-hippocampal pathways are integral to memory suppression, facilitating positive and adaptative responses following traumatic events. However, the role of these circuits in promoting resilience among adolescents remains largely unknown. This study used structural similarity analysis of MRI-based gray matter volume (GMV) to map connectivity networks centered on the hippocampus, investigating whether structural similarity between prefrontal regions and hippocampus were related to resilience in a cohort of 145 adolescents. Additionally, spatial correlation analyses of resilience-related structural similarity network and neurotransmitter distribution maps were conducted to identify molecular adaptations within prefrontal-hippocampal circuits associated with resilience. The results showed that higher resilience levels were correlated with stronger structural similarity between the prefrontal areas (i.e., middle frontal gyrus and orbitofrontal cortex) and hippocampus. Furthermore, the serotonergic neurotransmitter system, which modulates neural oscillations in prefrontal-hippocampal pathways, appears to be associated with resilience. The current findings suggest that structural and molecular adaptations within prefrontal-hippocampal circuits, which are implicated in the suppression of intrusive, unwanted memories, may foster resilience in young people. These insights advance our knowledge of the neurobiological markers of resilience, paving the way for more targeted and effective therapeutic interventions to bolster resilience and mitigate adverse outcomes in developmental populations.</p>","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":"2815-2823"},"PeriodicalIF":4.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143735642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}