European Child & Adolescent Psychiatry最新文献

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Transcranial direct current stimulation (tDCS) in psychiatric disorders in early childhood (aged under 10 years): a systematic review. 经颅直流电刺激(tDCS)治疗儿童早期(10岁以下)精神疾病:一项系统综述。
IF 6 2区 医学
European Child & Adolescent Psychiatry Pub Date : 2025-01-10 DOI: 10.1007/s00787-024-02635-z
Hannes Brehme, Josefin Utke, Christoph Berger, Michael Kölch, Johannes Buchmann
{"title":"Transcranial direct current stimulation (tDCS) in psychiatric disorders in early childhood (aged under 10 years): a systematic review.","authors":"Hannes Brehme, Josefin Utke, Christoph Berger, Michael Kölch, Johannes Buchmann","doi":"10.1007/s00787-024-02635-z","DOIUrl":"https://doi.org/10.1007/s00787-024-02635-z","url":null,"abstract":"<p><p>Transcranial direct current stimulation (tDCS) remains experimental for many psychiatric disorders in adults. Particularly in childhood, there is limited research on the evidence for the efficacy and mechanisms of action of tDCS on the developing brain. The objective of this review is to identify published experimental studies to examine the efficacy and mechanisms of tDCS in children with psychiatric or developmental disorders in early (prepubertal) childhood (aged under 10 years). Included Studies should meet the following criteria: (1) experimental studies (no reviews, no case reports), (2) studies published in international peer-reviewed journals, (3) written in English, (4) conducted on children under 10 under years of age, (5) at enrolment with a psychiatric or developmental disorder.Eight studies were identified that fulfilled the specified criteria. All studies investigated effect on children with autism-spectrum-disorder (ASD). Anodal tDCS, mainly targeting the left dorsolateral prefrontal cortex (dlPFC), showed positive effects on the reduction of ASD symptoms. There has also been evidence that these stimulations are feasible, have good tolerability and are safe. tDCS was found to be safe and partially effective, but a long-term effect of tDCS and changes in connectivity during tDCS in autism has not been proven. Other developmental or psychiatric diseases were not investigated. This results in a lack of knowledge regarding the reactivity of the brain during the prepubertal period, which is a critical phase in the pathogenesis of neurodevelopmental disorders such as attention deficit hyperactivity disorder (ADHD), ASD, Tourette's syndrome or dyslexia.</p>","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":""},"PeriodicalIF":6.0,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142946714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction: Results of N = 1 randomized, double-blind, placebo-controlled, cross-over discontinuation trials embedded in clinical practice after longer term methylphenidate use: a pilot study. 更正:N = 1个随机、双盲、安慰剂对照、交叉停药试验的结果嵌入在长期使用哌甲酯后的临床实践中:一项试点研究。
IF 6 2区 医学
European Child & Adolescent Psychiatry Pub Date : 2025-01-08 DOI: 10.1007/s00787-024-02627-z
Paul T Rosenau, Andrea Dietrich, Barbara J van den Hoofdakker, Pieter J Hoekstra
{"title":"Correction: Results of N = 1 randomized, double-blind, placebo-controlled, cross-over discontinuation trials embedded in clinical practice after longer term methylphenidate use: a pilot study.","authors":"Paul T Rosenau, Andrea Dietrich, Barbara J van den Hoofdakker, Pieter J Hoekstra","doi":"10.1007/s00787-024-02627-z","DOIUrl":"https://doi.org/10.1007/s00787-024-02627-z","url":null,"abstract":"","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":""},"PeriodicalIF":6.0,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142946709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Target profiles for suicidality prevention with role-playing interventions in adolescence: a call-to-action protocol. 青少年角色扮演干预预防自杀的目标概况:一项行动呼吁协议。
IF 6 2区 医学
European Child & Adolescent Psychiatry Pub Date : 2025-01-07 DOI: 10.1007/s00787-024-02630-4
P Mandarano
{"title":"Target profiles for suicidality prevention with role-playing interventions in adolescence: a call-to-action protocol.","authors":"P Mandarano","doi":"10.1007/s00787-024-02630-4","DOIUrl":"https://doi.org/10.1007/s00787-024-02630-4","url":null,"abstract":"<p><p>This protocol invites researchers and practitioners across Europe to establish a research network and disseminate role-playing interventions for suicidality prevention among adolescents. By understanding and targeting specific adolescent profiles, the aim is to improve preventive strategies that are evidence-based and cost-effective, incorporating methodologies similar to the Youth Aware of Mental Health (YAM) program while considering current restrictions due to ownership and copyright. This initiative seeks to facilitate better developmental trajectories for young people by fostering mental health and reducing suicide rates through collaborative efforts with public services, schools, and policymakers.</p>","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":""},"PeriodicalIF":6.0,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142946711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gene-environment interaction in ADHD traits: the role of school environment, personality, callousness-unemotional traits and satisfaction with life. 基因-环境相互作用在ADHD特征中的作用:学校环境、人格、冷酷无情特征和对生活的满意度。
IF 6 2区 医学
European Child & Adolescent Psychiatry Pub Date : 2025-01-06 DOI: 10.1007/s00787-024-02628-y
Inga Schwabe, Dirk H M Pelt, Corina U Greven
{"title":"Gene-environment interaction in ADHD traits: the role of school environment, personality, callousness-unemotional traits and satisfaction with life.","authors":"Inga Schwabe, Dirk H M Pelt, Corina U Greven","doi":"10.1007/s00787-024-02628-y","DOIUrl":"https://doi.org/10.1007/s00787-024-02628-y","url":null,"abstract":"<p><p>We investigated gene-environment interaction in ADHD traits, focusing on environmental variables related to personality traits, school environment, satisfaction with life, and callousness. Using data from 2170 16-year-old twins and state-of-the-art methodology to prevent spurious findings due to measurement scale artifacts, gene-environment interaction models were estimated separately for the two core ADHD dimensions, hyperactivity-impulsivity, and inattentiveness. Based on scores on the SWAN questionnaire, where high scores are reflective of low ADHD traits, results showed that additive genetic influences were more important in explaining individual differences in the degree of hyperactivity-impulsivity in twins with a high score on the trait conscientiousness than in twins with a moderate or low score (e.g., a positive gene-environment interaction). Similarly, additive genetic influences were relatively more important in explaining individual differences in the degree of inattentiveness in twins with a high score on conscientiousness or satisfaction with oneself. Lastly, a negative gene-environment interaction was found: For twins with a high score on the trait callousness, additive genetic influences were less important in explaining differences in the degree of inattentiveness than in twins with an average or low score on the trait. The finding of these specific gene-environment interactions is important for a deeper understanding of the etiology of ADHD traits and may assist in developing targeted interventions for genetically vulnerable individuals.</p>","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":""},"PeriodicalIF":6.0,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142930046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bidirectional associations between short sleep duration, insomnia symptoms, and psychotic-like experiences in adolescents. 青少年睡眠时间短、失眠症状和精神病样经历之间的双向关联。
IF 6 2区 医学
European Child & Adolescent Psychiatry Pub Date : 2025-01-01 Epub Date: 2024-06-04 DOI: 10.1007/s00787-024-02490-y
Dongfang Wang, Yuanyuan Li, Yunge Fan, Zijuan Ma, Meng Sun, Xianchen Liu, Fang Fan
{"title":"Bidirectional associations between short sleep duration, insomnia symptoms, and psychotic-like experiences in adolescents.","authors":"Dongfang Wang, Yuanyuan Li, Yunge Fan, Zijuan Ma, Meng Sun, Xianchen Liu, Fang Fan","doi":"10.1007/s00787-024-02490-y","DOIUrl":"10.1007/s00787-024-02490-y","url":null,"abstract":"<p><p>This study investigates the prospective associations between short sleep duration, insomnia symptoms, and psychotic-like experiences (PLEs) in a large sample of Chinese adolescents. This study utilized a three-timepoint repeated cross-sectional survey with two nested longitudinal subsamples. A total of 17,722 adolescents were assessed at baseline (April 21 to May 12, 2021) and six months later (December 17 to 26, 2021). Out of these, 15,694 adolescents provided complete responses to the questions at baseline and one year later (May 17 - June 6, 2022). A self-administered questionnaire was used to measure sample characteristics (at baseline), sleep duration, insomnia symptoms, and PLEs (at each assessment), and negative life events (at two follow-ups). Baseline short sleep duration and insomnia symptoms predicted frequent PLEs at both follow-up assessments. Additionally, baseline frequent PLEs also predicted insomnia symptoms at six months and one year later. However, when controlling for confounders, PLEs at baseline only predicted short sleep duration at six months, and not at one year. This study reveals bidirectional prospective relationships between short sleep duration, insomnia symptoms, and PLEs, even after controlling for covariates. Therefore, it is crucial to assess both sleep patterns and PLEs in order to promote optimal sleep and mental health among adolescents.</p>","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":"275-285"},"PeriodicalIF":6.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141246693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comprehensive investigation of factor structure and gender equivalence of the Beck Depression Inventory-II among nonclinical adolescents. 对非临床青少年贝克抑郁量表-II的因子结构和性别等同性进行综合调查。
IF 6 2区 医学
European Child & Adolescent Psychiatry Pub Date : 2025-01-01 Epub Date: 2024-06-07 DOI: 10.1007/s00787-024-02478-8
Ana Paula Ferreira-Maia, Clarice Gorenstein, Yuan-Pang Wang
{"title":"Comprehensive investigation of factor structure and gender equivalence of the Beck Depression Inventory-II among nonclinical adolescents.","authors":"Ana Paula Ferreira-Maia, Clarice Gorenstein, Yuan-Pang Wang","doi":"10.1007/s00787-024-02478-8","DOIUrl":"10.1007/s00787-024-02478-8","url":null,"abstract":"<p><p>The Beck Depression Inventory-II (BDI-II) is a widely used tool for rating the severity of depressive symptoms. Studies on the factor structure of the BDI-II in adolescents have yielded controversial findings. Most studies have reported an oblique two-factor model that describes the 'cognitive' and 'somatic-affective' dimensions. However, there is variation in the item composition of each factor across studies. Alternative factor structures have been proposed, including one-factor, three-factor, hierarchical, and bifactor models. Additionally, there is limited data on measurement invariance across genders. This study aimed to examine hypothetical factor structures and gender equivalence of the BDI-II in a sample of Brazilian nonclinical adolescents (N = 1,184, aged 13-18 years, 59.1% females). Cross-validation of the BDI-II was performed through exploratory (EFA) and confirmatory factor analysis (CFA). Measurement invariance was evaluated using multigroup-CFA (MG-CFA). EFA suggested an oblique two-factor model depicting \"affective-cognitive\" and \"somatic\" dimensions. CFA tested competing models for the structure of BDI-II, including the simple one- and two-factor models, a bifactor model, and the EFA model along with its corresponding bifactor model. All models demonstrated adequate and similar fitness, well-defined factors, and good reliability. Bifactor analyses indicated a robust general factor with low reliable variance in total scores attributed to multidimensionality caused by the group factors in bifactor models. MG-CFA supported invariance across gender, suggesting that the same BDI-II construct could be applied to both female and male adolescents. This study provides evidence that the BDI-II could be used as a unidimensional measure of depressive symptoms in adolescents by researchers and clinicians.</p>","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":"195-204"},"PeriodicalIF":6.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141287952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Atypical dynamic neural configuration in autism spectrum disorder and its relationship to gene expression profiles. 自闭症谱系障碍的非典型动态神经配置及其与基因表达谱的关系。
IF 6 2区 医学
European Child & Adolescent Psychiatry Pub Date : 2025-01-01 Epub Date: 2024-06-11 DOI: 10.1007/s00787-024-02476-w
Xiaolong Shan, Peng Wang, Qing Yin, Youyi Li, Xiaotian Wang, Yu Feng, Jinming Xiao, Lei Li, Xinyue Huang, Huafu Chen, Xujun Duan
{"title":"Atypical dynamic neural configuration in autism spectrum disorder and its relationship to gene expression profiles.","authors":"Xiaolong Shan, Peng Wang, Qing Yin, Youyi Li, Xiaotian Wang, Yu Feng, Jinming Xiao, Lei Li, Xinyue Huang, Huafu Chen, Xujun Duan","doi":"10.1007/s00787-024-02476-w","DOIUrl":"10.1007/s00787-024-02476-w","url":null,"abstract":"<p><p>Although it is well recognized that autism spectrum disorder (ASD) is associated with atypical dynamic functional connectivity patterns, the dynamic changes in brain intrinsic activity over each time point and the potential molecular mechanisms associated with atypical dynamic temporal characteristics in ASD remain unclear. Here, we employed the Hidden Markov Model (HMM) to explore the atypical neural configuration at every scanning time point in ASD, based on resting-state functional magnetic resonance imaging (rs-fMRI) data from the Autism Brain Imaging Data Exchange. Subsequently, partial least squares regression and pathway enrichment analysis were employed to explore the potential molecular mechanism associated with atypical neural dynamics in ASD. 8 HMM states were inferred from rs-fMRI data. Compared to typically developing, individuals on the autism spectrum showed atypical state-specific temporal characteristics, including number of states and occurrences, mean life time and transition probability between states. Moreover, these atypical temporal characteristics could predict communication difficulties of ASD, and states assoicated with negative activation in default mode network and frontoparietal network, and positive activation in somatomotor network, ventral attention network, and limbic network, had higher predictive contribution. Furthermore, a total of 321 genes was revealed to be significantly associated with atypical dynamic brain states of ASD, and these genes are mainly enriched in neurodevelopmental pathways. Our study provides new insights into characterizing the atypical neural dynamics from a moment-to-moment perspective, and indicates a linkage between atypical neural configuration and gene expression in ASD.</p>","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":"169-179"},"PeriodicalIF":6.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141300304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
First evidence on a general disease ("d") factor underlying psychopathology and physical illness in adolescents. 首次证明青少年心理变态和身体疾病背后的一般疾病("d")因素。
IF 6 2区 医学
European Child & Adolescent Psychiatry Pub Date : 2025-01-01 Epub Date: 2024-06-07 DOI: 10.1007/s00787-024-02488-6
Dejan Stevanovic, Nikola Cirovic, Samuele Cortese, Rajna Knez, Nóra Kerekes
{"title":"First evidence on a general disease (\"d\") factor underlying psychopathology and physical illness in adolescents.","authors":"Dejan Stevanovic, Nikola Cirovic, Samuele Cortese, Rajna Knez, Nóra Kerekes","doi":"10.1007/s00787-024-02488-6","DOIUrl":"10.1007/s00787-024-02488-6","url":null,"abstract":"<p><p>The coexistence of mental and physical health illnesses could be accounted for by an underlying general disease factor (termed d-factor), reflecting theoretical underpinnings based on possible genetic and pathophysiological overlapping mechanisms. This study evaluated whether the d-factor underlies mental and physical health illnesses in adolescents. A series of confirmatory factor analyses were conducted using data from 1120 adolescents. The proposed common underlying factor, we believe is the d-factor, was consistently present across different modeling approaches, including unidimensional, correlated-factor, and bifactor models. The best model fit was achieved with the bifactor model represented by mental, neurological, and psychical conditions tested. The first compelling evidence was provided supporting the existence of the transdiagnostic d-factor in youth, opening the door to innovative research of comorbid mental and physical health conditions.</p>","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":"357-360"},"PeriodicalIF":6.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141287953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The supporting role of dogs in the inpatient setting: a systematic review of the therapeutic effects of animal-assisted therapy with dogs for children and adolescents in an inpatient setting. 狗在住院环境中的辅助作用:对住院环境中使用狗对儿童和青少年进行动物辅助治疗的疗效进行系统回顾。
IF 6 2区 医学
European Child & Adolescent Psychiatry Pub Date : 2025-01-01 Epub Date: 2023-12-26 DOI: 10.1007/s00787-023-02326-1
Dustin Fornefeld, Undine Zellin, Peter Schmidt, Oliver Fricke
{"title":"The supporting role of dogs in the inpatient setting: a systematic review of the therapeutic effects of animal-assisted therapy with dogs for children and adolescents in an inpatient setting.","authors":"Dustin Fornefeld, Undine Zellin, Peter Schmidt, Oliver Fricke","doi":"10.1007/s00787-023-02326-1","DOIUrl":"10.1007/s00787-023-02326-1","url":null,"abstract":"<p><p>Animal-assisted therapy (AAT) is becoming increasingly popular. The possibilities and guidelines for interventions and methods are very diverse. Currently, published studies mainly concentrate on effects in paediatrics, outpatient therapy and schools. Specific recommendations for AAT in the context of inpatient child and adolescent psychiatry do not exist. This systematic review will attempt to evaluate the existing studies in terms of their methodological quality and specify positive and negative effects, aiming to provide a decision-making aid for everyday clinical practice. A systematic literature search (PubMed/MEDLINE, APA PsycINFO, PubPsych, ProQuest, Google Scholar, and Cochrane Library) according to the PRISMA criteria resulted in 1,908 identified hits, of which 49 articles were reviewed in full text. Three raters contributed to the review of the articles using a criteria-guided codebook. This systematic review is listed in the PROSPERO database (CRD42022358909). Quality analysis was conducted using Effective Public Health Practice Project (EPHPP). Five studies were identified. The majority of these showed deficits in quality. Therapeutic effects and positive influences on the psychopathological status, interpersonal relationships and subjective well-being or attitudes towards canine-assisted therapy (CAT) could be identified. Current studies indicate positive therapeutic effects of CAT in the inpatient treatment of children and adolescents. A cautiously positive perspective is warranted, but a general recommendation for CAT cannot be given. CAT should be carefully considered, planned, and implemented by professionals. For the future, further randomised controlled studies including follow-up studies, larger subject groups and clinically evaluated interventions are necessary to validate the current results.</p>","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":"3-17"},"PeriodicalIF":6.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11805780/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139037461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Internet- and mobile-based anxiety and depression interventions for children and adolescents: efficacy and negative effects - a systematic review and meta-analysis. 针对儿童和青少年的基于互联网和移动设备的焦虑和抑郁干预措施:疗效和负面影响--系统回顾和荟萃分析。
IF 6 2区 医学
European Child & Adolescent Psychiatry Pub Date : 2025-01-01 Epub Date: 2024-03-02 DOI: 10.1007/s00787-024-02404-y
Patrick Dülsen, Harald Baumeister
{"title":"Internet- and mobile-based anxiety and depression interventions for children and adolescents: efficacy and negative effects - a systematic review and meta-analysis.","authors":"Patrick Dülsen, Harald Baumeister","doi":"10.1007/s00787-024-02404-y","DOIUrl":"10.1007/s00787-024-02404-y","url":null,"abstract":"<p><p>Mental disorders, most commonly anxiety disorders and fourth most common depression, are prevalent in children and adolescents. Internet- and mobile-based interventions might represent a scalable approach to improve mental health care, however, evidence so far is inconclusive and systematic reports on negative effects are missing. Four data-bases were searched for randomized controlled trials evaluating internet- and mobile-based interventions (IMIs) targeting anxiety disorders or depression in children and adolescents up to 18 years exhibiting clinically relevant symptoms. Meta-analytic evaluations were conducted in comparison to active and passive control groups, furthermore, pre-defined sub-groups were explored and reported negative effects examined. Pooled estimates showed a moderate positive effect for IMIs targeting anxiety disorders compared to passive control groups (g = -0.69; CI -0.94 to -0.45; k = 8; n = 559; p ≤ 0,001), but not for depression. Pooled estimates compared to active control groups remained non-significant. Subgroup analyses were largely omitted due to an insufficient number of trials or were non-significant. Negative effects were mainly reported as drop-out rates and (non)-response rates, while additional negative effects, such as deterioration rates or the development of additional symptoms, were reported by only one third of included studies. The focus on children and adolescents with clinically relevant symptoms allowed the present findings to complement previous work, however, the limited amount of trials hindered many planned comparisons. The overview of reported negative effects highlighted that negative effects are being neglected in the majority of RCTs. Hence, in the future RCTs should include more information about potential negative effects, at best a combination of quantitative and qualitative information. Open Science Framework (osf.io/ch5nj).</p>","PeriodicalId":11856,"journal":{"name":"European Child & Adolescent Psychiatry","volume":" ","pages":"101-121"},"PeriodicalIF":6.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11805827/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140012461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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