Japanese Journal of Lactic Acid Bacteria最新文献_第9页

Lactobacillus casei YIT 9029（乳酸菌シロタ株）のアレルギー抑制効果：作用機序と臨床応用への可能性 Lactobacillus casei YIT 9029(乳酸菌白塔株)的过敏抑制效果:作用机制和临床应用潜力

Japanese Journal of Lactic Acid Bacteria Pub Date : 2010-07-01 DOI: 10.4109/JSLAB.21.107

寛志田

引用次数: 0

Pediococcus pentosaceus Sn26株のアレルギー性下痢症抑制作用及びその作用機序解析 Pediococcus pentosaceus Sn26株的过敏性腹泻抑制作用及其作用机制分析

Japanese Journal of Lactic Acid Bacteria Pub Date : 2010-03-15 DOI: 10.4109/JSLAB.21.42

健幸増田, 雅也中田, 早苗岡田, 久子保井

{"title":"Pediococcus pentosaceus Sn26株のアレルギー性下痢症抑制作用及びその作用機序解析","authors":"健幸増田, 雅也中田, 早苗岡田, 久子保井","doi":"10.4109/JSLAB.21.42","DOIUrl":"https://doi.org/10.4109/JSLAB.21.42","url":null,"abstract":"すんき漬から分離された乳酸菌の中にIgE産生を抑制する菌株が多数存在した。その中の1菌株（Pediococcus pentosaceus Sn26株（Sn26））は、経口投与により血中の卵白アルブミン（OVA）特異的IgEを減少させ、 OVAで誘導されるアレルギー性下痢症を有意に抑制した。このメカニズムを解析するために誘導組織である腸管パイエル板細胞及び実効組織である腸管粘膜固有層リンパ細胞の免疫応答性を調べた。その結果、Sn26の経口投与は、パイエル板細胞の1型ヘルパーT細胞(Th1)型サイトカイン産生能を上昇させ、Th1/ 2型ヘルパーT細胞(Th2)バランスを改善させ、総IgE産生能を減少させた。さらに、腸管粘膜固有層リンパ細胞のTh2型サイトカイン産生能を減少させ、OVA特異的IgE産生能を低下させた。以上のことから、経口投与されたSn26は、パイエル板に取り込まれた後、Th1/Th2バランスの改善を介して腸管粘膜でのIgE産生を抑制し、下痢発症を抑制することが推測された。","PeriodicalId":117947,"journal":{"name":"Japanese Journal of Lactic Acid Bacteria","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114400304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Respiration, a strategy to avoid oxidative stress in Lactococcus lactis, is regulated by the heme status 乳酸乳球菌的呼吸作用是一种避免氧化应激的策略，它受血红素状态的调节

Japanese Journal of Lactic Acid Bacteria Pub Date : 2010-03-15 DOI: 10.4109/JSLAB.21.10

B. Cesselin, Aurélie Derré-Bobillot, Annabelle Fernandez, G. Lamberet, D. Lechardeur, Yuji Yamamoto, M. Pedersen, C. Garrigues, P. Gaudu

{"title":"Respiration, a strategy to avoid oxidative stress in Lactococcus lactis, is regulated by the heme status","authors":"B. Cesselin, Aurélie Derré-Bobillot, Annabelle Fernandez, G. Lamberet, D. Lechardeur, Yuji Yamamoto, M. Pedersen, C. Garrigues, P. Gaudu","doi":"10.4109/JSLAB.21.10","DOIUrl":"https://doi.org/10.4109/JSLAB.21.10","url":null,"abstract":"Lactic acid bacteria (LAB) species like L. lactis are traditionally considered as obligate fermentative bacteria because even in aerobiosis they use sugar degradation for substrate-level phosphorylation, i.e. ATP production. However, recent studies revealed that this bacterium and some other LAB are capable of activating a heme-dependent cytochrome oxidase (CydAB) and thus undergo a respiration metabolism. Nevertheless, respiratory chain activation is allowed only when cells have access to heme (and additionally menaquinone for some LAB) in the environment because they cannot synthesize these compounds. Respiration increases the biomass yield and extends the long term survival of stored cells. These benefits of respiration are explained in different ways: i) Respiratory chain activity consumes oxygen, limiting the formation of toxic reactive oxygen species. ii) Respiratory chain generates a pH gradient, which potentially increases ATP production via H+-ATPase activity. iii) Respiration metabolism decreases lactic acid production, limiting acid stress. However, LAB have to cope with heme toxicity. Although heme has clear metabolic benefits the intracellular pool of free heme must be stringently controlled to prevent damage to macromolecules like DNA. In L. lactis, a potential efflux pump system, consisting of an ATPase (YgfA) and a permease (YgfB), is specifically highly induced in response to exogenous heme. Interestingly, the ygfA and ygfB genes are in an operon with ygfC, a potential regulator of the TetR family. Our studies implicate the ygfCBA operon is involved in modulating the free heme level and is regulated by YgfC.","PeriodicalId":117947,"journal":{"name":"Japanese Journal of Lactic Acid Bacteria","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129851966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

A Novel Type II Restriction Endonuclease from Leuconostoc mesenteroides in the Ariake Sea 一种来自有明海肠系膜白斑菌的新型II型限制性内切酶

Japanese Journal of Lactic Acid Bacteria Pub Date : 2008-06-15 DOI: 10.4109/JSLAB.19.96

G. Kobayashi, Y. Nakagawa, Y. Tashiro, Kanda Kohzo, F. Kato

引用次数: 0

Discovering the molecular foundations of Lactobacillus autochthony in the gastrointestinal tract 发现胃肠道中自体乳杆菌的分子基础

Japanese Journal of Lactic Acid Bacteria Pub Date : 2008-03-15 DOI: 10.4109/JSLAB.19.9

J. Walter

{"title":"Discovering the molecular foundations of Lactobacillus autochthony in the gastrointestinal tract","authors":"J. Walter","doi":"10.4109/JSLAB.19.9","DOIUrl":"https://doi.org/10.4109/JSLAB.19.9","url":null,"abstract":"Molecular technologies have facilitated detection and identification of intestinal lactobacilli and allowed insight into the occurrence, diversity and dynamics of Lactobacillus populations in the human gastrointestinal tract. These techniques showed that the majority of Lactobacillus strains found in human fecal samples are only transiently detectable and therefore likely to be allochthonous, probably originating from food or the oral cavity. Strains of some species, such as Lactobacillus reuteri and Lactobacillus ruminis, have been shown to be true inhabitants (autochthonous) and persist in significant numbers. Very little is known about the molecular traits that enable autochthonous lactobacilli to occupy a niche within the gut ecosystem. The main focus of our research has been to determine the molecular foundations of the ecological success of Lactobacillus reuteri strains that are autochthonous to the rodent gastrointestinal tract. These studies have begun to provide mechanistic explanations of the ecological success of this species as a result of the application of in vivo expression technology (IVET) and the investigation of the ecological performance of isogenic mutants in the murine gastrointestinal tract. Functional and comparative genomic studies with Lactobacillus reuteri have been initiated in order to identify phenotypic and genotypic traits essential for gut colonization and host/microbe coexistence. Research to decipher these ecological interactions is rewarding, as it not only increases fundamental knowledge about the gut ecosystem, but also provides valuable information to select lactobacilli for probiotics.","PeriodicalId":117947,"journal":{"name":"Japanese Journal of Lactic Acid Bacteria","volume":"301 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2008-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132931272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Immunostimulatory Activities of Lactic Acid Bacteria via Toll-like Receptors 乳酸菌通过toll样受体的免疫刺激活性

Japanese Journal of Lactic Acid Bacteria Pub Date : 2005-06-01 DOI: 10.4109/JSLAB1997.16.11

H. Kitazawa, T. Shimosato, M. Tohno, Tadao Saito

{"title":"Immunostimulatory Activities of Lactic Acid Bacteria via Toll-like Receptors","authors":"H. Kitazawa, T. Shimosato, M. Tohno, Tadao Saito","doi":"10.4109/JSLAB1997.16.11","DOIUrl":"https://doi.org/10.4109/JSLAB1997.16.11","url":null,"abstract":"Many works on the biological functions of dairy lactic acid bacteria (LAB) have contributed to the application of LAB in functional foods and supplements in the global market. More recently, the new term \"immunobiotics\", has been proposed to identify probiotic bacteria that promote health through activation of intestinal immunity from those with strictly local immunity, and expected for an appropriate evolutionary development. We have studied specific effector molecules and their receptor targets. Recently, we found that immunostimulatory AT oligonucleotide (AT-ODN), but not CpG ODN, from Lactobacillus gasseri JCM 1131 triggered. immune responses via Toll-like receptor 9 (TLR 9), which has been identified as a particular receptor for bacterial DNA containing the specific sequence pattern of unmethylated CpG dinucleotide. Through the discovery of TLR 9, possible molecular mechanisms in immune responses through bacterial DNA have been rapidly revealed in mice. Recently, we found that ATODN from Lactobacillus gasseri, possibly induces immunoactivation in Peyer's patches (Pps) via TLR 9. We demonstrated that TLR 9 is a receptor for not only CpG but also for non-CpG AT ODN as a result of the induction of nuclear factor-k B (NF-k B) activation by gene reporter assay. This review describes our recent study on the immunostimulatory activity of LAB via TLRs, especially TLR 9 and 2 and discuss future trends in the development of \"Immunobiotic Foods\" through intestinal immunoregulation mediated by \"Immunobiotic\" LAB","PeriodicalId":117947,"journal":{"name":"Japanese Journal of Lactic Acid Bacteria","volume":"425 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133829813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Development of Co-Culture Systems of Lactic Acid Bacteria and Yeasts for Bioproduction 生物生产用乳酸菌与酵母菌共培养体系的开发

Japanese Journal of Lactic Acid Bacteria Pub Date : 2005-06-01 DOI: 10.4109/JSLAB1997.16.2

H. Shimizu, B. Cheirsilp, S. Shioya

{"title":"Development of Co-Culture Systems of Lactic Acid Bacteria and Yeasts for Bioproduction","authors":"H. Shimizu, B. Cheirsilp, S. Shioya","doi":"10.4109/JSLAB1997.16.2","DOIUrl":"https://doi.org/10.4109/JSLAB1997.16.2","url":null,"abstract":"Co-culture systems of lactic acid bacteria and yeasts for bioproduction are described with two typical examples. A novel control method exploiting microbial interaction in the co-culture system is introduced as the first example. In order to control pH in an antimicrobial peptide (nisin) production process by Lactococcus lactis subsp. lactis (ATCC 11454), microbial interaction between L-lactate production by L. lactis and its assimilation by Kluyveromyces marxianus was utilized. A cascade pH controller coupled with DO control was newly developed and the specific lactate consumption rate of K. marxianus was controlled by changing the dissolved oxygen (DO) concentration. pH and lactate were kept at constant levels and nisin accumulated in medium to high levels, compared with other pH control strategies, such as processes without pH control and with pH control by addition of alkali. The second example is polysaccharide kefiran production by co-culture of Lactobacillus kefiranofaciens and Saccharomyces cerevisiae. Productivity of kefiran was increased in the co-culture system of S. cerevisiae under an aerobic condition. Not only the effect of removal of lactic acid but also the additional effect of S. cerevisiae are discussed through the simulation of the system.","PeriodicalId":117947,"journal":{"name":"Japanese Journal of Lactic Acid Bacteria","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121345465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

New approach to isolation and characterization of uncultured microorganisms 分离和鉴定非培养微生物的新方法

Japanese Journal of Lactic Acid Bacteria Pub Date : 2004-12-01 DOI: 10.4109/JSLAB1997.15.62

Y. Kamagata

引用次数: 0

Factors Affecting Kimchi Fermentation 影响泡菜发酵的因素

Japanese Journal of Lactic Acid Bacteria Pub Date : 2003-12-01 DOI: 10.4109/JSLAB1997.14.56

T. Mheen

引用次数: 8

境界域及び軽度高コレステロール血症に対しLactobacillus gasseri(ガゼリ菌SP株)を含有する発酵乳は血清コレステロール値を低下させる针对边界区域和轻度高胆固醇血症，含有Lactobacillus gasseri(gazellus SP株)的发酵乳能降低血清胆固醇

Japanese Journal of Lactic Acid Bacteria Pub Date : 2002-12-01 DOI: 10.4109/JSLAB1997.13.114

O. Kajimoto, Hiroshi Hirata, Sei-ichiro Aoe, Takeo Takahashi, Yutaka Suzuki, Hiroshi Tanaka

引用次数: 9