Engineering最新文献_第2页

Smart Grid Innovations: Increasing Resilience, Security, and Sustainability in the Era of Energy Transition 智能电网创新：在能源转型时代增强弹性、安全性和可持续性

IF 12.8 1区工程技术

Engineering Pub Date : 2025-07-11 DOI: 10.1016/j.eng.2025.07.014

Yixin Yu, Yanli Liu, Didi Yu

引用次数: 0

Editorial: Planning and Operating Power Systems to Proactively Respond to Climate Change 社论：规划和运行电力系统以积极应对气候变化

IF 12.8 1区工程技术

Engineering Pub Date : 2025-07-10 DOI: 10.1016/j.eng.2025.07.012

Jianbo Guo, Weisheng Wang

引用次数: 0

Innovative Strategies in Natural Product Drug Discovery: The Case of Anemoside B4 天然产物药物发现的创新策略：以海葵苷B4为例

IF 12.8 1区工程技术

Engineering Pub Date : 2025-07-10 DOI: 10.1016/j.eng.2025.06.036

Naixin Kang, Jianping Zhao, Penghao Gao, Yue Lu, Zhong Chen, Xiaoran Li, Ikhlas A. Khan, Shilin Yang, Qiongming Xu, Yanli Liu

{"title":"Innovative Strategies in Natural Product Drug Discovery: The Case of Anemoside B4","authors":"Naixin Kang, Jianping Zhao, Penghao Gao, Yue Lu, Zhong Chen, Xiaoran Li, Ikhlas A. Khan, Shilin Yang, Qiongming Xu, Yanli Liu","doi":"10.1016/j.eng.2025.06.036","DOIUrl":"https://doi.org/10.1016/j.eng.2025.06.036","url":null,"abstract":"Anemoside B4 (AB4), a triterpenoid saponin derived from Pulsatilla chinensis, has garnered considerable attention for its potent anti-inflammatory and immunomodulatory activities, culminating in its approval for clinical trials by the Center for Drug Evaluation, National Medical Products Administration, for the treatment of mild to moderate ulcerative colitis. Despite this, AB4’s therapeutic potential remained underexplored until the development of its injection formulation. This review discusses the scientific rationale and theoretical framework behind AB4’s development, offering a new paradigm and innovative research strategy for discovering lead compounds or drug candidates from natural medicines. In-depth investigations into AB4’s cellular targets, biochemical pathways, and administration routes have provided valuable insights into its druggability evaluation and clinical potential. The high water solubility of AB4, attributable to its multiple sugar units, imposes limitations on its bioavailability and pharmacokinetic profiles. To address this, structural modification via chemical methods and enzymatic hydrolysis have been employed, resulting in derivatives with reduced molecular weight, improved bioavailability, enhanced pharmacological activity, and greater clinical potential. These advances lay a solid foundation for the continued development of AB4 and its derivatives as promising therapeutic agents.","PeriodicalId":11783,"journal":{"name":"Engineering","volume":"9 1","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144603573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting IGF2BP2–CEMIP Boosts Antiangiogenic Therapy in Colorectal Cancer in Mice 靶向IGF2BP2-CEMIP促进小鼠结直肠癌抗血管生成治疗

IF 12.8 1区工程技术

Engineering Pub Date : 2025-07-10 DOI: 10.1016/j.eng.2025.06.035

Weikang Chen, Haojie Bai, Yani Huo, Yifan Wu, Wei Kang, Dong Zhang, Yongxin Zhang, Shiyan Wang, Lixia Xu, Chi Chun Wong, Ka Fai To, Xiaoxing Li, Jun Yu

{"title":"Targeting IGF2BP2–CEMIP Boosts Antiangiogenic Therapy in Colorectal Cancer in Mice","authors":"Weikang Chen, Haojie Bai, Yani Huo, Yifan Wu, Wei Kang, Dong Zhang, Yongxin Zhang, Shiyan Wang, Lixia Xu, Chi Chun Wong, Ka Fai To, Xiaoxing Li, Jun Yu","doi":"10.1016/j.eng.2025.06.035","DOIUrl":"https://doi.org/10.1016/j.eng.2025.06.035","url":null,"abstract":"Angiogenesis is essential for supporting tumor progression and metastasis. However, the potential role of the epitranscriptome in regulating angiogenesis remains unclear. Here, we identify the RNA N6-methyladenosine (m6A) reader insulin-like growth factor 2 (IGF2) messenger RNA (mRNA)-binding protein 2 (IGF2BP2) as the top enriched m6A regulator in hypervascular colorectal cancer (CRC), with its expression correlating with poor prognosis. Knockdown of IGF2BP2 in CRC cells suppressed their ability to promote pro-angiogenic phenotypes in endothelial cells in vitro, as well as vascular abnormalization, tumor progression, and metastasis in vivo. Supporting these findings, intestine-specific Igf2bp2 knock-in mice exhibited accelerated azoxymethane (AOM) plus dextran sulfate sodium (DSS)-induced CRC through enhanced angiogenesis and vascular abnormalities, whereas intestine-specific Igf2bp2 knockout inhibited tumor growth by normalizing tumor vasculature. Mechanistically, IGF2BP2 binds to m6A-modified cell migration inducing and hyaluronan binding protein (CEMIP) mRNA and enhanced its stability, leading to increased secretion of CEMIP. Secreted CEMIP interacts with membrane glucose-regulated protein 78 (GRP78) on endothelial cells, activating pro-angiogenic signaling. Importantly, targeting IGF2BP2 through genetic ablation, lipid nanoparticle (LNP)-encapsulated small interfering IGF2BP2, or the chemical inhibitor (CWI1-2) synergized with anti-angiogenic drugs to suppress tumor growth in multiple CRC models. Together, these findings suggest that targeting IGF2BP2 is a promising strategy to enhance the efficacy of anti-angiogenic therapy in CRC.","PeriodicalId":11783,"journal":{"name":"Engineering","volume":"48 1","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144594704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Material and Structural Optimization of Novel Phase-Change Thermal Diode for Dynamic Building Envelope 新型动态建筑围护结构相变热二极管的材料与结构优化

IF 12.8 1区工程技术

Engineering Pub Date : 2025-07-10 DOI: 10.1016/j.eng.2025.07.008

Hengxin Zhao, Yifan Wu, Guochen Jiang, Minlin Zhong, Hongli Sun, Borong Lin

{"title":"Material and Structural Optimization of Novel Phase-Change Thermal Diode for Dynamic Building Envelope","authors":"Hengxin Zhao, Yifan Wu, Guochen Jiang, Minlin Zhong, Hongli Sun, Borong Lin","doi":"10.1016/j.eng.2025.07.008","DOIUrl":"https://doi.org/10.1016/j.eng.2025.07.008","url":null,"abstract":"Passive energy savings through the building envelope represent a critical strategy for reducing both energy consumption and carbon emissions. However, traditional technologies are limited by cumbersome control mechanisms and narrow adjustment scopes. To overcome these limitations, we propose a novel phase-change thermal diode with an enhanced unidirectional heat-transfer capacity. This thermal diode utilizes hydrophobic and hydrophilic materials, presenting dual benefits in material fabrication and structural applications. To verify the potential of this approach for building applications, the effect of different hydrophobic materials and vacuum on the performance of the thermal diode were compared experimentally. The optimally formulated material, which is readily manufacturable over large areas, demonstrated thermal rectification ranging from 8.72 to 23.62, thus offering an extensive adjustment range. For structural applications, the thermal diode could be combined with the building envelope to create a dynamic envelope for passive heat dissipation and insulation. Simulation studies confirmed that this novel dynamic adjustment method provides superior adjustment capabilities and achieves greater energy conservation than conventional dynamic methods. Specifically, cooling energy savings between 11.83% and 21.36% were attainable across various climate zones in China. This research fosters cross-innovation in the fields of buildings and materials, serving as a foundational reference for developing dynamic building envelopes.","PeriodicalId":11783,"journal":{"name":"Engineering","volume":"13 1","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144594705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

On Decision-Dependent Uncertainties in Power Systems with High-Share Renewables 高份额可再生能源电力系统决策依赖不确定性研究

IF 12.8 1区工程技术

Engineering Pub Date : 2025-07-10 DOI: 10.1016/j.eng.2025.07.013

Yunfan Zhang, Yifan Su, Feng Liu

{"title":"On Decision-Dependent Uncertainties in Power Systems with High-Share Renewables","authors":"Yunfan Zhang, Yifan Su, Feng Liu","doi":"10.1016/j.eng.2025.07.013","DOIUrl":"https://doi.org/10.1016/j.eng.2025.07.013","url":null,"abstract":"The continuously increasing renewable energy sources (RES) and demand response (DR) are becoming crucial sources of system flexibility. Consequently, decision-dependent uncertainties (DDUs), interchangeably referred to as endogenous uncertainties, impose new characteristics on power system dispatch. The DDUs faced by system operators originate from uncertain dispatchable resources such as RES units or DR, while reserve providers encounter DDUs from the uncertain reserve deployment. Thus, a systematic framework was established in this study to address robust dispatch problems with DDUs. The main contributions are drawn as follows. ① The robust characterization of DDUs was unfolded with a dependency decomposition structure. ② A generic DDU coping mechanism was manifested as the bilateral matching between uncertainty and flexibility. ③ The influence of DDU incorporation on the convexity/non-convexity of robust dispatch problems was analyzed. ④ Generic solution algorithms adaptive for DDUs were proposed. Under this framework, the inherent distinctions and correlations between DDUs and decision-independent uncertainties (DIUs) were revealed, laying a fundamental theoretical foundation for the economic and reliable operation of RES-dominated power systems. Illustrative applications in the source and demand sides are provided to show the significance of considering DDUs and demonstrate the proposed theoretical results.","PeriodicalId":11783,"journal":{"name":"Engineering","volume":"51 1","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144603569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Toward Mobile Satellite Internet: The Fundamental Limitation of Wireless Transmission and Enabling Technologies 走向移动卫星互联网：无线传输的基本限制及其使能技术

IF 12.8 1区工程技术

Engineering Pub Date : 2025-07-09 DOI: 10.1016/j.eng.2025.07.007

Wenjin Wang, Yiming Zhu, Yafei Wang, Rui Ding, Symeon Chatzinotas

引用次数: 0

Booming Demand for Lithium Drives Extraction Innovation 蓬勃发展的锂需求推动了开采创新

IF 12.8 1区工程技术

Engineering Pub Date : 2025-07-09 DOI: 10.1016/j.eng.2025.07.010

引用次数: 0

Chinese AI Model Shocks the World—But What Comes Next? 中国人工智能模型震惊世界——接下来会发生什么？

IF 12.8 1区工程技术

Engineering Pub Date : 2025-07-09 DOI: 10.1016/j.eng.2025.07.009

引用次数: 0

Ecological Pathway to Achieve Carbon Neutrality in China’s Building Sector 中国建筑行业实现碳中和的生态路径

IF 12.8 1区工程技术

Engineering Pub Date : 2025-07-09 DOI: 10.1016/j.eng.2025.07.006

Shan Hu, Yi Jiang, Xudong Yang, Yungang Pan, Xiangyang Rong, Bin Hao, Ziyi Yang, Yang Zhang, Da Yan

{"title":"Ecological Pathway to Achieve Carbon Neutrality in China’s Building Sector","authors":"Shan Hu, Yi Jiang, Xudong Yang, Yungang Pan, Xiangyang Rong, Bin Hao, Ziyi Yang, Yang Zhang, Da Yan","doi":"10.1016/j.eng.2025.07.006","DOIUrl":"https://doi.org/10.1016/j.eng.2025.07.006","url":null,"abstract":"Buildings are crucial for achieving carbon reduction and mitigating climate change. China’s dual-carbon strategy includes ambitious goals for carbon peaking and carbon neutrality in the building sector. However, clear technical pathways and roadmaps for achieving these objectives remain lacking. In this study, we examined the trajectory and characteristics of energy consumption and emissions in China’s building sector and conducted future scenario analyses informed by global comparative studies. Ecological development pathways were proposed as target scenarios to achieve carbon neutrality in the building sector. Detailed pathways to achieve carbon neutrality were delineated, covering various tasks and timelines. These included managing building stocks, improving energy efficiency and sufficiency, promoting electrification, implementing photovoltaic–energy storage–direct current–flexibility (PEDF) buildings, decarbonizing heating systems, and developing new energy systems for rural areas. In addition, we discussed and recommended policy measures to enhance building service provisions within the framework of the ecological development concept and promote key technologies within the context of a low-carbon energy system transition. The findings of this study provide high-level recommendations for policymakers in the building and energy sectors and offer insights into technological perspectives and development targets for future research and engineering practice.","PeriodicalId":11783,"journal":{"name":"Engineering","volume":"26 1","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144594706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0