Environmental Toxicology最新文献

{"title":"RETRACTION: Integrated RNA Expression and Alternative Polyadenylation Analysis Identified CPSF1-CCDC137 Oncogenic Axis in Lung Adenocarcinoma.","authors":"","doi":"10.1002/tox.24478","DOIUrl":"https://doi.org/10.1002/tox.24478","url":null,"abstract":"<p><strong>Retraction: </strong>X. Xudong, L. Heng, C. Benchao, C. Wenjie, L. Bao, and L. Gaofeng, \"Integrated RNA Expression and Alternative Polyadenylation Analysis Identified CPSF1-CCDC137 Oncogenic Axis in Lung Adenocarcinoma,\" Environmental Toxicology 39, no. 4 (2024): 2405-2416, https://doi.org/10.1002/tox.24105. The above article, published online on 4 January 2024, in Wiley Online Library (http://onlinelibrary.wiley.com/), has been retracted by agreement between the journal Editor-in-Chief, Paul B. Tchounwou; and Wiley Periodicals LLC. Following an investigation by the publisher, the parties have concluded that this article was accepted solely on the basis of a compromised peer review process. Therefore, the article must be retracted.</p>","PeriodicalId":11756,"journal":{"name":"Environmental Toxicology","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined Effect of Nanoparticles of Silver and Silica to HeLa Cells: Synergistic Internalization and Toxicity.","authors":"Chen-Si Li, Jie Liu, Qiangqiang Zhang, Xue-Rui Tang, Yuan-Yuan Liu, Aoneng Cao, Haifang Wang","doi":"10.1002/tox.24480","DOIUrl":"https://doi.org/10.1002/tox.24480","url":null,"abstract":"<p><p>The wide range of applications and the enormous production of nanomaterials have raised the possibility that humans may simultaneously contact with various nanomaterials through multiple routes. Although numerous toxicity studies have been conducted on the toxicity of nanomaterials, knowledge of the combined toxicity of nanomaterials remains limited. Herein, the combined toxic effects of the two types of the most widely used nanomaterials, silver and silica, were studied on HeLa cells. In addition, considering there may have possible interplay between nanoparticles of different sizes, two different-sized silica nanoparticles (SNPs) were used. The results indicate that compared with individual exposure, the combined exposure to 35 nm silver nanoparticles (Ag35) and 40 nm or 120 nm SNPs (SNP40 or SNP120) at individual non-toxic concentrations causes more severe cytotoxicity, manifested by the ROS overgeneration, decreased mitochondrial membrane potential and ATP level, and increased apoptosis/necrosis. The internalized Ag35 and its dissolved Ag ions that are delivered into cells by adsorbing on SNPs are identified as the primary contributors to the combined toxicity. Although the cytotoxicity of the mixed Ag35 and SNP40 is comparable to that of the mixed Ag35 and SNP120, there are noticeable differences in their intracellular contents and their subcellular locations due to size effects. This study provides in-depth insights into the combined toxicity of inorganic nanoparticles and highlights the importance of the size effect of nanoparticles in their nanotoxicity assessment.</p>","PeriodicalId":11756,"journal":{"name":"Environmental Toxicology","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RETRACTION: Calcitriol Combined With High-Calcium and High-Phosphorus Diet Induces Vascular Calcification Model in Chronic Kidney Disease Rats.","authors":"","doi":"10.1002/tox.24476","DOIUrl":"https://doi.org/10.1002/tox.24476","url":null,"abstract":"<p><strong>Retraction: </strong>Y. Wang, W. Han, Y. Zhong, W. Li, and Q. Liu, \"Calcitriol Combined With High-Calcium and High-Phosphorus Diet Induces Vascular Calcification Model in Chronic Kidney Disease Rats,\" Environmental Toxicology 39, no. 3 (2024): 1769-1779, https://doi.org/10.1002/tox.24039. The above article, published online on 8 December 2023, in Wiley Online Library (http://onlinelibrary.wiley.com/), has been retracted by agreement between the journal Editor-in-Chief, Paul B. Tchounwou; and Wiley Periodicals LLC. Following an investigation by the publisher, the parties have concluded that this article was accepted solely on the basis of a compromised peer review process. Therefore, the article must be retracted.</p>","PeriodicalId":11756,"journal":{"name":"Environmental Toxicology","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RETRACTION: The Predictive Efficacy of Programmed Cell Death in Immunotherapy of Melanoma: A Comprehensive Analysis of Gene Expression Data for Programmed Cell Death Biomarker and Therapeutic Target Discovery.","authors":"","doi":"10.1002/tox.24477","DOIUrl":"https://doi.org/10.1002/tox.24477","url":null,"abstract":"<p><strong>Retraction: </strong>C. Yue, W. Lian, M. Duan, D. Xia, X. Cao, and J. Peng, \"The Predictive Efficacy of Programmed Cell Death in Immunotherapy of Melanoma: A Comprehensive Analysis of Gene Expression Data for Programmed Cell Death Biomarker and Therapeutic Target Discovery,\" Environmental Toxicology 39, no. 3 (2024): 1858-1873, https://doi.org/10.1002/tox.24051. The above article, published online on 22 December 2023, in Wiley Online Library (http://onlinelibrary.wiley.com/), has been retracted by agreement between the authors; the journal Editor-in-Chief, Paul B. Tchounwou; and Wiley Periodicals LLC. Following an investigation by the publisher, the parties have concluded that this article was accepted solely on the basis of a compromised peer review process. Therefore, the article must be retracted.</p>","PeriodicalId":11756,"journal":{"name":"Environmental Toxicology","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Zeolite Imidazole Framework‐8 Exacerbates Astrocyte Activation and Oxidative Stress in the Brain of Rats","authors":"Sadaf Abdi, Moein Shirzad, Maryam Ghasemi‐Kasman, Leyla Nadalinezhad, Shahram Ghasemi, Ebrahim Zabihi, Aliakbar Rajabzadeh","doi":"10.1002/tox.24467","DOIUrl":"https://doi.org/10.1002/tox.24467","url":null,"abstract":"Metal–organic frameworks (MOFs) have been gaining significant attention due to their potential application in medicine. Here, we investigated the effect of zeolite imidazole framework‐8 (ZIF‐8) on neuro‐behavioral parameters, histopathology, inflammation, and oxidative stress levels of rats' brain samples. Forty‐eight male Wistar rats were injected by four injections of saline or ZIF‐8 at different doses of 5, 10, or 20 mg/kg via the caudal vein. Y‐Maze, Morris‐Water Maze (MWM), and three chamber tests were conducted to explore working memory, spatial learning and memory, and social interactions, respectively. Histological staining and immunohistochemistry were used to evaluate pathological changes and astrocyte activation levels. The inflammation levels were measured using quantitative real‐time reverse‐transcription polymerase chain reaction (qRT‐PCR). The total antioxidant capacity (TAC) and oxidative stress production were assessed by biochemical assays. The results showed that ZIF‐8 induces neuromotor impairment dose‐dependently. Although histopathological studies indicated increased neuronal loss, inflammatory changes, and elevated active astrocytes in the hippocampus, the expression levels of <jats:italic>IL‐1β</jats:italic> and <jats:italic>TNF‐α</jats:italic> were not significantly increased in ZIF‐8‐treated rats. The TAC level significantly reduced and the malondialdehyde (MDA) level remarkably increased in the brain tissues. Our findings suggest that administration of ZIF‐8 induce neuromotor impairment, probably through amplified inflammation and oxidative stress.","PeriodicalId":11756,"journal":{"name":"Environmental Toxicology","volume":"20 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142935510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Sub‐Acute Potential Risk of Oxamyl in Male Albino Rats","authors":"Maher S. Salama, Khaled A. Osman, Rania Elbanna","doi":"10.1002/tox.24462","DOIUrl":"https://doi.org/10.1002/tox.24462","url":null,"abstract":"The current study aimed to investigate the sub‐acute effects of oxamyl on male Albino rats following oral administration of either 0.031 or 0.31 mg/kg/day for 14 consecutive days. The findings demonstrated that oxamyl produced a significant impact on most of the examined blood profile and biomarkers, along with a significant progressive and discernible alterations in the histology of organs. According to the results obtained, the potential mechanisms by which oxamyl causes its toxic effects on rats are identified as the inflammation indices, the inhibition of transaminases, alkaline phosphatase, and antioxidant enzymes, as well as the production of thiobarbituric acid reactive substances (TBARs) in organs following oxamyl treatment based on histopathological examinations. Due to the substantial genetic similarities between rats and humans, it is therefore anticipated that oxamyl will have comparable detrimental effects on humans.","PeriodicalId":11756,"journal":{"name":"Environmental Toxicology","volume":"43 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142888092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Berberine Attenuates Cerulein‐Induced Acute Pancreatitis by Modulating Nrf2/NOX2 Signaling Pathway via AMPK Activation","authors":"Sapana P. Bansod, Mohd Aslam Saifi, Shrilekha Chilvery, Nandkumar Doijad, Chandraiah Godugu","doi":"10.1002/tox.24468","DOIUrl":"https://doi.org/10.1002/tox.24468","url":null,"abstract":"AMP‐activated protein kinase (AMPK) is the master regulator of cellular energy which gets activated during energy stress and restores tissue homeostasis. AMPK is widely expressed in the pancreas and is involved in protein synthesis. In cerulein‐induced acute pancreatitis (AP), diminished AMPK activity in the pancreatic tissue may be associated with pancreatic inflammation and oxidative stress. Our results demonstrated that berberine (BR) treatment produced significant decrease in plasma amylase and lipase levels and improved histopathological features in AP mice model. Myeloperoxidase (MPO) activity indicated that BR suppressed the infiltration of neutrophils in pancreas. BR treatment markedly decreased the levels of proinflammatory cytokines including interleukins (IL)‐6, IL‐1β, and tumor necrosis factor‐α (TNF‐α) via inhibition of nicotinamide adenine dinucleotide phosphate oxidase 2 (NOX2) expression. In addition, BR activates the nuclear factor erythroid 2–related factor 2 (Nrf2) signaling and inhibits cerulein‐induced oxidative‐nitrosative stress. Mechanistically, we found inhibition of AMPK activity in cerulein‐induced AP, while BR‐treated animals showed marked increase in the AMPK expression. Together, our study indicated that BR‐mediated AMPK activation in pancreatic tissues demonstrated attenuation of cerulein‐induced oxidative stress and inflammation. Based on our observations, further exploration of this promising natural product against AP and associated complications may lead to promising therapeutic options.","PeriodicalId":11756,"journal":{"name":"Environmental Toxicology","volume":"19 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142888142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lead Mediated Lipopolysaccharides Exacerbates Fatty Liver Processes in High‐Fat Diets‐Induced Mice","authors":"Penghui Nie, Liehai Hu, Tao You, Tiantian Jia, Hengyi Xu","doi":"10.1002/tox.24463","DOIUrl":"https://doi.org/10.1002/tox.24463","url":null,"abstract":"Obesity leads to a variety of health risks, and lead, which is ranked second in Agency for Toxic Substances and Disease Registry's priority list of harmful substances, may be more harmful to individuals that are obese. C57BL/6 mice were fed a normal diet or a high‐fat diet with or without exposure to 1 g/L lead exposure in drinking water for 8 consecutive weeks. Serum and hepatic biochemistry analysis, histopathological observation, and RT‐qPCR were used to explore the potential mechanism of liver damage in obese individuals after Pb exposure, and fecal microbiota transplantation was performed to investigate the role of the gut microbiota in the progression of fatty liver disease. We found that the progression of fatty liver disease induced by high‐fat diets was accelerated by chronic lead intake. In addition, the occurrences of liver injury in recipient mice suggested the role of the gut microbiota. These findings indicated that the combination of lead and a HFD exacerbated hepatic lipotoxicity by activating LPS‐mediated inflammation, and that gut microbiota disorders and impaired intestinal barrier function play pivotal roles in the progression of fatty liver disease.","PeriodicalId":11756,"journal":{"name":"Environmental Toxicology","volume":"25 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142879848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Aluminum Oxide Nanoparticles in the Spinal Cord of Male Wistar Rats and the Potential Ameliorative Role of Melatonin","authors":"Nermeen G. Abdelhameed, Yasmine H. Ahmed, Noha A. E. Yasin, Mohamed Y. Mahmoud, Mohamed A. El‐sakhawy","doi":"10.1002/tox.24466","DOIUrl":"https://doi.org/10.1002/tox.24466","url":null,"abstract":"Aluminum oxide nanoparticles (Al<jats:sub>2</jats:sub>O<jats:sub>3</jats:sub> NPs) are widely utilized in vaccine manufacturing and other medical preparations. Melatonin has numerous effects as an antioxidant and anti‐apoptotic. The purpose of this study was to examine the beneficial impact of melatonin on Al<jats:sub>2</jats:sub>O<jats:sub>3</jats:sub> NPs toxicity in the spinal cord. Forty male rats were divided into four groups: Group I, the negative controls (received standard diet and distilled water); Group II, Al<jats:sub>2</jats:sub>O<jats:sub>3</jats:sub> NPs (received 30 mg/kg bw Al<jats:sub>2</jats:sub>O<jats:sub>3</jats:sub> NPs); Group III, melatonin and Al<jats:sub>2</jats:sub>O<jats:sub>3</jats:sub> NPs (received 30 mg/kg bw Al<jats:sub>2</jats:sub>O<jats:sub>3</jats:sub> NPs + 10 mg/kg bw melatonin); Group IV, melatonin (received 10 mg/kg bw melatonin). All treatments were administered daily for 28 days by gastric gavage. After that, all rats were sacrificed, then, the samples from different spinal cords were subjected to histopathological, biochemical, and immunohistochemical analyses. Al<jats:sub>2</jats:sub>O<jats:sub>3</jats:sub> NPs markedly elevated malondialdehyde and 8‐hydroxydeoxyguanosine while inhibiting superoxide dismutase and catalase. Al<jats:sub>2</jats:sub>O<jats:sub>3</jats:sub> NPs also induced histological alterations in both gray and white matter manifested by neuronal degeneration, vacuolation, axonal degeneration, ballooning, and fusion of myelin sheaths. Furthermore, immunohistochemical results displayed a strong positive expression of caspase‐3. Conversely, melatonin significantly mitigated the effects of Al<jats:sub>2</jats:sub>O<jats:sub>3</jats:sub> NPs by increasing the activities of antioxidant enzymes and inhibiting malondialdehyde and 8‐hydroxydeoxyguanosine. Moreover, melatonin alleviated most histological alterations induced by Al<jats:sub>2</jats:sub>O<jats:sub>3</jats:sub> NPs and reduced caspase‐3 immunoreactivity. Collectively, melatonin could protect the spinal cord and mitigate Al<jats:sub>2</jats:sub>O<jats:sub>3</jats:sub> NPs‐induced neurotoxicity.","PeriodicalId":11756,"journal":{"name":"Environmental Toxicology","volume":"14 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142867282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coleus vettiveroides Root Extract Protects Against Thioacetamide‐Induced Chronic Liver Injury by Inhibiting NF‐κB Signaling Pathway","authors":"Kadmad Abdul Hameed Mohamed Azar, Devaraj Ezhilarasan, Munusamy Karthick, Karthik Shree Harini, Venkatesan Kumar","doi":"10.1002/tox.24465","DOIUrl":"https://doi.org/10.1002/tox.24465","url":null,"abstract":"The roots of <jats:italic>Coleus vettiveroides</jats:italic> (CV) have been traditionally used in Indian medicinal systems such as Ayurveda and Siddha for its antioxidant, anti‐inflammatory, and antidiabetic effects. This study examines the antifibrotic potential of CV ethanolic root extract (CVERE) against thioacetamide (TAA)‐induced liver fibrosis in Wistar rats. TAA was administered via i.p., thrice weekly for 11 weeks to induce liver fibrosis in rats. In separate groups, rats were administered with TAA and were concurrently treated with CVERE 125 mg/kg, CVERE 250 mg/kg, and silymarin (SIL) 100 mg/kg. Liver marker enzymes of hepatotoxicity, oxidative stress markers, proinflammatory marker gene expression (TNF‐α, NF‐κB, COX, and ILs), fibrotic marker gene expression (collagen I and III), immune histochemical expression of fibrosis marker proteins, and histopathologic changes were analyzed. TAA administration led to a significant (<jats:italic>p</jats:italic> &lt; 0.001) increase in the serum level of hepatotoxic marker enzymes. The TAA‐treated group showed higher levels (<jats:italic>p</jats:italic> &lt; 0.001) of MDA and reduced activities of SOD and CAT in the liver. TAA administration increased CYP2E1 expression, proinflammatory, and fibrotic marker gene expressions in rat liver. The histopathology of the liver confirms TAA‐induced architectural distortion and fibrotic changes. CVERE and SIL simultaneous treatments significantly protected against TAA‐induced oxidative stress, inflammation, and liver fibrosis. In conclusion, CVERE inhibited TAA‐induced liver fibrosis through downregulation of TAA metabolic activation, redox imbalance, and inflammation through repression of the NF‐κB pathway.","PeriodicalId":11756,"journal":{"name":"Environmental Toxicology","volume":"24 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142867280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}