Environmental Toxicology最新文献

筛选
英文 中文
RETRACTION: Eosinophils and Risk of Ulcerative Colitis in European Population: Evidence from Mendelian Randomization Study 撤回:欧洲人群中嗜酸性粒细胞和溃疡性结肠炎的风险:来自孟德尔随机研究的证据
IF 4.5 3区 医学
Environmental Toxicology Pub Date : 2025-04-22 DOI: 10.1002/tox.24526
{"title":"RETRACTION: Eosinophils and Risk of Ulcerative Colitis in European Population: Evidence from Mendelian Randomization Study","authors":"","doi":"10.1002/tox.24526","DOIUrl":"https://doi.org/10.1002/tox.24526","url":null,"abstract":"<jats:mixed-citation publication-type=\"journal\">RETRACTION: <jats:string-name><jats:given-names>Y.</jats:given-names> <jats:surname>Shao</jats:surname></jats:string-name>, <jats:string-name><jats:given-names>C.</jats:given-names> <jats:surname>Liu</jats:surname></jats:string-name>, <jats:string-name><jats:given-names>X.</jats:given-names> <jats:surname>Wang</jats:surname></jats:string-name>, and <jats:string-name><jats:given-names>W.</jats:given-names> <jats:surname>Zhu</jats:surname></jats:string-name>, “,” <jats:source>Environmental Toxicology</jats:source> <jats:volume>39</jats:volume>, no. (<jats:year>2024</jats:year>): <jats:fpage>4669</jats:fpage>–<jats:lpage>4676</jats:lpage>, <jats:ext-link xmlns:xlink=\"http://www.w3.org/1999/xlink\" xlink:href=\"https://doi.org/10.1002/tox.24314\">https://doi.org/10.1002/tox.24314</jats:ext-link>.</jats:mixed-citation>The above article, published online on 29 April 2024 in Wiley Online Library (<jats:ext-link xmlns:xlink=\"http://www.w3.org/1999/xlink\" xlink:href=\"http://onlinelibrary.wiley.com/\">http://onlinelibrary.wiley.com/</jats:ext-link>), has been retracted by agreement between the journal Editor‐in‐Chief, April Rodd; and Wiley Periodicals LLC. Following an investigation by the publisher, the parties have concluded that this article was accepted solely on the basis of a compromised peer review process. Therefore, the article must be retracted. The authors have been informed of this decision.","PeriodicalId":11756,"journal":{"name":"Environmental Toxicology","volume":"24 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143862474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RETRACTION: Elucidating the Molecular Mechanisms of Sepsis: Identifying Key Aging‐Related Biomarkers and Potential Therapeutic Targets in the Treatment of Sepsis 撤稿:阐明脓毒症的分子机制:确定脓毒症治疗中关键的衰老相关生物标志物和潜在的治疗靶点
IF 4.5 3区 医学
Environmental Toxicology Pub Date : 2025-04-22 DOI: 10.1002/tox.24524
{"title":"RETRACTION: Elucidating the Molecular Mechanisms of Sepsis: Identifying Key Aging‐Related Biomarkers and Potential Therapeutic Targets in the Treatment of Sepsis","authors":"","doi":"10.1002/tox.24524","DOIUrl":"https://doi.org/10.1002/tox.24524","url":null,"abstract":"<jats:mixed-citation publication-type=\"journal\">RETRACTION: <jats:string-name><jats:given-names>J.</jats:given-names> <jats:surname>Zhou</jats:surname></jats:string-name>, <jats:string-name><jats:given-names>J.</jats:given-names> <jats:surname>Liu</jats:surname></jats:string-name>, <jats:string-name><jats:given-names>C.</jats:given-names> <jats:surname>Zhang</jats:surname></jats:string-name>, <jats:string-name><jats:given-names>Y.</jats:given-names> <jats:surname>Zhou</jats:surname></jats:string-name>, <jats:string-name><jats:given-names>Z.</jats:given-names> <jats:surname>Zheng</jats:surname></jats:string-name>, and <jats:string-name><jats:given-names>H.</jats:given-names> <jats:surname>Li</jats:surname></jats:string-name>, “,” <jats:source>Environmental Toxicology</jats:source> <jats:volume>39</jats:volume>, no. (<jats:year>2024</jats:year>): <jats:fpage>3341</jats:fpage>–<jats:lpage>3355</jats:lpage>, <jats:ext-link xmlns:xlink=\"http://www.w3.org/1999/xlink\" xlink:href=\"https://doi.org/10.1002/tox.24198\">https://doi.org/10.1002/tox.24198</jats:ext-link>.</jats:mixed-citation>The above article, published online on 5 March 2024, in Wiley Online Library (<jats:ext-link xmlns:xlink=\"http://www.w3.org/1999/xlink\" xlink:href=\"http://onlinelibrary.wiley.com/\">http://onlinelibrary.wiley.com/</jats:ext-link>), has been retracted by agreement between the journal Editor‐in‐Chief, April Rodd; and Wiley Periodicals LLC. Following an investigation by the publisher, the parties have concluded that this article was accepted solely on the basis of a compromised peer review process. Therefore, the article must be retracted. The authors have been informed of this decision.","PeriodicalId":11756,"journal":{"name":"Environmental Toxicology","volume":"188 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143862455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RETRACTION: Exosomal miRNA‐166‐5p Derived from G‐MDSCs Promotes Proliferation by Targeting ITM3E in Colorectal Cancer 结论:来自G - MDSCs的外泌体miRNA‐166‐5p通过靶向ITM3E促进结直肠癌的增殖
IF 4.5 3区 医学
Environmental Toxicology Pub Date : 2025-04-22 DOI: 10.1002/tox.24523
{"title":"RETRACTION: Exosomal miRNA‐166‐5p Derived from G‐MDSCs Promotes Proliferation by Targeting ITM3E in Colorectal Cancer","authors":"","doi":"10.1002/tox.24523","DOIUrl":"https://doi.org/10.1002/tox.24523","url":null,"abstract":"<jats:mixed-citation publication-type=\"journal\">RETRACTION: <jats:string-name><jats:given-names>T.</jats:given-names> <jats:surname>Ma</jats:surname></jats:string-name>, <jats:string-name><jats:given-names>J.</jats:given-names> <jats:surname>Jiang</jats:surname></jats:string-name>, <jats:string-name><jats:given-names>M.</jats:given-names> <jats:surname>Shi</jats:surname></jats:string-name>, and <jats:string-name><jats:given-names>H.</jats:given-names> <jats:surname>Xu</jats:surname></jats:string-name>, “,” <jats:source>Environmental Toxicology</jats:source> <jats:volume>39</jats:volume>, no. (<jats:year>2024</jats:year>): <jats:fpage>803</jats:fpage>–<jats:lpage>814</jats:lpage>, <jats:ext-link xmlns:xlink=\"http://www.w3.org/1999/xlink\" xlink:href=\"https://doi.org/10.1002/tox.23980\">https://doi.org/10.1002/tox.23980</jats:ext-link>.</jats:mixed-citation>The above article, published online on 4 October 2023, in Wiley Online Library (<jats:ext-link xmlns:xlink=\"http://www.w3.org/1999/xlink\" xlink:href=\"http://onlinelibrary.wiley.com/\">http://onlinelibrary.wiley.com/</jats:ext-link>), and its <jats:ext-link xmlns:xlink=\"http://www.w3.org/1999/xlink\" xlink:href=\"https://onlinelibrary.wiley.com/doi/10.1002/tox.24422\">correction</jats:ext-link>, has been retracted by agreement between the journal Editor‐in‐Chief, April Rodd; and Wiley Periodicals LLC. Following an investigation by the publisher, the parties have concluded that this article was accepted solely on the basis of a compromised peer review process. Additionally, no ethical approval was provided for the human studies portion. Therefore, the article must be retracted. The authors agree with this decision.","PeriodicalId":11756,"journal":{"name":"Environmental Toxicology","volume":"138 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143862464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RETRACTION: Scoparone Inhibits the Development of Hepatocellular Carcinoma by Modulating the p38 MAPK/Akt/NF‐κB Signaling in Nonalcoholic Fatty Liver Disease Mice Scoparone通过调节非酒精性脂肪肝小鼠p38 MAPK/Akt/NF‐κB信号通路抑制肝细胞癌的发展
IF 4.5 3区 医学
Environmental Toxicology Pub Date : 2025-04-22 DOI: 10.1002/tox.24521
{"title":"RETRACTION: Scoparone Inhibits the Development of Hepatocellular Carcinoma by Modulating the p38 MAPK/Akt/NF‐κB Signaling in Nonalcoholic Fatty Liver Disease Mice","authors":"","doi":"10.1002/tox.24521","DOIUrl":"https://doi.org/10.1002/tox.24521","url":null,"abstract":"<jats:mixed-citation publication-type=\"journal\">RETRACTION: <jats:string-name><jats:given-names>M.</jats:given-names> <jats:surname>Ye</jats:surname></jats:string-name>, <jats:string-name><jats:given-names>C.</jats:given-names> <jats:surname>Liu</jats:surname></jats:string-name>, <jats:string-name><jats:given-names>J.</jats:given-names> <jats:surname>Liu</jats:surname></jats:string-name>, <jats:string-name><jats:given-names>F.</jats:given-names> <jats:surname>Lu</jats:surname></jats:string-name>, <jats:string-name><jats:given-names>J.</jats:given-names> <jats:surname>Xue</jats:surname></jats:string-name>, <jats:string-name><jats:given-names>F.</jats:given-names> <jats:surname>Li</jats:surname></jats:string-name>, and <jats:string-name><jats:given-names>Y.</jats:given-names> <jats:surname>Tang</jats:surname></jats:string-name>, “,” <jats:source>Environmental Toxicology</jats:source> <jats:volume>39</jats:volume>, no. (<jats:year>2024</jats:year>): <jats:fpage>551</jats:fpage>–<jats:lpage>561</jats:lpage>, <jats:ext-link xmlns:xlink=\"http://www.w3.org/1999/xlink\" xlink:href=\"https://doi.org/10.1002/tox.23851\">https://doi.org/10.1002/tox.23851</jats:ext-link>.</jats:mixed-citation>The above article, published online on 12 July 2023, in Wiley Online Library (<jats:ext-link xmlns:xlink=\"http://www.w3.org/1999/xlink\" xlink:href=\"http://onlinelibrary.wiley.com/\">http://onlinelibrary.wiley.com/</jats:ext-link>), has been retracted by agreement between the journal Editor‐in‐Chief, April Rodd; and Wiley Periodicals LLC. Following an investigation by the publisher, the parties have concluded that this article was accepted solely on the basis of a compromised peer review process. Therefore, the article must be retracted. The authors have been informed of this decision.","PeriodicalId":11756,"journal":{"name":"Environmental Toxicology","volume":"3 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143862420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RETRACTION: Integrated Analysis of Gut Microbiota and Metabolomic Profiling in Colorectal Cancer Metastasis 撤回:结肠直肠癌转移的肠道微生物群和代谢组学综合分析。
IF 4.4 3区 医学
Environmental Toxicology Pub Date : 2025-04-21 DOI: 10.1002/tox.24525
{"title":"RETRACTION: Integrated Analysis of Gut Microbiota and Metabolomic Profiling in Colorectal Cancer Metastasis","authors":"","doi":"10.1002/tox.24525","DOIUrl":"10.1002/tox.24525","url":null,"abstract":"<p>\u0000 \u0000 <b>RETRACTION</b>: <span>Y. Xia</span>, <span>L. Duan</span>, <span>X.L. Zhang</span>, <span>Y.J. Niu</span>, and <span>X. Ling</span>, “ <span>Integrated Analysis of Gut Microbiota and Metabolomic Profiling in Colorectal Cancer Metastasis</span>,” <i>Environmental Toxicology</i> <span>39</span>, no. <span>10</span> (<span>2024</span>): <span>4467</span>–<span>4478</span>, https://doi.org/10.1002/tox.24228.\u0000 </p><p>The above article, published online on 14 March 2024 in Wiley Online Library (http://onlinelibrary.wiley.com/), has been retracted by agreement between the journal Editor-in-Chief, Christyn Bailey; and Wiley Periodicals LLC. Following an investigation by the publisher, the parties have concluded that this article was accepted solely on the basis of a compromised peer review process. Therefore, the article must be retracted.</p>","PeriodicalId":11756,"journal":{"name":"Environmental Toxicology","volume":"40 7","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/tox.24525","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143862046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RETRACTION: Value of Hepatic Artery Digital Subtraction Angiography in the Detection of Small Hepatocellular Carcinoma Lesions 收缩:肝动脉数字减影血管造影在肝细胞癌小病变检测中的价值
IF 4.4 3区 医学
Environmental Toxicology Pub Date : 2025-04-21 DOI: 10.1002/tox.24527
{"title":"RETRACTION: Value of Hepatic Artery Digital Subtraction Angiography in the Detection of Small Hepatocellular Carcinoma Lesions","authors":"","doi":"10.1002/tox.24527","DOIUrl":"10.1002/tox.24527","url":null,"abstract":"<p>\u0000 \u0000 <b>RETRACTION</b>: <span>T. Bai</span>, <span>S. Lu</span>, <span>J. Chen</span>, <span>J. Ye</span>, <span>X. Wang</span>, <span>Z. Tang</span>, <span>H. Fu</span>, <span>L. Li</span>, and <span>F. Wu</span>, “ <span>Value of Hepatic Artery Digital Subtraction Angiography in the Detection of Small Hepatocellular Carcinoma Lesions</span>,” <i>Environmental Toxicology</i> <span>39</span>, no. <span>10</span> (<span>2024</span>): <span>4754</span>–<span>4762</span>, https://doi.org/10.1002/tox.24316.\u0000 </p><p>The above article, published online on 20 August 2024, in Wiley Online Library (http://onlinelibrary.wiley.com/), has been retracted by agreement between the journal Editor-in-Chief, April Rodd; and Wiley Periodicals LLC. Following an investigation by the publisher, the parties have concluded that this article was accepted solely on the basis of a compromised peer review process. Therefore, the article must be retracted. The authors disagree with this decision.</p>","PeriodicalId":11756,"journal":{"name":"Environmental Toxicology","volume":"40 7","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/tox.24527","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143862426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to “Hydroxysafflor Yellow A Attenuates Allergic Response of Ovalbumin Induced Allergic Rhinitis via Nrf2/HO-1 and Inflammatory Signaling Pathways” 更正“羟基红花黄A通过Nrf2/HO‐1和炎症信号通路减弱卵清蛋白诱导的变应性鼻炎的过敏反应”
IF 4.4 3区 医学
Environmental Toxicology Pub Date : 2025-04-16 DOI: 10.1002/tox.24518
{"title":"Correction to “Hydroxysafflor Yellow A Attenuates Allergic Response of Ovalbumin Induced Allergic Rhinitis via Nrf2/HO-1 and Inflammatory Signaling Pathways”","authors":"","doi":"10.1002/tox.24518","DOIUrl":"10.1002/tox.24518","url":null,"abstract":"<p>Q. Ma, G. Li, J. He, J. Wang, and B. Ye. “Hydroxysafflor Yellow A Attenuates Allergic Response of Ovalbumin Induced Allergic Rhinitis via Nrf2/HO-1 and Inflammatory Signaling Pathways,” <i>Environmental Toxicology</i> 38, no. 7 (2023): 1520–1534, https://doi.org/10.1002/tox.23783.</p><p>This article published with corresponding author Ben Ye being linked incorrectly to two affiliations, Department of Otorhinolaryngology, Zibo Ninth People's Hospital, Zibo, China and Department of Otorhinolaryngology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.</p><p>The correct and only affiliation for Ben Ye should be Department of Otorhinolaryngology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.</p><p>This has been corrected on the article.</p><p>We apologize for this error.</p>","PeriodicalId":11756,"journal":{"name":"Environmental Toxicology","volume":"40 7","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/tox.24518","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143836886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of PM2.5 Morphology, Composition and Health Risk in a Multi-Chair Dental Clinic. 某多椅牙科诊所PM2.5形态、组成及健康风险分析
IF 4.4 3区 医学
Environmental Toxicology Pub Date : 2025-04-09 DOI: 10.1002/tox.24519
Fengqin Tang, Shengcai Qi, Xiaoshan Tang, Xueyun Wen, Yiming Zhang, Guotao Peng, Jieying Huang, Guangwei Shang, Xu Zhang, Fubo Chen, Yuanzhi Xu, Jing Cai
{"title":"Analysis of PM<sub>2.5</sub> Morphology, Composition and Health Risk in a Multi-Chair Dental Clinic.","authors":"Fengqin Tang, Shengcai Qi, Xiaoshan Tang, Xueyun Wen, Yiming Zhang, Guotao Peng, Jieying Huang, Guangwei Shang, Xu Zhang, Fubo Chen, Yuanzhi Xu, Jing Cai","doi":"10.1002/tox.24519","DOIUrl":"https://doi.org/10.1002/tox.24519","url":null,"abstract":"<p><p>Particulate matter with aerodynamic diameter ≤ 2.5 μm (PM<sub>2.5</sub>) at high concentrations in dental clinics poses significant health risks to healthcare professionals. However, the morphology and chemical composition of PM<sub>2.5</sub> in specific environments are not yet fully elucidated. In this study, we investigated the concentration, morphology, chemical composition, and health assessment of PM<sub>2.5</sub> collected in a multi-chair dental clinic in Shanghai, China. Scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDS) were performed to observe the morphology and elemental composition of indoor and outdoor PM<sub>2.5</sub>. Chemicals were measured for their concentrations using X-ray fluorescence spectrometry (XRF). In the dental clinic, the indoor PM<sub>2.5</sub> concentration ranged from 2.01 to 114.59 μg/m<sup>3</sup>, with a mean of 23.31 μg/m<sup>3</sup>, while the outdoor PM<sub>2.5</sub> concentration ranged from 2.88 to 157.4 μg/m<sup>3</sup>, with a mean of 30.98 μg/m<sup>3</sup>. Indoor particles showed more rough, irregular mineralization, which was confirmed as the dominant elements of Ca, P, Si, and zirconia (Zr) by EDS. The average concentrations of Ca, P, Cu, Sr, and Sb indoors were lower than those outdoors (p < 0.05). We also found that Cd, As, and Ni exceeded the annual limits of the Ambient Air Quality Standards of WHO. For the health assessment, the carcinogenic risks of Cd, As, and Cr were higher than the minimum acceptable level (1 × 10<sup>-6</sup>), with values of 3.68 × 10<sup>-5</sup>, 1.10 × 10,<sup>-5</sup> and 5.52 × 10<sup>-6</sup>, respectively, and the non-carcinogenic risk of Cd was the highest, as illustrated by the Hazard Quotient of 2.04. These findings indicate that dental healthcare professionals may be exposed to PM<sub>2.5</sub> containing high concentrations of toxic metals and carcinogenic elements over the long term. This study highlights the importance of protective measures (e.g., the adoption of efficient air purification systems) to minimize the risk of particle inhalation for both patients and professionals.</p>","PeriodicalId":11756,"journal":{"name":"Environmental Toxicology","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Induction of Cuproptosis by Dichloromethane Extract From Patrinia scabiosaefolia Fisch on K562 Cells. 二氯甲烷提取物对K562细胞铜增生的诱导作用。
IF 4.4 3区 医学
Environmental Toxicology Pub Date : 2025-04-03 DOI: 10.1002/tox.24516
Yuan Lu, Leyuan Mi, Peipei Zhang, Yang Chen, Xinyi Bai, Kejing Li, Ying Zhang, Juan Li
{"title":"Induction of Cuproptosis by Dichloromethane Extract From Patrinia scabiosaefolia Fisch on K562 Cells.","authors":"Yuan Lu, Leyuan Mi, Peipei Zhang, Yang Chen, Xinyi Bai, Kejing Li, Ying Zhang, Juan Li","doi":"10.1002/tox.24516","DOIUrl":"https://doi.org/10.1002/tox.24516","url":null,"abstract":"<p><p>Cuproptosis is a newly identified form of cell death that relies on copper (Cu) ionophores to transport Cu into cancer cells. As a perennial herb, Patrinia scabiosaefolia Fisch (PS) has garnered significant attention owing to its analgesic, anti-inflammatory, antibacterial, and antitumor properties. Previous research has shown that the extract from PS (DEPS) can inhibit the growth of leukemia cell lines. However, the specific mechanism of its anti-leukemic effect has not been fully clarified. Therefore, this study was conducted to investigate the molecular mechanism of cuproptosis in the treatment of leukemia with DEPS. Our results demonstrated that DEPS up-regulated SLC31A1 and down-regulated ATP7B expression, which increased intracellular copper concentration, down-regulated FDX1, influenced the lipoylation of DLAT and DLD, and subsequently increased the expression of the stress protein HSP70 and the expression of PDHA1, inducing copper death in K562 cells. In addition, we investigated the toxicity of DEPS in vivo and demonstrated its low in vivo toxicity and adequate in vivo safety. In conclusion, our results suggest that DEPS may induce cuproptosis in cells, offering valuable insights for the future application of PS in leukemia treatment.</p>","PeriodicalId":11756,"journal":{"name":"Environmental Toxicology","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of Glyphosate on Zebrafish (Danio rerio) Developmental Toxicity. 草甘膦对斑马鱼发育毒性的影响。
IF 4.4 3区 医学
Environmental Toxicology Pub Date : 2025-04-02 DOI: 10.1002/tox.24503
Ning Zhou, Ruirui Li, Jin Lu, Jiagao Cheng, Wenping Xu, Liming Tao, Yang Zhang
{"title":"Effects of Glyphosate on Zebrafish (Danio rerio) Developmental Toxicity.","authors":"Ning Zhou, Ruirui Li, Jin Lu, Jiagao Cheng, Wenping Xu, Liming Tao, Yang Zhang","doi":"10.1002/tox.24503","DOIUrl":"https://doi.org/10.1002/tox.24503","url":null,"abstract":"<p><p>Glyphosate has been widely used in agricultural production as a highly effective, low-toxic, broad-spectrum organophosphorus herbicide. However, there has been controversy about whether it is toxic to the nervous system. In order to explore this issue in depth, the present study analyzed the molecular mechanism of action of glyphosate from four perspectives, namely, gene regulation, protein expression, morphological changes, and behavioral changes, and assessed the potential effects of glyphosate on the development of the nervous system of zebrafish through the establishment of a zebrafish model. The results showed that zebrafish embryos at 6 hpf after fertilization were exposed to glyphosate until 72 and 120 hpf. After exposure, it was found that the central nervous development-related gene Elavl3 was down-regulated, and GAP-43, Neurog1, and GFAP were up-regulated. The expression of HuC protein, which is used to maintain neuronal axonal homeostasis, was significantly reduced, and the expression of GFAP protein, which is used to repair neurological damage and inflammation, was significantly increased. Under the regulation of related genes and proteins, zebrafish larvae show abnormal changes during the development of a series of nervous systems such as heart rate slowing, somite shortening, spinal and brain malformations. At the same time, the zebrafish's action behavior also changed, with a significant decrease in its total time share in the low-speed shift and high-speed shift states, and a delayed response to dark-light environmental stimuli. In summary, studies have shown that glyphosate exposure may induce damage and inflammation of the zebrafish nervous system, resulting in developmental malformations, abnormal motor behavior, and potential neurotoxicity. Therefore, the possible neurotoxicity and environmental risks of glyphosate to aquatic animals should not be ignored and should be of great concern.</p>","PeriodicalId":11756,"journal":{"name":"Environmental Toxicology","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信