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Epilepsy Currents最新文献

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Beneath the Spike: Laminar Microcircuits of Human Interictal Epileptiform Discharges. 尖峰之下：人类癫痫样间期放电的层流微电路。
IF 4.6 2区 医学
Epilepsy Currents Pub Date : 2026-07-27 DOI: 10.1177/15357597261471755
John D Rolston
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引用次数: 0
Is Patience a Virtue When Withdrawing Antiseizure Medications After Epilepsy Surgery? Maybe Not. 癫痫手术后停药时耐心是一种美德吗？也许不是。
IF 4.6 2区 医学
Epilepsy Currents Pub Date : 2026-07-27 DOI: 10.1177/15357597261462725
Claude Steriade
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引用次数: 0
Enhancing Lesion Detection With High Field MRI, How Much Can We? 用高场MRI增强病变检测，我们能做到什么程度？
IF 4.6 2区 医学
Epilepsy Currents Pub Date : 2026-07-27 DOI: 10.1177/15357597261466898
Eliane Kobayashi
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引用次数: 0
DEPDC5: Modeling of the Two-Hit Wonder in Cortical Organoids. DEPDC5：皮质类器官双击奇迹的建模。
IF 4.6 2区 医学
Epilepsy Currents Pub Date : 2026-07-13 DOI: 10.1177/15357597261464330
Erin L Heinzen
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引用次数: 0
Neuroimmunology of Epilepsy: Mechanisms, Treatments, and Clinical Insights. 癫痫的神经免疫学：机制、治疗和临床见解。
IF 4.6 2区 医学
Epilepsy Currents Pub Date : 2026-07-06 DOI: 10.1177/15357597261464381
Alica M Goldman, Nora Wong, Annamaria Vezzani, Krista Eschbach, Khalil Husari, Divyanshu Dubey, Anteneh M Feyissa, Teneille Gofton, Ignacio Valencia
{"title":"Neuroimmunology of Epilepsy: Mechanisms, Treatments, and Clinical Insights.","authors":"Alica M Goldman, Nora Wong, Annamaria Vezzani, Krista Eschbach, Khalil Husari, Divyanshu Dubey, Anteneh M Feyissa, Teneille Gofton, Ignacio Valencia","doi":"10.1177/15357597261464381","DOIUrl":"10.1177/15357597261464381","url":null,"abstract":"<p><p>Immune-mediated epilepsies represent an etiologically unique category defined by immune activation within the central nervous system that initiates a pathophysiological cascade resulting in seizures, encephalopathy, and sometimes epileptogenesis with long-term epilepsy. Once considered rare and largely confined to paraneoplastic or postinfectious syndromes, immune-mediated and inflammatory mechanisms are now recognized across a broad spectrum ranging from acute autoimmune encephalitis with reversible seizures, new-onset refractory status epilepticus, or febrile illness-related refractory status epilepticus, to chronic autoimmune-associated epilepsy and drug-refractory structural epilepsies. This review integrates historical perspectives, mechanistic insights from animal and human studies, and contemporary clinical frameworks. It synthesizes advances in neuroimmunology, clinical phenotyping, diagnostics, immunomodulatory and antiseizure therapies, neuromodulation, and patient and family centered outcomes, and outlines future directions focused on biomarker-driven precision medicine, disease-modifying strategies, and interdisciplinary care models.</p>","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":" ","pages":"15357597261464381"},"PeriodicalIF":4.6,"publicationDate":"2026-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13337561/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148403785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microglia-Mediated Disinhibition: Taking the Brakes off Epileptic Networks. 小胶质细胞介导的去抑制：使癫痫网络停止。
IF 4.6 2区 医学
Epilepsy Currents Pub Date : 2026-06-30 DOI: 10.1177/15357597261464325
Lauren Lau
{"title":"Microglia-Mediated Disinhibition: Taking the Brakes off Epileptic Networks.","authors":"Lauren Lau","doi":"10.1177/15357597261464325","DOIUrl":"10.1177/15357597261464325","url":null,"abstract":"","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":" ","pages":"15357597261464325"},"PeriodicalIF":4.6,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13318831/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148367368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hearing in Our Sleep-Can We Drown Out Epileptic Spikes and Boost Cognition? 在我们的睡眠中听——我们能淹没癫痫发作并提高认知能力吗？
IF 4.6 2区 医学
Epilepsy Currents Pub Date : 2026-06-30 DOI: 10.1177/15357597261458696
Jennifer N Gelinas
{"title":"Hearing in Our Sleep-Can We Drown Out Epileptic Spikes and Boost Cognition?","authors":"Jennifer N Gelinas","doi":"10.1177/15357597261458696","DOIUrl":"10.1177/15357597261458696","url":null,"abstract":"","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":" ","pages":"15357597261458696"},"PeriodicalIF":4.6,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13318823/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148367435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Brainstem Disinhibition Destabilizes Breathing in Dravet Syndrome, Leading to Sudden Unexpected Death in Epilepsy (SUDEP). 脑干去抑制使德拉韦综合征患者呼吸不稳定，导致癫痫猝死（SUDEP）。
IF 4.6 2区 医学
Epilepsy Currents Pub Date : 2026-06-30 DOI: 10.1177/15357597261465822
Crystal Dezha-Bolteada, Ian C Wenker
{"title":"Brainstem Disinhibition Destabilizes Breathing in Dravet Syndrome, Leading to Sudden Unexpected Death in Epilepsy (SUDEP).","authors":"Crystal Dezha-Bolteada, Ian C Wenker","doi":"10.1177/15357597261465822","DOIUrl":"10.1177/15357597261465822","url":null,"abstract":"","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":" ","pages":"15357597261465822"},"PeriodicalIF":4.6,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13318832/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148367433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Failure Validates a Fifth Predictive Preclinical Antiseizure Medicine Discovery Model. 临床失败验证了第五种预测临床前抗癫痫药物发现模型。
IF 4.6 2区 医学
Epilepsy Currents Pub Date : 2026-06-30 DOI: 10.1177/15357597261464336
Melissa Barker-Haliski
{"title":"Clinical Failure Validates a Fifth Predictive Preclinical Antiseizure Medicine Discovery Model.","authors":"Melissa Barker-Haliski","doi":"10.1177/15357597261464336","DOIUrl":"10.1177/15357597261464336","url":null,"abstract":"","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":" ","pages":"15357597261464336"},"PeriodicalIF":4.6,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13323043/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148374828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sleep Smarter: Optimal Sleep May Preserve Cognition and Reduce Dementia Risk in Focal Epilepsy. 更聪明的睡眠：最佳睡眠可以保持认知能力并降低局灶性癫痫患者痴呆的风险。
IF 4.6 2区 医学
Epilepsy Currents Pub Date : 2026-06-30 DOI: 10.1177/15357597261465330
Anteneh M Feyissa
{"title":"Sleep Smarter: Optimal Sleep May Preserve Cognition and Reduce Dementia Risk in Focal Epilepsy.","authors":"Anteneh M Feyissa","doi":"10.1177/15357597261465330","DOIUrl":"10.1177/15357597261465330","url":null,"abstract":"","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":" ","pages":"15357597261465330"},"PeriodicalIF":4.6,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13318824/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148367402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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