Epilepsy Currents最新文献

{"title":"Scientific Symposium: Biological Sex as a Factor in Epilepsy Research and Treatment.","authors":"Christina Gross, Catherine A Christian-Hinman, P Emanuela Voinescu, Julie M Ziobro, Judy S Liu","doi":"10.1177/15357597261427892","DOIUrl":"10.1177/15357597261427892","url":null,"abstract":"<p><p>Epilepsy disorders differ depending on sex, gender and hormonal status. This can change treatment efficacy and remains an understudied topic in epilepsy, despite several public health initiatives promoting the inclusion of female subjects in clinical and preclinical research over the last 40 years. Here, we summarize research presented at the 2025 American Epilepsy Meeting Scientific Symposium that described current knowledge in sex differences in epilepsy, including X chromosome-dependent and -independent genetic and epigenetic mechanisms, and discussed how these advances may impact epilepsy management. The importance of considering sex, gender and hormones in epilepsy is increasingly acknowledged in basic, preclinical and clinical research. It is crucial to leverage this momentum into large-scale population research to better characterize the differences alongside detailed mechanistic studies that can ultimately lead to improved care for all individuals with epilepsy.</p>","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":" ","pages":"15357597261427892"},"PeriodicalIF":4.6,"publicationDate":"2026-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12962990/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147376296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Balancing Act: Amyloid-β, Tau, and Excitation-Inhibition in Alzheimer's Disease.","authors":"Manuel Silva-Pérez, Jeannie Chin","doi":"10.1177/15357597261428564","DOIUrl":"10.1177/15357597261428564","url":null,"abstract":"","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":" ","pages":"257-259"},"PeriodicalIF":4.6,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12953166/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147354490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Translational Research Symposium: Current State of SUDEP Research.","authors":"Justin M Ryan, Elizabeth J Donner, Quratulain Zulfiqar-Ali, David S Auerbach, Edward Glasscock, Rama Maganti, Shobi Sivathamboo, Anli L Liu","doi":"10.1177/15357597261418785","DOIUrl":"10.1177/15357597261418785","url":null,"abstract":"<p><p>People with epilepsy are at 24-fold increased risk of sudden death compared to the general population. Sudden unexpected death in epilepsy (SUDEP) is defined as the sudden, unexpected, nontraumatic, and nondrowning death of an individual with epilepsy, with or without evidence of a seizure, in which postmortem examination does not reveal a structural or toxicologic cause of death. SUDEP is the leading cause of mortality in epilepsy. The SUDEP rate in general epilepsy is >1:1000 person-years, with rates in some drug-resistant epilepsies and developmental and epileptic encephalopathies exceeding 9:1000 person-years. This review summarizes the current state of the field of SUDEP research, including human cohort studies, genetic risk factors, the use of animal models of epilepsy and SUDEP, cardio-respiratory risk factors, EEG biomarkers during sleep, and the use of wearable devices to reduce SUDEP risk. Understanding of the current state of SUDEP research can help inform clinical care, motivate future research directions, and ultimately reduce the risk of SUDEP in the epilepsy population.</p>","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":" ","pages":"15357597261418785"},"PeriodicalIF":4.6,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12949730/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147343788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AES ILAE North America Symposium: Guiding Evidence-Based Epilepsy Management.","authors":"Nathalie Jette, Kette Valente, Nicholas S Abend, Lara Jehi, Lacey Smith, J Helen Cross","doi":"10.1177/15357597261416718","DOIUrl":"10.1177/15357597261416718","url":null,"abstract":"<p><p>Clinical practice guidelines (CPG) provide evidence-based recommendations to optimize patient care. Their development should be rigorous and include defining the scope, conducting systematic reviews, evaluating the quality of the evidence and formulating recommendations that are linked to the evidence. When peer reviewed evidence is insufficient to inform CPGs, consensus-based recommendations (CBR) are an alternative. Both CPG and CBR are essential to inform best practices and inform health policy. This review highlights recent epilepsy CPG and CBR about genetic testing, neonatal seizures, pediatric depression, epilepsy surgery referral timing and addresses their impact on outcomes.</p>","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":" ","pages":"15357597261416718"},"PeriodicalIF":4.6,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12948701/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147325014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Evolving Understanding of Interictal Epileptiform Discharges.","authors":"Samuel W Terman","doi":"10.1177/15357597251401688","DOIUrl":"10.1177/15357597251401688","url":null,"abstract":"","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":" ","pages":"15357597251401688"},"PeriodicalIF":4.6,"publicationDate":"2026-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12945734/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147325005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuromodulation in Pediatric Epilepsy: When All Is Not About Resection-A Review.","authors":"Juan Toro Perez, Kathryn Lalor, Monika Jones, Ahmed Abdelmoity, Kimberly Houck, Aria Fallah, Saadi Ghatan, Syed Anwar, Eisha Christian, Daniel San Juan Orta, Shilpa Reddy, Inna Hughes, Sarah A Kelley","doi":"10.1177/15357597261419178","DOIUrl":"10.1177/15357597261419178","url":null,"abstract":"<p><p>Nearly 1% of the global population suffers from epilepsy. There are over 65 million people worldwide with epilepsy and approximately 10.5 million of those are children. One third of these people have drug-resistant epilepsy (DRE). Neuromodulation is an adjunct treatment option for these patients. This manuscript aims to describe the history, patient/parent perspective, current use, and future directions of neuromodulation in the management of pediatric DRE. We conducted a nonsystematic search of the literature through different databases as part of the Pediatric State of The Art Symposium at the 2025 American Epilepsy Society meeting in Atlanta. Three neuromodulation therapies, all using implanted devices and electrodes, have been approved by the Food and Drug Administration (FDA) to treat DRE, namely, vagus nerve stimulation (VNS) (1997 and lately 2017), deep brain stimulation of the anterior nucleus of the thalamus (ANT-DBS) in 2018 (2010 in Europe), and responsive neurostimulation (RNS) in 2013. Only VNS is approved in pediatric patients. Emerging noninvasive neuromodulation modalities such as noninvasive VNS and transcranial magnetic stimulation showed mild adverse effects and exhibit the most encouraging seizure and neurocognitive outcomes to date, but larger multicenter studies are essential before these modalities can be offered and integrated into standard pediatric epilepsy care.</p>","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":" ","pages":"15357597261419178"},"PeriodicalIF":4.6,"publicationDate":"2026-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13534356/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148879620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanistic Target of Rapamycin and Megalencephaly: Novel Research Strategies for Therapeutic Discovery.","authors":"Tong Pan, Whitney Parker, Philip H Iffland, Louis Dang, Peter B Crino","doi":"10.1177/15357597261419528","DOIUrl":"10.1177/15357597261419528","url":null,"abstract":"<p><p>Megalencephaly (ME) is a malformation of cortical development defined by an enlarged brain. Individuals with ME often suffer from drug resistant epilepsy, intellectual disability, and autism spectrum disorder. Several clinical ME subtypes result from pathogenic variants in mTOR pathway genes (MPG) which cause diffuse brain overgrowth likely as a consequence of hyperactive mechanistic target of rapamycin (mTOR) signaling during brain development. Unfortunately, resected surgical or post-mortem ME brain tissue specimens are not widely available, and thus, there is only limited understanding of the histopathology of MPG associated ME. Thus, research strategies including new mouse models and human cerebral organoids have been developed to study the developmental pathogenesis of ME linked to MPG variants. These model systems provide a platform to study the mechanisms leading to brain overgrowth in ME as well as the establishment of the epileptic network. Perhaps most compelling, pre-clinical research approaches in ME models may pave the way for therapeutic development that could be deployed in utero to prevent ME formation.</p>","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":" ","pages":"15357597261419528"},"PeriodicalIF":4.6,"publicationDate":"2026-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12945743/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147325075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Merritt-Putnam Symposium | Tumor-Associated Epilepsy and Epilepsy-Associated Tumors: Exploring the Bidirectional Crosstalk Between Tumors and Seizures.","authors":"Tracy A Bedrosian, Michael Wong, Erin L Heinzen, Benjamin Deneen, Catherine A Christian-Hinman","doi":"10.1177/15357597261418332","DOIUrl":"10.1177/15357597261418332","url":null,"abstract":"<p><p>Links between cancerous and noncancerous brain tumors and epilepsy have long been recognized. However, recent clinical and preclinical studies emphasize that not only do tumors impinge on surrounding brain tissue in ways that promote hyperexcitability and epileptogenesis, but that neural activity also influences tumor progression. In this review, inspired by the Merritt-Putnam Symposium of the 2025 meeting of the American Epilepsy Society, we present a cross-disciplinary dialog between cancer and epilepsy research, including discussion of tumors and epilepsies that are more prominent in pediatric versus adult populations. First, we discuss the neuropathology, genetics, and surgical outcomes of epileptogenic brain tumors, and associated mechanisms of epileptogenesis. Second, we evaluate tuberous sclerosis complex as a model disease for clinical and mechanistic investigation of tumor-epilepsy relationships. Third, we review recent evidence for somatic gene mutations as underlying factors in hypothalamic hamartomas. Lastly, we present evidence for bidirectional relationships between gliomas and neuronal activity.</p>","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":" ","pages":"15357597261418332"},"PeriodicalIF":4.6,"publicationDate":"2026-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12945727/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147325068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep in Epilepsy Special Interest Group | Brain Flow Dynamics and Sleep Alterations Effect on EpilepsyFrom Babies to Late Adults and Breathing to Cognition: The Impact of Sleep on Seizures and Cognitive Function in Epilepsy Through the Lens of Water Exchange Dynamics.","authors":"Myriam Abdennadher, Laurie Douglass, Rani Sarkis, Rup K Sainju, Rinat Jonas, Ning Hua, Marcus Ng, Milena K Pavlova","doi":"10.1177/15357597261418772","DOIUrl":"10.1177/15357597261418772","url":null,"abstract":"<p><p>Decades of research have demonstrated the complex intersection between sleep and epilepsy, which significantly impacts seizure control and epilepsy-related comorbidities. However, further investigation is needed to understand the underlying mechanisms linking sleep and epilepsy. Brain exchanges are dynamic processes that include blood-to-brain transport across the blood-brain barrier (BBB), where metabolism is regulated to sustain neural activity, and brain-to-blood and cerebrospinal fluid clearance via the glymphatic system. Together, the BBB and glymphatic system maintain brain milieu homeostasis, and dysfunction at any level can contribute to neurological disorders, including epilepsy. This review highlights the dynamics of water flow within the brain and explores the interrelationship between exchange and clearance pathways across the lifespan, as presented at the 2025 American Epilepsy Society Sleep and Epilepsy Special Interest Group Session. We provide an overview of (1) sleep-related breathing disturbances, their effects on seizures and cognitive function throughout the lifespan, and their implications for sudden unexpected death in epilepsy; and (2) the role of water dynamics mediated by the BBB and the glymphatic system in modulating sleep and epilepsy. These insights deepen our understanding of epilepsy severity and the role of sleep in modifying disease progression, offering promising directions for future research to advance therapeutic strategies.</p>","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":" ","pages":"15357597261418772"},"PeriodicalIF":4.6,"publicationDate":"2026-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12935584/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147325053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Needs and Gaps in Education and Utilization of Social Determinants of Health in Epilepsy Care: A Survey of American Epilepsy Society Members.","authors":"Yinchen Song, Meghann Kelly, Erin Fecske, Lisa Clifford, Crystal Epley, Joel M Oster, Hae Won Shin","doi":"10.1177/15357597261425347","DOIUrl":"10.1177/15357597261425347","url":null,"abstract":"<p><strong>Background: </strong>Social determinants of health (SDoH) are increasingly recognized as critical drivers of health outcomes, influencing care access, treatment adherence, and disease management in people with epilepsy. However, it is unclear how clinicians integrate SDoH concepts into daily practice and what needs remain unmet in the field.</p><p><strong>Methods: </strong>A mixed-methods survey was conducted among members of the American Epilepsy Society (AES) between December 2024 and February 2025 to assess current understanding, practices, challenges, and educational needs related to SDoH. Quantitative and qualitative data analyses were conducted on the survey results.</p><p><strong>Results: </strong>A total of 189 responses were collected, with 80% from U.S.-based healthcare professionals. Approximately 69.5% reported addressing SDoH in their practice, most frequently focusing on healthcare access and quality, followed by social and community context. Common strategies for addressing SDoH commonly involve systematic screening, telemedicine expansion, and collaboration with social workers or community organizations. Benefits from addressing SDoH-related issues were reflected in improved medication adherence, appointment attendance, and patient engagement. However, effective implementation of SDoH in epilepsy care continues to be challenged by several key barriers, including limited institutional support, lack of standardized screening tools, time constraints, and inadequate access to social work services, mental-health services, and language support.</p><p><strong>Conclusions: </strong>While SDoH awareness among AES members is high, significant implementation gaps persist. Respondents emphasized the need for expanded education, multidisciplinary resources, and institutional alignment. These findings underscore opportunities for AES to advance advocacy, professional development, and dissemination of best practices, supporting clinicians and institutions in promoting equitable, outcomes-driven epilepsy care across diverse populations.</p>","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":" ","pages":"15357597261425347"},"PeriodicalIF":4.6,"publicationDate":"2026-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12935572/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147325043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}