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Epilepsy Currents最新文献

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Seizing Control of the CA2. 控制CA2。
IF 6.3 2区 医学
Epilepsy Currents Pub Date : 2026-04-24 DOI: 10.1177/15357597261445156
Jennifer C Wong
{"title":"Seizing Control of the CA2.","authors":"Jennifer C Wong","doi":"10.1177/15357597261445156","DOIUrl":"https://doi.org/10.1177/15357597261445156","url":null,"abstract":"","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":" ","pages":"15357597261445156"},"PeriodicalIF":6.3,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13109240/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147766341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epilepsy Therapy Screening From 1975 to 2026 and Beyond: Merging Established and New Approaches to Develop Novel Therapies. 从1975年到2026年及以后的癫痫治疗筛选：合并现有和新方法开发新疗法。
IF 6.3 2区 医学
Epilepsy Currents Pub Date : 2026-04-20 DOI: 10.1177/15357597261439480
Cameron S Metcalf, Peter J West, Misty D Smith, Karen S Wilcox
{"title":"Epilepsy Therapy Screening From 1975 to 2026 and Beyond: Merging Established and New Approaches to Develop Novel Therapies.","authors":"Cameron S Metcalf, Peter J West, Misty D Smith, Karen S Wilcox","doi":"10.1177/15357597261439480","DOIUrl":"https://doi.org/10.1177/15357597261439480","url":null,"abstract":"","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":" ","pages":"15357597261439480"},"PeriodicalIF":6.3,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13096057/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147766262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Shining Light on the Neuropathology of Temporal Lobe Epilepsy. 颞叶癫痫的神经病理学研究。
IF 6.3 2区 医学
Epilepsy Currents Pub Date : 2026-04-20 DOI: 10.1177/15357597261444605
Helen E Scharfman
{"title":"Shining Light on the Neuropathology of Temporal Lobe Epilepsy.","authors":"Helen E Scharfman","doi":"10.1177/15357597261444605","DOIUrl":"https://doi.org/10.1177/15357597261444605","url":null,"abstract":"","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":" ","pages":"15357597261444605"},"PeriodicalIF":6.3,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13096012/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147766331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Beyond the Usual Suspects: Cerebellar Involvement in Epilepsy. 超越通常的怀疑：小脑参与癫痫。
IF 6.3 2区 医学
Epilepsy Currents Pub Date : 2026-04-20 DOI: 10.1177/15357597261443072
Lauren A Lau
{"title":"Beyond the Usual Suspects: Cerebellar Involvement in Epilepsy.","authors":"Lauren A Lau","doi":"10.1177/15357597261443072","DOIUrl":"https://doi.org/10.1177/15357597261443072","url":null,"abstract":"","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":" ","pages":"15357597261443072"},"PeriodicalIF":6.3,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13095995/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147766159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Glymphatic System Dysfunction in Epilepsy: Clinical and Translational Perspectives. 癫痫的淋巴系统功能障碍：临床和转化的观点。
IF 6.3 2区 医学
Epilepsy Currents Pub Date : 2026-04-20 DOI: 10.1177/15357597261443067
Dong Ah Lee, Ho-Joon Lee, Kang Min Park
{"title":"Glymphatic System Dysfunction in Epilepsy: Clinical and Translational Perspectives.","authors":"Dong Ah Lee, Ho-Joon Lee, Kang Min Park","doi":"10.1177/15357597261443067","DOIUrl":"https://doi.org/10.1177/15357597261443067","url":null,"abstract":"<p><p>Epilepsy has traditionally been viewed as a disorder involving neuronal hyperexcitability and brain network dysfunction. However, growing evidence indicates that recurrent seizures are associated with widespread disturbances in brain homeostasis, including metabolic stress, neuroinflammation, vascular dysregulation, and sleep disruption. These processes extend beyond neurons and involve brain-wide clearance mechanisms that have received limited attention in epilepsy research. The glymphatic system is a specialized pathway that facilitates cerebrospinal fluid-interstitial fluid exchange and promotes the clearance of metabolic waste and neurotoxic solutes from the brain. Glymphatic transport depends on astrocytic aquaporin-4 channels and is strongly modulated by sleep-wake state, which is highly relevant to epilepsy given the close bidirectional relationship between seizures and sleep disturbances. Impaired glymphatic clearance has been linked to protein accumulation, neuroinflammation, and cognitive decline during aging and in neurodegenerative diseases, suggesting that similar mechanisms may contribute to epilepsy-related disease progression. In this review, we summarize current knowledge of glymphatic anatomy and physiology, focusing on advances in neuroimaging. We then synthesize emerging evidence demonstrating glymphatic dysfunction across multiple epilepsy syndromes. We discuss the clinical implications of impaired cerebral waste clearance for disease burden, treatment outcomes, and cognitive dysfunction and highlight potential therapeutic strategies aimed at modulating glymphatic function. Finally, we address the ongoing debates regarding glymphatic mechanisms, imaging biomarkers, and causal relationships in epilepsy. Collectively, the available data suggest that glymphatic system dysfunction represents a system-level abnormality in epilepsy, offering a complementary framework that integrates the metabolic, vascular, and sleep-related aspects of epileptic brain dysfunction.</p>","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":" ","pages":"15357597261443067"},"PeriodicalIF":6.3,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13096015/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147766302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IsCHEMiA in Vascular Epilepsy: Identifying Risks for Post Stroke Epilepsy. 血管性癫痫的缺血：卒中后癫痫的风险识别。
IF 6.3 2区 医学
Epilepsy Currents Pub Date : 2026-04-20 DOI: 10.1177/15357597261443079
Peter Widdess-Walsh
{"title":"IsCHEMiA in Vascular Epilepsy: Identifying Risks for Post Stroke Epilepsy.","authors":"Peter Widdess-Walsh","doi":"10.1177/15357597261443079","DOIUrl":"https://doi.org/10.1177/15357597261443079","url":null,"abstract":"","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":" ","pages":"15357597261443079"},"PeriodicalIF":6.3,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13095997/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147766279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Context Matters for GluN1 Variants in Epilepsy. 癫痫患者GluN1变异的背景因素
IF 6.3 2区 医学
Epilepsy Currents Pub Date : 2026-04-16 DOI: 10.1177/15357597261442410
Tracy A Bedrosian
{"title":"Context Matters for GluN1 Variants in Epilepsy.","authors":"Tracy A Bedrosian","doi":"10.1177/15357597261442410","DOIUrl":"https://doi.org/10.1177/15357597261442410","url":null,"abstract":"","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":" ","pages":"15357597261442410"},"PeriodicalIF":6.3,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13086753/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147722281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Honey, We Shrunk the Mice! The Maximal Electroshock Model Goes In Vitro. 亲爱的，我们把老鼠缩小了！体外最大电休克模型。
IF 6.3 2区 医学
Epilepsy Currents Pub Date : 2026-04-15 DOI: 10.1177/15357597261439091
Sara Eyal
{"title":"Honey, We Shrunk the Mice! The Maximal Electroshock Model Goes In Vitro.","authors":"Sara Eyal","doi":"10.1177/15357597261439091","DOIUrl":"https://doi.org/10.1177/15357597261439091","url":null,"abstract":"","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":" ","pages":"15357597261439091"},"PeriodicalIF":6.3,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13083282/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147722331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
To Seize or Not to Seize? That is the (Epigenetic) Question. 抓住还是不抓住？这就是（表观遗传）问题。
IF 6.3 2区 医学
Epilepsy Currents Pub Date : 2026-04-15 DOI: 10.1177/15357597261442389
Corey St Romain, Jeannie Chin
{"title":"To Seize or Not to Seize? That is the (Epigenetic) Question.","authors":"Corey St Romain, Jeannie Chin","doi":"10.1177/15357597261442389","DOIUrl":"10.1177/15357597261442389","url":null,"abstract":"","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":" ","pages":"15357597261442389"},"PeriodicalIF":6.3,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13083274/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147722272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antiseizure Networks. 抗癫痫网络。
IF 6.3 2区 医学
Epilepsy Currents Pub Date : 2026-04-15 DOI: 10.1177/15357597261436900
Frederic L W V J Schaper, Davide Giampiccolo, Ghassan S Makhoul, Annaelle D Devergnas, Dario J Englot, Patrick A Forcelli
{"title":"Antiseizure Networks.","authors":"Frederic L W V J Schaper, Davide Giampiccolo, Ghassan S Makhoul, Annaelle D Devergnas, Dario J Englot, Patrick A Forcelli","doi":"10.1177/15357597261436900","DOIUrl":"10.1177/15357597261436900","url":null,"abstract":"<p><p>Epilepsy is increasingly recognized as a disorder of brain networks rather than a solely focal disease. Beyond the seizure focus, connected brain networks can exert inhibitory control over seizure initiation and propagation resulting in antiseizure effects. Here, we present data from animal and human studies on antiseizure networks and integrate recent results from lesion-, stimulation- and neurophysiological-experiments. Consistent with these results, we present the Interictal Suppression Hypothesis that posits that strong inward connectivity to the seizure focus maintains seizure freedom between events, while collapse of this connectivity accompanies seizure spread and generalization. Workshop discussions highlighted future directions, including mechanistic stimulation studies to interrogate the role of antiseizure networks seizure control and design of therapeutic studies towards network-guided neuromodulation for epilepsy. A deeper mechanistic understanding of antiseizure networks may enable development of precision therapies that target endogenous seizure control rather than simply target the seizure focus.</p>","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":" ","pages":"15357597261436900"},"PeriodicalIF":6.3,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13083275/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147722293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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