Christina Gross, Catherine A Christian-Hinman, P Emanuela Voinescu, Julie M Ziobro, Judy S Liu
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引用次数: 0
Abstract
Epilepsy disorders differ depending on sex, gender and hormonal status. This can change treatment efficacy and remains an understudied topic in epilepsy, despite several public health initiatives promoting the inclusion of female subjects in clinical and preclinical research over the last 40 years. Here, we summarize research presented at the 2025 American Epilepsy Meeting Scientific Symposium that described current knowledge in sex differences in epilepsy, including X chromosome-dependent and -independent genetic and epigenetic mechanisms, and discussed how these advances may impact epilepsy management. The importance of considering sex, gender and hormones in epilepsy is increasingly acknowledged in basic, preclinical and clinical research. It is crucial to leverage this momentum into large-scale population research to better characterize the differences alongside detailed mechanistic studies that can ultimately lead to improved care for all individuals with epilepsy.
期刊介绍：
Epilepsy Currents is an open access, bi-monthly current-awareness journal providing reviews, commentaries and abstracts from the world’s literature on the research and treatment of epilepsy. Epilepsy Currents surveys and comments on all important research and developments in a format that is easy to read and reference. Each issue is divided into two main sections: Basic Science and Clinical Science. An outstanding Editorial Board reviews the literature and assigns topics and articles to world experts for comment. In addition, the Editors commission authoritative review articles on important subjects.
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