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Epilepsy Currents最新文献

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Underutilization of Neurodiagnostic Resources in Drug-Resistant Epilepsy. 耐药性癫痫的神经诊断资源利用不足。
IF 5.8 2区 医学
Epilepsy Currents Pub Date : 2024-10-29 eCollection Date: 2024-09-01 DOI: 10.1177/15357597241280486
Danielle M Andrade
{"title":"Underutilization of Neurodiagnostic Resources in Drug-Resistant Epilepsy.","authors":"Danielle M Andrade","doi":"10.1177/15357597241280486","DOIUrl":"10.1177/15357597241280486","url":null,"abstract":"","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":"24 5","pages":"339-341"},"PeriodicalIF":5.8,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11536416/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142592500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preclinical Testing Strategies for Epilepsy Therapy Development. 癫痫治疗开发的临床前测试策略。
IF 5.8 2区 医学
Epilepsy Currents Pub Date : 2024-10-25 DOI: 10.1177/15357597241292197
Victoria A Riley, Steve C Danzer
{"title":"Preclinical Testing Strategies for Epilepsy Therapy Development.","authors":"Victoria A Riley, Steve C Danzer","doi":"10.1177/15357597241292197","DOIUrl":"10.1177/15357597241292197","url":null,"abstract":"<p><p>The development of antiepileptogenic and disease-modifying treatments for epilepsy is a key goal of epilepsy research. Technological and scientific advances over the past two decades have seen the development of numerous therapeutic approaches, many of which show great promise in animal models. To facilitate and de-risk the translation of these promising approaches, however, rigorous preclinical testing is needed. For the present review, we discuss challenges and approaches to conduct preclinical testing of antiepileptogenic and disease-modifying treatments in animal models.</p>","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":" ","pages":"15357597241292197"},"PeriodicalIF":5.8,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11556302/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142616966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Have We Solved the Chicken-and-Egg Conundrum? Hippocampal Sclerosis and Temporal Lobe Epilepsy Following Febrile Status Epilepticus: Results of the 10-Year Follow-up FEBSTAT Study. 我们解决了鸡和蛋的难题吗？热性癫痫状态后的海马硬化和颞叶癫痫：FEBSTAT十年随访研究的结果。
IF 5.8 2区 医学
Epilepsy Currents Pub Date : 2024-10-24 eCollection Date: 2024-11-01 DOI: 10.1177/15357597241279746
Anteneh M Feyissa
{"title":"Have We Solved the Chicken-and-Egg Conundrum? Hippocampal Sclerosis and Temporal Lobe Epilepsy Following Febrile Status Epilepticus: Results of the 10-Year Follow-up FEBSTAT Study.","authors":"Anteneh M Feyissa","doi":"10.1177/15357597241279746","DOIUrl":"10.1177/15357597241279746","url":null,"abstract":"","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":"24 6","pages":"400-402"},"PeriodicalIF":5.8,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11556380/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142616768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Emotional Blind Spots in Juvenile Myoclonic Epilepsy. 青少年肌阵挛性癫痫的情感盲点。
IF 5.8 2区 医学
Epilepsy Currents Pub Date : 2024-10-24 eCollection Date: 2024-11-01 DOI: 10.1177/15357597241280481
Krzysztof Bujarski
{"title":"Emotional Blind Spots in Juvenile Myoclonic Epilepsy.","authors":"Krzysztof Bujarski","doi":"10.1177/15357597241280481","DOIUrl":"10.1177/15357597241280481","url":null,"abstract":"","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":"24 6","pages":"415-416"},"PeriodicalIF":5.8,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11556289/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142635945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nav1.1gating Against the Current: Ndnf Interneurons Hold Strong in Dravet Syndrome. 逆流而上的 Nav1.1gating：Ndnf 内euron 在 Dravet 综合征中保持强势。
IF 5.8 2区 医学
Epilepsy Currents Pub Date : 2024-10-16 eCollection Date: 2024-11-01 DOI: 10.1177/15357597241284350
Yuliya Voskobiynyk, Jeanne T Paz
{"title":"Nav1.1gating Against the Current: Ndnf Interneurons Hold Strong in Dravet Syndrome.","authors":"Yuliya Voskobiynyk, Jeanne T Paz","doi":"10.1177/15357597241284350","DOIUrl":"10.1177/15357597241284350","url":null,"abstract":"","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":"24 6","pages":"431-433"},"PeriodicalIF":5.8,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11556329/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142635948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
When Considering Supplemental SEEG, Remember the Die is Cast Before the First Implantation. 在考虑补充 SEEG 时，请记住在第一次植入前就已经定型。
IF 5.8 2区 医学
Epilepsy Currents Pub Date : 2024-10-16 eCollection Date: 2024-11-01 DOI: 10.1177/15357597241280483
Vineet Punia
{"title":"When Considering Supplemental SEEG, Remember the Die is Cast Before the First Implantation.","authors":"Vineet Punia","doi":"10.1177/15357597241280483","DOIUrl":"10.1177/15357597241280483","url":null,"abstract":"","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":"24 6","pages":"406-408"},"PeriodicalIF":5.8,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11556305/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142635951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neuronal Excitability in Trisomy 21-Up or Down? 21 三体综合征的神经元兴奋性上升还是下降？
IF 5.8 2区 医学
Epilepsy Currents Pub Date : 2024-10-16 eCollection Date: 2024-11-01 DOI: 10.1177/15357597241285779
Carl E Stafstrom
{"title":"Neuronal Excitability in Trisomy 21-Up or <i>Down</i>?","authors":"Carl E Stafstrom","doi":"10.1177/15357597241285779","DOIUrl":"10.1177/15357597241285779","url":null,"abstract":"","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":"24 6","pages":"440-442"},"PeriodicalIF":5.8,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11556655/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142635949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
KCN Channels "Cue" Up GABA Release from Astrocytes. KCN 通道 "提示 "星形胶质细胞释放 GABA
IF 5.8 2区 医学
Epilepsy Currents Pub Date : 2024-10-16 eCollection Date: 2024-11-01 DOI: 10.1177/15357597241280504
Matthew C Weston
{"title":"KCN Channels \"Cue\" Up GABA Release from Astrocytes.","authors":"Matthew C Weston","doi":"10.1177/15357597241280504","DOIUrl":"10.1177/15357597241280504","url":null,"abstract":"","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":"24 6","pages":"429-430"},"PeriodicalIF":5.8,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11556643/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142635946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Need for Speed; Investigating Channelopathy-Associated Epilepsy Using High Throughput Electrophysiological Approaches. 需要速度；利用高通量电生理学方法研究通道病相关癫痫。
IF 5.8 2区 医学
Epilepsy Currents Pub Date : 2024-10-16 eCollection Date: 2024-09-01 DOI: 10.1177/15357597241280484
Alfred L George, Evangelos Kiskinis
{"title":"The Need for Speed; Investigating Channelopathy-Associated Epilepsy Using High Throughput Electrophysiological Approaches.","authors":"Alfred L George, Evangelos Kiskinis","doi":"10.1177/15357597241280484","DOIUrl":"10.1177/15357597241280484","url":null,"abstract":"<p><p>Pathogenic variants in genes encoding ion channels are frequently discovered in monogenic disorders associated with epilepsy and neurodevelopmental disorders. This review covers advances in the use of automated patch clamp recording for determining the functional consequences of epilepsy-associated ion channel variants and the use of induced pluripotent stem cell (iPSC) derived neurons for in-depth investigations of the physiological consequences of such variants. The combination of these advanced technologies was a focus of the recently completed NINDS-funded Channelopathy-associated Epilepsy Research Center without Walls.</p>","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":"24 5","pages":"345-349"},"PeriodicalIF":5.8,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11536426/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142592496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
More is Different in mTORopathies. 在 mTOR 病症中，"更多 "就是 "不同"。
IF 5.8 2区 医学
Epilepsy Currents Pub Date : 2024-10-16 eCollection Date: 2024-09-01 DOI: 10.1177/15357597241280470
Yu Wang
{"title":"More is Different in mTORopathies.","authors":"Yu Wang","doi":"10.1177/15357597241280470","DOIUrl":"10.1177/15357597241280470","url":null,"abstract":"","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":"24 5","pages":"358-360"},"PeriodicalIF":5.8,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11536400/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142590250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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