Epidemiology and Infection最新文献

{"title":"The rising cost of infective endocarditis in West Virginia.","authors":"Ruchi Bhandari, Noor Abdulhay, R Constance Wiener, Dalton Smith, Melanie Fisher","doi":"10.1017/S0950268824001869","DOIUrl":"10.1017/S0950268824001869","url":null,"abstract":"<p><p>The financial burden of hospitalization from life-threatening infectious diseases on the U.S. healthcare system is substantial and continues to increase. The purpose of this study was to identify key predictors of high hospital charges for infective endocarditis at a major university-affiliated cardiac care centre in West Virginia.A retrospective electronic medical records' review was undertaken of all adult patients admitted for endocarditis between 2014-2018. Multiple linear regression analysis assessed the total charges billed to the patient account for their endocarditis hospitalization in the medical record.Hospital charges have increased 12-fold during 2014-2018. Among the 486 patients, the median hospital charge was $198 678. About 47% of the patients underwent surgery incurring 70% of the total charges. Patients with hospital stays of ≥50 days accounted for a third of all charges. The multiple linear regression model accounted for 85% of the linear variance in the hospital charges. Median charges increased by 30.87% for patients with ≥9 consultations, 60.32% for those who died in the hospital, and 81.85% for those who underwent surgical intervention.The study findings showed that complex care requiring multiple consultations, surgical interventions, and longer hospital stays were significantly associated with higher hospital charges for endocarditis treatment.</p>","PeriodicalId":11721,"journal":{"name":"Epidemiology and Infection","volume":" ","pages":"e9"},"PeriodicalIF":2.5,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11729478/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142892853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case-control association study between polygenic risk score and COVID-19 severity in a Russian population using low-pass genome sequencing.","authors":"Arina Nostaeva, Valentin Shimansky, Svetlana Apalko, Ivan Kuznetsov, Natalya Sushentseva, Oleg Popov, Anna Asinovskaya, Sergei Mosenko, Lennart Karssen, Andrey Sarana, Yurii Aulchenko, Sergey Shcherbak","doi":"10.1017/S0950268824001778","DOIUrl":"10.1017/S0950268824001778","url":null,"abstract":"<p><p>The course of COVID-19 is highly variable, with genetics playing a significant role. Through large-scale genetic association studies, a link between single nucleotide polymorphisms and disease susceptibility and severity was established. However, individual single nucleotide polymorphisms identified thus far have shown modest effects, indicating a polygenic nature of this trait, and individually have limited predictive performance. To address this limitation, we investigated the performance of a polygenic risk score model in the context of COVID-19 severity in a Russian population. A genome-wide polygenic risk score model including information from over a million common single nucleotide polymorphisms was developed using summary statistics from the COVID-19 Host Genetics Initiative consortium. Low-coverage sequencing (5x) was performed for ~1000 participants, and polygenic risk score values were calculated for each individual. A multivariate logistic regression model was used to analyse the association between polygenic risk score and COVID-19 outcomes. We found that individuals in the top 10% of the polygenic risk score distribution had a markedly elevated risk of severe COVID-19, with adjusted odds ratio of 2.9 (95% confidence interval: 1.8-4.6, <i>p</i>-value = 4e-06), and more than four times higher risk of mortality from COVID-19 (adjusted odds ratio = 4.3, <i>p</i>-value = 2e-05). This study highlights the potential of polygenic risk score as a valuable tool for identifying individuals at increased risk of severe COVID-19 based on their genetic profile.</p>","PeriodicalId":11721,"journal":{"name":"Epidemiology and Infection","volume":" ","pages":"e13"},"PeriodicalIF":2.5,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11748017/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142892498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Group A streptococcal infections in Alberta, Canada 2018-2023.","authors":"Gregory J Tyrrell, Matthew Croxen, Emily McCullough, Vincent Li, Alyssa R Golden, Irene Martin","doi":"10.1017/S0950268824001857","DOIUrl":"10.1017/S0950268824001857","url":null,"abstract":"<p><p>Group A streptococcal or <i>Streptococcus pyogenes</i> infections have been increasing post-COVID-19 pandemic. We describe the epidemiology of <i>S. pyogenes</i> pharyngitis and invasive disease in Alberta, Canada 2018-2023. Positive pharyngitis specimens were identified from throat swabs collected from pharyngitis patients. Invasive <i>S. pyogenes</i> was defined as the isolation of <i>S. pyogenes</i> from a normally sterile site or severe skin infection. <i>S. pyogenes</i> isolates were <i>emm</i> typed. Pharyngitis and invasive disease displayed seasonal trends preceding the COVID-19 pandemic followed by a sharp decrease during COVID-19 intervention measures. After the lifting of interventions, rates of pharyngitis and invasive disease rose. There were 182 983 positive pharyngitis specimens between 2018 and 2023 for a positivity rate of 17.6%. The highest rates occurred in the 0-9 age group in 2023 (41.5%). Invasive disease increased in 2022-2023 driven by <i>emm</i>1 and 12 types. M1_UK strain was the most frequent M1 type associated with invasive disease (59% of M1 isolates sequenced). Notably, out of 182 983 pharyngitis cases, there were 111 cases of invasive <i>S. pyogenes</i> detected for an invasive disease rate of 0.06%. This descriptive epidemiology of <i>S. pyogenes</i> pharyngitis and invasive <i>S. pyogenes</i> disease highlights the rapid increase in cases of <i>S. pyogenes</i> occurring in western Canada and illustrates the critical need for a vaccine.</p>","PeriodicalId":11721,"journal":{"name":"Epidemiology and Infection","volume":" ","pages":"e35"},"PeriodicalIF":2.5,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11869071/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142876424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology and clinical characteristics of Mediterranean spotted fever suspects in a university hospital, Tunisia, 2000-2020.","authors":"Meriam Lamloumi, Aida Berriche, Souheil Zayet, Boutheina Mahdi, Imen Beji, Rim Abdelmalek, Lamia Ammari, Badreddine Kilani","doi":"10.1017/S095026882400178X","DOIUrl":"10.1017/S095026882400178X","url":null,"abstract":"<p><p>Mediterranean spotted fever (MSF) is a rickettsial disease caused by <i>Rickettsia conorii</i>, transmitted by brown dog ticks, and endemic in the Mediterranean region. Its incidence is increasing, with varied presentations and potential complications because of delayed diagnosis. This study retrospectively included 173 adult patients hospitalized for MSF at La Rabta University Hospital, Tunis, from 2000 to 2020. Patients, predominantly male (67.6%) and averaging 40 years of age, mostly resided in urban areas (82.7%). Animal exposure was reported in 74.6%, and cases peaked during the hot season (68.8%), with no cases in winter months. The classic triad of fever, rash, and eschar was observed in 69.9%, with maculopapular lesions affecting palms and soles in 83.8%. Headache (64.5%), myalgia (60.7%), and arthralgia (57.2%) were also common. Laboratory findings included elevated white blood cell count (36.4%), thrombocytopenia (48%), and increased aspartate aminotransferase (50.9%). Treatment with doxycycline (<i>n</i> = 161) resolved fever within 2.8±1.3 [1-5] days. Complications, including encephalitis, chorioretinitis, anterior uveitis and vasculitis, occurred in 2.3% of cases, but all patients recovered without relapse. No significant risk factors for severe forms were identified. Improved awareness of MSF's clinical features may be the key to an early diagnosis and successful treatment.</p>","PeriodicalId":11721,"journal":{"name":"Epidemiology and Infection","volume":" ","pages":"e37"},"PeriodicalIF":2.5,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11869075/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142876420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Queensland JEV vaccine program response to the 2022 Australian outbreak.","authors":"Angus Misan, Stephen B Lambert, Hai Phung, Megan K Young","doi":"10.1017/S0950268824001730","DOIUrl":"10.1017/S0950268824001730","url":null,"abstract":"<p><p>In 2022, the largest ever virgin soil outbreak of Japanese encephalitis (JE) occurred in Australia resulting in 45 reported human cases of JE, with seven fatalities. Japanese encephalitis virus (JEV) was detected in 84 piggeries across Australia. In response, states implemented targeted vaccination programs for those individuals at the highest risk of JEV exposure. A mixed methods approach, including geospatial mapping of JEV vaccine distribution in Queensland, a case series of Queensland human cases and interviews with Queensland Health staff, assessed the JEV vaccination response program. Five notified human cases were reviewed, with three having occupational outdoor risk and local travel-related exposure. Vaccine coverage ranged from 0 to 7.4 doses per 100 people after 12 months of the program. The highest uptake was in southern Queensland, where 95% of the state's commercial pig population is located. The vaccination program was limited by a heavy reliance on general practitioners, vast geographical distribution of eligible populations, difficulties mobilising and engaging eligible cohorts, and suboptimal One Health collaboration. Population and climate factors make it possible for the virus to become endemic. Targeted vaccination programs remain an important strategy to protect people at the highest risk of exposure, however, program improvements are required to optimize vaccine accessibility.</p>","PeriodicalId":11721,"journal":{"name":"Epidemiology and Infection","volume":"152 ","pages":"e176"},"PeriodicalIF":2.5,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11696590/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142863235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with COVID-19 in-hospital death and COVID-19 vaccine effectiveness against COVID-19 hospitalization in the Philippines during pre-omicron and omicron period: A case-control study (MOTIVATE-P study).","authors":"Takeshi Arashiro, Rontgene Solante, Ana Ria Sayo, Reby Marie Garcia, Marie Kris, Shuichi Suzuki, Greco Mark Malijan, Mary Jane Salazar, Mary Ann Salazar, Abby Ortal-Cruz, Grace Devota Go, Edna Miranda, Michelle Carandang-Cuvin, Joy Potenciano Calayo, Jinho Shin, Martin Hibberd, Koya Ariyoshi, Chris Smith","doi":"10.1017/S0950268824001845","DOIUrl":"10.1017/S0950268824001845","url":null,"abstract":"<p><p>COVID-19 vaccine effectiveness (VE) studies are limited in low- and middle-income countries. A case-control study was conducted among COVID-19 and other pneumonia patients admitted to a hospital in the Philippines during the pre-Omicron and Omicron periods. To elucidate factors associated with in-hospital death, 1782 COVID-19 patients were assessed. To estimate absolute VE for various severe outcomes, 1059 patients were assessed (869 [82.1%] COVID-19 cases; 190 [17.9%] controls). Factors associated with in-hospital death included older age, tuberculosis (adjusted odds ratio [aOR] 2.45 [95% confidence interval {95% CI} 1.69-3.57]), HIV (aOR 3.30 [95% CI 2.03-5.37]), and current smokers (aOR 2.65 [95% CI 1.72-4.10]). Pre-Omicron, the primary series provided high protection within a median of 2 months (hospitalization: 85.4% [95% CI 35.9-96.7%]; oxygen requirement: 91.0% [95% CI 49.4-98.4%]; invasive mechanical ventilation (IMV): 97.0% [95% CI 65.7-99.7%]; death: 96.5% [95% CI 67.1-99.6%]). During Omicron, the primary series provided moderate-high protection within a median of 6-9 months (hospitalization: 70.2% [95% CI 27.0-87.8%]; oxygen requirement: 71.4% [95% CI 29.3-88.4%]; IMV: 72.7% [95% CI -11.6-93.3%]; death: 58.9% [95% CI -82.8-90.8%]). Primary series VE against severe COVID-19 outcomes was consistently high for both pre-Omicron and Omicron in a setting where approximately half of the vaccinees received inactivated vaccines.</p>","PeriodicalId":11721,"journal":{"name":"Epidemiology and Infection","volume":" ","pages":"e18"},"PeriodicalIF":2.5,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11748018/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142863282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A six-year epidemiological study of selected zoonotic abortifacient agents in ovine and caprine foetuses in Türkiye.","authors":"Murat Şevik","doi":"10.1017/S0950268824001699","DOIUrl":"10.1017/S0950268824001699","url":null,"abstract":"<p><p>Abortion is one of the major threats to the livestock industry, and it also poses significant threats to public health since some of the abortifacient agents are considered zoonotic. <i>Chlamydia abortus</i> (<i>C. abortus</i>), <i>Coxiella burnetii</i> (<i>C. burnetii</i>), <i>Listeria monocytogenes</i> (<i>L. monocytogenes</i>), and Cache Valley virus (CVV) are recognized as important zoonotic and abortifacient agents of reproductive failure in small ruminants. This study determined the prevalence of these agents in ovine and caprine foetuses in Türkiye. A total of 1 226 foetuses were collected from the sheep (n = 1 144) and goats (n = 82) from different flocks between 2012 and 2017. Molecular detection methods were used to detect <i>C. abortus</i>, <i>C. burnetii</i>, and <i>L. monocytogenes</i> DNA and CVV RNA in aborted foetuses. In this study, <i>C. abortus</i> was the most prevalent abortifacient agent among the investigated ovine (264/1144) and caprine (12/82) foetuses, followed by <i>C. burnetii</i> with a frequency of 2.8% (32/1144) and 8.5% (7/82) in ovine and caprine foetuses, respectively. <i>L. monocytogenes</i> DNA was detected in 28 (2.4%) and 2 (2.4%) of the ovine and caprine foetuses, respectively. However, CVV RNA was not detected. Although the predominant mixed infection was <i>C. abortus</i> and <i>C. burnetii</i>, mixed infection of <i>C. abortus</i> and <i>L. monocytogenes</i>, and <i>C. burnetii</i> and <i>L. monocytogenes</i> were also found. The information presented in this study contributes to the understanding of the roles of <i>C. abortus</i>, <i>C. burnetii</i>, <i>L. monocytogenes</i>, and CVV in abortions in small ruminants, and could be beneficial for developing more effective control strategies.</p>","PeriodicalId":11721,"journal":{"name":"Epidemiology and Infection","volume":"152 ","pages":"e173"},"PeriodicalIF":2.5,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11696601/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142853556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The epidemiology and healthcare costs of pregnancy-related listeriosis in British Columbia, Canada, 2005-2014.","authors":"Antonela Ilic, Dimitra Panagiotoglou, Eleni Galanis, Marsha Taylor, Zahid A Butt, Shannon E Majowicz","doi":"10.1017/S0950268824001821","DOIUrl":"10.1017/S0950268824001821","url":null,"abstract":"<p><p>This study investigated cases of pregnancy-related listeriosis in British Columbia (BC), Canada, from 2005 to 2014. We described all diagnosed cases in pregnant women (<i>n</i> = 15) and neonates (<i>n</i> = 7), estimated the excess healthcare costs associated with listeriosis, and calculated the fraction of stillbirths attributable to listeriosis, and mask cell sizes 1-5 due to data requirements. Pregnant women had a median gestational age of 31 weeks at listeriosis onset (range: 20-39) and on average delivered at a median of 37 weeks gestation (range: 20-40). Neonates experienced complications but no fatalities. Stillbirths occurred in 1-5 of 15 pregnant women with listeriosis, and very few (0.05-0.24%) of the 2,088 stillbirths in BC in the 10 years were attributed to listeriosis (exact numbers masked). Pregnant women and neonates with listeriosis had significantly more hospital visits, days in the hospital and physician visits than those without listeriosis. Pregnant women with listeriosis had 2.59 times higher mean total healthcare costs during their pregnancy, and neonates with listeriosis had 9.85 times higher mean total healthcare costs during their neonatal period, adjusting for various factors. Despite small case numbers and no reported deaths, these results highlight the substantial additional health service use and costs associated with individual cases of pregnancy-related listeriosis in BC.</p>","PeriodicalId":11721,"journal":{"name":"Epidemiology and Infection","volume":" ","pages":"e7"},"PeriodicalIF":2.5,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11704930/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recurring bacterial strains, subclusters, and the importance of practising lessons learned.","authors":"Craig W Hedberg, Melanie J Firestone, Jeff B Bender","doi":"10.1017/S0950268824001195","DOIUrl":"10.1017/S0950268824001195","url":null,"abstract":"","PeriodicalId":11721,"journal":{"name":"Epidemiology and Infection","volume":"152 ","pages":"e171"},"PeriodicalIF":2.5,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11696593/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142827386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of SARS-CoV-2 infection and COVID-19 vaccination during pregnancy on neonatal outcomes.","authors":"Anne J Huiberts, Ilse J Oosting, Hester E de Melker, Janneke H H M van de Wijgert, Diederick E Grobbee, Susan van den Hof, Mirjam J Knol","doi":"10.1017/S0950268824001766","DOIUrl":"10.1017/S0950268824001766","url":null,"abstract":"<p><p>This study explored the effect of SARS-CoV-2 infection and COVID-19 vaccination during pregnancy on neonatal outcomes among women from the general Dutch population. VASCO is an ongoing prospective cohort study aimed at assessing vaccine effectiveness of COVID-19 vaccination. Pregnancy status was reported at baseline and through regular follow-up questionnaires. As an extension to the main study, all female participants who reported to have been pregnant between enrolment (May-December 2021) and January 2023 were requested to complete an additional questionnaire on neonatal outcomes. Multivariable linear and logistic regression analyses were used to determine the associations between self-reported SARS-CoV-2 infection or COVID-19 vaccination during pregnancy and neonatal outcomes, adjusted for age, educational level, and presence of a medical risk condition. Infection analyses were additionally adjusted for COVID-19 vaccination before and during pregnancy, and vaccination analyses for SARS-CoV-2 infection before and during pregnancy. Of 312 eligible participants, 232 (74%) completed the questionnaire. In total, 196 COVID-19 vaccinations and 115 SARS-CoV-2 infections during pregnancy were reported. Infections were mostly first infections (86; 75%), caused by the Omicron variant (95; 83%), in women who had received ≥1 vaccination prior to infection (101; 88%). SARS-CoV-2 infection during pregnancy was not significantly associated with gestational age (<i>β</i> = 1.7; 95%CI: -1.6-5.0), birth weight (<i>β</i> = 82; -59 to 223), Apgar score <9 (odds ratio (OR): 1.3; 0.6-2.9), postpartum hospital stay (OR: 1.0; 0.6-1.8), or neonatal intensive care unit admission (OR: 0.8; 0.2-3.2). COVID-19 vaccination during pregnancy was not significantly associated with gestational age (<i>β</i> = -0.4; -4.0 to 3.2), birth weight (<i>β</i> = 88; -64 to 240), Apgar score <9 (OR: 0.9; 0.4-2.3), postpartum hospital stay (OR: 0.9; 0.5-1.7), or neonatal intensive care unit admission (OR: 1.6; 0.4-8.6). In conclusion, this study did not find an effect of SARS-CoV-2 infection or COVID-19 vaccination during pregnancy on any of the studied neonatal outcomes among a general Dutch, largely vaccinated, population. Together with data from other studies, this supports the safety of COVID-19 vaccination during pregnancy.</p>","PeriodicalId":11721,"journal":{"name":"Epidemiology and Infection","volume":" ","pages":"e5"},"PeriodicalIF":2.5,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11704939/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142827381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}