Environmental Health and Preventive Medicine最新文献

{"title":"The association between maternal social support levels during pregnancy and child development at three years of age: the Japan Environment and Children's Study.","authors":"Yousuke Imanishi, Satoyo Ikehara, Yuri Aochi, Tomotaka Sobue, Hiroyasu Iso","doi":"10.1265/ehpm.23-00211","DOIUrl":"10.1265/ehpm.23-00211","url":null,"abstract":"<p><strong>Background: </strong>Social relationships are essential in maintaining the physical and mental health of mothers and their children. However, there is limited evidence on how social support provided to the mother during pregnancy could impact child development. Herein, we examined whether maternal social support levels during pregnancy was associated with the risk of developmental delay in 3-year-old children.</p><p><strong>Methods: </strong>Overall, 68,442 mother-child pairs completed questionnaires on maternal social support during pregnancy and development delay in 3-year-old children. The maternal social support level was evaluated using four items. The risk of development delay was evaluated using the Japanese version of the Ages and Stages Questionnaire-3 (ASQ-3) with five domains of communication, gross motor, fine motor, problem-solving, and personal-social. Odds ratios (OR) and 95% confidence intervals (CI) were calculated using logistic regression according to the quintiles of maternal social support levels after adjusting for potential confounding factors.</p><p><strong>Results: </strong>Social support during pregnancy was associated with a lower risk of development delay at 3 years of age. Beneficial effects were detected in all domains of the ASQ-3 (p for trend <0.001). Multivariable ORs (95% CIs) for the highest versus lowest quartiles of maternal social support level were 0.57 (0.50-0.65) for communication, 0.49 (0.43-0.55) for gross motor delay, 0.58 (0.53-0.64) for fine motor delay, 0.56 (0.51-0.62) for problem-solving delay, and 0.52 (0.45-0.60) for personal social delay. The associations remained unchanged when stratified by maternal education level, paternal education level, living with children, household income, and postpartum depression.</p><p><strong>Conclusion: </strong>Maternal social support during pregnancy was inversely associated with the risk of developmental delay at 3 years of age.</p>","PeriodicalId":11707,"journal":{"name":"Environmental Health and Preventive Medicine","volume":"29 ","pages":"18"},"PeriodicalIF":4.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10965412/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140179478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic syndrome and depression: evidence from a cross-sectional study of real-world data in Japan.","authors":"Kumi Sugimoto, Takuya Yamada, Atsushi Kitazawa, Yoshiharu Fukuda","doi":"10.1265/ehpm.23-00369","DOIUrl":"10.1265/ehpm.23-00369","url":null,"abstract":"<p><strong>Background: </strong>Both metabolic syndrome (MetS) and depression are high priority health problems, especially for working age. Numerous studies have explored the link between metabolic syndrome and depression; however, not all of them have consistently demonstrated an association. The objective of this study was to determine whether there is an association between MetS and depression by analyzing extensive real-world data (RWD).</p><p><strong>Methods: </strong>Our data was drawn from insurance claims and health checkups of local government officials across all prefectures in Japan except for Tokyo in the 2019 fiscal year. According to the number of months with diagnosis of depression and prescription of antidepressants, the study participants were classified into the following categories: Certainly not Depression (CN), Possibly not Depression (PN), Possible Depression (PD), and Certain Depression (CD). Associations between MetS and its components-visceral obesity, hypertension, hyperlipidemia, and diabetes- and these categories of depression were analyzed by logistic regression.</p><p><strong>Results: </strong>The depression categories of the 130,059 participants were as follows: CN 85.2%; PN 6.9%; PD 3.9%; and CD 4.1%. For men, the adjusted odds ratio (AOR) for MetS were PN 0.94 (95% CI: 0.86-1.02), PD 1.31 (1.19-1.43), and CD 1.63 (1.50-1.76), with reference to CN. For women, AOR of MetS were PN 1.10 (0.91-1.32), PD 1.54 (1.24-1.91), and CD 2.24 (1.81-2.78). Among the MetS components, visceral obesity, hyperlipidemia, and diabetes were significantly associated with depression categories.</p><p><strong>Conclusions: </strong>In this study, we found a significant association between MetS and depression, this association being similar to that previously reported. Our findings provide robust evidence for linkage between MetS and depression, suggesting that analysis of RWD is useful for providing concrete evidence.</p>","PeriodicalId":11707,"journal":{"name":"Environmental Health and Preventive Medicine","volume":"29 ","pages":"33"},"PeriodicalIF":4.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11240112/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141497484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emergency transportation for acute alcohol intoxication four years after the coronavirus disease 2019 pandemic: a retrospective observational study.","authors":"Marina Minami, Natsuko Nakamura, Masamitsu Eitoku, Atsufumi Kawauchi, Takeshi Murakami, Narufumi Suganuma, Kingo Nishiyama, Masato Miyauchi","doi":"10.1265/ehpm.24-00182","DOIUrl":"10.1265/ehpm.24-00182","url":null,"abstract":"<p><strong>Background: </strong>In a study conducted in Kochi Prefecture, Shikoku, Japan, during the early stages of the pandemic in spring 2020, we found that emergency transportations due to acute alcohol intoxication decreased. We aimed to determine how the decline in the number of emergency transportations due to acute alcohol intoxication changed during the four years following the COVID-19 pandemic's onset.</p><p><strong>Methods: </strong>This study used data of 107,013 emergency transportations from the Kochi-Iryo-Net database, Kochi Prefecture's emergency medical and wide-area disaster information system. We categorized emergency transportation cases according to the diagnoses entered into the system by the attending physician, which were then divided into alcohol- and non-alcohol-related intoxication cases based on the diagnostic codes in the International Classification of Diseases Manual, 10th edition, Clinical Modification. We performed chi-square tests and multiple logistic regression to examine the association between emergency transportations and acute alcohol intoxication.</p><p><strong>Results: </strong>The number of emergency transportations due to acute alcohol intoxication was 412 (1.8%) in 2019, and it declined to 268 (1.4%), 248 (1.2%), 270 (1.2%), and 283 (1.3%) in 2020, 2021, 2022, and 2023, respectively. After adjusting for confounding factors such as fire department and age, a significant decrease was observed in the subsequent years compared with 2019 (2020: adjusted odds ratio, 0.79; 95% confidence interval, 0.68-0.93; 2021: adjusted odds ratio, 0.74; 95% confidence interval, 0.63-0.87; 2022: adjusted odds ratio, 0.73; 95% confidence interval, 0.62-0.85; 2023: adjusted odds ratio, 0.76; 95% confidence interval, 0.65-0.89).</p><p><strong>Conclusions: </strong>This study examined changes in emergency transportation due to acute alcohol intoxication during and after the COVID-19 pandemic, especially when social events and other activities returned to \"normal.\" Compared with 2021, which was when emergency transportations due to acute alcohol intoxication were at their lowest, a slight increase was observed in the number of transportations in subsequent years.</p>","PeriodicalId":11707,"journal":{"name":"Environmental Health and Preventive Medicine","volume":"29 ","pages":"53"},"PeriodicalIF":4.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11473389/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142389004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between excessive screen time and school-level proportion of no family rules among elementary school children in Japan: a multilevel analysis.","authors":"Masaaki Yamada, Michikazu Sekine, Takashi Tatsuse","doi":"10.1265/ehpm.23-00268","DOIUrl":"10.1265/ehpm.23-00268","url":null,"abstract":"<p><strong>Background: </strong>Excessive screen time (ST) in children is a global concern. We assessed the association between individual- and school-level factors and excessive ST in Japanese children using a multilevel analysis.</p><p><strong>Methods: </strong>A school-based cross-sectional study was conducted in Toyama, Japan in 2018. From 110 elementary schools in Toyama Prefecture, 13,413 children in the 4th-6th grades (boys, 50.9%; mean, 10.5 years old) participated. We assessed lifestyle, recreational ST (not for study use), psychological status, and school and family environment including family rules. We defined ≥3 hours ST as excessive. We calculated the school-level proportions of no family rules and divided them into four categories (<20%, 20% to <30%, 30% to <40%, and ≥40%). A modified multilevel Poisson regression analysis was performed.</p><p><strong>Results: </strong>In total, 12,611 children were included in the analysis (94.0%). The average school-level proportion of those with no family rules was 32.1% (SD = 9.6). The prevalence of excessive ST was 29.9% (34.9% in boys; 24.8% in girls). The regression analysis showed that excessive ST was significantly associated with both individual-level factors, such as boys (adjusted prevalence ratio (aPR); 1.39), older grades (aPR; 1.18 for 5th grades and 1.28 for 6th grades), late wakeup (aPR; 1.13), physical inactivity (aPR; 1.18 for not so much and 1.31 for rarely), late bedtime (aPR; 1.43 for 10 to 11 p.m. and 1.76 for ≥11 p.m.), frequent irritability (aPR; 1.24 for sometimes and 1.46 for often), feelings of school avoidance (aPR; 1.17 for sometimes and 1.22 for often), infrequent child-parental interaction (aPR; 1.16 for rare and 1.21 for none), no family rules (aPR; 1.56), smartphone ownership (aPR; 1.18), and the school-level proportion of no family rules (aPR; 1.20 for 20% to <30%, 1.29 for 30% to <40%, and 1.43 for ≥40%, setting <20% as reference).</p><p><strong>Conclusion: </strong>Besides individual factors, a higher school-level proportion of no family rules seemed influential on excessive ST. Increasing the number of households with family rules and addressing individual factors, could be deterrents against excessive ST in children.</p>","PeriodicalId":11707,"journal":{"name":"Environmental Health and Preventive Medicine","volume":"29 ","pages":"16"},"PeriodicalIF":4.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10957336/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140142968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interaction between CYP1A1 gene polymorphism and environment factors on risk of endometrial cancer.","authors":"Jian Xu, Cheng Tan","doi":"10.1265/ehpm.24-00007","DOIUrl":"10.1265/ehpm.24-00007","url":null,"abstract":"<p><strong>Background: </strong>The purpose of this study was to investigate the impact of single nucleotide polymorphisms (SNPs) of the CYP1A1 gene and the gene-environment interaction on the susceptibility to endometrial cancer in Chinese women.</p><p><strong>Method: </strong>Logistic regression was performed to investigate the association between the four SNPs of the CYP1A1 gene and the risk of endometrial cancer. Generalized multifactor dimensionality reduction (GMDR) was employed to analyze the gene-environmental interaction.</p><p><strong>Results: </strong>A total of 934 women with a mean age of 61.7 ± 10.5 years were selected, including 310 endometrial cancer patients and 624 normal controls. The frequency of rs4646421- T allele was higher in endometrial cancer patients than normal controls, the T allele of rs4646421 was 28.1% in endometrial cancer patients and 21.0% in normal controls (p < 0.001). Logistic regression analysis showed that the rs4646421 - T allele was associated with increased risk of endometrial cancer, OR (95% CI) were 1.52 (1.11-1.97) and 1.91 (1.35-2.52), respectively. GMDR analysis found a significant two-locus model (p = 0.0107) involving rs4646421 and abdominal obesity (defined by waist circumference), indicating a potential gene-environment interaction between rs4646421 and abdominal obesity. Abdominal obese subjects with rs4646421- CT or TT genotype have the highest risk of endometrial cancer, compared to non-abdominal obese subjects with the rs4646421- CC genotype, the OR (95%CI) was 2.23 (1.62-2.91).</p><p><strong>Conclusions: </strong>Both the rs4646421- T allele and the interaction between rs4646421 and abdominal obesity were associated with increased risk of endometrial cancer.</p>","PeriodicalId":11707,"journal":{"name":"Environmental Health and Preventive Medicine","volume":"29 ","pages":"54"},"PeriodicalIF":4.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11473388/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142389005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal association between frequency of Internet use and incident disability among community-dwelling older people during the COVID-19 pandemic.","authors":"Kimiko Tomioka, Midori Shima, Keigo Saeki","doi":"10.1265/ehpm.23-00207","DOIUrl":"10.1265/ehpm.23-00207","url":null,"abstract":"<p><strong>Background: </strong>There is limited evidence of a protective effect of Internet use for incident disability (ID) during the COVID-19 pandemic. We investigated the association between frequency of Internet use (FIU) and ID among community-dwelling older people.</p><p><strong>Methods: </strong>We used longitudinal data from the 2019 and 2022 surveys, including 7,913 residents aged ≥65 without disability at baseline. ID was defined as a new public long-term care insurance certification. FIU at baseline was categorized into daily, weekly, monthly, yearly, and non-users. Changes in FIU before and during the COVID-19 pandemic were categorized into continuing frequent (i.e., daily or weekly), continuing moderate (i.e., monthly or yearly), increase in frequency, from non-users to users, decrease in frequency, from users to non-users, and continuing non-users. Covariates included age, gender, education, perceived economic situation, family structure, body mass index, chronic medical conditions, dietary variety, working status, walking time, and cognitive functioning. Multivariable Poisson regression models were used to estimate adjusted cumulative incidence ratio (aCIR) and 95% confidence interval (CI) for ID.</p><p><strong>Results: </strong>During the 3-year follow-up, 132 of 4,453 people aged 65-74, 595 of 3,460 people aged ≥75, 287 of 3,660 men, and 440 of 4,253 women developed ID. For FIU at baseline, among people aged ≥75 or men, there was a dose-response relationship between more frequent Internet use at baseline and a lower risk of ID (P-trend was 0.005 in people aged ≥75, and <0.001 in men). Compared to non-users, daily users had a significantly lower risk of ID [aCIR (95% CI) = 0.69 (0.53-0.90) in people aged ≥75, and 0.49 (0.34-0.70) in men]. For changes in FIU, \"continuing frequent\" and \"from non-users to users\" had a lower risk of ID than continuing non-users. After stratified analyses, \"continuing frequent\" remained a significant association in people aged ≥75 or in men, while \"from non-users to users\" had a significant association in those with daily walking time <30 minutes.</p><p><strong>Conclusions: </strong>Although FIU may act as a marker of disability, or indicate individual adaptability, our findings suggest that Internet use may be a potential preventive measure against ID in community-dwelling older people when social distancing is required.</p>","PeriodicalId":11707,"journal":{"name":"Environmental Health and Preventive Medicine","volume":"29 ","pages":"13"},"PeriodicalIF":4.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10937244/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140049023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mask use in Chinese children admitted to the outpatient department: a single-center cross-sectional study.","authors":"Qian Yang, Jin Yu Chen, Qi Jiang, Yan Fang Zhang, Dao Ting Li, Cai Yun Xia, Ying Cai, Man Man Niu, Jin Wei Ruan, Peng Hu","doi":"10.1265/ehpm.24-00106","DOIUrl":"10.1265/ehpm.24-00106","url":null,"abstract":"<p><strong>Background: </strong>Mask use is a critical precaution to prevent the transmission of SARS-CoV-2 in a crowded or densely populated indoor environment. There is still a lack of large-sample studies on mask use in children during the COVID-19 pandemic.</p><p><strong>Methods: </strong>A questionnaire was distributed to individuals under 18 years of age from the pediatric outpatient department from November 2021 to May 2022. Participants who were willing to be interviewed and had good communication and judgment skills participated in our study.</p><p><strong>Results: </strong>5053 (a boy-to-girl ratio of 1.13:1 and a median age of 5 years) from 6200 individuals admitted to the pediatric outpatient department were enrolled in the study. The mask-wearing time increased in parallel with age. Children aged 3-5 years wore masks more correctly (χ² = 41.591, P < 0.05), complained more about the discomfort (χ² = 193.871, P < 0.05), and their parents/caregivers were significantly better aware of the preventive effect of masks on respiratory disease (χ² = 19.501, P < 0.05) than parents/caregivers of other age groups. Masks designed for children were more used by those aged 3-5 years in outdoor settings. The commonest adverse events of mask-wearing were respiratory symptoms (61.2%), followed by dermatological symptoms (28.9%) and psychological symptoms (19.7%). Girls wore masks for a longer time and more correctly (χ² = 10.598, P < 0.05) than boys. Compared with the pre-COVID-19 pandemic, wearing masks could significantly decrease the median frequency of respiratory infections during the COVID-19 pandemic (2[1-4] vs 3[2-4]; z = -2.692, P < 0.05).</p><p><strong>Conclusions: </strong>Wearing proper and well-fitted masks could significantly protect children from respiratory infections in a crowded or densely populated indoor environment during the COVID-19 pandemic. However, mask-associated adverse events, particularly in psychological symptoms, are needed to draw adequate attention, calling for early identifications and psychological interventions.</p>","PeriodicalId":11707,"journal":{"name":"Environmental Health and Preventive Medicine","volume":"29 ","pages":"60"},"PeriodicalIF":4.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11551440/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142575807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seasonal variations of the prevalence of metabolic syndrome and its markers using big-data of health check-ups.","authors":"Hiroe Seto, Hiroshi Toki, Shuji Kitora, Asuka Oyama, Ryohei Yamamoto","doi":"10.1265/ehpm.23-00216","DOIUrl":"10.1265/ehpm.23-00216","url":null,"abstract":"<p><strong>Background: </strong>It is crucial to understand the seasonal variation of Metabolic Syndrome (MetS) for the detection and management of MetS. Previous studies have demonstrated the seasonal variations in MetS prevalence and its markers, but their methods are not robust. To clarify the concrete seasonal variations in the MetS prevalence and its markers, we utilized a powerful method called Seasonal Trend Decomposition Procedure based on LOESS (STL) and a big dataset of health checkups.</p><p><strong>Methods: </strong>A total of 1,819,214 records of health checkups (759,839 records for men and 1,059,375 records for women) between April 2012 and December 2017 were included in this study. We examined the seasonal variations in the MetS prevalence and its markers using 5 years and 9 months health checkup data and STL analysis. MetS markers consisted of waist circumference (WC), systolic blood pressure (SBP), diastolic blood pressure (DBP), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), fasting plasma glucose (FPG).</p><p><strong>Results: </strong>We found that the MetS prevalence was high in winter and somewhat high in August. Among men, MetS prevalence was 2.64 ± 0.42 (mean ± SD) % higher in the highest month (January) than in the lowest month (June). Among women, MetS prevalence was 0.53 ± 0.24% higher in the highest month (January) than in the lowest month (June). Additionally, SBP, DBP, and HDL-C exhibited simple variations, being higher in winter and lower in summer, while WC, TG, and FPG displayed more complex variations.</p><p><strong>Conclusions: </strong>This finding, complex seasonal variations of MetS prevalence, WC, TG, and FPG, could not be derived from previous studies using just the mean values in spring, summer, autumn and winter or the cosinor analysis. More attention should be paid to factors affecting seasonal variations of central obesity, dyslipidemia and insulin resistance.</p>","PeriodicalId":11707,"journal":{"name":"Environmental Health and Preventive Medicine","volume":"29 ","pages":"2"},"PeriodicalIF":4.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10808004/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139512124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Challenges in health risk assessment of multiple chemical exposures in epidemiological studies.","authors":"Chiharu Tohyama, Yasushi Honda","doi":"10.1265/ehpm.23-00312","DOIUrl":"10.1265/ehpm.23-00312","url":null,"abstract":"","PeriodicalId":11707,"journal":{"name":"Environmental Health and Preventive Medicine","volume":"29 ","pages":"6"},"PeriodicalIF":4.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10898861/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139702136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A decrease in serum dihydrotestosterone levels in 9-year-old Vietnamese children from a dioxin exposure area.","authors":"Oanh Thi Phuong Nguyen, Seijiro Honma, Phuc Duc Hoang, Khanh Van Nguyen, Anh Thai Le, Shoji F Nakayama, Manh Dung Ho, Viet Hoang Nguyen, Tung Van Dao, Nhu Duc Dang, Tan Thi Minh Ngo, Thuc Van Pham, Toan Van Ngo, Chi Van Vo, Hideaki Nakagawa, Teruhiko Kido","doi":"10.1265/ehpm.24-00190","DOIUrl":"10.1265/ehpm.24-00190","url":null,"abstract":"<p><strong>Background: </strong>Dioxin is an environmental pollutant as well as an endocrine disruptor in humans. Our longitudinal study wants to clarify the relationship between dioxin exposure and endocrine disorders in children living in the Vietnamese dioxin hotspot.</p><p><strong>Method: </strong>Seventeen congeners of polychlorinated dibenzo-p-dioxins/polychlorinated dibenzo-furans (PCDDs/PCDFs) in maternal breast milk and seven serum steroid hormones in children of 43 and 46 mothers and their 9-year-old children from the non-exposure and the hotspot areas were measured, respectively. The steroid metabolic enzyme ratios were calculated based on the hormone level ratio.</p><p><strong>Results: </strong>Most dioxin/furan congeners and toxic equivalents (TEQs) levels were significantly higher in the hotspot than in the non-exposure area, except for 2,4,7,8-TeCDF. The height and weight of girls from the hotspot area were substantially lower and inversely correlated with dioxin congener levels/total TEQs level dioxin. The dihydrotestosterone (DHT) levels in the hotspot were markedly lower than those in non-exposed in both genders. The cortisol concentrations were significantly higher in the hotspot than those from the non-exposure area only in the girls. The DHT/testosterone ratios that exhibited the 5α- or 5β-reductase activity declined by 50% in the hotspot area for both genders. The DHT levels showed strong inverse correlations with almost the PCDDs/PCDFs congeners and total TEQs dioxin in breast milk.</p><p><strong>Conclusions: </strong>This finding suggests that dioxin exposure in maternal breast milk might impact children's endocrine system until 9 years old, especially on the DHT biosynthesis.</p>","PeriodicalId":11707,"journal":{"name":"Environmental Health and Preventive Medicine","volume":"29 ","pages":"58"},"PeriodicalIF":4.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11524748/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142516358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}