Environmental Health and Preventive Medicine最新文献

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Emergency transportation for acute alcohol intoxication four years after the coronavirus disease 2019 pandemic: a retrospective observational study. 2019年冠状病毒病大流行四年后急性酒精中毒的紧急转运:一项回顾性观察研究。
IF 4 3区 医学
Environmental Health and Preventive Medicine Pub Date : 2024-01-01 DOI: 10.1265/ehpm.24-00182
Marina Minami, Natsuko Nakamura, Masamitsu Eitoku, Atsufumi Kawauchi, Takeshi Murakami, Narufumi Suganuma, Kingo Nishiyama, Masato Miyauchi
{"title":"Emergency transportation for acute alcohol intoxication four years after the coronavirus disease 2019 pandemic: a retrospective observational study.","authors":"Marina Minami, Natsuko Nakamura, Masamitsu Eitoku, Atsufumi Kawauchi, Takeshi Murakami, Narufumi Suganuma, Kingo Nishiyama, Masato Miyauchi","doi":"10.1265/ehpm.24-00182","DOIUrl":"10.1265/ehpm.24-00182","url":null,"abstract":"<p><strong>Background: </strong>In a study conducted in Kochi Prefecture, Shikoku, Japan, during the early stages of the pandemic in spring 2020, we found that emergency transportations due to acute alcohol intoxication decreased. We aimed to determine how the decline in the number of emergency transportations due to acute alcohol intoxication changed during the four years following the COVID-19 pandemic's onset.</p><p><strong>Methods: </strong>This study used data of 107,013 emergency transportations from the Kochi-Iryo-Net database, Kochi Prefecture's emergency medical and wide-area disaster information system. We categorized emergency transportation cases according to the diagnoses entered into the system by the attending physician, which were then divided into alcohol- and non-alcohol-related intoxication cases based on the diagnostic codes in the International Classification of Diseases Manual, 10th edition, Clinical Modification. We performed chi-square tests and multiple logistic regression to examine the association between emergency transportations and acute alcohol intoxication.</p><p><strong>Results: </strong>The number of emergency transportations due to acute alcohol intoxication was 412 (1.8%) in 2019, and it declined to 268 (1.4%), 248 (1.2%), 270 (1.2%), and 283 (1.3%) in 2020, 2021, 2022, and 2023, respectively. After adjusting for confounding factors such as fire department and age, a significant decrease was observed in the subsequent years compared with 2019 (2020: adjusted odds ratio, 0.79; 95% confidence interval, 0.68-0.93; 2021: adjusted odds ratio, 0.74; 95% confidence interval, 0.63-0.87; 2022: adjusted odds ratio, 0.73; 95% confidence interval, 0.62-0.85; 2023: adjusted odds ratio, 0.76; 95% confidence interval, 0.65-0.89).</p><p><strong>Conclusions: </strong>This study examined changes in emergency transportation due to acute alcohol intoxication during and after the COVID-19 pandemic, especially when social events and other activities returned to \"normal.\" Compared with 2021, which was when emergency transportations due to acute alcohol intoxication were at their lowest, a slight increase was observed in the number of transportations in subsequent years.</p>","PeriodicalId":11707,"journal":{"name":"Environmental Health and Preventive Medicine","volume":"29 ","pages":"53"},"PeriodicalIF":4.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11473389/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142389004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between excessive screen time and school-level proportion of no family rules among elementary school children in Japan: a multilevel analysis. 日本小学生屏幕时间过长与学校层面无家规比例之间的关系:多层次分析。
IF 4.7 3区 医学
Environmental Health and Preventive Medicine Pub Date : 2024-01-01 DOI: 10.1265/ehpm.23-00268
Masaaki Yamada, Michikazu Sekine, Takashi Tatsuse
{"title":"Association between excessive screen time and school-level proportion of no family rules among elementary school children in Japan: a multilevel analysis.","authors":"Masaaki Yamada, Michikazu Sekine, Takashi Tatsuse","doi":"10.1265/ehpm.23-00268","DOIUrl":"10.1265/ehpm.23-00268","url":null,"abstract":"<p><strong>Background: </strong>Excessive screen time (ST) in children is a global concern. We assessed the association between individual- and school-level factors and excessive ST in Japanese children using a multilevel analysis.</p><p><strong>Methods: </strong>A school-based cross-sectional study was conducted in Toyama, Japan in 2018. From 110 elementary schools in Toyama Prefecture, 13,413 children in the 4th-6th grades (boys, 50.9%; mean, 10.5 years old) participated. We assessed lifestyle, recreational ST (not for study use), psychological status, and school and family environment including family rules. We defined ≥3 hours ST as excessive. We calculated the school-level proportions of no family rules and divided them into four categories (<20%, 20% to <30%, 30% to <40%, and ≥40%). A modified multilevel Poisson regression analysis was performed.</p><p><strong>Results: </strong>In total, 12,611 children were included in the analysis (94.0%). The average school-level proportion of those with no family rules was 32.1% (SD = 9.6). The prevalence of excessive ST was 29.9% (34.9% in boys; 24.8% in girls). The regression analysis showed that excessive ST was significantly associated with both individual-level factors, such as boys (adjusted prevalence ratio (aPR); 1.39), older grades (aPR; 1.18 for 5th grades and 1.28 for 6th grades), late wakeup (aPR; 1.13), physical inactivity (aPR; 1.18 for not so much and 1.31 for rarely), late bedtime (aPR; 1.43 for 10 to 11 p.m. and 1.76 for ≥11 p.m.), frequent irritability (aPR; 1.24 for sometimes and 1.46 for often), feelings of school avoidance (aPR; 1.17 for sometimes and 1.22 for often), infrequent child-parental interaction (aPR; 1.16 for rare and 1.21 for none), no family rules (aPR; 1.56), smartphone ownership (aPR; 1.18), and the school-level proportion of no family rules (aPR; 1.20 for 20% to <30%, 1.29 for 30% to <40%, and 1.43 for ≥40%, setting <20% as reference).</p><p><strong>Conclusion: </strong>Besides individual factors, a higher school-level proportion of no family rules seemed influential on excessive ST. Increasing the number of households with family rules and addressing individual factors, could be deterrents against excessive ST in children.</p>","PeriodicalId":11707,"journal":{"name":"Environmental Health and Preventive Medicine","volume":"29 ","pages":"16"},"PeriodicalIF":4.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10957336/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140142968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interaction between CYP1A1 gene polymorphism and environment factors on risk of endometrial cancer. CYP1A1 基因多态性与环境因素对子宫内膜癌风险的相互作用
IF 4 3区 医学
Environmental Health and Preventive Medicine Pub Date : 2024-01-01 DOI: 10.1265/ehpm.24-00007
Jian Xu, Cheng Tan
{"title":"Interaction between CYP1A1 gene polymorphism and environment factors on risk of endometrial cancer.","authors":"Jian Xu, Cheng Tan","doi":"10.1265/ehpm.24-00007","DOIUrl":"10.1265/ehpm.24-00007","url":null,"abstract":"<p><strong>Background: </strong>The purpose of this study was to investigate the impact of single nucleotide polymorphisms (SNPs) of the CYP1A1 gene and the gene-environment interaction on the susceptibility to endometrial cancer in Chinese women.</p><p><strong>Method: </strong>Logistic regression was performed to investigate the association between the four SNPs of the CYP1A1 gene and the risk of endometrial cancer. Generalized multifactor dimensionality reduction (GMDR) was employed to analyze the gene-environmental interaction.</p><p><strong>Results: </strong>A total of 934 women with a mean age of 61.7 ± 10.5 years were selected, including 310 endometrial cancer patients and 624 normal controls. The frequency of rs4646421- T allele was higher in endometrial cancer patients than normal controls, the T allele of rs4646421 was 28.1% in endometrial cancer patients and 21.0% in normal controls (p < 0.001). Logistic regression analysis showed that the rs4646421 - T allele was associated with increased risk of endometrial cancer, OR (95% CI) were 1.52 (1.11-1.97) and 1.91 (1.35-2.52), respectively. GMDR analysis found a significant two-locus model (p = 0.0107) involving rs4646421 and abdominal obesity (defined by waist circumference), indicating a potential gene-environment interaction between rs4646421 and abdominal obesity. Abdominal obese subjects with rs4646421- CT or TT genotype have the highest risk of endometrial cancer, compared to non-abdominal obese subjects with the rs4646421- CC genotype, the OR (95%CI) was 2.23 (1.62-2.91).</p><p><strong>Conclusions: </strong>Both the rs4646421- T allele and the interaction between rs4646421 and abdominal obesity were associated with increased risk of endometrial cancer.</p>","PeriodicalId":11707,"journal":{"name":"Environmental Health and Preventive Medicine","volume":"29 ","pages":"54"},"PeriodicalIF":4.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11473388/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142389005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Longitudinal association between frequency of Internet use and incident disability among community-dwelling older people during the COVID-19 pandemic. 在 COVID-19 大流行期间,社区老年人使用互联网的频率与残疾事件之间的纵向联系。
IF 4 3区 医学
Environmental Health and Preventive Medicine Pub Date : 2024-01-01 DOI: 10.1265/ehpm.23-00207
Kimiko Tomioka, Midori Shima, Keigo Saeki
{"title":"Longitudinal association between frequency of Internet use and incident disability among community-dwelling older people during the COVID-19 pandemic.","authors":"Kimiko Tomioka, Midori Shima, Keigo Saeki","doi":"10.1265/ehpm.23-00207","DOIUrl":"10.1265/ehpm.23-00207","url":null,"abstract":"<p><strong>Background: </strong>There is limited evidence of a protective effect of Internet use for incident disability (ID) during the COVID-19 pandemic. We investigated the association between frequency of Internet use (FIU) and ID among community-dwelling older people.</p><p><strong>Methods: </strong>We used longitudinal data from the 2019 and 2022 surveys, including 7,913 residents aged ≥65 without disability at baseline. ID was defined as a new public long-term care insurance certification. FIU at baseline was categorized into daily, weekly, monthly, yearly, and non-users. Changes in FIU before and during the COVID-19 pandemic were categorized into continuing frequent (i.e., daily or weekly), continuing moderate (i.e., monthly or yearly), increase in frequency, from non-users to users, decrease in frequency, from users to non-users, and continuing non-users. Covariates included age, gender, education, perceived economic situation, family structure, body mass index, chronic medical conditions, dietary variety, working status, walking time, and cognitive functioning. Multivariable Poisson regression models were used to estimate adjusted cumulative incidence ratio (aCIR) and 95% confidence interval (CI) for ID.</p><p><strong>Results: </strong>During the 3-year follow-up, 132 of 4,453 people aged 65-74, 595 of 3,460 people aged ≥75, 287 of 3,660 men, and 440 of 4,253 women developed ID. For FIU at baseline, among people aged ≥75 or men, there was a dose-response relationship between more frequent Internet use at baseline and a lower risk of ID (P-trend was 0.005 in people aged ≥75, and <0.001 in men). Compared to non-users, daily users had a significantly lower risk of ID [aCIR (95% CI) = 0.69 (0.53-0.90) in people aged ≥75, and 0.49 (0.34-0.70) in men]. For changes in FIU, \"continuing frequent\" and \"from non-users to users\" had a lower risk of ID than continuing non-users. After stratified analyses, \"continuing frequent\" remained a significant association in people aged ≥75 or in men, while \"from non-users to users\" had a significant association in those with daily walking time <30 minutes.</p><p><strong>Conclusions: </strong>Although FIU may act as a marker of disability, or indicate individual adaptability, our findings suggest that Internet use may be a potential preventive measure against ID in community-dwelling older people when social distancing is required.</p>","PeriodicalId":11707,"journal":{"name":"Environmental Health and Preventive Medicine","volume":"29 ","pages":"13"},"PeriodicalIF":4.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10937244/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140049023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mask use in Chinese children admitted to the outpatient department: a single-center cross-sectional study. 门诊部收治的中国儿童口罩使用情况:一项单中心横断面研究。
IF 4 3区 医学
Environmental Health and Preventive Medicine Pub Date : 2024-01-01 DOI: 10.1265/ehpm.24-00106
Qian Yang, Jin Yu Chen, Qi Jiang, Yan Fang Zhang, Dao Ting Li, Cai Yun Xia, Ying Cai, Man Man Niu, Jin Wei Ruan, Peng Hu
{"title":"Mask use in Chinese children admitted to the outpatient department: a single-center cross-sectional study.","authors":"Qian Yang, Jin Yu Chen, Qi Jiang, Yan Fang Zhang, Dao Ting Li, Cai Yun Xia, Ying Cai, Man Man Niu, Jin Wei Ruan, Peng Hu","doi":"10.1265/ehpm.24-00106","DOIUrl":"10.1265/ehpm.24-00106","url":null,"abstract":"<p><strong>Background: </strong>Mask use is a critical precaution to prevent the transmission of SARS-CoV-2 in a crowded or densely populated indoor environment. There is still a lack of large-sample studies on mask use in children during the COVID-19 pandemic.</p><p><strong>Methods: </strong>A questionnaire was distributed to individuals under 18 years of age from the pediatric outpatient department from November 2021 to May 2022. Participants who were willing to be interviewed and had good communication and judgment skills participated in our study.</p><p><strong>Results: </strong>5053 (a boy-to-girl ratio of 1.13:1 and a median age of 5 years) from 6200 individuals admitted to the pediatric outpatient department were enrolled in the study. The mask-wearing time increased in parallel with age. Children aged 3-5 years wore masks more correctly (χ<sup>2</sup> = 41.591, P < 0.05), complained more about the discomfort (χ<sup>2</sup> = 193.871, P < 0.05), and their parents/caregivers were significantly better aware of the preventive effect of masks on respiratory disease (χ<sup>2</sup> = 19.501, P < 0.05) than parents/caregivers of other age groups. Masks designed for children were more used by those aged 3-5 years in outdoor settings. The commonest adverse events of mask-wearing were respiratory symptoms (61.2%), followed by dermatological symptoms (28.9%) and psychological symptoms (19.7%). Girls wore masks for a longer time and more correctly (χ<sup>2</sup> = 10.598, P < 0.05) than boys. Compared with the pre-COVID-19 pandemic, wearing masks could significantly decrease the median frequency of respiratory infections during the COVID-19 pandemic (2[1-4] vs 3[2-4]; z = -2.692, P < 0.05).</p><p><strong>Conclusions: </strong>Wearing proper and well-fitted masks could significantly protect children from respiratory infections in a crowded or densely populated indoor environment during the COVID-19 pandemic. However, mask-associated adverse events, particularly in psychological symptoms, are needed to draw adequate attention, calling for early identifications and psychological interventions.</p>","PeriodicalId":11707,"journal":{"name":"Environmental Health and Preventive Medicine","volume":"29 ","pages":"60"},"PeriodicalIF":4.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11551440/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142575807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Seasonal variations of the prevalence of metabolic syndrome and its markers using big-data of health check-ups. 利用健康体检大数据研究代谢综合征及其标志物发病率的季节性变化。
IF 4 3区 医学
Environmental Health and Preventive Medicine Pub Date : 2024-01-01 DOI: 10.1265/ehpm.23-00216
Hiroe Seto, Hiroshi Toki, Shuji Kitora, Asuka Oyama, Ryohei Yamamoto
{"title":"Seasonal variations of the prevalence of metabolic syndrome and its markers using big-data of health check-ups.","authors":"Hiroe Seto, Hiroshi Toki, Shuji Kitora, Asuka Oyama, Ryohei Yamamoto","doi":"10.1265/ehpm.23-00216","DOIUrl":"10.1265/ehpm.23-00216","url":null,"abstract":"<p><strong>Background: </strong>It is crucial to understand the seasonal variation of Metabolic Syndrome (MetS) for the detection and management of MetS. Previous studies have demonstrated the seasonal variations in MetS prevalence and its markers, but their methods are not robust. To clarify the concrete seasonal variations in the MetS prevalence and its markers, we utilized a powerful method called Seasonal Trend Decomposition Procedure based on LOESS (STL) and a big dataset of health checkups.</p><p><strong>Methods: </strong>A total of 1,819,214 records of health checkups (759,839 records for men and 1,059,375 records for women) between April 2012 and December 2017 were included in this study. We examined the seasonal variations in the MetS prevalence and its markers using 5 years and 9 months health checkup data and STL analysis. MetS markers consisted of waist circumference (WC), systolic blood pressure (SBP), diastolic blood pressure (DBP), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), fasting plasma glucose (FPG).</p><p><strong>Results: </strong>We found that the MetS prevalence was high in winter and somewhat high in August. Among men, MetS prevalence was 2.64 ± 0.42 (mean ± SD) % higher in the highest month (January) than in the lowest month (June). Among women, MetS prevalence was 0.53 ± 0.24% higher in the highest month (January) than in the lowest month (June). Additionally, SBP, DBP, and HDL-C exhibited simple variations, being higher in winter and lower in summer, while WC, TG, and FPG displayed more complex variations.</p><p><strong>Conclusions: </strong>This finding, complex seasonal variations of MetS prevalence, WC, TG, and FPG, could not be derived from previous studies using just the mean values in spring, summer, autumn and winter or the cosinor analysis. More attention should be paid to factors affecting seasonal variations of central obesity, dyslipidemia and insulin resistance.</p>","PeriodicalId":11707,"journal":{"name":"Environmental Health and Preventive Medicine","volume":"29 ","pages":"2"},"PeriodicalIF":4.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10808004/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139512124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Challenges in health risk assessment of multiple chemical exposures in epidemiological studies. 流行病学研究中多重化学品暴露的健康风险评估挑战。
IF 4.7 3区 医学
Environmental Health and Preventive Medicine Pub Date : 2024-01-01 DOI: 10.1265/ehpm.23-00312
Chiharu Tohyama, Yasushi Honda
{"title":"Challenges in health risk assessment of multiple chemical exposures in epidemiological studies.","authors":"Chiharu Tohyama, Yasushi Honda","doi":"10.1265/ehpm.23-00312","DOIUrl":"10.1265/ehpm.23-00312","url":null,"abstract":"","PeriodicalId":11707,"journal":{"name":"Environmental Health and Preventive Medicine","volume":"29 ","pages":"6"},"PeriodicalIF":4.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10898861/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139702136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A decrease in serum dihydrotestosterone levels in 9-year-old Vietnamese children from a dioxin exposure area. 来自二恶英暴露区的 9 岁越南儿童血清中二氢睾酮水平下降。
IF 4 3区 医学
Environmental Health and Preventive Medicine Pub Date : 2024-01-01 DOI: 10.1265/ehpm.24-00190
Oanh Thi Phuong Nguyen, Seijiro Honma, Phuc Duc Hoang, Khanh Van Nguyen, Anh Thai Le, Shoji F Nakayama, Manh Dung Ho, Viet Hoang Nguyen, Tung Van Dao, Nhu Duc Dang, Tan Thi Minh Ngo, Thuc Van Pham, Toan Van Ngo, Chi Van Vo, Hideaki Nakagawa, Teruhiko Kido
{"title":"A decrease in serum dihydrotestosterone levels in 9-year-old Vietnamese children from a dioxin exposure area.","authors":"Oanh Thi Phuong Nguyen, Seijiro Honma, Phuc Duc Hoang, Khanh Van Nguyen, Anh Thai Le, Shoji F Nakayama, Manh Dung Ho, Viet Hoang Nguyen, Tung Van Dao, Nhu Duc Dang, Tan Thi Minh Ngo, Thuc Van Pham, Toan Van Ngo, Chi Van Vo, Hideaki Nakagawa, Teruhiko Kido","doi":"10.1265/ehpm.24-00190","DOIUrl":"10.1265/ehpm.24-00190","url":null,"abstract":"<p><strong>Background: </strong>Dioxin is an environmental pollutant as well as an endocrine disruptor in humans. Our longitudinal study wants to clarify the relationship between dioxin exposure and endocrine disorders in children living in the Vietnamese dioxin hotspot.</p><p><strong>Method: </strong>Seventeen congeners of polychlorinated dibenzo-p-dioxins/polychlorinated dibenzo-furans (PCDDs/PCDFs) in maternal breast milk and seven serum steroid hormones in children of 43 and 46 mothers and their 9-year-old children from the non-exposure and the hotspot areas were measured, respectively. The steroid metabolic enzyme ratios were calculated based on the hormone level ratio.</p><p><strong>Results: </strong>Most dioxin/furan congeners and toxic equivalents (TEQs) levels were significantly higher in the hotspot than in the non-exposure area, except for 2,4,7,8-TeCDF. The height and weight of girls from the hotspot area were substantially lower and inversely correlated with dioxin congener levels/total TEQs level dioxin. The dihydrotestosterone (DHT) levels in the hotspot were markedly lower than those in non-exposed in both genders. The cortisol concentrations were significantly higher in the hotspot than those from the non-exposure area only in the girls. The DHT/testosterone ratios that exhibited the 5α- or 5β-reductase activity declined by 50% in the hotspot area for both genders. The DHT levels showed strong inverse correlations with almost the PCDDs/PCDFs congeners and total TEQs dioxin in breast milk.</p><p><strong>Conclusions: </strong>This finding suggests that dioxin exposure in maternal breast milk might impact children's endocrine system until 9 years old, especially on the DHT biosynthesis.</p>","PeriodicalId":11707,"journal":{"name":"Environmental Health and Preventive Medicine","volume":"29 ","pages":"58"},"PeriodicalIF":4.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11524748/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142516358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Blood pressure, pulse rate, and skin temperature during hot-water bathing in real-world settings among community-dwelling older adults: the HEIJO-KYO Study. 社区老年人在实际环境中进行热水沐浴时的血压、脉搏和皮肤温度:HEIJO-KYO 研究。
IF 4.7 3区 医学
Environmental Health and Preventive Medicine Pub Date : 2024-01-01 DOI: 10.1265/ehpm.23-00320
Yoshiaki Tai, Kenji Obayashi, Kazuki Okumura, Yuki Yamagami, Keigo Saeki
{"title":"Blood pressure, pulse rate, and skin temperature during hot-water bathing in real-world settings among community-dwelling older adults: the HEIJO-KYO Study.","authors":"Yoshiaki Tai, Kenji Obayashi, Kazuki Okumura, Yuki Yamagami, Keigo Saeki","doi":"10.1265/ehpm.23-00320","DOIUrl":"10.1265/ehpm.23-00320","url":null,"abstract":"<p><strong>Background: </strong>Home hot-tub bathing substantially increases drowning mortality rates among older adults in Japan. Previous laboratory studies on hemodynamic responses during hot-tub bathing have been inconsistent depending on the thermal conditions. Furthermore, real-world hemodynamic changes that occur during bathing remain poorly understood. This study investigated the association between individual thermal states and hemodynamic parameters during hot-tub bathing among community-dwelling older adults.</p><p><strong>Methods: </strong>In this cross-sectional study conducted between January 2016 and April 2019, which involved 1,479 older adults (median [range] age, 68 [40-90] years), skin temperature on the abdominal surface was measured every minute. Ambulatory blood pressure and pulse rate were recorded at 15-min intervals for 24 h. Participants underwent simultaneous living room temperature measurements in their homes, and the time and methods of bathing were recorded. Associations between skin temperature and hemodynamic parameters during bathing and between the pre-bath living room temperature and in-bath maximum proximal skin temperature were evaluated using mixed-effects and linear regression models, respectively.</p><p><strong>Results: </strong>A 1 °C increase in skin temperature was significantly associated with a 2.41 mmHg (95% confidence interval [CI]: 2.03-2.79) increase in systolic blood pressure and a 2.99 bpm (95% CI: 2.66-3.32) increase in pulse rate, after adjusting for potential confounders, including age, sex, body mass index, antihypertensive medication use, dyslipidemia, diabetes, and living room and outdoor temperatures. Significant interactions were not observed between sex and skin temperature in relation to systolic blood pressure and pulse rate (P = 0.088 and 0.490, respectively). One standard deviation lower living room temperature before bathing was significantly associated with a 0.41 °C (95% CI: 0.35-0.47) higher maximum skin temperature during bathing.</p><p><strong>Conclusions: </strong>Our findings suggest that pre-bath cold exposure may increase the skin temperature during hot-tub bathing, possibly resulting in excessive hemodynamic changes. This provides a framework for future interventions that utilize pre-bath thermal conditions and bathing environments to prevent bath-related deaths.</p>","PeriodicalId":11707,"journal":{"name":"Environmental Health and Preventive Medicine","volume":"29 ","pages":"12"},"PeriodicalIF":4.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10937243/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140049022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Risk and attributable fraction estimation for the impact of exposure to compound drought and hot events on daily stroke admissions. 暴露于复合干旱和高温事件对每日中风入院人数影响的风险和可归因分数估计。
IF 4 3区 医学
Environmental Health and Preventive Medicine Pub Date : 2024-01-01 DOI: 10.1265/ehpm.24-00168
Hui Zhang, Xuezhu Li, Wenjin Shang, Tao Wu, Siyue Wang, Li Ling, Wensu Zhou
{"title":"Risk and attributable fraction estimation for the impact of exposure to compound drought and hot events on daily stroke admissions.","authors":"Hui Zhang, Xuezhu Li, Wenjin Shang, Tao Wu, Siyue Wang, Li Ling, Wensu Zhou","doi":"10.1265/ehpm.24-00168","DOIUrl":"10.1265/ehpm.24-00168","url":null,"abstract":"<p><strong>Background: </strong>The projection indicates that compound drought and hot events (CDHEs) will intensify, posing risks to cardiovascular health by potentially increasing stroke incidents. However, epidemiological evidence on this topic remains scarce. This study investigates the association between exposure to CDHEs and the risk of daily stroke admissions, specifically examining the effects on various stroke categories such as Subarachnoid Hemorrhage (SAH), Intracerebral Hemorrhage (ICH), Ischemic Stroke (IS), Transient Ischemic Attack (TIA), and other types of stroke.</p><p><strong>Methods: </strong>Data on daily stroke admissions from 2010 to 2015 were obtained from the Urban Employee Basic Medical Insurance (UEBMI) and Urban Resident Basic Medical Insurance (URBMI) claims databases in Guangzhou, China. Hot events were identified as days when the daily mean temperature exceeded the 75th percentile during the warm season (May to October) over the study period. The Standardized Precipitation Evapotranspiration Index (SPEI) was utilized to identify drought conditions, with thresholds set at -1 and -1.5 for low-severity and high-severity drought events, respectively. Through a generalized additive model (GAM), we analyzed the cumulative effects of CDHE exposure on daily stroke admissions and calculated the Attributable Fraction (AF) related to CDHEs.</p><p><strong>Results: </strong>The analysis included 179,963 stroke admission records. We observed a significant increase in stroke admission risks due to exposure to hot events coupled with high-severity drought conditions (RR = 1.18, 95%CI: 1.01-1.38), with IS being the most affected category (RR = 1.20, 95%CI: 1.03-1.40). The AF of total stroke admission attributed to hot events in conjunction with high-severity drought conditions was 24.40% (95%CI: 1.86%-50.20%).</p><p><strong>Conclusion: </strong>The combination of hot events with high-severity drought conditions is likely linked to an increased risk of stroke and IS admissions, which providing new insights into the impact of temperature and climate-related hazards on cardiovascular health.</p>","PeriodicalId":11707,"journal":{"name":"Environmental Health and Preventive Medicine","volume":"29 ","pages":"56"},"PeriodicalIF":4.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11524747/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142460854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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