Is Japan at low risk for PFAS immunotoxicity?: human biomonitoring study in contaminated areas in Japan.

IF 4 3区医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Environmental Health and Preventive Medicine Pub Date : 2024-01-01 DOI:10.1265/ehpm.24-00047

Zhaoqing Lyu, Kouji H Harada, Junko Kimura-Kuroda, Yasuharu Tokuda

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引用次数: 0

Abstract

Background: Per- and polyfluoroalkyl substances (PFAS) are now considered global contaminants posing health risks. Recent human biomonitoring data in Japan are presented.

Methods: Human biomonitoring data from Japan, dating back to 2000, were reviewed. In addition, 399 serum samples collected in a primary care clinic in Urayasu City, Okinawa Island-one of the highest PFAS-exposed areas in Japan-between 2021 and 2022 were analyzed. Serum levels of four PFAS were compared with risk levels based on the assessment by Sonne et al. and the European Food Safety Agency.

Results: The PFAS levels in the general population from various areas other than Hokkaido (16.1-43.5 ng/mL) are classified at moderate to severe risk for immunotoxicity based on the assessment.

Conclusions: A portion of the Japanese population has had high exposure to PFAS and was at high risk of immunotoxicity, and this situation remained in PFAS-contaminated areas in the 2020s.

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日本的全氟辛烷磺酸免疫毒性风险低吗？

背景：全氟烷基和多氟烷基物质 (PFAS) 现已被视为具有健康风险的全球性污染物。方法：对日本 2000 年以来的人体生物监测数据进行了回顾。此外，还分析了 2021 年至 2022 年期间在冲绳岛浦安市一家初级保健诊所采集的 399 份血清样本，浦安市是日本 PFAS 暴露最高的地区之一。根据 Sonne 等人和欧洲食品安全局的评估结果，将四种 PFAS 的血清水平与风险水平进行了比较：结果：根据评估结果，除北海道外，其他地区普通人群的 PFAS 水平（16.1-43.5 纳克/毫升）被归类为免疫毒性中度至重度风险：结论：一部分日本人接触过大量全氟辛烷磺酸，免疫毒性风险较高，这种情况在 2020 年代仍会在全氟辛烷磺酸污染地区持续存在。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Environmental Health and Preventive Medicine PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH -

CiteScore

7.90

自引率

2.10%

发文量

审稿时长

10 weeks

期刊介绍： The official journal of the Japanese Society for Hygiene, Environmental Health and Preventive Medicine (EHPM) brings a comprehensive approach to prevention and environmental health related to medical, biological, molecular biological, genetic, physical, psychosocial, chemical, and other environmental factors. Environmental Health and Preventive Medicine features definitive studies on human health sciences and provides comprehensive and unique information to a worldwide readership.