Environmental Health and Preventive Medicine最新文献

{"title":"Workplace adjustments equivalent to reasonable accommodations and workplace maladjustment in a general working population, with a focus on high autism spectrum disorder (ASD) and attention deficit/hyperactivity disorder (ADHD) traits.","authors":"Tomoko Suzuki, Michiko Nakazato, Toshiyuki Ohtani, Shunya Ikeda","doi":"10.1265/ehpm.26-00080","DOIUrl":"10.1265/ehpm.26-00080","url":null,"abstract":"<p><strong>Background: </strong>The potential effectiveness of reasonable accommodations for workers with autism spectrum disorder (ASD) and attention deficit/hyperactivity disorder (ADHD) has been reported, but quantitative evidence remains limited. It is also unclear whether ASD- or ADHD-equivalent workplace adjustments benefit workers with lower ASD or ADHD trait levels in the general population. This study aimed to quantitatively examine whether individuals with high or non-high levels of ASD or ADHD traits experience greater workplace maladjustment in environments without ASD- or ADHD-equivalent adjustments compared with those where such adjustments are provided.</p><p><strong>Methods: </strong>Participants were 1,000 randomly selected workers from across Japan who completed a self-administered online survey conducted as a cross-sectional study. Workplace adjustments equivalent to reasonable accommodations were identified from 14 examples drawn from two case collections published by the Ministry of Health, Labour and Welfare. ASD traits, ADHD traits, and workplace maladjustment were assessed using the Autism-Spectrum Quotient, the Adult ADHD Self-Report Scale, and the Social Adaptation Self-evaluation Scale, respectively. Logistic regression analysis was performed to estimate odds ratios and 95% confidence intervals for workplace maladjustment.</p><p><strong>Results: </strong>Among workers with high ASD or ADHD trait scores, the odds of workplace maladjustment were higher when ASD- or ADHD-equivalent adjustments were not provided than when such adjustments were available; a comparable but less pronounced association was also observed among those with non-high trait scores.</p><p><strong>Conclusions: </strong>These quantitative findings suggest that workplace adjustments equivalent to reasonable accommodations are associated with a lower risk of workplace maladjustment and improved workplace adaptation among employees with high ASD or ADHD trait levels, and may also be beneficial for those with milder traits.</p>","PeriodicalId":11707,"journal":{"name":"Environmental Health and Preventive Medicine","volume":"31 ","pages":"62"},"PeriodicalIF":2.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13617183/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148982331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LncRNA OIP5-AS1 knockdown is associated with attenuated nonylphenol-induced cardiac fibrosis.","authors":"Jie He, Jie Xu, Huawen Yu, Ya Luo, Kai Pan, Feng Li, Jie Yu","doi":"10.1265/ehpm.25-00436","DOIUrl":"10.1265/ehpm.25-00436","url":null,"abstract":"<p><strong>Background: </strong>Environmental endocrine disruptors (EEDs), endocrine-interfering pollutants, attract attention for potentially affecting heart diseases via epigenetics. Nonylphenol (NP), a classical representative of endocrine-disrupting chemicals, has previously been demonstrated by our research group to induce myocardial fibrosis in rats. LncRNA, a gene regulator, mediates EED-induced heart cell damage and fibrosis.</p><p><strong>Objective: </strong>This study aimed to investigate the role of long noncoding RNA OIP5 antisense RNA 1 (lncRNA OIP5-AS1) knockdown in NP-induced myocardial fibrosis.</p><p><strong>Methods: </strong>Small interfering RNA (siRNA) transfection was used to interfere with the expression of lncRNA OIP5-AS1 in H9C2 cells. Lactate dehydrogenase (LDH), cell Counting Kit-8 (CCK-8), transwell, quantitative real time polymerase chain reaction (qRT-PCR), and Western blot assays were employed to detect cell membrane integrity, proliferation, migration ability, and the expression of fibrosis-related genes/proteins in H9C2 cells. This process was also validated in Sprague Dawley (SD) rats.</p><p><strong>Results: </strong>The expression of fibrosis-related factor mRNA and proteins in H9C2 cells increased, and the expression of lncRNA OIP5-AS1 was significantly upregulated after 24 h of exposure to 70 µmol/L NP. The knockdown of lncRNA OIP5-AS1 did not show differential changes in LDH activity across treatment groups. However, the knockdown of lncRNA OIP5-AS1 significantly attenuated NP-induced proliferation and migration abilities of H9C2 cells and inhibited the increase in the expression of fibrosis-related factor mRNA/proteins caused by NP. This suggested that the interference with lncRNA OIP5-AS1 expression inhibited the NP-induced myocardial fibrosis in H9C2 cells. In vivo results suggested that NP exposure and isoproterenol hydrochloride groups in rats showed accumulation of myocardial collagen fibers in the interstitial space, increased distribution and content of collagen fibers, and elevated expression of fibrosis-related proteins. The distribution range, content of collagen fibers, and expression of fibrosis-related proteins significantly reduced in rats with lncRNA OIP5-AS1 knockdown exposed to NP compared with those in the NP group.</p><p><strong>Conclusions: </strong>The expression of lncRNA OIP5-AS1 was upregulated in NP-treated H9C2 cells, rat hearts, and myocardial fibrosis model rats. Knockdown of lncRNA OIP5-AS1 was associated with attenuated NP-induced myocardial fibrosis and reduced collagen deposition.</p>","PeriodicalId":11707,"journal":{"name":"Environmental Health and Preventive Medicine","volume":"31 ","pages":"39"},"PeriodicalIF":2.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13366185/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148316355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between maternal exposure to per- and polyfluoroalkyl substances and functional constipation in children at 3 and 4 years: the Japan Environment and Children's Study.","authors":"Kohei Hasegawa, Yuji Inaba, Shoji Saito, Takumi Shibazaki, Margareta Laurence Pisonningtyas, Shoji F Nakayama, Michihiro Kamijima, Teruomi Tsukahara, Tetsuo Nomiyama","doi":"10.1265/ehpm.25-00399","DOIUrl":"10.1265/ehpm.25-00399","url":null,"abstract":"<p><strong>Background: </strong>Research over the past decade has indicated that exposure to per- and polyfluoroalkyl substances (PFAS) disrupts the intestinal barrier, potentially contributing to the development of gastrointestinal disorders. More recently, constipation has been hypothesized as one such outcome. However, epidemiological studies examining this association remain limited.</p><p><strong>Methods: </strong>We analyzed data from 17,686 mothers and their children from the Japan Environment and Children's Study, a Japanese birth cohort study. We used maternal plasma samples collected during pregnancy to determine PFAS concentrations. Of the 28 PFAS compounds analyzed, we included seven compounds that were quantified in more than 80% of the samples. We assessed functional constipation in children at ages 3 and 4 using caregiver-completed questionnaires based on the Rome III criteria. Logistic regression models were used to examine associations between maternal PFAS concentrations and childhood functional constipation, applying a Bonferroni-corrected significance threshold of P < 0.0035 to account for multiple comparisons.</p><p><strong>Results: </strong>Functional constipation was observed in 11.3% of children at age 3 and 9.8% at age 4. After adjusting for potential confounders, we observed no significant associations between any of the seven maternal PFAS concentrations and functional constipation in children at 3 years of age. However, at 4 years, perfluorooctanoic acid (PFOA) concentrations were significantly associated with functional constipation, with an adjusted odds ratio of 1.13 (95% confidence interval: 1.05-1.21, P = 0.00057) per doubling of concentration. The remaining six PFAS compounds showed no significant associations at 4 years.</p><p><strong>Conclusions: </strong>The single positive association between maternal PFOA concentration and functional constipation at 4 years of age is unlikely to reflect a true causal relationship, given limited biological plausibility. Our results do not provide evidence of an association between prenatal PFAS exposure and functional constipation in children, although further investigation is warranted.</p>","PeriodicalId":11707,"journal":{"name":"Environmental Health and Preventive Medicine","volume":"31 ","pages":"34"},"PeriodicalIF":2.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13222743/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147981103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health information sources and behaviour changes in a community population: a longitudinal study.","authors":"Yoshitomo Fujita, Sachie Mori, Takehiro Michikawa, Haruhiko Imamura, Minami Sugimoto, Keiko Asakura, Yuji Nishiwaki","doi":"10.1265/ehpm.26-00060","DOIUrl":"10.1265/ehpm.26-00060","url":null,"abstract":"<p><strong>Background: </strong>Accessible and trustworthy health information sources support informed decisions. Longitudinal evidence on how health information sources influence behavioural changes in community-dwelling populations remains limited. Thus, we examined associations between health information sources and behaviour changes in walking time, balanced meal consumption, and smoking cessation.</p><p><strong>Methods: </strong>Baseline (2021) and follow-up (2023) survey questionnaires were distributed to residents randomly selected from the 18 residential areas. Health information sources were classified into five categories: print media, television (TV) and radio, the Internet, family and friends, and professionals. Desirable health behaviours were defined as walking for ≥60 min/day; consuming ≥2 meals per day comprising staple grains, main dishes, and side items (SMS); and smoking cessation. Meeting these criteria was classified as good; not meeting them as poor. Improvement was defined as poor at baseline and good at follow-up. Maintenance was defined as good at both surveys. Improvement analyses included participants with poor baseline conditions. Maintenance analyses included those with good baseline conditions. Associations were analysed using multilevel modified Poisson regression models, accounting for clustering within residential areas and adjusting for covariates. Risk ratios (RRs) and 95% confidence intervals (95% CIs) were calculated.</p><p><strong>Results: </strong>Of the 12 119 baseline participants, 6620 (54.6%) completed the follow-up. The most common health information sources were TV and radio (68.5%), the Internet (56.8%), and print media (48.9%). Use of family and friends as information sources was associated with improvement in walking time (RR: 1.19; 95% CI: 1.02-1.39), as was use of professionals (RR: 1.15; 95% CI: 1.03-1.28). Professionals showed a marginal association with sustained walking time (RR: 1.07; 95% CI: 0.99-1.15). TV and radio was associated with improvement in SMS meal consumption (RR: 1.13; 95% CI: 1.02-1.26), while print media was associated with maintenance of SMS meal consumption (RR: 1.05; 95% CI: 1.01-1.08). No sources were related to smoking cessation.</p><p><strong>Conclusions: </strong>Health information sources showed distinct associations with improved and maintained health behaviours. Interpersonal sources were relevant for improving walking time, while mass media were linked to dietary improvement and maintenance. These findings suggest tailoring health communication strategies to specific health behaviours.</p>","PeriodicalId":11707,"journal":{"name":"Environmental Health and Preventive Medicine","volume":"31 ","pages":"48"},"PeriodicalIF":2.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13413660/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148455022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social capital and the number of children's cafeterias (kodomo shokudo) in Japan: a longitudinal ecological analysis.","authors":"Hiroshi Murayama, Takumi Suda, Takahiro Tabuchi","doi":"10.1265/ehpm.25-00366","DOIUrl":"10.1265/ehpm.25-00366","url":null,"abstract":"<p><strong>Background: </strong>In Japan, community-driven dining spaces known as children's cafeterias (kodomo shokudo) have increased rapidly. Despite their rapid expansion, the role of social environmental factors in the development of children's cafeterias, particularly social capital, has received limited empirical attention. We examined the association between social capital and changes in the number of children's cafeterias in Japan.</p><p><strong>Methods: </strong>We conducted a longitudinal ecological study. The outcome was the change in the number of children's cafeterias per municipality between 2020 and 2022. Social capital indicators (trust in neighbors, norm of reciprocity, trust in the national government, neighborhood ties, and social participation) were derived from a nationwide internet survey.</p><p><strong>Results: </strong>A total of 512 local municipalities were analyzed. Multiple regression analyses showed that higher neighborhood trust was positively associated with increases in the number of children's cafeterias, whereas denser neighborhood ties were inversely associated with such increases.</p><p><strong>Conclusions: </strong>The findings suggest that cognitive and structural dimensions of social capital may operate differently in the diffusion of children's cafeterias. These results indicate that community social contexts are associated with the spread of child-focused initiatives.</p>","PeriodicalId":11707,"journal":{"name":"Environmental Health and Preventive Medicine","volume":"31 ","pages":"49"},"PeriodicalIF":2.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13413657/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148455016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patterns of daily ambulatory activity and the onset of metabolic syndrome in middle-aged and older Japanese women: the Toon Health Study.","authors":"Naofumi Yamamoto, Koutatsu Maruyama, Isao Saito, Kiyohide Tomooka, Takeshi Tanigawa, Ryoichi Kawamura, Yasunori Takata, Haruhiko Osawa","doi":"10.1265/ehpm.24-00313","DOIUrl":"10.1265/ehpm.24-00313","url":null,"abstract":"<p><strong>Background: </strong>This cohort study aimed to identify the accumulation patterns of objectively measured ambulatory activity (AA) variables in the middle-aged and older Japanese women and examine the relationship of these derivative patterns with onset of metabolic syndrome (MetS).</p><p><strong>Methods: </strong>A total of 794 women (mean age: 56.2 years) provided objectively assessed AA data using a uniaxial accelerometer. The number of steps, time accumulated in light-intensity AA (LIAA) and moderate-to-vigorous intensity AA (MVAA) and the ratio of MVAA to total AA (LIAA + MVAA) were calculated. Latent profile analysis was used to identify participant groups based on their distinct AA patterns. Logistic regression models were used to assess the association of groups with the onset of MetS after adjusting for age, sex, education, alcohol habit, smoking habit, energy intake, and the number of MetS components present at baseline.</p><p><strong>Results: </strong>Four distinct groups were identified: Group A had low levels of the AA variable; group B accumulated a certain number or more steps primarily through MVAA; group C accumulated a certain number or more steps primarily through LIAA; and group D had high level of the AA variables. Over the course of the 5-year follow-up period, 61 participants (7.7%) developed MetS. The multivariate-adjusted odds ratio (95% confidence interval) for onset of MetS in groups B, C, and D relative to group A were 0.416 (0.166-1.218), 0.451 (0.223-0.914), and 0.933 (0.365-2.382), respectively. Group C had a significantly lower odds ratio of MetS onset than group A.</p><p><strong>Conclusion: </strong>AA patterns accumulating a certain number or more steps, regardless of the intensity of AA, may help reduce the risk of MetS compared to inactive AA patterns.</p>","PeriodicalId":11707,"journal":{"name":"Environmental Health and Preventive Medicine","volume":"30 ","pages":"11"},"PeriodicalIF":4.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11875726/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of ethylene oxide exposure and obstructive sleep apnea.","authors":"Shanni Ma, Shangfen Xie","doi":"10.1265/ehpm.24-00248","DOIUrl":"10.1265/ehpm.24-00248","url":null,"abstract":"<p><strong>Background: </strong>Ethylene oxide (EO) is a widely utilized industrial compound known to pose health hazards. Although its carcinogenic characteristics have been thoroughly investigated, recent findings indicate possible links to respiratory disease. The correlation between EO exposure and the likelihood of developing obstructive sleep apnea (OSA) in individuals remains unclear. The study aimed to explore the association between EO exposure and OSA within the broader US population.</p><p><strong>Methods: </strong>From 2015 to 2020, 4355 participants were analyzed cross-sectionally in the National Health and Nutrition Examination Survey (NHANES). As the primary indicator of EO exposure, hemoglobin adducts of EO (HbEO) were used in this study. The relationship between EO exposure and OSA prevalence was assessed using weighted multivariable regression analysis and smoothing curve fitting. Using subgroup analysis and interaction tests, we investigated whether this association remained consistent across populations.</p><p><strong>Results: </strong>According to the study, higher HbEO level was positively correlated with a higher prevalence of OSA. Compared to the first HbEO quartile (Q1), participants within the highest quartile (Q4) presented a higher OSA prevalence in the fully model (OR = 1.32, 95% CI: 1.08-1.62, P = 0.01, P for trend = 0.001). This correlation was particularly evident among females and individuals who are insufficiently physically active.</p><p><strong>Conclusions: </strong>This research found a positive relationship between the extent of exposure to EO and OSA prevalence among a representative sample of Americans.</p>","PeriodicalId":11707,"journal":{"name":"Environmental Health and Preventive Medicine","volume":"30 ","pages":"9"},"PeriodicalIF":4.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11839282/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lead exposure promotes NF2-wildtype meningioma cell proliferation through the Merlin-Hippo signaling pathway.","authors":"Nenghua Zhang, Xiaohua Shen, Yunnong Yu, Long Xu, Zheng Wang, Jia Zhu","doi":"10.1265/ehpm.24-00216","DOIUrl":"10.1265/ehpm.24-00216","url":null,"abstract":"<p><strong>Background: </strong>Lead is a persistent inorganic environmental pollutant with global implication for human health. Among the diseases associated with lead exposure, the damage to the central nervous system has received considerable attention. It has been reported that long-term lead exposure increases the risk of meningioma; however, the underlying mechanism remains poorly understood. Clinical studies have indicated that loss-of-function and mutations in the neurofibromin-2 (NF2) gene play a crucial role in promoting meningioma formation.</p><p><strong>Methods: </strong>The effect of Pb on meningioma were tested in-vitro and in-vivo. Two human meningioma cell lines were used in this study, including NF2-wildtype IOMM-Lee cell and NF2-null CH157-MN cell. Cell viability, cell cycle and cell size were examined after Pb exposure. The expression of Merlin, mammalian sterile 20-like kinases 1 and 2 (MST1/2) and Yes-associated protein (YAP) from these two meningioma cells were analyzed by Western blot. A xenograft mouse model was constructed by subcutaneous injection of IOMM-Lee meningioma cells.</p><p><strong>Results: </strong>This study demonstrated that treatment with lead induce dose-dependent proliferation in IOMM-Lee cell (with an EC₅₀ value of 19.6 µM). Moreover, IOMM-Lee cell exhibited augmented cell size in conjunction with elevated levels of phosphorylated histone H3, indicative of altered cell cycle progression resulting from lead exposure. However, no significant change was observed in the CH157-MN cell. Additionally, the Merlin-Hippo signaling pathway was inactivated with decreased Merlin and phosphorylation levels of MST1/2 and YAP, leading to increased YAP nuclear translocation in IOMM-Lee cells. However, there was no change in the Merlin-Hippo signaling pathway in CH157-MN cells after lead treatment. The administration of Pb resulted in an acceleration of the subcutaneous IOMM-Lee meningioma xenograft growth in mice.</p><p><strong>Conclusions: </strong>Overall, the current study elucidates the potential mechanism by which lead exposure promotes the proliferation of meningioma with NF2 expression for the first time.</p>","PeriodicalId":11707,"journal":{"name":"Environmental Health and Preventive Medicine","volume":"30 ","pages":"8"},"PeriodicalIF":4.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11790403/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143078987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between maternal distress during pregnancy and lower 5-min-Apgar score of the offspring: the Japan Environment and Children's Study.","authors":"Gita Nirmala Sari, Satoyo Ikehara, Kanami Tanigawa, Yoko Kawanishi, Ehab S Eshak, Tadashi Kimura, Tomotaka Sobue, Hiroyasu Iso","doi":"10.1265/ehpm.24-00305","DOIUrl":"https://doi.org/10.1265/ehpm.24-00305","url":null,"abstract":"<p><strong>Background: </strong>Although the influence of maternal distress during pregnancy on newborn Apgar scores has been studied in various populations, there is limited research specifically addressing this issue among Asian women. This study of Japanese women aims to investigate the association between maternal distress during pregnancy and the risk of a low 5-min-Apgar score among newborns.</p><p><strong>Methods: </strong>We analyzed data from 87,765 mother-newborn pairs in the Japan Environment and Children's Study. Using multivariable logistic regression, we estimated odds ratios (OR) and 95% confidence intervals (CI) for low Apgar scores (<7) at 5 minutes about maternal distress during early and mid-late pregnancy, as measured by the Kessler Psychological Distress Scale (K6). Apgar scores were obtained from newborns' medical records.</p><p><strong>Results: </strong>A higher risk of low Apgar score in newborns at 5 minutes was found in mothers with moderate to severe distress than in those with low distress during mid-late pregnancy. The adjusted OR (95% CI) was 1.22 (1.05-1.42) for moderate distress (K6 = 5-12) and 1.42 (1.00-2.01) for severe distress compared to low distress (p for trend = 0.002). The positive association between maternal distress and the risk of low Apgar score was observed in preterm birth (<37 weeks) and low birth weight (<2,500 g) but not in term birth and normal birth weight.</p><p><strong>Conclusion: </strong>Maternal distress during mid-late pregnancy was positively associated with the risk of low Apgar score of newborns, specifically in preterm birth and low birth weight.</p>","PeriodicalId":11707,"journal":{"name":"Environmental Health and Preventive Medicine","volume":"30 ","pages":"25"},"PeriodicalIF":4.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12006027/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143970743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influences of radiographic silicosis and drug supervisor on the development of multi drug resistant-tuberculosis in West Java, Indonesia.","authors":"Leli Hesti Indriyati, Masamitsu Eitoku, Naw Awn J-P, Miki Nishimori, Norihiko Hamada, Neni Sawitri, Narufumi Suganuma","doi":"10.1265/ehpm.24-00169","DOIUrl":"10.1265/ehpm.24-00169","url":null,"abstract":"<p><strong>Background: </strong>Indonesia is among countries with a high incidence of multi drug-resistant tuberculosis (MDR-TB) globally. In this study, we aim to determine the prevalence of silico-tuberculosis among TB patients and to investigate the association of radiographic silicosis and the role of drug supervisor as well as other socio-clinical factors, in the development of MDR-TB in Indonesia.</p><p><strong>Methods: </strong>A hospital-based study in West Java among 148 MDR-TB patients (case) and 164 drug-sensitive/DS-TB patients (control) was conducted. Chest x-rays were evaluated by two radiologists and one NIOSH B reader according to the ILO Classification. Face-to-face interviews were conducted using structured questionnaires to collect patients' information, including the task of drug supervisor.</p><p><strong>Results: </strong>Findings indicate that supportive drug supervisor reduces the risk of developing MDR-TB, but silicosis showed no significant association. Nevertheless, in this study we found that 17 cases (5.4%) had silico-tuberculosis mostly exhibited as ILO profusion 3; predominated by q shape, 52.9% with large opacities and dominated by size A. Other factors significantly associated with the risk of developing MDR-TB were marital status, low income, longer traveling time to hospital, unsuccessful previous treatment and suffering drug side effects.</p><p><strong>Conclusion: </strong>This study reveals that one of preventive healthcare strategy to protect TB patients from developing MDR-TB is supportive drug supervisor. While, the development of MDR-TB was not significantly influenced by silicosis; however, there is a notable prevalence of silicosis as determined by chest radiography, highlighting the critical need for dust control, occupational hygiene, and health screening for high-risk populations.</p>","PeriodicalId":11707,"journal":{"name":"Environmental Health and Preventive Medicine","volume":"30 ","pages":"20"},"PeriodicalIF":4.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11955800/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}