Drug Delivery最新文献_第5页

Photo-crosslinkable polyester microneedles as sustained drug release systems toward hypertrophic scar treatment. 光交联聚酯微针作为药物持续释放系统用于增生性疤痕治疗。

IF 6 2区医学

Drug Delivery Pub Date : 2024-12-01 Epub Date: 2024-02-29 DOI: 10.1080/10717544.2024.2305818

Anna Szabó, Ignace De Decker, Sam Semey, Karel E Y Claes, Phillip Blondeel, Stan Monstrey, Jo Van Dorpe, Sandra Van Vlierberghe

{"title":"Photo-crosslinkable polyester microneedles as sustained drug release systems toward hypertrophic scar treatment.","authors":"Anna Szabó, Ignace De Decker, Sam Semey, Karel E Y Claes, Phillip Blondeel, Stan Monstrey, Jo Van Dorpe, Sandra Van Vlierberghe","doi":"10.1080/10717544.2024.2305818","DOIUrl":"10.1080/10717544.2024.2305818","url":null,"abstract":"Burn injuries can result in a significant inflammatory response, often leading to hypertrophic scarring (HTS). Local drug therapies e.g. corticoid injections are advised to treat HTS, although they are invasive, operator-dependent, extremely painful and do not permit extended drug release. Polymer-based microneedle (MN) arrays can offer a viable alternative to standard care, while allowing for direct, painless dermal drug delivery with tailorable drug release profile. In the current study, we synthesized photo-crosslinkable, acrylate-endcapped urethane-based poly(ε-caprolactone) (AUP-PCL) toward the fabrication of MNs. Physico-chemical characterization (1H-NMR, evaluation of swelling, gel fraction) of the developed polymer was performed and confirmed successful acrylation of PCL-diol. Subsequently, AUP-PCL, and commercially available PCL-based microneedle arrays were fabricated for comparative evaluation of the constructs. Hydrocortisone was chosen as model drug. To enhance the drug release efficiency of the MNs, Brij®35, a nonionic surfactant was exploited. The thermal properties of the MNs were evaluated via differential scanning calorimetry. Compression testing of the arrays confirmed that the MNs stay intact upon applying a load of 7 N, which correlates to the standard dermal insertion force of MNs. The drug release profile of the arrays was evaluated, suggesting that the developed PCL arrays can offer efficient drug delivery for up to two days, while the AUP-PCL arrays can provide a release up to three weeks. Finally, the insertion of MN arrays into skin samples was performed, followed by histological analysis demonstrating the AUP-PCL MNs outperforming the PCL arrays upon providing pyramidical-shaped perforations through the epidermal layer of the skin.","PeriodicalId":11679,"journal":{"name":"Drug Delivery","volume":"31 1","pages":"2305818"},"PeriodicalIF":6.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10956933/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139995927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Statement of Retraction. 撤回声明。

IF 6.5 2区医学

Drug Delivery Pub Date : 2024-12-01 Epub Date: 2021-01-20 DOI: 10.1080/10717544.2021.1868133

引用次数: 0

Retraction. 撤回。

IF 6 2区医学

Drug Delivery Pub Date : 2024-12-01 Epub Date: 2022-12-28 DOI: 10.1080/10717544.2022.2157154

引用次数: 0

Enhanced anti-glioma activity of annonaceous acetogenins based on a novel liposomal co-delivery system with ginsenoside Rh2. 基于新型脂质体与人参皂苷 Rh2 共同给药系统的壬基皂苷增强抗胶质瘤活性的研究

IF 6 2区医学

Drug Delivery Pub Date : 2024-12-01 Epub Date: 2024-03-31 DOI: 10.1080/10717544.2024.2324716

Hui Ao, Huizhu Song, Jing Li, Xiangtao Wang

{"title":"Enhanced anti-glioma activity of annonaceous acetogenins based on a novel liposomal co-delivery system with ginsenoside Rh2.","authors":"Hui Ao, Huizhu Song, Jing Li, Xiangtao Wang","doi":"10.1080/10717544.2024.2324716","DOIUrl":"10.1080/10717544.2024.2324716","url":null,"abstract":"Annonaceous acetogenins (ACGs) have potent anti-tumor activity, and the problems of their low solubility, hemolysis, and in vivo delivery have been solved by encapsulation into nanoparticles. However, the high toxicity still limits their application in clinic. In this paper, the co-delivery strategy was tried to enhance the in vivo anti-tumor efficacy and reduce the toxic effects of ACGs. Ginsenoside Rh2, a naturally derived biologically active compound, which was reported to have synergistic effect with paclitaxel, was selected to co-deliver with ACGs. And due to its similarity with cholesterol in chemical structure, the co-loading liposomes, (ACGs + Rh2)-Lipo, were successfully constructed using Rh2 instead of cholesterol as the membrane material. The obtained (ACGs + Rh2)-Lipo and ACGs-Lipo had similar mean particle size (about 80 nm), similar encapsulation efficiency (EE, about 97%) and good stability. The MTS assay indicated that (ACGs + Rh2)-Lipo had stronger toxicity in vitro. In the in vivo study, in contrast to ACGs-Lipo, (ACGs + Rh2)-Lipo demonstrated an improved tumor targetability (3.3-fold in relative tumor targeting index) and significantly enhanced the antitumor efficacy (tumor inhibition rate, 72.9 ± 5.4% vs. 60.5 ± 5.4%, p < .05). The body weight change, liver index, and spleen index of tumor-bearing mice showed that Rh2 can attenuate the side effects of ACGs themselves. In conclusion, (ACGs + Rh2)-Lipo not only alleviated the toxicity of ACGs to the organism, but also enhanced their anti-tumor activity, which is expected to break through their bottleneck.","PeriodicalId":11679,"journal":{"name":"Drug Delivery","volume":"31 1","pages":"2324716"},"PeriodicalIF":6.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10984232/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140331621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Disordered mesoporous silica particles: an emerging platform to deliver proteins to the lungs. 无序介孔二氧化硅颗粒：向肺部输送蛋白质的新兴平台。

IF 6.5 2区医学

Drug Delivery Pub Date : 2024-12-01 Epub Date: 2024-07-23 DOI: 10.1080/10717544.2024.2381340

Aura Rocío Hernández, Ekaterina Bogdanova, Jesus E Campos Pacheco, Vitaly Kocherbitov, Mikael Ekström, Georgia Pilkington, Sabrina Valetti

{"title":"Disordered mesoporous silica particles: an emerging platform to deliver proteins to the lungs.","authors":"Aura Rocío Hernández, Ekaterina Bogdanova, Jesus E Campos Pacheco, Vitaly Kocherbitov, Mikael Ekström, Georgia Pilkington, Sabrina Valetti","doi":"10.1080/10717544.2024.2381340","DOIUrl":"10.1080/10717544.2024.2381340","url":null,"abstract":"Pulmonary delivery and formulation of biologics are among the more complex and growing scientific topics in drug delivery. We herein developed a dry powder formulation using disordered mesoporous silica particles (MSP) as the sole excipient and lysozyme, the most abundant antimicrobial proteins in the airways, as model protein. The MSP had the optimal size for lung deposition (2.43 ± 0.13 µm). A maximum lysozyme loading capacity (0.35 mg/mg) was achieved in 150 mM PBS, which was seven times greater than that in water. After washing and freeze-drying, we obtained a dry powder consisting of spherical, non-aggregated particles, free from residual buffer, or unabsorbed lysozyme. The presence of lysozyme was confirmed by TGA and FT-IR, while N2 adsorption/desorption and SAXS analysis indicate that the protein is confined within the internal mesoporous structure. The dry powder exhibited excellent aerodynamic performance (fine particle fraction <5 µm of 70.32%). Lysozyme was released in simulated lung fluid in a sustained kinetics and maintaining high enzymatic activity (71-91%), whereas LYS-MSP were shown to degrade into aggregated nanoparticulate microstructures, reaching almost complete dissolution (93%) within 24 h. MSPs were nontoxic to in vitro lung epithelium. The study demonstrates disordered MSP as viable carriers to successfully deliver protein to the lungs, with high deposition and retained activity.","PeriodicalId":11679,"journal":{"name":"Drug Delivery","volume":"31 1","pages":"2381340"},"PeriodicalIF":6.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11268259/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141747745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surface saturation of drug-loaded hollow manganese dioxide nanoparticles with human serum albumin for treating rheumatoid arthritis. 载药空心二氧化锰纳米粒子表面饱和人血清白蛋白用于治疗类风湿性关节炎。

IF 6.5 2区医学

Drug Delivery Pub Date : 2024-12-01 Epub Date: 2024-07-23 DOI: 10.1080/10717544.2024.2380538

Ming Jia, Wei Ren, Minrui Wang, Yan Liu, Chenglong Wang, Zongquan Zhang, Maochang Xu, Nianhui Ding, Chunhong Li, Hong Yang

{"title":"Surface saturation of drug-loaded hollow manganese dioxide nanoparticles with human serum albumin for treating rheumatoid arthritis.","authors":"Ming Jia, Wei Ren, Minrui Wang, Yan Liu, Chenglong Wang, Zongquan Zhang, Maochang Xu, Nianhui Ding, Chunhong Li, Hong Yang","doi":"10.1080/10717544.2024.2380538","DOIUrl":"10.1080/10717544.2024.2380538","url":null,"abstract":"Rheumatoid arthritis (RA) is a chronic inflammatory joint disease accompanied by energy depletion and accumulation of reactive oxygen species (ROS). Inorganic nanoparticles (NPs) offer great promise for the treatment of RA because they mostly have functions beyond being drug carriers. However, conventional nanomaterials become coated with a protein corona (PC) or lose their cargo prematurely in vivo, reducing their therapeutic efficacy. To avoid these problems, we loaded methotrexate (MTX) into hollow structured manganese dioxide nanoparticles (H-MnO2 NPs), then coated them with a 'pseudo-corona' of human serum albumin (HSA) at physiological concentrations to obtain HSA-MnO2@MTX NPs. Efficacy of MTX, MnO2@MTX, and HSA-MnO2@MTX NPs was compared in vitro and in vivo. Compared to MnO2@MTX, HSA-coated NPs were taken up better by lipopolysaccharide-activated RAW264.7 and were more effective at lowering levels of pro-inflammatory cytokines and preventing ROS accumulation. HSA-MnO2@MTX NPs were also more efficient at blocking the proliferation and migration of fibroblast-like synoviocytes from rats with collagen-induced arthritis. In this rat model, HSA-MnO2@MTX NPs showed better biodistribution than other treatments, specifically targeting the ankle joint. Furthermore, HSA-MnO2@MTX NPs reduced swelling in the paw, regulated pro-inflammatory cytokine production, and limited cartilage degradation and signs of inflammation. These results establish the therapeutic potential of HSA-MnO2@MTX NPs against RA.","PeriodicalId":11679,"journal":{"name":"Drug Delivery","volume":"31 1","pages":"2380538"},"PeriodicalIF":6.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11271085/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141751402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances of injectable in situ-forming hydrogels for preventing postoperative tumor recurrence. 用于预防术后肿瘤复发的可注射原位成形水凝胶的最新进展。

IF 6 2区医学

Drug Delivery Pub Date : 2024-09-10 DOI: 10.1080/10717544.2024.2400476

Zhanpeng Wang,Bingtao Zhai,Jing Sun,Xiaofei Zhang,Junbo Zou,Yajun Shi,Dongyan Guo

{"title":"Recent advances of injectable in situ-forming hydrogels for preventing postoperative tumor recurrence.","authors":"Zhanpeng Wang,Bingtao Zhai,Jing Sun,Xiaofei Zhang,Junbo Zou,Yajun Shi,Dongyan Guo","doi":"10.1080/10717544.2024.2400476","DOIUrl":"https://doi.org/10.1080/10717544.2024.2400476","url":null,"abstract":"The unavoidable residual tumor tissue from surgery and the strong aggressiveness of tumor cells pose challenges to the postoperative treatment of tumor patients, accompanied by in situ tumor recurrence and decreased quality of life. Therefore, there is an urgent need to explore appropriate postoperative therapeutic strategies to remove residual tumor cells after surgery to inhibit tumor recurrence and metastasis after surgery. In recent years, with the rapid development of biomedical materials, the study of local delivery systems as postoperative delivery of therapeutic agents has gradually attracted the attention of researchers. Injectable in situ-forming hydrogel is a locally administered agent injected in situ as a solution that can be loaded with various therapeutic agents and rapidly gels to form a semi-solid gel at the treatment site. This type of hydrogel tightly fills the surgical site and covers irregular excision surfaces. In this paper, we review the recent advances in the application of injectable in situ-forming hydrogels in postoperative therapy, focusing on the matrix materials of this type of hydrogel and its application in the postoperative treatment of different types of tumors, as well as discussing the challenges and prospects of its clinical application.","PeriodicalId":11679,"journal":{"name":"Drug Delivery","volume":"5 1","pages":"2400476"},"PeriodicalIF":6.0,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142222144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Self-micellizing solid dispersion of thymoquinone with enhanced biopharmaceutical and nephroprotective effects 具有增强生物制药和肾脏保护作用的胸腺醌自胶化固体分散体

IF 6 2区医学

Drug Delivery Pub Date : 2024-04-08 DOI: 10.1080/10717544.2024.2337423

Shimul Halder, Sanjida Afrose, Manik Chandra Shill, Nahid Sharmin, Patricia Prova Mollick, Madhabi Lata Shuma, Md. Abdul Muhit, S. M. Abdur Rahman

引用次数: 0

A mini-review on gene delivery technique using nanoparticles-mediated photoporation induced by nanosecond pulsed laser 纳秒脉冲激光诱导的纳米颗粒介导光穿透基因递送技术微型综述

IF 6 2区医学

Drug Delivery Pub Date : 2024-01-21 DOI: 10.1080/10717544.2024.2306231

Xiaofan Du, Meng Zhao, Le Jiang, Lihui Pang, Jing Wang, Yi Lv, Cuiping Yao, Rongqian Wu

引用次数: 0

Quality by design aided self-nano emulsifying drug delivery systems development for the oral delivery of Benidipine: Improvement of biopharmaceutical performance 通过设计提高质量，开发用于贝尼地平口服给药的自纳米乳化给药系统：改善生物制药性能