Endoscopy International Open最新文献

{"title":"Association of semaglutide with retained gastric contents on endoscopy: Retrospective analysis.","authors":"Garrick Han Gu, Connor Pauplis, Taylor Seacor, Deepika Devuni, Anita Krishnarao","doi":"10.1055/a-2550-1468","DOIUrl":"https://doi.org/10.1055/a-2550-1468","url":null,"abstract":"<p><strong>Background and study aims: </strong>We investigated the effect of semaglutide, a glucagon-like peptide-1 (GLP-1) agonist therapy, on retained gastric contents during endoscopy through a retrospective case-control study.</p><p><strong>Patients and methods: </strong>We performed a retrospective case-control study to evaluate the effect of semaglutide on rates of retained gastric contents (RGC) visualized during esophagogastroduodenoscopy (EGD). Cases and controls were matched using multidimensional propensity score matching: age, gender, body mass index, and EGD indication. Pairs were analyzed using McNemar testing and Mann-Whitney non-parametric tests.</p><p><strong>Results: </strong>Of the patients on GLP-1 therapy at time of EGD, 12.5% had RGC, compared with 1.3% in the control group (confidence interval [CI] 7.2% to 17.7%, <i>P</i> < 0.0001). Approximately 23% of patients prescribed GLP-1 therapy for weight loss had RGC at time of EGD compared with the control group (CI 13.4% to 32.6%, <i>P</i> < 0.0001). Only 2.6% of patients prescribed GLP-1 therapy for diabetes had RGC at time of EGD compared with the control group (CI -0.9% to 6.1%, <i>P</i> = 0.5). Patients receiving GLP-1 therapy with RGC at time of EGD did not differ from non-RGC patients in dosing of GLP-1 agonist ( <i>P</i> = 0.23) or duration of GLP-1 agonist use prior to EGD ( <i>P</i> = 0.98).</p><p><strong>Conclusions: </strong>Semaglutide use appears to increase risk of having retained gastric contents visualized during endoscopy. Patients on semaglutide for weight loss appear to have a greater risk of RGC compared with patients on semaglutide for glycemic control. This observation may have clinical implications for management of GLP-1 agonist use prior to endoscopy.</p>","PeriodicalId":11671,"journal":{"name":"Endoscopy International Open","volume":"13 ","pages":"a25501468"},"PeriodicalIF":2.2,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11996017/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143973124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of retained gastrointestinal debris during upper endoscopy.","authors":"Jake Sheraj Jacob, Jeffrey Than, Christine Tang, Joseph Cano, Rehman Sheikh, Sharon Wolfson, Aaron P Thrift, Uma Munnur, Robert J Sealock","doi":"10.1055/a-2544-2468","DOIUrl":"https://doi.org/10.1055/a-2544-2468","url":null,"abstract":"<p><strong>Background and study aims: </strong>Gastrointestinal debris retention (GIDR) during endoscopy can result in aborted procedures, intubation, and aspiration. GIDR has increased significance with uptake of glucagon-like peptide-1 receptor agonist (GLP-1RA) use. Outcome analysis is vital to risk-stratify patients with GIDR during endoscopy. Our study evaluated the effect of GIDR on endoscopic complications.</p><p><strong>Patients and methods: </strong>This was a retrospective review of patients who underwent endoscopy between May 2016 and December 2021 with documented GIDR. The study included 138 patients with GIDR and 275 controls. Propensity score matching between patients with GIDR and controls was performed in a 1:2 ratio based on age, sex, body mass index (BMI), and American Society of Anesthesiologists (ASA) status. T-tests and chi square tests were used to compare continuous and categorical variables.</p><p><strong>Results: </strong>The GIDR group was younger and had lower BMI, with no difference in sex, race, American Society of Anesthesiologists status, or use of monitored anesthesia care. GIDR was more frequently encountered when indications were abnormal imaging, pain, and pancreatico-biliary. Amount of GIDR was quantified as \"large\" in 37.7% of cases and size of debris was associated with rate of aborted procedures.</p><p><strong>Conclusions: </strong>Our study did not demonstrate a significant increase in post-procedure complications in patients with GIDR. Further, the GIDR group had higher rates of opiate use, which can guide stratification of retention risk.</p>","PeriodicalId":11671,"journal":{"name":"Endoscopy International Open","volume":"13 ","pages":"a25442468"},"PeriodicalIF":2.2,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11996021/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143969669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic ultrasound-guided therapies versus retrograde transvenous obliteration for gastric varices: Multicenter propensity matched analysis.","authors":"Suprabhat Giri, Ranjan Kumar Patel, Radhika Chavan, Bhavik Bharat Shah, Jimmy Narayan, Taraprasad Tripathy, Sushant Babbar, Lalit Garg, Rozil Gandhi, Karan Manoj Anandpara, Swati Das, Manjit Kanungo, Girish Kumar Pati, Hemanta K Nayak, Manas Kumar Panigrahi, Preetam Nath, Saroj Kanta Sahu, Dibya Lochan Praharaj, Bipadabhanjan Mallick, Sarat Chandra Panigrahi, Sanjay Rajput, Jimil Shah, Anil Chandra Anand, Manoj Kumar Sahu","doi":"10.1055/a-2549-1165","DOIUrl":"https://doi.org/10.1055/a-2549-1165","url":null,"abstract":"<p><strong>Background and study aims: </strong>Retrograde transvenous obliteration (RTO) is an established technique for managing fundal varices. Endoscopic ultrasound (EUS)-guided glue injection with or without coil is an alternate approach. The present study compared outcomes of EUS-guided therapies with RTO for managing fundal varices.</p><p><strong>Patients and methods: </strong>We retrospectively analyzed data from patients with fundal varices undergoing EUS-guided intervention or RTO at 10 tertiary centers in India and compared after propensity score matching. The primary outcome was variceal bleeding within 1 year. Secondary outcomes included procedure-related adverse events (AEs), variceal obliteration, reintervention, and mortality.</p><p><strong>Results: </strong>A total of 167 patients (EUS 108, RTO 59) were included, with 59 in each group after propensity score matching. Incidence of variceal bleeding (15.3% vs. 13.6%, <i>P</i> = 0.793) within 1 year was comparable between the groups. Procedure-related AEs were higher in the RTO group (22% vs. 5.1%, <i>P</i> = 0.007), primarily new onset or worsening of ascites. Variceal obliteration at 4 weeks was similar between groups (83.1% vs. 91.5%, <i>P</i> = 0.167). Although reintervention within 1 year of the index procedure (30.5% vs. 22.0%, <i>P</i> = 0.296) was comparable, the EUS group required more frequent reintervention for GVs (28.8% vs. 5.1%, <i>P</i> = 0.001), and the RTO group required more frequent reintervention for EVs (16.9% vs. 1.7%, <i>P</i> = 0.008).</p><p><strong>Conclusions: </strong>EUS-guided therapy offers a safe and effective alternative to RTO for managing fundal varices. Although reintervention rate for GVs were higher than for EUS, incidence of AEs and reintervention for EVs was higher with RTO.</p>","PeriodicalId":11671,"journal":{"name":"Endoscopy International Open","volume":"13 ","pages":"a25491165"},"PeriodicalIF":2.2,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11996024/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143973070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eye movement patterns associated with colorectal adenoma detection: Post hoc analysis of randomized controlled trial.","authors":"Fumiaki Ishibashi, Kosuke Okusa, Mizuki Nagai, Kentaro Mochida, Eri Ozaki, Sho Suzuki","doi":"10.1055/a-2549-1033","DOIUrl":"https://doi.org/10.1055/a-2549-1033","url":null,"abstract":"<p><strong>Background and study aims: </strong>The adenoma detection rate is higher among endoscopists who spend more time observing screen edges during colonoscopies. Nonetheless, eye movement parameters related to lesion detection remain unknown. This study aimed to determine the specific eye movement parameters related to colorectal adenoma detection, including the gaze rate in a particular area and eye movement speed.</p><p><strong>Patients and methods: </strong>This study was a post hoc analysis of a randomized controlled trial investigating the effect of modifying eye movements of endoscopists on colorectal adenoma detection. Gaze rate at a specific area and eye movement speed were calculated based on endoscopist gaze coordinates in each examination. Time required for observation and treatment of polyps was excluded. The lower peripheral area was defined as the bottom row when the screen was divided into 6×6 sections. These parameters were compared between patients with and without adenomas.</p><p><strong>Results: </strong>Five physicians performed 158 colonoscopies. The adenoma detection group exhibited a lower peripheral gaze rate (13.7% vs. 9.5%, <i>P</i> = 0.004) and smaller average eye movement distance (29.9 pixels/30 ms vs. 33.3 pixels/30 ms, <i>P</i> = 0.022). Logistic regression analysis showed that a lower peripheral gaze rate > 13.0% and an average eye movement distance <30 pixels/30 ms were increased independent predictors of adenoma detection ( <i>P</i> = 0.024, odds ratio [OR] 2.53, 95% confidence interval [CI] 1.71-3.28; <i>P</i> = 0.045, OR 4.57, 95% CI 1.03-20.2), whereas age, sex, and withdrawal time were not.</p><p><strong>Conclusions: </strong>Lower peripheral gaze rate and slow eye movement are associated with colorectal adenoma detection.</p>","PeriodicalId":11671,"journal":{"name":"Endoscopy International Open","volume":"13 ","pages":"a25491033"},"PeriodicalIF":2.2,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11996023/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143995133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Useful treatment selection strategy for endoscopic hemostasis in colonic diverticular bleeding according to endoscopic findings (with video).","authors":"Takaaki Kishino, Yoko Kitamura, Takashi Okuda, Naoki Okamoto, Takayuki Sawa, Maiko Yamakawa, Kazuyuki Kanemasa","doi":"10.1055/a-2569-9279","DOIUrl":"https://doi.org/10.1055/a-2569-9279","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1055/a-2471-1016.].</p>","PeriodicalId":11671,"journal":{"name":"Endoscopy International Open","volume":"13 ","pages":"a25699279"},"PeriodicalIF":2.2,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11996016/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143969667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Peroral endoscopic myotomy with fundoplication (POEM-F) for achalasia: Systematic review and meta-analysis.","authors":"Harishankar Gopakumar, Eugene Annor, Ishaan Vohra, Iman Andalib, Amy Tyberg, Avik Sarkar, Haroon Shahid, Mine Carames, Juan Carlos Carames, Giovanna Porfilio Gularte, Abed Al-Lehibi, Resheed Alkhiari, Amol Bapaye, Carlos Robles-Medranda, Michel Kahaleh","doi":"10.1055/a-2562-4787","DOIUrl":"https://doi.org/10.1055/a-2562-4787","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1055/a-2536-8132.].</p>","PeriodicalId":11671,"journal":{"name":"Endoscopy International Open","volume":"13 ","pages":"a25624787"},"PeriodicalIF":2.2,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11924297/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic submucosal dissection for high-risk lesions in the right colon: Limited benefits and significant challenges.","authors":"Francesco Vito Mandarino, Julia L Gauci, Sunil Gupta, Nicholas Burgess, Michael J Bourke","doi":"10.1055/a-2543-1484","DOIUrl":"10.1055/a-2543-1484","url":null,"abstract":"","PeriodicalId":11671,"journal":{"name":"Endoscopy International Open","volume":"13 ","pages":"a25431484"},"PeriodicalIF":2.2,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11922304/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of a higher-flexibility duodenal stent for palliation of gastric outlet obstruction.","authors":"Noa Eveline Adriana Kapteijn, Pauline A Zellenrath, Peter Siersema, Agnes N Reijm, Lydi Van Driel, Pieter J F de Jonge, Wim J Lammers, Judith Honing, Manon C W Spaander","doi":"10.1055/a-2539-9270","DOIUrl":"10.1055/a-2539-9270","url":null,"abstract":"<p><strong>Background and study aims: </strong>Duodenal self-expandable metallic stent (SEMS) placement is a common palliative treatment for malignant gastric outlet obstruction symptoms (GOOS). The higher flexibility of the WallFlex Duodenal Soft stent aims to ease stent placement and reduce adverse events (AE). This descriptive study compared the WallFlex Soft stent with other duodenal SEMS designs with regard to efficacy and safety.</p><p><strong>Patients and methods: </strong>Patients receiving the WallFlex Duodenal Soft stent as first-line treatment for GOOS were included in a prospective cohort (2019-2023). A retrospective cohort (1998-2019) with patients treated with other duodenal SEMS designs as first-line treatment for GOOS was used for comparison.</p><p><strong>Results: </strong>In the prospective cohort, 11 patients were treated with the WallFlex Duodenal Soft, achieving 100% technical and 82% clinical success rates. The retrospective cohort of 147 patients with various types of duodenal SEMS showed 97% technical and 86% clinical success. For the WallFlex Duodenal Soft vs. the other duodenal SEMS, the overall survival was 101 vs. 82 days and median symptom-free survival was 83 vs. 28 days. AE rates were 18% vs. 28%, respectively.</p><p><strong>Conclusions: </strong>The WallFlex Duodenal Soft stent effectively treats GOOS in palliative patients and seems to be associated with longer symptom-free survival and lower AE rates compared with previous duodenal SEMS designs.</p>","PeriodicalId":11671,"journal":{"name":"Endoscopy International Open","volume":"13 ","pages":"a25399270"},"PeriodicalIF":2.2,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11922175/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing diagnostics: ChatGPT-4 performance in ulcerative colitis endoscopic assessment.","authors":"Asaf Levartovsky, Ahmad Albshesh, Ana Grinman, Eyal Shachar, Adi Lahat, Rami Eliakim, Uri Kopylov","doi":"10.1055/a-2542-0943","DOIUrl":"10.1055/a-2542-0943","url":null,"abstract":"<p><strong>Background and study aims: </strong>The Mayo Endoscopic Subscore (MES) is widely utilized for assessing mucosal activity in ulcerative colitis (UC). Artificial intelligence has emerged as a promising tool for enhancing diagnostic precision and addressing interobserver variability. This study evaluated the diagnostic accuracy of ChatGPT-4, a multimodal large language model, in identifying and grading endoscopic images of UC patients using the MES.</p><p><strong>Patients and methods: </strong>Real-world endoscopic images of UC patients were reviewed by an expert consensus board. Each image was graded based on the MES. Only images that were uniformly graded were subsequently provided to three inflammatory bowel disease (IBD) specialists and ChatGPT-4. Severity gradings of the IBD specialists and ChatGPT-4 were compared with assessments made by the expert consensus board.</p><p><strong>Results: </strong>Thirty of 50 images were graded with complete agreement among the experts. Compared with the consensus board, ChatGPT-4 gradings had a mean accuracy rate of 78.9% whereas the mean accuracy rate for the IBD specialists was 81.1%. Between the two groups, there was no statistically significant difference in mean accuracy rates ( <i>P</i> = 0.71) and a high degree of reliability was found.</p><p><strong>Conclusions: </strong>ChatGPT-4 has the potential to assess mucosal inflammation severity from endoscopic images of UC patients, without prior configuration or fine-tuning. Performance rates were comparable to those of IBD specialists.</p>","PeriodicalId":11671,"journal":{"name":"Endoscopy International Open","volume":"13 ","pages":"a25420943"},"PeriodicalIF":2.2,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11922305/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implementing educational interventions and key performance measures sustains quality of endoscopic assessment in patients with Barrett's esophagus.","authors":"Deloshaan Subhaharan, Pradeep Kakkadasam Ramaswamy, Mark Jones, Sneha John","doi":"10.1055/a-2542-0618","DOIUrl":"10.1055/a-2542-0618","url":null,"abstract":"<p><strong>Background and study aims: </strong>Quality metrics for Barrett's esophagus (BE) are anticipated to improve outcomes for patients through earlier detection of neoplasia. The European Society of Gastrointestinal Endoscopy has developed guidelines to homogenize endoscopic quality in BE. Our study aimed to assess the impact of recommended key performance measures (KPMs) and their sustainability.</p><p><strong>Patients and methods: </strong>A single-center, retrospective study (Phase 1) was conducted over 8 weeks. The KPMs assessed were: 1) pre-procedure metrics including indication, consent, safety checklist (target of 100%); and 2) Prague classification, Seattle protocol, or targeted biopsies, inspection time of 1 minute per cm, advanced imaging and surveillance recommendations (target of 90%). Following baseline analysis, multimodal educational interventions were implemented and repeated at 6-month intervals. Repeat analysis was performed at 6 months and 1 and 3 years (Phases 2, 3 and 4 respectively).</p><p><strong>Results: </strong>In Phase 1, 39 patients with BE underwent endoscopy. Phase 2 evaluated 40 patients with BE. Phase 3 analyzed 59 patients with BE, and Phase 4 identified 34 patients with BE. Pre-procedure metrics were met in 100% of patients across the 3-year period. Baseline analysis displayed suboptimal performance at 45% to 75% for all other KPMs. However, after regular multimodal educational interventions, quality standards significantly improved and were able to be maintained over all phases, achieving pre-set targets of >9 0% for all KPMs except one.</p><p><strong>Conclusions: </strong>Sustaining improvements in quality metrics in Barrett's endoscopy is important. Our study suggests that regular, replicable education interventions have a positive effect and allow sustained long-term improvements in quality metrics.</p>","PeriodicalId":11671,"journal":{"name":"Endoscopy International Open","volume":"13 ","pages":"a25420618"},"PeriodicalIF":2.2,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11922174/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}